| 富达投资FMR LLC |
| <0.01% | <0.01% | #39 | $9,729.4万 | 283.0万股 | $8,705.8万 | 281.6万股 | +1.4万股+0.49% | 加仓 |
| TCG Crossover 管理TCG Crossover Management, LLC |
| 1% | 1.07% | #4 | $4,141.8万 | 120.5万股 | $3,724.3万 | 120.5万股 | 00.00% | 持仓不变 |
| 安本标准投资Aberdeen Group plc |
| 0.06% | 0.06% | #22 | $3,925.0万 | 114.2万股 | $3,529.4万 | 114.2万股 | 00.00% | 持仓不变 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #63 | $2,965.2万 | 86.3万股 | $2,659.3万 | 86.0万股 | +2,240股+0.26% | 加仓 |
| First Light Asset Management, LLC |
| 1.67% | 1.79% | #3 | $2,752.5万 | 80.1万股 | $2,002.2万 | 64.8万股 | +15.3万股+23.62% | 加仓 |
| 贝克兄弟顾问BAKER BROS. ADVISORS LP |
| 0.1% | 0.11% | #20 | $2,089.3万 | 60.8万股 | $1,878.7万 | 60.8万股 | 00.00% | 持仓不变 |
| 5AM Venture Management, LLC |
| 7.24% | 5.21% | #1 | $2,085.4万 | 60.7万股 | $1,875.2万 | 60.7万股 | 00.00% | 持仓不变 |
| BRAIDWELL LP |
| 0.76% | 0.87% | #6 | $2,051.8万 | 59.7万股 | $2,618.5万 | 84.7万股 | -25.0万股-29.54% | 减仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #66 | $1,680.3万 | 48.9万股 | $1,463.7万 | 47.4万股 | +1.5万股+3.23% | 加仓 |
| Vestal Point 资本Vestal Point Capital, LP |
| 0.34% | 0.28% | #8 | $1,460.9万 | 42.5万股 | $1,013.8万 | 32.8万股 | +9.7万股+29.57% | 加仓 |
| Bollard Group LLC |
| 0.32% | 0.29% | #9 | $1,041.4万 | 30.3万股 | $936.4万 | 30.3万股 | 00.00% | 持仓不变 |
| 肯尼迪资本管理KENNEDY CAPITAL MANAGEMENT LLC |
| 0.17% | 0.19% | #15 | $970.1万 | 28.2万股 | $886.1万 | 28.7万股 | -4,480股-1.56% | 减仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #60 | $929.9万 | 27.0万股 | $829.4万 | 26.8万股 | +2,188股+0.82% | 加仓 |
| 奥比梅德顾问ORBIMED ADVISORS LLC |
| 0.15% | 0.14% | #16 | $778.9万 | 22.7万股 | $700.4万 | 22.7万股 | 00.00% | 持仓不变 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #70 | $755.9万 | 22.0万股 | $659.9万 | 21.4万股 | +6,403股+3.00% | 加仓 |
| Ikarian Capital, LLC |
| 0.75% | 0.4% | #7 | $707.6万 | 20.6万股 | $486.9万 | 15.8万股 | +4.8万股+30.66% | 加仓 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #59 | $645.3万 | 18.8万股 | $907.1万 | 29.3万股 | -10.6万股-36.04% | 减仓 |
| D.E.肖D. E. Shaw & Co., Inc. |
| <0.01% | <0.01% | #41 | $641.3万 | 18.7万股 | $358.9万 | 11.6万股 | +7.0万股+60.65% | 加仓 |
| 马歇尔·韦斯MARSHALL WACE, LLP |
| <0.01% | 0.01% | #37 | $591.7万 | 17.2万股 | $709.7万 | 23.0万股 | -5.7万股-25.04% | 减仓 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #47 | $569.0万 | 16.6万股 | $180.4万 | 5.8万股 | +10.7万股+183.69% | 加仓 |
| SquarepointSquarepoint Ops LLC |
| 0.01% | 0.01% | #34 | $498.5万 | 14.5万股 | $508.2万 | 16.4万股 | -1.9万股-11.79% | 减仓 |
| 阿默普莱斯金融AMERIPRISE FINANCIAL INC |
| <0.01% | <0.01% | #51 | $489.7万 | 14.2万股 | $443.3万 | 14.3万股 | -984股-0.69% | 减仓 |
| 富国银行WELLS FARGO & COMPANY/MN |
| <0.01% | <0.01% | #54 | $403.7万 | 11.7万股 | $348.2万 | 11.3万股 | +4,764股+4.23% | 加仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #62 | $391.5万 | 11.4万股 | $242.2万 | 7.8万股 | +3.6万股+45.37% | 加仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #64 | $369.2万 | 10.7万股 | $162.0万 | 5.2万股 | +5.5万股+104.95% | 加仓 |
