| Flagship Pioneering, LLC |
| 68.66% | 67.44% | #1 | $10.57亿 | 6,267.3万股 | $7.83亿 | 6,267.3万股 | 00.00% | 持仓不变 |
| 富达投资FMR LLC |
| <0.01% | <0.01% | #29 | $8,808.8万 | 522.2万股 | $5,271.9万 | 421.8万股 | +100.4万股+23.81% | 加仓 |
| 资本世界投资者Capital World Investors |
| 0.01% | 0.01% | #21 | $7,111.8万 | 421.6万股 | $5,005.2万 | 400.4万股 | +21.1万股+5.28% | 加仓 |
| BRAIDWELL LP |
| 2.05% | 1.5% | #5 | $5,539.8万 | 328.4万股 | $4,491.2万 | 359.3万股 | -30.9万股-8.60% | 减仓 |
| 普信集团PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | <0.01% | #30 | $3,638.2万 | 215.7万股 | $2,637.1万 | 211.0万股 | +4.7万股+2.23% | 加仓 |
| 挪威央行投资管理NORGES BANK |
| <0.01% | — | #31 | $3,533.6万 | 209.5万股 | $0 | 0股 | +209.5万股 | 新买入 |
| ARCH Venture Management, LLC |
| 2.98% | 3.59% | #3 | $3,280.2万 | 194.4万股 | $2,430.5万 | 194.4万股 | 00.00% | 持仓不变 |
| HARBOURVEST PARTNERS LLC |
| 17.09% | 21.33% | #2 | $2,905.4万 | 172.2万股 | $2,152.8万 | 172.2万股 | 00.00% | 持仓不变 |
| 贝莱德BlackRock, Inc. |
| <0.01% | — | #48 | $2,800.4万 | 166.0万股 | $0 | 0股 | +166.0万股 | 新买入 |
| 贝克兄弟顾问BAKER BROS. ADVISORS LP |
| 0.12% | 0.1% | #12 | $2,401.6万 | 142.4万股 | $1,779.5万 | 142.4万股 | 00.00% | 持仓不变 |
| 摩根大通JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #34 | $2,383.7万 | 141.0万股 | $3,392.3万 | 294.7万股 | -153.8万股-52.17% | 减仓 |
| 深轨资本Deep Track Capital, LP |
| 0.33% | — | #8 | $2,250.1万 | 133.4万股 | $0 | 0股 | +133.4万股 | 新买入 |
| ARK投资管理ARK Investment Management LLC |
| 0.14% | 0.05% | #11 | $2,167.1万 | 128.5万股 | $623.0万 | 49.8万股 | +78.6万股+157.74% | 加仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #49 | $1,910.9万 | 113.3万股 | $164.1万 | 13.1万股 | +100.1万股+762.59% | 加仓 |
| HARVARD 管理HARVARD MANAGEMENT CO INC |
| 0.44% | 0.76% | #7 | $1,874.4万 | 111.1万股 | $1,388.9万 | 111.1万股 | 00.00% | 持仓不变 |
| 英伟达NVIDIA CORP |
| 0.02% | 0.06% | #18 | $1,405.8万 | 83.3万股 | $1,041.7万 | 83.3万股 | 00.00% | 持仓不变 |
| Davern Capital Partners, LP |
| 2.37% | 2.03% | #4 | $1,391.2万 | 82.5万股 | $739.8万 | 59.2万股 | +23.3万股+39.35% | 加仓 |
| Siren, L.L.C. |
| 0.25% | 0.26% | #10 | $1,241.8万 | 73.6万股 | $920.1万 | 73.6万股 | 00.00% | 持仓不变 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #42 | $1,240.3万 | 73.5万股 | $147.8万 | 11.8万股 | +61.7万股+521.60% | 加仓 |
| 道富集团STATE STREET CORP |
| <0.01% | — | #57 | $888.3万 | 52.7万股 | $0 | 0股 | +52.7万股 | 新买入 |
| Affinity Asset Advisors, LLC |
| 0.3% | 0.23% | #9 | $674.8万 | 40.0万股 | $437.5万 | 35.0万股 | +5.0万股+14.29% | 加仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | — | #54 | $637.7万 | 37.8万股 | $0 | 0股 | +37.8万股 | 新买入 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #41 | $550.4万 | 32.6万股 | $445.9万 | 35.7万股 | -3.0万股-8.53% | 减仓 |
| SPHERA FUNDS MANAGEMENT LTD. |
