| 富达投资FMR LLC |
| <0.01% | <0.01% | #33 | $1.11亿 | 569.1万股 | $8,890.8万 | 485.0万股 | +84.1万股+17.34% | 加仓 |
| TPG集团TPG GP A, LLC |
| 1.46% | 1.98% | #5 | $7,315.4万 | 376.1万股 | $7,272.3万 | 396.7万股 | -20.6万股-5.20% | 减仓 |
| Red Tree Management, LLC |
| 29.13% | 36.15% | #2 | $4,290.0万 | 220.6万股 | $4,043.0万 | 220.6万股 | 00.00% | 持仓不变 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #63 | $3,765.7万 | 193.6万股 | $3,323.5万 | 181.3万股 | +12.3万股+6.78% | 加仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #72 | $2,198.5万 | 113.0万股 | $2,084.4万 | 113.7万股 | -6,786股-0.60% | 减仓 |
| KCM Capital Inc |
| 1.38% | 4.13% | #6 | $2,188.1万 | 112.5万股 | $2,566.2万 | 140.0万股 | -27.5万股-19.64% | 减仓 |
| Federated HermesFEDERATED HERMES, INC. |
| 0.03% | 0.03% | #25 | $1,827.5万 | 94.0万股 | $1,722.0万 | 93.9万股 | +136股+0.01% | 加仓 |
| 富兰克林资源FRANKLIN RESOURCES INC |
| <0.01% | <0.01% | #37 | $1,786.2万 | 91.8万股 | $1,483.8万 | 81.0万股 | +10.9万股+13.44% | 加仓 |
| Adage资本合伙人ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.02% | 0.02% | #26 | $1,750.5万 | 90.0万股 | $1,387.1万 | 75.7万股 | +14.3万股+18.93% | 加仓 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| <0.01% | <0.01% | #41 | $1,743.7万 | 89.6万股 | $2,127.7万 | 116.1万股 | -26.4万股-22.77% | 减仓 |
| 时代广场资本管理TimesSquare Capital Management, LLC |
| 0.22% | 0.22% | #10 | $1,518.2万 | 78.1万股 | $1,313.3万 | 71.6万股 | +6.4万股+8.94% | 加仓 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #34 | $1,414.5万 | 72.7万股 | $1,011.9万 | 55.2万股 | +17.5万股+31.74% | 加仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #61 | $1,299.8万 | 66.8万股 | $1,122.0万 | 61.2万股 | +5.6万股+9.18% | 加仓 |
| Royce联营ROYCE & ASSOCIATES LP |
| 0.09% | 0.09% | #16 | $1,176.7万 | 60.5万股 | $945.3万 | 51.6万股 | +8.9万股+17.31% | 加仓 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #77 | $1,064.0万 | 54.7万股 | $963.1万 | 52.5万股 | +2.2万股+4.11% | 加仓 |
| Silvercrest资产管理集团SILVERCREST ASSET MANAGEMENT GROUP LLC |
| 0.06% | 0.06% | #20 | $911.8万 | 46.9万股 | $897.7万 | 49.0万股 | -2.1万股-4.27% | 减仓 |
| MFS马萨诸塞金融服务MASSACHUSETTS FINANCIAL SERVICES CO /MA/ |
| <0.01% | <0.01% | #42 | $757.9万 | 39.0万股 | $932.1万 | 50.8万股 | -11.9万股-23.37% | 减仓 |
| Redmile Group, LLC |
| 0.51% | 0.47% | #7 | $752.3万 | 38.7万股 | $709.0万 | 38.7万股 | 00.00% | 持仓不变 |
| 摩根大通JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #75 | $688.9万 | 34.5万股 | $510.1万 | 28.7万股 | +5.8万股+20.18% | 加仓 |
| Yu Fan |
| 6.17% | 10.38% | #3 | $666.0万 | 34.2万股 | $1,007.1万 | 54.9万股 | -20.7万股-37.68% | 减仓 |
| PEREGRINE 资本管理PEREGRINE CAPITAL MANAGEMENT LLC |
| 0.21% | 0.24% | #12 | $644.6万 | 33.1万股 | $638.3万 | 34.8万股 | -1.7万股-4.83% | 减仓 |
| Creek Drive Management Group LLC |
| 2.84% | 1.35% | #4 | $585.2万 | 30.1万股 | $592.1万 | 32.3万股 | -2.2万股-6.85% | 减仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #81 | $555.6万 | 28.6万股 | $177.6万 | 15.5万股 | +13.1万股+84.84% | 加仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #70 | $545.2万 | 28.0万股 | $753.4万 | 41.1万股 | -13.1万股-31.80% | 减仓 |
| ABG-WTT Global Life Science Capital Partners GP Ltd |
