| 富达投资FMR LLC |
| <0.01% | <0.01% | #20 | $6,517.0万 | 499.4万股 | $4,059.4万 | 383.7万股 | +115.7万股+30.16% | 加仓 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #30 | $5,587.3万 | 428.1万股 | $3,511.9万 | 331.9万股 | +96.2万股+28.98% | 加仓 |
| Foresite Capital Management IV, LLC |
| 8.74% | 8.67% | #1 | $2,536.5万 | 194.4万股 | $2,056.4万 | 194.4万股 | 00.00% | 持仓不变 |
| Merck & Co., Inc. |
| 4.13% | 5.05% | #3 | $2,175.0万 | 166.7万股 | $1,763.3万 | 166.7万股 | 00.00% | 持仓不变 |
| 普信投资管理T. Rowe Price Investment Management, Inc. |
| 0.01% | 0.01% | #13 | $2,081.8万 | 159.5万股 | $1,293.4万 | 122.2万股 | +37.3万股+30.49% | 加仓 |
| Foresite Capital Management V, LLC |
| 4.75% | 5.15% | #2 | $1,721.3万 | 131.9万股 | $1,395.5万 | 131.9万股 | 00.00% | 持仓不变 |
| 资本世界投资者Capital World Investors |
| <0.01% | <0.01% | #24 | $1,534.6万 | 117.6万股 | $1,210.0万 | 114.4万股 | +3.2万股+2.82% | 加仓 |
| 普信集团PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | <0.01% | #27 | $1,311.6万 | 100.5万股 | $1,032.5万 | 97.6万股 | +2.9万股+2.99% | 加仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #48 | $1,204.1万 | 92.3万股 | $1,025.7万 | 96.9万股 | -4.7万股-4.82% | 减仓 |
| EcoR1 Capital, LLC |
| 0.46% | 0.33% | #7 | $956.1万 | 73.3万股 | $775.1万 | 73.3万股 | 00.00% | 持仓不变 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #42 | $727.1万 | 55.7万股 | $290.0万 | 27.4万股 | +28.3万股+103.32% | 加仓 |
| 贝克兄弟顾问BAKER BROS. ADVISORS LP |
| 0.04% | 0.03% | #12 | $725.0万 | 55.6万股 | $587.8万 | 55.6万股 | 00.00% | 持仓不变 |
| 联博ALLIANCEBERNSTEIN L.P. |
| <0.01% | <0.01% | #22 | $679.1万 | 64.2万股 | $1,081.5万 | 102.2万股 | -38.0万股-37.20% | 减仓 |
| SOROS CAPITAL MANAGEMENT LLC |
| 1.13% | 2.23% | #6 | $632.5万 | 48.5万股 | $512.8万 | 48.5万股 | 00.00% | 持仓不变 |
| 加拿大养老金计划投资委员会(CPPIB)CANADA PENSION PLAN INVESTMENT BOARD |
| <0.01% | <0.01% | #21 | $494.6万 | 37.9万股 | $401.0万 | 37.9万股 | 00.00% | 持仓不变 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #53 | $462.1万 | 35.4万股 | $42.5万 | 4.0万股 | +31.4万股+781.93% | 加仓 |
| 富兰克林资源FRANKLIN RESOURCES INC |
| <0.01% | <0.01% | #29 | $456.8万 | 35.0万股 | $370.3万 | 35.0万股 | 00.00% | 持仓不变 |
| StepStone Group LP |
| 1.83% | 2.02% | #5 | $418.3万 | 39.5万股 | $418.3万 | 39.5万股 | 00.00% | 持仓不变 |
| General Catalyst Group Management, LLC |
| 2.11% | 1.76% | #4 | $398.3万 | 30.5万股 | $322.9万 | 30.5万股 | 00.00% | 持仓不变 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #40 | $344.4万 | 26.4万股 | $105.2万 | 9.9万股 | +16.5万股+165.50% | 加仓 |
| Parkman Healthcare Partners LLC |
| 0.34% | — | #8 | $334.1万 | 25.6万股 | $0 | 0股 | +25.6万股 | 新买入 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #44 | $237.6万 | 18.2万股 | $138.7万 | 13.1万股 | +5.1万股+38.93% | 加仓 |
| Schonfeld战略顾问Schonfeld Strategic Advisors LLC |
| 0.01% | — | #15 | $234.6万 | 18.0万股 | $0 | 0股 | +18.0万股 | 新买入 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #47 | $229.6万 | 17.6万股 | $48.2万 | 4.6万股 | +13.0万股+286.39% | 加仓 |
