| 詹尼森联营JENNISON ASSOCIATES LLC |
| 0.04% | 0.02% | #21 | $6,230.5万 | 2,003.4万股 | $2,413.1万 | 897.1万股 | +1,106.3万股+123.33% | 加仓 |
| 普信投资管理T. Rowe Price Investment Management, Inc. |
| 0.04% | 0.02% | #20 | $5,868.5万 | 1,887.0万股 | $2,980.6万 | 1,108.0万股 | +779.0万股+70.31% | 加仓 |
| Bain Capital Life Sciences Investors, LLC |
| 3.19% | 2.35% | #1 | $5,362.1万 | 1,724.1万股 | $2,603.1万 | 967.7万股 | +756.4万股+78.17% | 加仓 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #80 | $3,344.7万 | 1,075.5万股 | $638.3万 | 237.3万股 | +838.2万股+353.21% | 加仓 |
| Adage资本合伙人ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.04% | 0.04% | #18 | $2,853.3万 | 917.5万股 | $2,375.2万 | 883.0万股 | +34.5万股+3.91% | 加仓 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #69 | $2,438.0万 | 783.9万股 | $126.4万 | 47.0万股 | +736.9万股+1,568.02% | 加仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #81 | $2,247.6万 | 722.7万股 | $1,083.8万 | 402.9万股 | +319.8万股+79.38% | 加仓 |
| Cormorant Asset Management, LP |
| 0.79% | 0.74% | #5 | $1,555.0万 | 500.0万股 | $1,479.5万 | 550.0万股 | -50.0万股-9.09% | 减仓 |
| 普信集团PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | <0.01% | #58 | $1,374.2万 | 441.9万股 | $119.1万 | 44.2万股 | +397.6万股+899.07% | 加仓 |
| Woodline合伙人Woodline Partners LP |
| 0.04% | 0.01% | #17 | $1,306.2万 | 420.0万股 | $336.3万 | 125.0万股 | +295.0万股+235.95% | 加仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #56 | $1,285.3万 | 413.3万股 | $150.9万 | 56.1万股 | +357.2万股+636.95% | 加仓 |
| 挪威央行投资管理NORGES BANK |
| <0.01% | — | #59 | $1,279.0万 | 411.2万股 | $0 | 0股 | +411.2万股 | 新买入 |
| Opaleye Management Inc. |
| 1.09% | 0.49% | #4 | $1,201.6万 | 386.4万股 | $371.2万 | 138.0万股 | +248.4万股+179.99% | 加仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #76 | $1,076.2万 | 345.9万股 | $305.0万 | 113.3万股 | +232.6万股+205.27% | 加仓 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #70 | $911.1万 | 293.0万股 | $300.2万 | 111.6万股 | +181.3万股+162.48% | 加仓 |
| 富兰克林资源FRANKLIN RESOURCES INC |
| <0.01% | — | #55 | $750.7万 | 241.4万股 | $0 | 0股 | +241.4万股 | 新买入 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #74 | $687.9万 | 221.2万股 | $277.0万 | 103.0万股 | +118.2万股+114.80% | 加仓 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| <0.01% | 0.01% | #49 | $643.3万 | 206.8万股 | $1,588.0万 | 590.3万股 | -383.5万股-64.96% | 减仓 |
| 马歇尔·韦斯MARSHALL WACE, LLP |
| <0.01% | 0.01% | #45 | $487.0万 | 156.6万股 | $586.4万 | 218.0万股 | -61.4万股-28.16% | 减仓 |
| 文艺复兴科技RENAISSANCE TECHNOLOGIES LLC |
| 0.01% | 0.01% | #36 | $477.5万 | 153.5万股 | $547.9万 | 203.7万股 | -50.1万股-24.62% | 减仓 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #75 | $457.8万 | 147.2万股 | $163.2万 | 60.7万股 | +86.5万股+142.62% | 加仓 |
| Qube研究科技Qube Research & Technologies Ltd |
| <0.01% | 0.01% | #44 | $443.7万 | 142.7万股 | $520.5万 | 193.5万股 | -50.8万股-26.26% | 减仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | — | #95 | $441.0万 | 141.8万股 | $0 | 0股 | +141.8万股 | 新买入 |
| Two Sigma投资TWO SIGMA INVESTMENTS, LP |
