| 蒙塔诺瓦资本MONTANOVA CAPITAL, LLC |
| 0.54% | 0.18% | #4 | $2,971.8万 | 638.4万股 | $717.5万 | 125.0万股 | +513.4万股+410.74% | 加仓 |
| Affinity Asset Advisors, LLC |
| 1.22% | 1.5% | #2 | $2,703.4万 | 580.8万股 | $2,898.8万 | 505.0万股 | +75.7万股+15.00% | 加仓 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #66 | $2,671.7万 | 573.9万股 | $2,933.6万 | 511.1万股 | +62.9万股+12.30% | 加仓 |
| RA资本管理RA CAPITAL MANAGEMENT, L.P. |
| 0.2% | 0.3% | #13 | $2,327.5万 | 500.0万股 | $2,870.0万 | 500.0万股 | 00.00% | 持仓不变 |
| Frazier Life Sciences 管理Frazier Life Sciences Management, L.P. |
| 0.49% | 0.65% | #5 | $2,245.9万 | 482.5万股 | $2,539.8万 | 442.5万股 | +40.0万股+9.04% | 加仓 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #58 | $2,027.1万 | 435.5万股 | $2,048.2万 | 356.8万股 | +78.7万股+22.04% | 加仓 |
| Vestal Point 资本Vestal Point Capital, LP |
| 0.47% | 0.72% | #6 | $2,011.0万 | 432.0万股 | $2,568.7万 | 447.5万股 | -15.5万股-3.46% | 减仓 |
| 范式生物资本Paradigm Biocapital Advisors LP |
| 0.36% | 0.73% | #8 | $1,943.6万 | 417.5万股 | $3,549.7万 | 618.4万股 | -200.9万股-32.48% | 减仓 |
| 木星资产管理Jupiter Topco LLC |
| 0.01% | — | #32 | $1,840.9万 | 395.5万股 | $0 | 0股 | +395.5万股 | 新买入 |
| 奥比梅德顾问ORBIMED ADVISORS LLC |
| 0.35% | 0.41% | #9 | $1,837.7万 | 394.8万股 | $2,067.8万 | 360.2万股 | +34.5万股+9.59% | 加仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #42 | $1,814.8万 | 389.9万股 | $2,207.4万 | 384.6万股 | +5.3万股+1.37% | 加仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #67 | $1,455.1万 | 312.6万股 | $1,726.1万 | 300.7万股 | +11.9万股+3.95% | 加仓 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #37 | $1,319.1万 | 283.4万股 | $925.7万 | 161.3万股 | +122.1万股+75.70% | 加仓 |
| Woodline合伙人Woodline Partners LP |
| 0.04% | 0.06% | #22 | $1,164.0万 | 250.1万股 | $1,578.8万 | 275.1万股 | -25.0万股-9.09% | 减仓 |
| Balyasny资产管理BALYASNY ASSET MANAGEMENT L.P. |
| 0.01% | 0.01% | #26 | $1,123.1万 | 241.3万股 | $912.4万 | 159.0万股 | +82.3万股+51.78% | 加仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #48 | $1,000.6万 | 215.0万股 | $1,119.2万 | 195.0万股 | +20.0万股+10.24% | 加仓 |
| 683 Capital Management, LLC |
| 0.43% | 0.36% | #7 | $872.8万 | 187.5万股 | $688.8万 | 120.0万股 | +67.5万股+56.25% | 加仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #63 | $813.9万 | 174.8万股 | $869.1万 | 151.4万股 | +23.4万股+15.47% | 加仓 |
| ADAR1 Capital Management, LLC |
| 0.34% | 0.5% | #10 | $728.9万 | 156.6万股 | $842.3万 | 146.7万股 | +9.9万股+6.72% | 加仓 |
| Avoro资本顾问Avoro Capital Advisors LLC |
| 0.06% | 0.11% | #21 | $693.2万 | 148.9万股 | $1,076.3万 | 187.5万股 | -38.6万股-20.58% | 减仓 |
| Qube研究科技Qube Research & Technologies Ltd |
| 0.01% | <0.01% | #35 | $640.6万 | 137.6万股 | $267.2万 | 46.6万股 | +91.1万股+195.63% | 加仓 |
| Nantahala 资本管理Nantahala Capital Management, LLC |
| 0.2% | 0.25% | #14 | $605.2万 | 130.0万股 | $688.8万 | 120.0万股 | +10.0万股+8.33% | 加仓 |
| 维度基金顾问DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #46 | $599.3万 | 128.7万股 | $633.2万 | 110.4万股 | +18.4万股+16.64% | 加仓 |
| Spruce Street Capital LP |
| 0.85% | 1.28% | #3 | $432.3万 | 92.9万股 | $533.0万 | 92.9万股 | 00.00% | 持仓不变 |
| 黑石集团Blackstone Inc. |