| Ensign Peak顾问Ensign Peak Advisors, Inc |
| <0.01% | <0.01% | #18 | $222.5万 | 17.0万股 | $211.6万 | 20.0万股 | -3.0万股-14.76% | 减仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #57 | $194.3万 | 14.9万股 | $14.4万 | 1.4万股 | +13.5万股+993.77% | 加仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #41 | $193.7万 | 14.8万股 | $139.6万 | 13.2万股 | +1.6万股+12.47% | 加仓 |
| 法国巴黎银行资产管理BNP Paribas Asset Management Holding S.A. |
| <0.01% | — | #25 | $175.5万 | 13.4万股 | $0 | 0股 | +13.4万股 | 新买入 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #37 | $173.6万 | 13.3万股 | $185.8万 | 17.6万股 | -4.3万股-24.26% | 减仓 |
| Comprehensive Financial 管理Comprehensive Financial Management LLC |
| 0.05% | 0.04% | #11 | $151.7万 | 11.6万股 | $123.0万 | 11.6万股 | 00.00% | 持仓不变 |
| Burkehill Global 管理Burkehill Global Management, LP |
| 0.05% | 0.06% | #10 | $150.1万 | 11.5万股 | $121.7万 | 11.5万股 | 00.00% | 持仓不变 |
| Affinity Asset Advisors, LLC |
| 0.06% | — | #9 | $127.9万 | 9.8万股 | $0 | 0股 | +9.8万股 | 新买入 |
| 道明资产管理TD ASSET MANAGEMENT INC |
| <0.01% | <0.01% | #34 | $74.5万 | 5.7万股 | $60.4万 | 5.7万股 | 00.00% | 持仓不变 |
| ALPS顾问ALPS ADVISORS INC |
| <0.01% | — | #19 | $71.7万 | 5.5万股 | $0 | 0股 | +5.5万股 | 新买入 |
| 景顺Invesco Ltd. |
| <0.01% | — | #61 | $66.4万 | 5.1万股 | $0 | 0股 | +5.1万股 | 新买入 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| <0.01% | — | #54 | $62.4万 | 4.8万股 | $0 | 0股 | +4.8万股 | 新买入 |
| TCG Crossover 管理TCG Crossover Management, LLC |
| 0.01% | — | #14 | $49.5万 | 3.8万股 | $0 | 0股 | +3.8万股 | 新买入 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #65 | $49.0万 | 3.8万股 | $91.1万 | 8.6万股 | -4.9万股-56.38% | 减仓 |
| Polen资本管理POLEN CAPITAL MANAGEMENT LLC |
| <0.01% | — | #17 | $46.6万 | 3.6万股 | $0 | 0股 | +3.6万股 | 新买入 |
| 宏利人寿MANUFACTURERS LIFE INSURANCE COMPANY, THE |
| <0.01% | <0.01% | #43 | $46.1万 | 3.5万股 | $30.3万 | 2.9万股 | +6,734股+23.53% | 加仓 |
| ProShare顾问ProShare Advisors LLC |
| <0.01% | — | #38 | $38.7万 | 3.0万股 | $0 | 0股 | +3.0万股 | 新买入 |
| 纽文Nuveen, LLC |
| <0.01% | — | #56 | $37.8万 | 2.9万股 | $0 | 0股 | +2.9万股 | 新买入 |
| XTX资本XTX Topco Ltd |
| <0.01% | <0.01% | #16 | $35.8万 | 2.7万股 | $27.6万 | 2.6万股 | +1,399股+5.37% | 加仓 |
| 文艺复兴科技RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | — | #39 | $35.0万 | 2.7万股 | $0 | 0股 | +2.7万股 | 新买入 |
| RhumbLine顾问RHUMBLINE ADVISERS |
| <0.01% | — | #49 | $31.9万 | 2.4万股 | $0 | 0股 | +2.4万股 | 新买入 |
| Integrated Wealth ConceptsIntegrated Wealth Concepts LLC |
| <0.01% | — | #26 | $28.4万 | 2.2万股 | $0 | 0股 | +2.2万股 | 新买入 |
| DEUTSCHE 银行 AG\DEUTSCHE BANK AG\ |
| <0.01% | — | #58 | $28.1万 | 2.2万股 | $0 | 0股 | +2.2万股 | 新买入 |
| 富国银行WELLS FARGO & COMPANY/MN |
| <0.01% | — | #64 | $25.2万 | 1.9万股 | $0 | 0股 | +1.9万股 | 新买入 |
| 跳跃金融Jump Financial, LLC |
| <0.01% | — | #23 | $23.6万 | 1.8万股 | $0 | 0股 | +1.8万股 | 新买入 |
| 花旗集团CITIGROUP INC |
| <0.01% | — | #59 | $21.9万 | 1.7万股 | $0 | 0股 | +1.7万股 | 新买入 |