| 62.61% | 65.87% | #1 | $535.5万 | 27.5万股 | $809.9万 | 44.2万股 | -16.6万股-37.68% | 减仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #89 | $496.9万 | 25.5万股 | $392.6万 | 21.4万股 | +4.1万股+19.26% | 加仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #79 | $461.9万 | 23.7万股 | $586.3万 | 32.0万股 | -8.2万股-25.75% | 减仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #71 | $406.4万 | 20.9万股 | $349.6万 | 19.1万股 | +1.8万股+9.56% | 加仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #67 | $380.2万 | 19.5万股 | $347.3万 | 18.9万股 | +5,989股+3.16% | 加仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #73 | $378.7万 | 19.5万股 | $528.1万 | 28.8万股 | -9.3万股-32.41% | 减仓 |
| 简街集团JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #84 | $340.4万 | 17.5万股 | $78.8万 | 4.3万股 | +13.2万股+307.30% | 加仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #59 | $323.9万 | 16.7万股 | $298.9万 | 16.3万股 | +3,464股+2.12% | 加仓 |
| HRT金融HRT FINANCIAL LP |
| 0.01% | 0.01% | #31 | $323.5万 | 16.6万股 | $248.2万 | 13.5万股 | +3.1万股+22.81% | 加仓 |
| D.E.肖D. E. Shaw & Co., Inc. |
| <0.01% | <0.01% | #48 | $289.9万 | 14.9万股 | $155.3万 | 8.5万股 | +6.4万股+75.92% | 加仓 |
| Quantinno资本管理Quantinno Capital Management LP |
| <0.01% | <0.01% | #39 | $272.8万 | 14.0万股 | $257.3万 | 14.0万股 | -97股-0.07% | 减仓 |
| 法国巴黎银行金融市场BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | <0.01% | #51 | $252.1万 | 13.0万股 | $194.2万 | 10.6万股 | +2.4万股+22.30% | 加仓 |
| ExodusPoint资本ExodusPoint Capital Management, LP |
| 0.01% | — | #28 | $231.9万 | 11.9万股 | $0 | 0股 | +11.9万股 | 新买入 |
| Two Sigma投资TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #45 | $213.7万 | 11.0万股 | $597.6万 | 32.6万股 | -21.6万股-66.30% | 减仓 |
| 野村资产管理国际NOMURA ASSET MANAGEMENT INTERNATIONAL INC. |
| <0.01% | — | #40 | $213.2万 | 11.0万股 | $0 | 0股 | +11.0万股 | 新买入 |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. |
| 0.13% | 0.03% | #14 | $207.8万 | 10.7万股 | $51.4万 | 2.8万股 | +7.9万股+280.82% | 加仓 |
| Point72资产管理Point72 Asset Management, L.P. |
| <0.01% | <0.01% | #44 | $187.2万 | 9.6万股 | $142.5万 | 7.8万股 | +1.9万股+23.82% | 加仓 |
| AQR资本管理AQR CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #62 | $186.1万 | 9.6万股 | $96.8万 | 5.3万股 | +4.3万股+81.21% | 加仓 |
| 沃利昂资本管理Voleon Capital Management LP |
| 0.03% | 0.02% | #23 | $183.9万 | 9.5万股 | $111.9万 | 6.1万股 | +3.4万股+54.89% | 加仓 |
| DEUTSCHE 银行 AG\DEUTSCHE BANK AG\ |
| <0.01% | <0.01% | #68 | $174.2万 | 9.0万股 | $162.2万 | 8.9万股 | +1,079股+1.22% | 加仓 |
| EMERALD MUTUAL FUND ADVISERS 信托EMERALD MUTUAL FUND ADVISERS TRUST |
| 0.06% | 0.08% | #19 | $173.8万 | 8.9万股 | $162.0万 | 8.8万股 | +994股+1.13% | 加仓 |
| F/m Investments LLC |
| 0.09% | 0.11% | #17 | $173.8万 | 8.9万股 | $162.0万 | 8.8万股 | +994股+1.13% | 加仓 |
| 惠灵顿管理集团WELLINGTON MANAGEMENT GROUP LLP |
| <0.01% | <0.01% | #82 | $170.6万 | 8.8万股 | $152.4万 | 8.3万股 | +4,572股+5.50% | 加仓 |
| Numerai GP LLC |
| 0.14% | 0.13% | #13 | $169.7万 | 8.7万股 | $126.6万 | 6.9万股 | +1.8万股+26.38% | 加仓 |
| 花旗集团CITIGROUP INC |
| <0.01% | <0.01% | #65 | $156.6万 | 8.0万股 | $78.0万 | 4.3万股 | +3.8万股+89.20% | 加仓 |
| 纽文Nuveen, LLC |
| <0.01% | <0.01% | #85 | $114.4万 | 5.9万股 | $100.6万 | 5.5万股 | +3,921股+7.15% | 加仓 |
