| 富达投资FMR LLC |
| <0.01% | — | #29 | $9,690.4万 | 517.9万股 | $0 | 0股 | +517.9万股 | 新买入 |
| SR ONE CAPITAL MANAGEMENT, LP |
| 6.83% | — | #3 | $7,100.2万 | 379.5万股 | $0 | 0股 | +379.5万股 | 新买入 |
| TPG集团TPG GP A, LLC |
| 1.38% | — | #9 | $6,904.3万 | 369.0万股 | $0 | 0股 | +369.0万股 | 新买入 |
| Lightspeed Management Company, L.L.C. |
| 2.81% | — | #5 | $6,751.4万 | 360.8万股 | $0 | 0股 | +360.8万股 | 新买入 |
| 奥比梅德顾问ORBIMED ADVISORS LLC |
| 1.06% | — | #10 | $5,615.2万 | 300.1万股 | $0 | 0股 | +300.1万股 | 新买入 |
| Sanofi |
| 6.98% | — | #2 | $3,726.9万 | 199.2万股 | $0 | 0股 | +199.2万股 | 新买入 |
| Deerfield管理DEERFIELD MANAGEMENT COMPANY, L.P. |
| 0.2% | — | #17 | $1,957.3万 | 104.6万股 | $0 | 0股 | +104.6万股 | 新买入 |
| Sands Capital Alternatives, LLC |
| 2.67% | — | #6 | $1,637.1万 | 87.5万股 | $0 | 0股 | +87.5万股 | 新买入 |
| 高瓴资本Hillhouse Capital Advisors, Ltd. |
| 1.87% | — | #7 | $1,556.0万 | 83.2万股 | $0 | 0股 | +83.2万股 | 新买入 |
| General Catalyst Group Management, LLC |
| 8.04% | — | #1 | $1,516.0万 | 81.0万股 | $0 | 0股 | +81.0万股 | 新买入 |
| Affinity Asset Advisors, LLC |
| 0.65% | — | #12 | $1,433.8万 | 76.6万股 | $0 | 0股 | +76.6万股 | 新买入 |
| Adage资本合伙人ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.02% | — | #24 | $1,356.5万 | 72.5万股 | $0 | 0股 | +72.5万股 | 新买入 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | — | #42 | $1,347.9万 | 72.0万股 | $0 | 0股 | +72.0万股 | 新买入 |
| Foresite Capital Management V, LLC |
| 3.68% | — | #4 | $1,334.2万 | 71.3万股 | $0 | 0股 | +71.3万股 | 新买入 |
| Vivo Capital, LLC |
| 0.98% | — | #11 | $1,075.8万 | 57.5万股 | $0 | 0股 | +57.5万股 | 新买入 |
| EcoR1 Capital, LLC |
| 0.51% | — | #14 | $1,039.4万 | 55.6万股 | $0 | 0股 | +55.6万股 | 新买入 |
| Logos Global Management LP |
| 0.42% | — | #15 | $976.2万 | 52.2万股 | $0 | 0股 | +52.2万股 | 新买入 |
| 马歇尔·韦斯MARSHALL WACE, LLP |
| 0.01% | — | #27 | $921.8万 | 49.3万股 | $0 | 0股 | +49.3万股 | 新买入 |
| 普信集团PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | — | #37 | $883.1万 | 47.2万股 | $0 | 0股 | +47.2万股 | 新买入 |
| Catalio Capital Management, LP |
| 1.61% | — | #8 | $856.6万 | 45.8万股 | $0 | 0股 | +45.8万股 | 新买入 |
| Redmile Group, LLC |
| 0.53% | — | #13 | $795.2万 | 42.5万股 | $0 | 0股 | +42.5万股 | 新买入 |
| Balyasny资产管理BALYASNY ASSET MANAGEMENT L.P. |
| 0.01% | — | #26 | $736.9万 | 39.4万股 | $0 | 0股 | +39.4万股 | 新买入 |
| Woodline合伙人Woodline Partners LP |
| 0.02% | — | #23 | $646.9万 | 34.6万股 | $0 | 0股 | +34.6万股 | 新买入 |
| 富兰克林资源FRANKLIN RESOURCES INC |
| <0.01% | — | #36 | $514.6万 | 27.5万股 | $0 | 0股 | +27.5万股 | 新买入 |
| Boxer Capital Management, LLC |
| 0.39% | — | #16 | $514.5万 | 27.5万股 | $0 | 0股 | +27.5万股 | 新买入 |