| <0.01% | 0.01% | #47 | $438.8万 | 141.1万股 | $671.9万 | 249.8万股 | -108.7万股-43.52% | 减仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #92 | $418.5万 | 134.6万股 | $345.1万 | 147.5万股 | -12.9万股-8.76% | 减仓 |
| SPHERA FUNDS MANAGEMENT LTD. |
| 0.54% | — | #7 | $413.3万 | 132.9万股 | $0 | 0股 | +132.9万股 | 新买入 |
| SUPERSTRING CAPITAL MANAGEMENT LP |
| 2.19% | 2.05% | #2 | $347.8万 | 127.9万股 | $286.8万 | 106.6万股 | +21.2万股+19.92% | 加仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #68 | $338.6万 | 108.9万股 | $153.4万 | 57.0万股 | +51.8万股+90.92% | 加仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #87 | $313.2万 | 100.7万股 | $64.1万 | 23.8万股 | +76.9万股+322.37% | 加仓 |
| 维度基金顾问DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #78 | $300.8万 | 96.7万股 | $199.0万 | 74.1万股 | +22.7万股+30.59% | 加仓 |
| Stonepine Capital Management, LLC |
| 0.44% | 0.05% | #8 | $285.2万 | 91.7万股 | $13.5万 | 5.0万股 | +86.7万股+1,734.20% | 加仓 |
| 施罗德投资管理SCHRODER INVESTMENT MANAGEMENT GROUP |
| <0.01% | <0.01% | #52 | $266.4万 | 85.7万股 | $186.9万 | 75.7万股 | +10.0万股+13.22% | 加仓 |
| 阿默普莱斯金融AMERIPRISE FINANCIAL INC |
| <0.01% | — | #79 | $257.6万 | 82.8万股 | $0 | 0股 | +82.8万股 | 新买入 |
| 康托·菲茨杰拉德CANTOR FITZGERALD, L. P. |
| 0.03% | 0.03% | #22 | $248.8万 | 80.0万股 | $205.8万 | 76.5万股 | +3.5万股+4.58% | 加仓 |
| HEIGHTS CAPITAL MANAGEMENT, INC |
| 0.54% | — | #6 | $235.0万 | 75.6万股 | $0 | 0股 | +75.6万股 | 新买入 |
| Blue Owl Capital Holdings LP |
| 0.32% | — | #9 | $222.3万 | 71.5万股 | $0 | 0股 | +71.5万股 | 新买入 |
| Ikarian Capital, LLC |
| 0.23% | 0.2% | #10 | $217.7万 | 70.0万股 | $242.1万 | 90.0万股 | -20.0万股-22.22% | 减仓 |
| Burkehill Global 管理Burkehill Global Management, LP |
| 0.08% | 0.09% | #15 | $217.7万 | 70.0万股 | $188.3万 | 70.0万股 | 00.00% | 持仓不变 |
| GSA CAPITAL PARTNERS LLP |
| 0.13% | 0.09% | #11 | $207.9万 | 66.9万股 | $151.1万 | 56.2万股 | +10.7万股+19.02% | 加仓 |
| 纽文Nuveen, LLC |
| <0.01% | — | #82 | $201.0万 | 64.6万股 | $0 | 0股 | +64.6万股 | 新买入 |
| Caption管理Caption Management, LLC |
| 0.01% | <0.01% | #30 | $186.4万 | 60.0万股 | $26.9万 | 10.0万股 | +50.0万股+499.50% | 加仓 |
| KVP Capital Advisors, LP |
| 1.15% | 1.02% | #3 | $157.2万 | 50.5万股 | $136.0万 | 50.5万股 | 00.00% | 持仓不变 |
| Simplex交易SIMPLEX TRADING, LLC |
| <0.01% | <0.01% | #64 | $154.8万 | 49.8万股 | $110.3万 | 41.0万股 | +8.8万股+21.44% | 加仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #109 | $153.4万 | 49.3万股 | $72.4万 | 26.9万股 | +22.4万股+83.21% | 加仓 |
| 简街集团JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #103 | $153.3万 | 49.3万股 | $114.0万 | 42.4万股 | +6.9万股+16.31% | 加仓 |
| Group One交易GROUP ONE TRADING LLC |
| <0.01% | <0.01% | #51 | $152.5万 | 49.0万股 | $243.7万 | 90.6万股 | -41.6万股-45.88% | 减仓 |
| 跳跃金融Jump Financial, LLC |
| 0.01% | <0.01% | #28 | $152.0万 | 48.9万股 | $4.5万 | 1.7万股 | +47.2万股+2,826.80% | 加仓 |
| 赖夫艾森国际银行Raiffeisen Bank International AG |
| 0.02% | 0.02% | #26 | $133.7万 | 43.0万股 | $111.2万 | 45.0万股 | -2.0万股-4.44% | 减仓 |
| 道明资产管理TD ASSET MANAGEMENT INC |
| <0.01% | <0.01% | #62 | $121.7万 | 39.1万股 | $18.0万 | 6.7万股 | +32.5万股+484.95% | 加仓 |
| 萨斯奎汉纳组合策略Susquehanna Portfolio Strategies, LLC |
| 0.02% | <0.01% | #24 | $119.2万 | 38.3万股 | $4.7万 | 1.8万股 | +36.6万股+2,078.43% | 加仓 |
