| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #57 | $5,083.1万 | 657.6万股 | $418.0万 | 80.0万股 | +577.6万股+722.03% | 加仓 |
| Balyasny资产管理BALYASNY ASSET MANAGEMENT L.P. |
| 0.03% | — | #27 | $2,803.0万 | 362.6万股 | $0 | 0股 | +362.6万股 | 新买入 |
| Woodline合伙人Woodline Partners LP |
| 0.07% | 0.02% | #20 | $2,319.5万 | 300.1万股 | $523.0万 | 100.1万股 | +200.0万股+199.78% | 加仓 |
| SILVERARC CAPITAL MANAGEMENT, LLC |
| 2.35% | — | #2 | $2,263.1万 | 292.8万股 | $0 | 0股 | +292.8万股 | 新买入 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #71 | $1,983.7万 | 256.6万股 | $574.2万 | 109.9万股 | +146.7万股+133.53% | 加仓 |
| BVF INC/IL |
| 0.49% | — | #10 | $1,932.5万 | 250.0万股 | $0 | 0股 | +250.0万股 | 新买入 |
| Caligan Partners LP |
| 0.91% | — | #5 | $1,932.5万 | 250.0万股 | $0 | 0股 | +250.0万股 | 新买入 |
| Affinity Asset Advisors, LLC |
| 0.87% | 0.23% | #6 | $1,930.8万 | 249.8万股 | $453.5万 | 86.8万股 | +163.0万股+187.77% | 加仓 |
| Federated HermesFEDERATED HERMES, INC. |
| 0.02% | <0.01% | #31 | $1,613.0万 | 208.7万股 | $4,081 | 781股 | +208.6万股+267,085.02% | 加仓 |
| GREAT POINT PARTNERS LLC |
| 2.97% | — | #1 | $1,569.1万 | 203.0万股 | $0 | 0股 | +203.0万股 | 新买入 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #68 | $1,542.2万 | 199.5万股 | $67.3万 | 12.9万股 | +186.6万股+1,449.13% | 加仓 |
| Saturn V Capital Management LP |
| 1.64% | — | #3 | $1,144.0万 | 148.0万股 | $0 | 0股 | +148.0万股 | 新买入 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #61 | $1,116.5万 | 144.4万股 | $161.8万 | 31.0万股 | +113.4万股+366.53% | 加仓 |
| Blue Owl Capital Holdings LP |
| 1.42% | 0.47% | #4 | $974.4万 | 126.1万股 | $174.5万 | 33.4万股 | +92.7万股+277.55% | 加仓 |
| 贝克兄弟顾问BAKER BROS. ADVISORS LP |
| 0.04% | 0.03% | #26 | $736.7万 | 95.3万股 | $497.9万 | 95.3万股 | 00.00% | 持仓不变 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #45 | $724.3万 | 93.7万股 | $450.6万 | 86.2万股 | +7.5万股+8.67% | 加仓 |
| 安本标准投资Aberdeen Group plc |
| 0.01% | — | #35 | $655.3万 | 84.8万股 | $0 | 0股 | +84.8万股 | 新买入 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #65 | $586.8万 | 75.9万股 | $88.4万 | 16.9万股 | +59.0万股+348.48% | 加仓 |
| 高瓴资本Hillhouse Capital Advisors, Ltd. |
| 0.67% | 0.23% | #7 | $560.3万 | 72.5万股 | $378.7万 | 72.5万股 | 00.00% | 持仓不变 |
| 阿默普莱斯金融AMERIPRISE FINANCIAL INC |
| <0.01% | — | #54 | $449.3万 | 58.1万股 | $0 | 0股 | +58.1万股 | 新买入 |
| Vestal Point 资本Vestal Point Capital, LP |
| 0.1% | — | #17 | $413.9万 | 53.5万股 | $0 | 0股 | +53.5万股 | 新买入 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #78 | $376.2万 | 48.7万股 | $168.9万 | 32.3万股 | +16.4万股+50.66% | 加仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #72 | $362.1万 | 46.8万股 | $29.0万 | 5.6万股 | +41.3万股+743.77% | 加仓 |
| 布斯湾基金管理BOOTHBAY FUND MANAGEMENT, LLC |
| 0.05% | — | #24 | $358.7万 | 46.4万股 | $0 | 0股 | +46.4万股 | 新买入 |
| ADAR1 Capital Management, LLC |
| 0.16% | — | #14 | $338.2万 | 43.8万股 | $0 | 0股 | +43.8万股 | 新买入 |
