| TCG Crossover 管理TCG Crossover Management, LLC |
| 0.48% | 0.62% | #5 | $2,010.0万 | 1,000.0万股 | $2,150.0万 | 1,000.0万股 | 00.00% | 持仓不变 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #60 | $1,577.4万 | 784.8万股 | $1,664.4万 | 774.1万股 | +10.7万股+1.38% | 加仓 |
| ACADIAN ASSET MANAGEMENT LLC |
| 0.01% | 0.01% | #21 | $887.3万 | 441.4万股 | $867.5万 | 403.9万股 | +37.6万股+9.30% | 加仓 |
| Nantahala 资本管理Nantahala Capital Management, LLC |
| 0.29% | 0.22% | #12 | $867.9万 | 431.8万股 | $605.4万 | 281.6万股 | +150.2万股+53.34% | 加仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #65 | $805.9万 | 400.9万股 | $790.9万 | 367.9万股 | +33.1万股+8.99% | 加仓 |
| Kynam Capital Management, LP |
| 0.42% | 0.27% | #7 | $765.5万 | 380.8万股 | $430.0万 | 200.0万股 | +180.8万股+90.42% | 加仓 |
| Balyasny资产管理BALYASNY ASSET MANAGEMENT L.P. |
| 0.01% | 0.01% | #23 | $754.0万 | 375.1万股 | $631.1万 | 293.5万股 | +81.6万股+27.80% | 加仓 |
| Merck & Co., Inc. |
| 1.35% | 2.18% | #2 | $712.7万 | 354.6万股 | $762.3万 | 354.6万股 | 00.00% | 持仓不变 |
| 683 Capital Management, LLC |
| 0.32% | 0.36% | #10 | $643.2万 | 320.0万股 | $688.0万 | 320.0万股 | 00.00% | 持仓不变 |
| D.E.肖D. E. Shaw & Co., Inc. |
| <0.01% | <0.01% | #29 | $595.0万 | 296.0万股 | $716.6万 | 333.3万股 | -37.3万股-11.19% | 减仓 |
| ADAR1 Capital Management, LLC |
| 0.27% | 0.13% | #13 | $579.6万 | 288.4万股 | $225.8万 | 105.0万股 | +183.4万股+174.63% | 加仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #58 | $566.9万 | 282.0万股 | $555.5万 | 258.4万股 | +23.7万股+9.17% | 加仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #57 | $493.4万 | 245.4万股 | $491.6万 | 228.6万股 | +16.8万股+7.35% | 加仓 |
| Spruce Street Capital LP |
| 0.83% | 1.09% | #3 | $422.3万 | 210.1万股 | $451.7万 | 210.1万股 | 00.00% | 持仓不变 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #37 | $399.8万 | 198.9万股 | $425.5万 | 197.9万股 | +9,609股+0.49% | 加仓 |
| Ikarian Capital, LLC |
| 0.42% | 0.36% | #8 | $398.5万 | 198.3万股 | $447.8万 | 208.3万股 | -10.0万股-4.80% | 减仓 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #75 | $377.8万 | 188.0万股 | $401.1万 | 186.6万股 | +1.4万股+0.76% | 加仓 |
| Jacobs Levy股票管理JACOBS LEVY EQUITY MANAGEMENT, INC |
| 0.01% | 0.02% | #20 | $355.0万 | 176.6万股 | $463.2万 | 215.4万股 | -38.8万股-18.03% | 减仓 |
| MEDICI CAPITAL LLC |
| 6.51% | 4.37% | #1 | $332.2万 | 165.3万股 | $355.3万 | 165.3万股 | 00.00% | 持仓不变 |
| Affinity Asset Advisors, LLC |
| 0.14% | 0.06% | #15 | $303.5万 | 151.0万股 | $107.5万 | 50.0万股 | +101.0万股+202.00% | 加仓 |
| Eversept Partners, LP |
| 0.15% | 0.15% | #14 | $286.2万 | 142.4万股 | $290.5万 | 135.1万股 | +7.3万股+5.39% | 加仓 |
| 富达投资FMR LLC |
| <0.01% | <0.01% | #72 | $280.7万 | 139.6万股 | $386.2万 | 179.6万股 | -40.0万股-22.25% | 减仓 |
| AQR资本管理AQR CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #41 | $263.2万 | 131.0万股 | $152.9万 | 71.1万股 | +59.8万股+84.10% | 加仓 |
| Euclidean Capital LLC |
| 0.6% | 0.72% | #4 | $262.9万 | 130.8万股 | $281.2万 | 130.8万股 | 00.00% | 持仓不变 |
| 麦肯齐金融MACKENZIE FINANCIAL CORP |
| <0.01% | <0.01% | #32 | $223.1万 | 111.0万股 | $184.3万 | 85.7万股 | +25.2万股+29.44% | 加仓 |
