| 深轨资本Deep Track Capital, LP |
| 1.58% | 1.35% | #8 | $1.09亿 | 335.3万股 | $8,268.0万 | 335.3万股 | 00.00% | 持仓不变 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #51 | $8,874.2万 | 273.4万股 | $6,093.1万 | 247.1万股 | +26.3万股+10.66% | 加仓 |
| RA资本管理RA CAPITAL MANAGEMENT, L.P. |
| 0.62% | 0.58% | #15 | $7,168.0万 | 220.9万股 | $5,446.4万 | 220.9万股 | 00.00% | 持仓不变 |
| Trails Edge Capital Partners, LP |
| 7.85% | 7.45% | #3 | $4,943.0万 | 152.3万股 | $3,253.5万 | 131.9万股 | +20.4万股+15.44% | 加仓 |
| 摩根大通JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #42 | $4,887.2万 | 149.7万股 | $3,319.1万 | 142.8万股 | +7.0万股+4.88% | 加仓 |
| Commodore Capital LP |
| 2.9% | 2.14% | #4 | $4,868.3万 | 150.0万股 | $3,699.0万 | 150.0万股 | 00.00% | 持仓不变 |
| TCG Crossover 管理TCG Crossover Management, LLC |
| 1.13% | 1.3% | #11 | $4,697.2万 | 144.7万股 | $4,528.0万 | 183.9万股 | -39.2万股-21.32% | 减仓 |
| Caligan Partners LP |
| 2.2% | 2.3% | #6 | $4,667.3万 | 143.8万股 | $3,462.9万 | 143.8万股 | 00.00% | 持仓不变 |
| Spruce Street Capital LP |
| 8.76% | 8.09% | #2 | $4,466.3万 | 137.6万股 | $3,364.5万 | 137.6万股 | 00.00% | 持仓不变 |
| Nantahala 资本管理Nantahala Capital Management, LLC |
| 1.14% | 0.96% | #10 | $3,417.2万 | 105.3万股 | $2,596.4万 | 105.3万股 | 00.00% | 持仓不变 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #62 | $3,151.9万 | 97.1万股 | $2,206.2万 | 89.5万股 | +7.7万股+8.55% | 加仓 |
| Balyasny资产管理BALYASNY ASSET MANAGEMENT L.P. |
| 0.04% | 0.03% | #28 | $2,990.6万 | 92.1万股 | $2,277.8万 | 92.4万股 | -2,223股-0.24% | 减仓 |
| Alyeska投资集团Alyeska Investment Group, L.P. |
| 0.07% | 0.06% | #26 | $2,803.9万 | 86.4万股 | $2,128.3万 | 86.4万股 | 00.00% | 持仓不变 |
| Vivo Capital, LLC |
| 2.37% | 1.64% | #5 | $2,596.4万 | 80.0万股 | $1,972.8万 | 80.0万股 | 00.00% | 持仓不变 |
| Nan Fung Group Holdings Ltd |
| 15.57% | 12.82% | #1 | $2,046.8万 | 63.1万股 | $1,555.2万 | 63.1万股 | 00.00% | 持仓不变 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #54 | $1,989.3万 | 61.3万股 | $1,278.3万 | 51.8万股 | +9.5万股+18.25% | 加仓 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #66 | $1,953.9万 | 60.2万股 | $1,243.8万 | 50.4万股 | +9.8万股+19.36% | 加仓 |
| Logos Global Management LP |
| 0.82% | 1.13% | #13 | $1,898.6万 | 58.5万股 | $2,256.4万 | 91.5万股 | -33.0万股-36.07% | 减仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #47 | $1,870.9万 | 57.6万股 | $897.1万 | 36.4万股 | +21.3万股+58.45% | 加仓 |
| 詹尼森联营JENNISON ASSOCIATES LLC |
| 0.01% | 0.01% | #35 | $1,755.5万 | 54.1万股 | $1,327.2万 | 53.8万股 | +2,686股+0.50% | 加仓 |
| GREAT POINT PARTNERS LLC |
| 1.95% | 1.7% | #7 | $1,029.5万 | 31.7万股 | $739.8万 | 30.0万股 | +1.7万股+5.74% | 加仓 |
| 布斯湾基金管理BOOTHBAY FUND MANAGEMENT, LLC |
| 0.12% | — | #23 | $894.7万 | 27.6万股 | $0 | 0股 | +27.6万股 | 新买入 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #41 | $841.3万 | 25.9万股 | $337.8万 | 13.7万股 | +12.2万股+89.26% | 加仓 |
| 阿默普莱斯金融AMERIPRISE FINANCIAL INC |
| <0.01% | <0.01% | #48 | $738.3万 | 22.7万股 | $267.1万 | 10.8万股 | +11.9万股+110.04% | 加仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #59 | $700.9万 | 21.6万股 | $1,028.1万 | 41.7万股 | -20.1万股-48.20% | 减仓 |
