| 蒙塔诺瓦资本MONTANOVA CAPITAL, LLC |
| 0.85% | 0.95% | #11 | $4,656.9万 | 284.1万股 | $3,710.8万 | 284.1万股 | 00.00% | 持仓不变 |
| 木星资产管理Jupiter Topco LLC |
| 0.02% | — | #28 | $4,476.9万 | 273.5万股 | $0 | 0股 | +273.5万股 | 新买入 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #60 | $3,383.5万 | 206.4万股 | $873.9万 | 66.9万股 | +139.5万股+208.52% | 加仓 |
| JOHNSON & JOHNSON |
| 4.06% | 3.96% | #4 | $3,243.9万 | 197.9万股 | $2,584.8万 | 197.9万股 | 00.00% | 持仓不变 |
| 富兰克林资源FRANKLIN RESOURCES INC |
| 0.01% | 0.01% | #36 | $3,014.5万 | 183.9万股 | $2,402.0万 | 183.9万股 | 00.00% | 持仓不变 |
| Balyasny资产管理BALYASNY ASSET MANAGEMENT L.P. |
| 0.03% | 0.03% | #27 | $2,495.9万 | 152.3万股 | $2,201.4万 | 168.6万股 | -16.3万股-9.66% | 减仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #64 | $2,165.7万 | 132.1万股 | $1,585.7万 | 121.4万股 | +10.7万股+8.83% | 加仓 |
| 洞察顾问PERCEPTIVE ADVISORS LLC |
| 0.31% | 0.32% | #16 | $2,057.9万 | 125.6万股 | $1,639.8万 | 125.6万股 | 00.00% | 持仓不变 |
| 富达投资FMR LLC |
| <0.01% | <0.01% | #52 | $1,704.8万 | 104.0万股 | $1,064.2万 | 81.5万股 | +22.5万股+27.64% | 加仓 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| 0.01% | 0.01% | #37 | $1,527.1万 | 93.2万股 | $2,005.3万 | 153.5万股 | -60.4万股-39.32% | 减仓 |
| GREAT POINT PARTNERS LLC |
| 2.85% | 2.4% | #5 | $1,510.3万 | 92.1万股 | $1,045.1万 | 80.0万股 | +12.1万股+15.16% | 加仓 |
| Longaeva 合伙人Longaeva Partners L.P. |
| 0.29% | 0.35% | #17 | $1,332.1万 | 81.3万股 | $956.1万 | 73.2万股 | +8.1万股+11.02% | 加仓 |
| Ikarian Capital, LLC |
| 1.41% | 0.86% | #7 | $1,324.1万 | 80.8万股 | $1,055.1万 | 80.8万股 | 00.00% | 持仓不变 |
| SECTORAL ASSET MANAGEMENT INC |
| 8.32% | 7.87% | #1 | $1,192.5万 | 72.8万股 | $950.2万 | 72.8万股 | 00.00% | 持仓不变 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #56 | $1,136.4万 | 69.3万股 | $368.5万 | 28.2万股 | +41.1万股+145.78% | 加仓 |
| 高瓴资本Hillhouse Capital Advisors, Ltd. |
| 1.32% | 0.52% | #9 | $1,097.0万 | 66.9万股 | $874.2万 | 66.9万股 | 00.00% | 持仓不变 |
| Red Tree Management, LLC |
| 7.1% | 7.45% | #2 | $1,045.9万 | 63.8万股 | $833.4万 | 63.8万股 | 00.00% | 持仓不变 |
| Versant Venture Management, LLC |
| 5.47% | 5.01% | #3 | $889.4万 | 54.3万股 | $708.7万 | 54.3万股 | 00.00% | 持仓不变 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #53 | $815.0万 | 49.7万股 | $401.1万 | 30.7万股 | +19.0万股+61.92% | 加仓 |
| Boxer Capital Management, LLC |
| 0.61% | 0.85% | #13 | $809.7万 | 49.4万股 | $645.2万 | 49.4万股 | 00.00% | 持仓不变 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #72 | $698.1万 | 42.6万股 | $132.3万 | 10.1万股 | +32.5万股+320.53% | 加仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #51 | $649.6万 | 39.6万股 | $457.4万 | 35.0万股 | +4.6万股+13.18% | 加仓 |
| Adage资本合伙人ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.01% | — | #34 | $537.6万 | 32.8万股 | $0 | 0股 | +32.8万股 | 新买入 |
| SILVERARC CAPITAL MANAGEMENT, LLC |
| 0.5% | 0.4% | #14 | $485.4万 | 29.6万股 | $394.1万 | 30.2万股 | -5,594股-1.85% | 减仓 |
| ADAR1 Capital Management, LLC |