| 贝莱德BlackRock, Inc. |
| <0.01% | — | #51 | $450.3万 | 24.1万股 | $0 | 0股 | +24.1万股 | 新买入 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | — | #38 | $416.2万 | 22.2万股 | $0 | 0股 | +22.2万股 | 新买入 |
| Siren, L.L.C. |
| 0.08% | — | #19 | $374.2万 | 20.0万股 | $0 | 0股 | +20.0万股 | 新买入 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | — | #45 | $354.7万 | 18.9万股 | $0 | 0股 | +18.9万股 | 新买入 |
| Cormorant Asset Management, LP |
| 0.17% | — | #18 | $327.4万 | 17.5万股 | $0 | 0股 | +17.5万股 | 新买入 |
| 安本标准投资Aberdeen Group plc |
| <0.01% | — | #28 | $308.7万 | 16.5万股 | $0 | 0股 | +16.5万股 | 新买入 |
| Two Sigma投资TWO SIGMA INVESTMENTS, LP |
| <0.01% | — | #33 | $293.0万 | 15.7万股 | $0 | 0股 | +15.7万股 | 新买入 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | — | #44 | $248.5万 | 13.3万股 | $0 | 0股 | +13.3万股 | 新买入 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | — | #43 | $190.0万 | 10.2万股 | $0 | 0股 | +10.2万股 | 新买入 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | — | #41 | $188.8万 | 10.1万股 | $0 | 0股 | +10.1万股 | 新买入 |
| 哈德逊湾资本管理Hudson Bay Capital Management LP |
| <0.01% | — | #31 | $136.4万 | 7.3万股 | $0 | 0股 | +7.3万股 | 新买入 |
| 瑞银集团UBS Group AG |
| <0.01% | — | #47 | $128.6万 | 6.9万股 | $0 | 0股 | +6.9万股 | 新买入 |
| Ensign Peak顾问Ensign Peak Advisors, Inc |
| <0.01% | — | #34 | $120.9万 | 6.5万股 | $0 | 0股 | +6.5万股 | 新买入 |
| SEVEN GRAND MANAGERS, LLC |
| 0.04% | — | #21 | $93.6万 | 5.0万股 | $0 | 0股 | +5.0万股 | 新买入 |
| Eversept Partners, LP |
| 0.05% | — | #20 | $92.9万 | 5.0万股 | $0 | 0股 | +5.0万股 | 新买入 |
| 都铎投资TUDOR INVESTMENT CORP ET AL |
| <0.01% | — | #35 | $82.6万 | 4.4万股 | $0 | 0股 | +4.4万股 | 新买入 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | — | #49 | $64.7万 | 3.5万股 | $0 | 0股 | +3.5万股 | 新买入 |
| 宏利人寿MANUFACTURERS LIFE INSURANCE COMPANY, THE |
| <0.01% | — | #40 | $60.1万 | 3.2万股 | $0 | 0股 | +3.2万股 | 新买入 |
| 道明资产管理TD ASSET MANAGEMENT INC |
| <0.01% | — | #39 | $54.5万 | 2.9万股 | $0 | 0股 | +2.9万股 | 新买入 |
| 摩根大通JPMORGAN CHASE & CO |
| <0.01% | — | #52 | $52.5万 | 2.8万股 | $0 | 0股 | +2.8万股 | 新买入 |
| 吉萨洛资本管理Ghisallo Capital Management LLC |
| <0.01% | — | #32 | $46.8万 | 2.5万股 | $0 | 0股 | +2.5万股 | 新买入 |
| Burkehill Global 管理Burkehill Global Management, LP |
| 0.01% | — | #25 | $37.4万 | 2.0万股 | $0 | 0股 | +2.0万股 | 新买入 |
| D.E.肖D. E. Shaw & Co., Inc. |
| <0.01% | — | #46 | $37.1万 | 2.0万股 | $0 | 0股 | +2.0万股 | 新买入 |
| XTX资本XTX Topco Ltd |
| <0.01% | — | #30 | $31.0万 | 1.7万股 | $0 | 0股 | +1.7万股 | 新买入 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | — | #53 | $25.6万 | 1.4万股 | $0 | 0股 | +1.4万股 | 新买入 |
