| Caligan Partners LP |
| 1.45% | 1.84% | #9 | $3,085.7万 | 816.3万股 | $2,761.1万 | 497.5万股 | +318.8万股+64.09% | 加仓 |
| Samsara BioCapital, LLC |
| 1.96% | 2.8% | #7 | $2,387.0万 | 631.5万股 | $2,883.1万 | 519.5万股 | +112.0万股+21.56% | 加仓 |
| 范式生物资本Paradigm Biocapital Advisors LP |
| 0.28% | 0.45% | #20 | $1,512.0万 | 400.0万股 | $2,220.0万 | 400.0万股 | 00.00% | 持仓不变 |
| Andera Partners |
| 6.65% | 5.7% | #1 | $1,373.3万 | 363.3万股 | $1,009.1万 | 181.8万股 | +181.5万股+99.83% | 加仓 |
| ADAR1 Capital Management, LLC |
| 0.63% | 0.71% | #14 | $1,363.3万 | 360.7万股 | $1,206.8万 | 217.4万股 | +143.2万股+65.87% | 加仓 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| <0.01% | 0.01% | #45 | $1,327.6万 | 351.2万股 | $1,658.1万 | 298.8万股 | +52.5万股+17.56% | 加仓 |
| Nantahala 资本管理Nantahala Capital Management, LLC |
| 0.34% | — | #18 | $1,015.5万 | 268.6万股 | $0 | 0股 | +268.6万股 | 新买入 |
| Trails Edge Capital Partners, LP |
| 1.6% | 3.38% | #8 | $1,004.7万 | 265.8万股 | $1,475.2万 | 265.8万股 | 00.00% | 持仓不变 |
| 富兰克林资源FRANKLIN RESOURCES INC |
| <0.01% | <0.01% | #49 | $998.9万 | 264.3万股 | $1,366.2万 | 246.2万股 | +18.1万股+7.35% | 加仓 |
| Squadron Capital Management LLC |
| 2.86% | 1.09% | #4 | $920.4万 | 243.5万股 | $296.9万 | 53.5万股 | +190.0万股+355.14% | 加仓 |
| Woodline合伙人Woodline Partners LP |
| 0.03% | — | #33 | $878.2万 | 232.3万股 | $0 | 0股 | +232.3万股 | 新买入 |
| 安本标准投资Aberdeen Group plc |
| 0.01% | — | #35 | $872.3万 | 230.8万股 | $0 | 0股 | +230.8万股 | 新买入 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #57 | $871.4万 | 230.5万股 | $1,286.9万 | 231.9万股 | -1.4万股-0.58% | 减仓 |
| 布斯湾基金管理BOOTHBAY FUND MANAGEMENT, LLC |
| 0.1% | 0.11% | #24 | $757.4万 | 200.4万股 | $816.1万 | 147.0万股 | +53.3万股+36.27% | 加仓 |
| Patient Square Capital LP |
| 1.15% | — | #10 | $743.6万 | 196.7万股 | $0 | 0股 | +196.7万股 | 新买入 |
| NEXTBio Capital Management LP |
| 3.11% | 3.44% | #3 | $675.9万 | 178.8万股 | $740.1万 | 133.3万股 | +45.5万股+34.08% | 加仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #61 | $674.6万 | 178.5万股 | $36.0万 | 6.5万股 | +172.0万股+2,647.60% | 加仓 |
| 阿默普莱斯金融AMERIPRISE FINANCIAL INC |
| <0.01% | <0.01% | #55 | $641.5万 | 169.7万股 | $468.5万 | 84.4万股 | +85.3万股+101.03% | 加仓 |
| Point72资产管理Point72 Asset Management, L.P. |
| 0.01% | 0.01% | #39 | $636.2万 | 168.3万股 | $530.7万 | 95.6万股 | +72.7万股+76.01% | 加仓 |
| Integral Health 资产管理Integral Health Asset Management, LLC |
| 0.23% | 0.11% | #22 | $574.6万 | 152.0万股 | $222.0万 | 40.0万股 | +112.0万股+280.00% | 加仓 |
| Yu Fan |
| 5.25% | 8.58% | #2 | $567.0万 | 150.0万股 | $832.5万 | 150.0万股 | 00.00% | 持仓不变 |
| NEA Management Company, LLC |
| 0.35% | 0.46% | #17 | $552.9万 | 146.3万股 | $803.0万 | 146.3万股 | 00.00% | 持仓不变 |
| STEMPOINT CAPITAL LP |
| 0.77% | — | #12 | $539.1万 | 142.6万股 | $0 | 0股 | +142.6万股 | 新买入 |
| Propel Bio Management, LLC |
| 2.53% | 2.52% | #5 | $484.3万 | 128.1万股 | $399.5万 | 72.5万股 | +55.7万股+76.80% | 加仓 |
| KINGDON CAPITAL MANAGEMENT, L.L.C. |