| HighVista Strategies LLC |
| 1.57% | 1.18% | #9 | $686.5万 | 21.2万股 | $428.1万 | 17.4万股 | +3.8万股+21.84% | 加仓 |
| 贝克兄弟顾问BAKER BROS. ADVISORS LP |
| 0.03% | 0.03% | #29 | $649.1万 | 20.0万股 | $493.2万 | 20.0万股 | 00.00% | 持仓不变 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #57 | $634.4万 | 19.5万股 | $458.9万 | 18.6万股 | +9,391股+5.05% | 加仓 |
| 富达投资FMR LLC |
| <0.01% | <0.01% | #81 | $613.1万 | 18.9万股 | $548.7万 | 22.3万股 | -3.4万股-15.10% | 减仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #60 | $603.8万 | 18.6万股 | $380.7万 | 15.4万股 | +3.2万股+20.49% | 加仓 |
| Eversept Partners, LP |
| 0.31% | 0.13% | #17 | $596.1万 | 18.4万股 | $247.1万 | 10.0万股 | +8.3万股+83.30% | 加仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #52 | $528.4万 | 16.3万股 | $388.2万 | 15.7万股 | +5,375股+3.41% | 加仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #85 | $493.8万 | 15.2万股 | $277.4万 | 11.2万股 | +4.0万股+35.26% | 加仓 |
| Integral Health 资产管理Integral Health Asset Management, LLC |
| 0.19% | 0.18% | #20 | $486.8万 | 15.0万股 | $369.9万 | 15.0万股 | 00.00% | 持仓不变 |
| 雷蒙德詹姆斯金融RAYMOND JAMES FINANCIAL INC |
| <0.01% | — | #58 | $297.5万 | 9.2万股 | $0 | 0股 | +9.2万股 | 新买入 |
| 法国巴黎银行金融市场BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | <0.01% | #50 | $280.3万 | 8.6万股 | $10.0万 | 4,052股 | +8.2万股+2,031.56% | 加仓 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #75 | $279.0万 | 8.6万股 | $340.1万 | 13.8万股 | -5.2万股-37.69% | 减仓 |
| Longbow Finance SA |
| 0.34% | — | #16 | $267.2万 | 8.2万股 | $0 | 0股 | +8.2万股 | 新买入 |
| Boxer Capital Management, LLC |
| 0.17% | 0.23% | #21 | $227.2万 | 7.0万股 | $172.6万 | 7.0万股 | 00.00% | 持仓不变 |
| NEXTBio Capital Management LP |
| 1.02% | — | #12 | $221.5万 | 6.8万股 | $0 | 0股 | +6.8万股 | 新买入 |
| 惠灵顿管理集团WELLINGTON MANAGEMENT GROUP LLP |
| <0.01% | <0.01% | #78 | $191.1万 | 5.9万股 | $129.8万 | 5.3万股 | +6,251股+11.88% | 加仓 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| <0.01% | <0.01% | #80 | $178.4万 | 5.5万股 | $112.1万 | 4.5万股 | +9,522股+20.95% | 加仓 |
| ALERUS FINANCIAL NA |
| 0.08% | — | #25 | $178.1万 | 5.5万股 | $0 | 0股 | +5.5万股 | 新买入 |
| 纽文Nuveen, LLC |
| <0.01% | <0.01% | #70 | $169.2万 | 5.2万股 | $56.6万 | 2.3万股 | +2.9万股+127.04% | 加仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #96 | $166.2万 | 5.1万股 | $15.2万 | 9,605股 | +4.2万股+433.13% | 加仓 |
| Two Sigma投资TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #53 | $157.9万 | 4.9万股 | $31.4万 | 1.3万股 | +3.6万股+282.48% | 加仓 |
| XTX资本XTX Topco Ltd |
| 0.02% | — | #32 | $152.6万 | 4.7万股 | $0 | 0股 | +4.7万股 | 新买入 |
| Y截距(香港)Y-Intercept (Hong Kong) Ltd |
| 0.03% | — | #31 | $127.9万 | 3.9万股 | $0 | 0股 | +3.9万股 | 新买入 |
| 罗素投资集团Russell Investments Group, Ltd. |
| <0.01% | <0.01% | #56 | $110.6万 | 3.4万股 | $177.7万 | 7.2万股 | -3.8万股-52.72% | 减仓 |
| STEMPOINT CAPITAL LP |
| 0.15% | 0.23% | #22 | $103.2万 | 3.2万股 | $123.3万 | 5.0万股 | -1.8万股-36.43% | 减仓 |