| 0.21% | 0.21% | #19 | $457.2万 | 27.9万股 | $361.3万 | 27.7万股 | +2,300股+0.83% | 加仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #59 | $455.3万 | 27.8万股 | $86.1万 | 6.6万股 | +21.2万股+321.37% | 加仓 |
| Squadron Capital Management LLC |
| 1.32% | — | #8 | $426.1万 | 26.0万股 | $0 | 0股 | +26.0万股 | 新买入 |
| 布斯湾基金管理BOOTHBAY FUND MANAGEMENT, LLC |
| 0.05% | 0.04% | #25 | $364.4万 | 22.2万股 | $290.4万 | 22.2万股 | 00.00% | 持仓不变 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #62 | $350.9万 | 21.4万股 | $188.1万 | 14.4万股 | +7.0万股+48.66% | 加仓 |
| Ishara Investments LP |
| 2.43% | 1.76% | #6 | $336.0万 | 20.5万股 | $185.5万 | 14.2万股 | +6.3万股+44.37% | 加仓 |
| SPHERA FUNDS MANAGEMENT LTD. |
| 0.39% | 0.36% | #15 | $300.7万 | 18.3万股 | $226.6万 | 17.3万股 | +1.0万股+5.76% | 加仓 |
| Qube研究科技Qube Research & Technologies Ltd |
| <0.01% | <0.01% | #39 | $299.0万 | 18.2万股 | $303.7万 | 23.3万股 | -5.0万股-21.55% | 减仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | — | #80 | $295.5万 | 18.0万股 | $0 | 0股 | +18.0万股 | 新买入 |
| 维度基金顾问DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #58 | $292.5万 | 17.9万股 | $78.2万 | 6.0万股 | +11.9万股+198.06% | 加仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #54 | $290.6万 | 17.7万股 | $201.0万 | 15.4万股 | +2.3万股+15.17% | 加仓 |
| 惠灵顿管理集团WELLINGTON MANAGEMENT GROUP LLP |
| <0.01% | <0.01% | #65 | $247.2万 | 15.1万股 | $72.6万 | 5.6万股 | +9.5万股+171.17% | 加仓 |
| Casdin Capital, LLC |
| 0.12% | 0.15% | #23 | $243.1万 | 14.8万股 | $193.7万 | 14.8万股 | 00.00% | 持仓不变 |
| Eversept Partners, LP |
| 0.13% | 0.1% | #22 | $242.6万 | 14.8万股 | $191.2万 | 14.6万股 | +1,606股+1.10% | 加仓 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #69 | $214.1万 | 13.1万股 | $300.9万 | 23.0万股 | -10.0万股-43.30% | 减仓 |
| DIADEMA PARTNERS LP |
| 0.24% | — | #18 | $196.2万 | 12.0万股 | $0 | 0股 | +12.0万股 | 新买入 |
| 马歇尔·韦斯MARSHALL WACE, LLP |
| <0.01% | <0.01% | #44 | $193.5万 | 11.8万股 | $295.6万 | 22.6万股 | -10.8万股-47.83% | 减仓 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #83 | $147.3万 | 9.0万股 | $500.1万 | 38.3万股 | -29.3万股-76.53% | 减仓 |
| Trexquant投资Trexquant Investment LP |
| 0.01% | <0.01% | #32 | $145.0万 | 8.8万股 | $62.4万 | 4.8万股 | +4.1万股+85.31% | 加仓 |
| Verdad Advisers, LP |
| 1.27% | 1.26% | #10 | $132.8万 | 8.1万股 | $112.4万 | 8.6万股 | -5,018股-5.83% | 减仓 |
| 法国巴黎银行金融市场BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | <0.01% | #55 | $129.3万 | 7.9万股 | $52.1万 | 4.0万股 | +3.9万股+97.90% | 加仓 |
| Schonfeld战略顾问Schonfeld Strategic Advisors LLC |
| <0.01% | — | #38 | $113.8万 | 6.9万股 | $0 | 0股 | +6.9万股 | 新买入 |
| 文艺复兴科技RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | <0.01% | #45 | $110.3万 | 6.7万股 | $90.6万 | 6.9万股 | -2,100股-3.03% | 减仓 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| <0.01% | — | #76 | $107.5万 | 6.6万股 | $0 | 0股 | +6.6万股 | 新买入 |
| ACUTA CAPITAL PARTNERS, LLC |
| 0.72% | — | #12 | $103.4万 | 6.3万股 | $0 | 0股 | +6.3万股 | 新买入 |
| Seven Fleet Capital Management LP |
| 0.16% | 0.11% | #21 | $99.2万 | 6.1万股 | $35.3万 | 2.7万股 | +3.3万股+123.78% | 加仓 |