| 0.49% | — | #15 | $480.1万 | 127.0万股 | $0 | 0股 | +127.0万股 | 新买入 |
| 摩根大通JPMORGAN CHASE & CO |
| <0.01% | — | #68 | $464.7万 | 130.9万股 | $0 | 0股 | +130.9万股 | 新买入 |
| Adage资本合伙人ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.01% | — | #41 | $423.4万 | 112.0万股 | $0 | 0股 | +112.0万股 | 新买入 |
| Ikarian Capital, LLC |
| 0.44% | 0.64% | #16 | $415.3万 | 112.9万股 | $784.3万 | 142.9万股 | -30.0万股-20.99% | 减仓 |
| 极地资本控股Polar Capital Holdings Plc |
| 0.01% | 0.04% | #37 | $406.1万 | 107.4万股 | $1,183.3万 | 213.2万股 | -105.8万股-49.62% | 减仓 |
| 马歇尔·韦斯MARSHALL WACE, LLP |
| <0.01% | <0.01% | #48 | $365.1万 | 96.6万股 | $363.1万 | 65.4万股 | +31.2万股+47.64% | 加仓 |
| SYQUANT CAPITAL SAS |
| 0.78% | — | #11 | $345.2万 | 91.3万股 | $0 | 0股 | +91.3万股 | 新买入 |
| Alyeska投资集团Alyeska Investment Group, L.P. |
| 0.01% | — | #38 | $343.6万 | 90.9万股 | $0 | 0股 | +90.9万股 | 新买入 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #70 | $340.8万 | 90.2万股 | $17.2万 | 3.0万股 | +87.2万股+2,927.67% | 加仓 |
| 简街集团JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #66 | $340.7万 | 90.1万股 | $38.5万 | 6.9万股 | +83.2万股+1,198.17% | 加仓 |
| HighVista Strategies LLC |
| 0.72% | 0.94% | #13 | $314.3万 | 83.1万股 | $341.7万 | 61.6万股 | +21.6万股+35.05% | 加仓 |
| 深轨资本Deep Track Capital, LP |
| 0.04% | 0.11% | #28 | $302.4万 | 80.0万股 | $678.5万 | 122.2万股 | -42.2万股-34.56% | 减仓 |
| Two Sigma投资TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #50 | $275.2万 | 72.8万股 | $125.7万 | 22.6万股 | +50.2万股+221.60% | 加仓 |
| DIADEMA PARTNERS LP |
| 0.34% | 0.33% | #19 | $272.6万 | 74.1万股 | $193.5万 | 35.2万股 | +38.8万股+110.21% | 加仓 |
| BVF INC/IL |
| 0.07% | 0.12% | #25 | $259.3万 | 68.6万股 | $380.8万 | 68.6万股 | 00.00% | 持仓不变 |
| 富达投资FMR LLC |
| <0.01% | — | #73 | $259.1万 | 68.5万股 | $0 | 0股 | +68.5万股 | 新买入 |
| Ally Bridge Group (NY) LLC |
| 2.12% | 3.34% | #6 | $240.0万 | 63.5万股 | $413.6万 | 74.5万股 | -11.1万股-14.83% | 减仓 |
| Qube研究科技Qube Research & Technologies Ltd |
| <0.01% | — | #53 | $150.3万 | 39.8万股 | $0 | 0股 | +39.8万股 | 新买入 |
| J. Goldman & Co LP |
| 0.03% | 0.02% | #30 | $127.6万 | 33.8万股 | $57.5万 | 10.4万股 | +23.4万股+226.03% | 加仓 |
| 简化资产管理Simplify Asset Management Inc. |
| 0.02% | 0.02% | #34 | $118.5万 | 31.3万股 | $126.5万 | 22.8万股 | +8.6万股+37.54% | 加仓 |
| 工匠合伙人Artisan Partners Limited Partnership |
| <0.01% | <0.01% | #52 | $99.6万 | 26.4万股 | $179.3万 | 32.3万股 | -5.9万股-18.41% | 减仓 |
| 吉萨洛资本管理Ghisallo Capital Management LLC |
| 0.01% | — | #42 | $94.5万 | 25.0万股 | $0 | 0股 | +25.0万股 | 新买入 |
| Burkehill Global 管理Burkehill Global Management, LP |
| 0.03% | — | #31 | $85.1万 | 22.5万股 | $0 | 0股 | +22.5万股 | 新买入 |
| SEVEN GRAND MANAGERS, LLC |
| 0.03% | — | #29 | $85.1万 | 22.5万股 | $0 | 0股 | +22.5万股 | 新买入 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #77 | $84.9万 | 22.4万股 | $102.6万 | 18.5万股 | +4.0万股+21.41% | 加仓 |
| XTX资本XTX Topco Ltd |
| 0.01% | 0.01% | #36 | $81.0万 | 21.4万股 | $36.7万 | 6.6万股 | +14.8万股+224.08% | 加仓 |
