| ARCH Venture Management, LLC |
| 12.42% | — | #2 | $1.37亿 | 629.5万股 | $0 | 0股 | +629.5万股 | 新买入 |
| GENERAL ATLANTIC, L.P. |
| 4.56% | — | #4 | $1.33亿 | 610.2万股 | $0 | 0股 | +610.2万股 | 新买入 |
| Sofinnova Investments, Inc. |
| 4% | — | #5 | $7,742.9万 | 356.5万股 | $0 | 0股 | +356.5万股 | 新买入 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | — | #26 | $4,732.0万 | 217.9万股 | $0 | 0股 | +217.9万股 | 新买入 |
| TRV GP VI, LLC |
| 19.27% | — | #1 | $4,477.0万 | 206.1万股 | $0 | 0股 | +206.1万股 | 新买入 |
| 加拿大养老金计划投资委员会(CPPIB)CANADA PENSION PLAN INVESTMENT BOARD |
| 0.02% | — | #17 | $4,291.4万 | 197.6万股 | $0 | 0股 | +197.6万股 | 新买入 |
| 摩根大通JPMORGAN CHASE & CO |
| <0.01% | — | #31 | $4,089.3万 | 181.6万股 | $0 | 0股 | +181.6万股 | 新买入 |
| Foresite Capital Management VI LLC |
| 6.02% | — | #3 | $3,865.1万 | 178.0万股 | $0 | 0股 | +178.0万股 | 新买入 |
| 普信集团PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | — | #29 | $2,842.3万 | 130.9万股 | $0 | 0股 | +130.9万股 | 新买入 |
| 富达投资FMR LLC |
| <0.01% | — | #33 | $2,574.0万 | 118.5万股 | $0 | 0股 | +118.5万股 | 新买入 |
| Bellevue 集团Bellevue Group AG |
| 0.5% | — | #6 | $2,389.2万 | 110.0万股 | $0 | 0股 | +110.0万股 | 新买入 |
| Siren, L.L.C. |
| 0.48% | — | #8 | $2,379.0万 | 109.5万股 | $0 | 0股 | +109.5万股 | 新买入 |
| 詹尼森联营JENNISON ASSOCIATES LLC |
| 0.01% | — | #19 | $2,345.0万 | 108.0万股 | $0 | 0股 | +108.0万股 | 新买入 |
| RA资本管理RA CAPITAL MANAGEMENT, L.P. |
| 0.13% | — | #13 | $1,520.4万 | 70.0万股 | $0 | 0股 | +70.0万股 | 新买入 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | — | #43 | $1,301.5万 | 59.9万股 | $0 | 0股 | +59.9万股 | 新买入 |
| Woodline合伙人Woodline Partners LP |
| 0.04% | — | #15 | $1,273.5万 | 58.6万股 | $0 | 0股 | +58.6万股 | 新买入 |
| 洞察顾问PERCEPTIVE ADVISORS LLC |
| 0.16% | — | #11 | $1,086.0万 | 50.0万股 | $0 | 0股 | +50.0万股 | 新买入 |
| BRAIDWELL LP |
| 0.4% | — | #9 | $1,086.0万 | 50.0万股 | $0 | 0股 | +50.0万股 | 新买入 |
| 信安金融集团PRINCIPAL FINANCIAL GROUP INC |
| <0.01% | — | #24 | $900.7万 | 41.5万股 | $0 | 0股 | +41.5万股 | 新买入 |
| 安本标准投资Aberdeen Group plc |
| 0.01% | — | #21 | $674.1万 | 31.0万股 | $0 | 0股 | +31.0万股 | 新买入 |
| 瑞银集团UBS Group AG |
| <0.01% | — | #35 | $606.4万 | 27.9万股 | $0 | 0股 | +27.9万股 | 新买入 |
| 贝莱德BlackRock, Inc. |
| <0.01% | — | #46 | $499.3万 | 23.0万股 | $0 | 0股 | +23.0万股 | 新买入 |
| SEVEN GRAND MANAGERS, LLC |
| 0.2% | — | #10 | $488.7万 | 22.5万股 | $0 | 0股 | +22.5万股 | 新买入 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | — | #38 | $415.2万 | 19.1万股 | $0 | 0股 | +19.1万股 | 新买入 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | — | #44 | $382.2万 | 17.6万股 | $0 | 0股 | +17.6万股 | 新买入 |
| Pier Capital, LLC |