| 0.54% | 0.37% | #6 | $413.3万 | 24.5万股 | $231.3万 | 18.5万股 | +6.0万股+32.43% | 加仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | — | #46 | $378.9万 | 22.5万股 | $0 | 0股 | +22.5万股 | 新买入 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | — | #51 | $333.3万 | 19.8万股 | $0 | 0股 | +19.8万股 | 新买入 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #43 | $295.8万 | 17.5万股 | $21.8万 | 1.7万股 | +15.8万股+904.56% | 加仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | — | #66 | $282.2万 | 16.7万股 | $0 | 0股 | +16.7万股 | 新买入 |
| CenterBook Partners LP |
| 0.11% | 0.18% | #13 | $221.9万 | 13.2万股 | $333.5万 | 26.7万股 | -13.5万股-50.69% | 减仓 |
| ALPS顾问ALPS ADVISORS INC |
| 0.01% | — | #20 | $218.3万 | 12.9万股 | $0 | 0股 | +12.9万股 | 新买入 |
| SEVEN GRAND MANAGERS, LLC |
| 0.08% | 0.1% | #15 | $210.9万 | 12.5万股 | $156.3万 | 12.5万股 | 00.00% | 持仓不变 |
| 巴克莱BARCLAYS PLC |
| <0.01% | <0.01% | #53 | $197.2万 | 11.7万股 | $88.6万 | 7.1万股 | +4.6万股+64.90% | 加仓 |
| LMR合伙人LMR Partners LLP |
| 0.01% | <0.01% | #24 | $168.7万 | 10.0万股 | $125.0万 | 10.0万股 | 00.00% | 持仓不变 |
| 阿默普莱斯金融AMERIPRISE FINANCIAL INC |
| <0.01% | <0.01% | #55 | $153.7万 | 9.1万股 | $109.2万 | 8.7万股 | +3,765股+4.31% | 加仓 |
| 宏利人寿MANUFACTURERS LIFE INSURANCE COMPANY, THE |
| <0.01% | <0.01% | #36 | $143.1万 | 8.5万股 | $92.9万 | 7.4万股 | +1.0万股+14.12% | 加仓 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| <0.01% | — | #64 | $96.7万 | 5.7万股 | $0 | 0股 | +5.7万股 | 新买入 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #74 | $93.5万 | 5.5万股 | $42.7万 | 3.4万股 | +2.1万股+62.09% | 加仓 |
| 道明资产管理TD ASSET MANAGEMENT INC |
| <0.01% | <0.01% | #40 | $85.6万 | 5.1万股 | $53.6万 | 4.3万股 | +7,882股+18.39% | 加仓 |
| 纽文Nuveen, LLC |
| <0.01% | — | #61 | $75.0万 | 4.4万股 | $0 | 0股 | +4.4万股 | 新买入 |
| 文艺复兴科技RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | — | #38 | $66.9万 | 4.0万股 | $0 | 0股 | +4.0万股 | 新买入 |
| 三井住友信托集团Sumitomo Mitsui Trust Group, Inc. |
| <0.01% | <0.01% | #52 | $65.2万 | 3.9万股 | $50.4万 | 4.0万股 | -1,679股-4.16% | 减仓 |
| Amova资产管理Amova Asset Management Americas, Inc. |
| 0.01% | 0.01% | #22 | $64.4万 | 3.8万股 | $49.9万 | 4.0万股 | -2,126股-5.27% | 减仓 |
| IQ EQ FUND MANAGEMENT (IRELAND) Ltd |
| 0.04% | 0.02% | #16 | $62.8万 | 3.7万股 | $24.0万 | 1.9万股 | +1.8万股+93.86% | 加仓 |
| 正交资本Quadrature Capital Ltd |
| <0.01% | — | #28 | $53.2万 | 3.2万股 | $0 | 0股 | +3.2万股 | 新买入 |
| SquarepointSquarepoint Ops LLC |
| <0.01% | <0.01% | #45 | $53.0万 | 3.1万股 | $46.5万 | 3.7万股 | -5,797股-15.58% | 减仓 |
| RhumbLine顾问RHUMBLINE ADVISERS |
| <0.01% | — | #50 | $51.7万 | 3.1万股 | $0 | 0股 | +3.1万股 | 新买入 |
| 花旗集团CITIGROUP INC |
| <0.01% | <0.01% | #63 | $51.6万 | 3.1万股 | $2.8万 | 2,244股 | +2.8万股+1,263.06% | 加仓 |
| Virtus Investment Advisers, LLC |
| 0.1% | — | #14 | $44.6万 | 2.6万股 | $0 | 0股 | +2.6万股 | 新买入 |
| XTX资本XTX Topco Ltd |
| 0.01% | — | #26 | $42.1万 | 2.5万股 | $0 | 0股 | +2.5万股 | 新买入 |
| DEUTSCHE 银行 AG\DEUTSCHE BANK AG\ |
| <0.01% | — | #69 | $40.7万 | 2.4万股 | $0 | 0股 | +2.4万股 | 新买入 |