| 法伦资本FARALLON CAPITAL MANAGEMENT, L.L.C. |
| 0.01% | — | #33 | $320.8万 | 41.5万股 | $0 | 0股 | +41.5万股 | 新买入 |
| Seven Fleet Capital Management LP |
| 0.51% | — | #8 | $311.9万 | 40.4万股 | $0 | 0股 | +40.4万股 | 新买入 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | — | #92 | $311.9万 | 40.3万股 | $0 | 0股 | +40.3万股 | 新买入 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #60 | $309.8万 | 40.1万股 | $85.0万 | 16.3万股 | +23.8万股+146.49% | 加仓 |
| 维度基金顾问DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #63 | $307.7万 | 39.8万股 | $141.5万 | 27.1万股 | +12.7万股+46.74% | 加仓 |
| 文艺复兴科技RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | 0.01% | #41 | $268.2万 | 34.7万股 | $326.8万 | 62.5万股 | -27.9万股-44.53% | 减仓 |
| Atom Investors LP |
| 0.24% | — | #13 | $267.5万 | 34.6万股 | $0 | 0股 | +34.6万股 | 新买入 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #75 | $262.8万 | 34.0万股 | $153.6万 | 29.4万股 | +4.6万股+15.65% | 加仓 |
| 雷蒙德詹姆斯金融RAYMOND JAMES FINANCIAL INC |
| <0.01% | <0.01% | #59 | $256.7万 | 33.2万股 | $165.9万 | 31.8万股 | +1.4万股+4.56% | 加仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #83 | $224.1万 | 29.0万股 | $110.1万 | 21.1万股 | +7.9万股+37.56% | 加仓 |
| Palo Alto Investors LP |
| 0.28% | — | #12 | $193.3万 | 25.0万股 | $0 | 0股 | +25.0万股 | 新买入 |
| Rock Springs Capital Management LP |
| 0.09% | — | #18 | $193.3万 | 25.0万股 | $0 | 0股 | +25.0万股 | 新买入 |
| 巴克莱BARCLAYS PLC |
| <0.01% | <0.01% | #76 | $176.2万 | 22.8万股 | $14.3万 | 2.7万股 | +20.1万股+730.99% | 加仓 |
| Pale Fire Capital SE |
| 0.12% | 0.1% | #16 | $171.5万 | 22.2万股 | $115.9万 | 22.2万股 | 00.00% | 持仓不变 |
| 桥道资本管理BRIDGEWAY CAPITAL MANAGEMENT, LLC |
| 0.03% | 0.03% | #29 | $171.3万 | 22.2万股 | $156.6万 | 30.0万股 | -7.8万股-26.06% | 减仓 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| <0.01% | — | #84 | $155.1万 | 20.1万股 | $0 | 0股 | +20.1万股 | 新买入 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #88 | $135.9万 | 17.6万股 | $7.8万 | 1.5万股 | +16.1万股+1,072.48% | 加仓 |
| Driehaus资本管理DRIEHAUS CAPITAL MANAGEMENT LLC |
| 0.01% | — | #36 | $128.8万 | 16.7万股 | $0 | 0股 | +16.7万股 | 新买入 |
| Sofinnova Investments, Inc. |
| 0.07% | — | #21 | $128.8万 | 16.7万股 | $0 | 0股 | +16.7万股 | 新买入 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #106 | $111.1万 | 14.4万股 | $22.9万 | 4.4万股 | +10.0万股+227.61% | 加仓 |
| 纽文Nuveen, LLC |
| <0.01% | — | #82 | $108.7万 | 14.1万股 | $0 | 0股 | +14.1万股 | 新买入 |
| Propel Bio Management, LLC |
| 0.51% | — | #9 | $97.3万 | 12.6万股 | $0 | 0股 | +12.6万股 | 新买入 |
| 法国巴黎银行金融市场BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | <0.01% | #69 | $92.8万 | 12.0万股 | $12.1万 | 2.3万股 | +9.7万股+420.40% | 加仓 |
| FNY Investment Advisers, LLC |
| 0.31% | 0.35% | #11 | $84.5万 | 10.9万股 | $78.2万 | 15.0万股 | -4.1万股-27.05% | 减仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #111 | $79.0万 | 10.2万股 | $168.8万 | 24.6万股 | -14.4万股-58.46% | 减仓 |