| 0.49% | — | #7 | $369.2万 | 17.0万股 | $0 | 0股 | +17.0万股 | 新买入 |
| 阿默普莱斯金融AMERIPRISE FINANCIAL INC |
| <0.01% | — | #37 | $286.2万 | 13.2万股 | $0 | 0股 | +13.2万股 | 新买入 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | — | #42 | $212.2万 | 9.8万股 | $0 | 0股 | +9.8万股 | 新买入 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | — | #39 | $190.6万 | 8.8万股 | $0 | 0股 | +8.8万股 | 新买入 |
| Pentwater资本管理Pentwater Capital Management LP |
| 0.01% | — | #20 | $180.3万 | 8.3万股 | $0 | 0股 | +8.3万股 | 新买入 |
| 宏利人寿MANUFACTURERS LIFE INSURANCE COMPANY, THE |
| <0.01% | — | #32 | $179.3万 | 8.3万股 | $0 | 0股 | +8.3万股 | 新买入 |
| Alyeska投资集团Alyeska Investment Group, L.P. |
| <0.01% | — | #25 | $162.9万 | 7.5万股 | $0 | 0股 | +7.5万股 | 新买入 |
| ALPS顾问ALPS ADVISORS INC |
| 0.01% | — | #22 | $118.0万 | 5.4万股 | $0 | 0股 | +5.4万股 | 新买入 |
| 道明资产管理TD ASSET MANAGEMENT INC |
| <0.01% | — | #34 | $104.1万 | 4.8万股 | $0 | 0股 | +4.8万股 | 新买入 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| <0.01% | — | #41 | $98.5万 | 4.5万股 | $0 | 0股 | +4.5万股 | 新买入 |
| GSA CAPITAL PARTNERS LLP |
| 0.05% | — | #14 | $72.1万 | 3.3万股 | $0 | 0股 | +3.3万股 | 新买入 |
| DAFNA Capital Management LLC |
| 0.13% | — | #12 | $70.4万 | 3.2万股 | $0 | 0股 | +3.2万股 | 新买入 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | — | #45 | $69.1万 | 3.2万股 | $0 | 0股 | +3.2万股 | 新买入 |
| ADAR1 Capital Management, LLC |
| 0.03% | — | #16 | $56.5万 | 2.6万股 | $0 | 0股 | +2.6万股 | 新买入 |
| 吉萨洛资本管理Ghisallo Capital Management LLC |
| <0.01% | — | #27 | $54.3万 | 2.5万股 | $0 | 0股 | +2.5万股 | 新买入 |
| Burkehill Global 管理Burkehill Global Management, LP |
| 0.02% | — | #18 | $54.3万 | 2.5万股 | $0 | 0股 | +2.5万股 | 新买入 |
| SquarepointSquarepoint Ops LLC |
| <0.01% | — | #36 | $53.8万 | 2.5万股 | $0 | 0股 | +2.5万股 | 新买入 |
| HighTower顾问HighTower Advisors, LLC |
| <0.01% | — | #40 | $36.2万 | 1.7万股 | $0 | 0股 | +1.7万股 | 新买入 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | — | #51 | $25.4万 | 1.2万股 | $0 | 0股 | +1.2万股 | 新买入 |
| XTX资本XTX Topco Ltd |
| <0.01% | — | #28 | $23.9万 | 1.1万股 | $0 | 0股 | +1.1万股 | 新买入 |
| 韦斯资产管理Weiss Asset Management LP |
| <0.01% | — | #30 | $21.7万 | 1.0万股 | $0 | 0股 | +1.0万股 | 新买入 |
| Zimmer 合伙人Zimmer Partners, LP |
| 0.01% | — | #23 | $21.7万 | 1.0万股 | $0 | 0股 | +1.0万股 | 新买入 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | — | #52 | $19.7万 | 9,081股 | $0 | 0股 | +9,081股 | 新买入 |
| 先锋环球顾问Vanguard Global Advisers, LLC |
| <0.01% | — | #47 | $15.5万 | 7,159股 | $0 | 0股 | +7,159股 | 新买入 |
| 花旗集团CITIGROUP INC |
| <0.01% | — | #50 | $5.3万 | 2,454股 | $0 | 0股 | +2,454股 | 新买入 |