| DEUTSCHE 银行 AG\DEUTSCHE BANK AG\ |
| <0.01% | <0.01% | #46 | $220.8万 | 109.8万股 | $235.0万 | 109.3万股 | +5,485股+0.50% | 加仓 |
| Deerfield管理DEERFIELD MANAGEMENT COMPANY, L.P. |
| 0.02% | 0.03% | #17 | $212.1万 | 105.5万股 | $226.9万 | 105.5万股 | 00.00% | 持仓不变 |
| Two Sigma投资TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #34 | $210.1万 | 104.5万股 | $275.1万 | 127.9万股 | -23.4万股-18.29% | 减仓 |
| 文艺复兴科技RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | <0.01% | #30 | $188.0万 | 93.5万股 | $276.9万 | 128.8万股 | -35.3万股-27.38% | 减仓 |
| DAFNA Capital Management LLC |
| 0.35% | 0.44% | #9 | $182.6万 | 90.8万股 | $195.3万 | 90.8万股 | 00.00% | 持仓不变 |
| Elmind Capital, LP |
| 0.45% | 0.55% | #6 | $180.9万 | 90.0万股 | $193.5万 | 90.0万股 | 00.00% | 持仓不变 |
| PanAgora资产管理PANAGORA ASSET MANAGEMENT INC |
| 0.01% | <0.01% | #25 | $170.0万 | 84.6万股 | $126.9万 | 59.0万股 | +25.6万股+43.30% | 加仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #61 | $164.6万 | 81.9万股 | $169.3万 | 78.7万股 | +3.1万股+3.99% | 加仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #63 | $155.5万 | 77.3万股 | $148.8万 | 69.2万股 | +8.1万股+11.73% | 加仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #56 | $133.4万 | 66.4万股 | $124.3万 | 57.8万股 | +8.6万股+14.82% | 加仓 |
| 马歇尔·韦斯MARSHALL WACE, LLP |
| <0.01% | <0.01% | #40 | $120.3万 | 59.9万股 | $133.4万 | 62.0万股 | -2.2万股-3.52% | 减仓 |
| 布斯湾基金管理BOOTHBAY FUND MANAGEMENT, LLC |
| 0.01% | 0.02% | #19 | $107.1万 | 53.3万股 | $120.3万 | 56.0万股 | -2.7万股-4.80% | 减仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #73 | $100.5万 | 50.0万股 | $23.5万 | 10.9万股 | +39.1万股+357.81% | 加仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #88 | $87.2万 | 43.4万股 | $130.0万 | 60.5万股 | -17.1万股-28.23% | 减仓 |
| XTX资本XTX Topco Ltd |
| 0.01% | 0.02% | #22 | $80.3万 | 40.0万股 | $120.4万 | 56.0万股 | -16.0万股-28.62% | 减仓 |
| 康托·菲茨杰拉德CANTOR FITZGERALD, L. P. |
| 0.01% | — | #24 | $59.4万 | 29.5万股 | $0 | 0股 | +29.5万股 | 新买入 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #90 | $55.0万 | 27.4万股 | $31.2万 | 14.5万股 | +12.8万股+88.37% | 加仓 |
| 景顺Invesco Ltd. |
| <0.01% | <0.01% | #99 | $51.7万 | 25.7万股 | $57.0万 | 26.5万股 | -7,928股-2.99% | 减仓 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| <0.01% | <0.01% | #84 | $50.3万 | 25.0万股 | $54.2万 | 25.2万股 | -2,204股-0.87% | 减仓 |
| 阿默普莱斯金融AMERIPRISE FINANCIAL INC |
| <0.01% | <0.01% | #81 | $45.1万 | 22.5万股 | $58.3万 | 27.1万股 | -4.7万股-17.23% | 减仓 |
| LMR合伙人LMR Partners LLP |
| <0.01% | — | #35 | $40.2万 | 20.0万股 | $0 | 0股 | +20.0万股 | 新买入 |
| NANO CAP NEW MILLENNIUM GROWTH FUND L P |
| 0.31% | 0.4% | #11 | $40.2万 | 20.0万股 | $43.0万 | 20.0万股 | 00.00% | 持仓不变 |
| 纽文Nuveen, LLC |
| <0.01% | <0.01% | #83 | $35.4万 | 17.6万股 | $33.3万 | 15.5万股 | +2.1万股+13.75% | 加仓 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #108 | $34.7万 | 17.2万股 | $57.9万 | 26.9万股 | -9.7万股-35.97% | 减仓 |
| 犹他州退休系统Utah Retirement Systems |
| <0.01% | <0.01% | #28 | $31.0万 | 15.4万股 | $33.2万 | 15.4万股 | 00.00% | 持仓不变 |