| 0.01% | 0.02% | #27 | $421.7万 | 90.5万股 | $519.4万 | 90.5万股 | 00.00% | 持仓不变 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #60 | $403.8万 | 86.7万股 | $283.4万 | 49.4万股 | +37.4万股+75.70% | 加仓 |
| 安本标准投资Aberdeen Group plc |
| <0.01% | <0.01% | #38 | $314.3万 | 67.5万股 | $141.1万 | 24.6万股 | +42.9万股+174.53% | 加仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #87 | $285.7万 | 61.4万股 | $331.3万 | 57.7万股 | +3.7万股+6.35% | 加仓 |
| Ikarian Capital, LLC |
| 0.25% | 0.24% | #12 | $238.8万 | 51.3万股 | $294.5万 | 51.3万股 | 00.00% | 持仓不变 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #82 | $228.2万 | 49.0万股 | $282.1万 | 49.2万股 | -1,201股-0.24% | 减仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #62 | $200.5万 | 43.1万股 | $220.8万 | 38.5万股 | +4.6万股+11.95% | 加仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #97 | $183.9万 | 39.5万股 | $65.1万 | 9.8万股 | +29.7万股+302.93% | 加仓 |
| 法国巴黎银行金融市场BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | <0.01% | #49 | $180.8万 | 38.8万股 | $131.0万 | 22.8万股 | +16.0万股+70.20% | 加仓 |
| DAFNA Capital Management LLC |
| 0.33% | 0.49% | #11 | $175.5万 | 37.7万股 | $216.4万 | 37.7万股 | 00.00% | 持仓不变 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #74 | $164.8万 | 35.4万股 | $184.7万 | 32.2万股 | +3.2万股+10.04% | 加仓 |
| Trexquant投资Trexquant Investment LP |
| 0.01% | — | #30 | $146.6万 | 31.5万股 | $0 | 0股 | +31.5万股 | 新买入 |
| SquarepointSquarepoint Ops LLC |
| <0.01% | <0.01% | #44 | $137.2万 | 29.5万股 | $183.2万 | 31.9万股 | -2.4万股-7.62% | 减仓 |
| Hennion & Walsh Asset Management, Inc. |
| 0.04% | — | #23 | $123.7万 | 26.6万股 | $0 | 0股 | +26.6万股 | 新买入 |
| AQR资本管理AQR CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #65 | $119.5万 | 25.7万股 | $194.9万 | 34.0万股 | -8.3万股-24.43% | 减仓 |
| 文艺复兴科技RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | — | #43 | $116.5万 | 25.0万股 | $0 | 0股 | +25.0万股 | 新买入 |
| 惠灵顿管理集团WELLINGTON MANAGEMENT GROUP LLP |
| <0.01% | <0.01% | #77 | $94.2万 | 20.2万股 | $99.1万 | 17.3万股 | +3.0万股+17.19% | 加仓 |
| 纽文Nuveen, LLC |
| <0.01% | <0.01% | #72 | $93.3万 | 20.0万股 | $105.0万 | 18.3万股 | +1.7万股+9.53% | 加仓 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| <0.01% | <0.01% | #84 | $85.6万 | 18.4万股 | $91.2万 | 15.9万股 | +2.5万股+15.72% | 加仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #94 | $80.3万 | 17.3万股 | $104.5万 | 18.2万股 | -9,460股-5.20% | 减仓 |
| 萨斯奎汉纳组合策略Susquehanna Portfolio Strategies, LLC |
| 0.01% | 0.01% | #28 | $75.0万 | 16.1万股 | $64.9万 | 11.3万股 | +4.8万股+42.56% | 加仓 |
| Privium Fund Management B.V. |
| 0.13% | 0.24% | #17 | $72.2万 | 15.5万股 | $117.7万 | 20.5万股 | -5.0万股-24.39% | 减仓 |
| XTX资本XTX Topco Ltd |
| 0.01% | 0.01% | #29 | $67.8万 | 14.6万股 | $57.7万 | 10.1万股 | +4.5万股+44.68% | 加仓 |
| 富达投资FMR LLC |
| <0.01% | <0.01% | #115 | $65.7万 | 14.1万股 | $14.0万 | 2.4万股 | +11.7万股+478.75% | 加仓 |
| 布斯湾基金管理BOOTHBAY FUND MANAGEMENT, LLC |
| 0.01% | 0.01% | #31 | $63.5万 | 13.6万股 | $78.3万 | 13.6万股 | 00.00% | 持仓不变 |
| Burkehill Global 管理Burkehill Global Management, LP |
| 0.02% | 0.04% | #25 | $58.2万 | 12.5万股 | $71.8万 | 12.5万股 | 00.00% | 持仓不变 |