| Soleus 资本管理Soleus Capital Management, L.P. |
| 0.12% | 0.15% | #19 | $349.5万 | 10.2万股 | $376.1万 | 12.2万股 | -2.0万股-16.44% | 减仓 |
| Woodline合伙人Woodline Partners LP |
| 0.01% | 0.01% | #30 | $343.8万 | 10.0万股 | $309.1万 | 10.0万股 | 00.00% | 持仓不变 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #83 | $324.5万 | 9.4万股 | $196.6万 | 6.4万股 | +3.1万股+48.43% | 加仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #71 | $254.1万 | 7.4万股 | $193.0万 | 6.2万股 | +1.1万股+18.42% | 加仓 |
| 雷蒙德詹姆斯金融RAYMOND JAMES FINANCIAL INC |
| <0.01% | <0.01% | #53 | $249.8万 | 7.3万股 | $198.4万 | 6.4万股 | +8,478股+13.21% | 加仓 |
| SECTORAL ASSET MANAGEMENT INC |
| 1.7% | 0.52% | #2 | $244.1万 | 7.1万股 | $62.8万 | 1.9万股 | +5.2万股+272.57% | 加仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #57 | $235.1万 | 6.8万股 | $209.9万 | 6.8万股 | +499股+0.73% | 加仓 |
| 简街集团JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #75 | $226.3万 | 6.6万股 | $213.3万 | 6.9万股 | -3,179股-4.61% | 减仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #87 | $224.7万 | 6.5万股 | $164.3万 | 10.5万股 | -3.9万股-37.58% | 减仓 |
| Connor Clark & Lunn投资管理Connor, Clark & Lunn Investment Management Ltd. |
| <0.01% | <0.01% | #38 | $223.2万 | 6.5万股 | $207.1万 | 6.7万股 | -2,054股-3.07% | 减仓 |
| 布斯湾基金管理BOOTHBAY FUND MANAGEMENT, LLC |
| 0.03% | 0.02% | #24 | $208.9万 | 6.1万股 | $142.6万 | 4.6万股 | +1.5万股+31.72% | 加仓 |
| 摩根大通JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #91 | $183.2万 | 5.5万股 | $170.0万 | 5.9万股 | -3,506股-5.96% | 减仓 |
| 普信集团PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | <0.01% | #80 | $165.0万 | 4.8万股 | $507.2万 | 16.4万股 | -11.6万股-70.74% | 减仓 |
| Tetragon Partners GP Ltd |
| 0.25% | 0.23% | #10 | $159.9万 | 4.7万股 | $116.2万 | 3.8万股 | +8,928股+23.75% | 加仓 |
| PFM Health Sciences, LP |
| 0.13% | 0.13% | #17 | $156.9万 | 4.6万股 | $142.6万 | 4.6万股 | -498股-1.08% | 减仓 |
| HRT金融HRT FINANCIAL LP |
| <0.01% | — | #43 | $153.1万 | 4.5万股 | $0 | 0股 | +4.5万股 | 新买入 |
| 跳跃金融Jump Financial, LLC |
| 0.01% | 0.02% | #28 | $149.2万 | 4.3万股 | $133.2万 | 4.3万股 | +302股+0.70% | 加仓 |
| Prosight Management, LP |
| 0.24% | 0.4% | #11 | $136.6万 | 4.0万股 | $246.9万 | 8.0万股 | -4.0万股-50.26% | 减仓 |
| Trexquant投资Trexquant Investment LP |
| 0.01% | — | #32 | $127.2万 | 3.7万股 | $0 | 0股 | +3.7万股 | 新买入 |
| Aldebaran Capital, LLC |
| 0.95% | 0.88% | #5 | $126.5万 | 3.7万股 | $114.9万 | 3.7万股 | -387股-1.04% | 减仓 |
| ExodusPoint资本ExodusPoint Capital Management, LP |
| 0.01% | — | #31 | $121.1万 | 3.5万股 | $0 | 0股 | +3.5万股 | 新买入 |
| 惠灵顿管理集团WELLINGTON MANAGEMENT GROUP LLP |
| <0.01% | <0.01% | #76 | $108.0万 | 3.1万股 | $90.4万 | 2.9万股 | +2,192股+7.50% | 加仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #86 | $104.6万 | 3.0万股 | $90.0万 | 2.9万股 | +1,328股+4.56% | 加仓 |
| MONIMUS CAPITAL MANAGEMENT, LP |
| 0.22% | 0.23% | #12 | $96.7万 | 2.8万股 | $82.7万 | 2.7万股 | +1,390股+5.20% | 加仓 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| <0.01% | <0.01% | #84 | $86.8万 | 2.5万股 | $76.5万 | 2.5万股 | +487股+1.97% | 加仓 |
