| SR ONE CAPITAL MANAGEMENT, LP |
| 9.09% | 7.59% | #1 | $9,443.8万 | 652.6万股 | $6,944.2万 | 652.6万股 | 00.00% | 持仓不变 |
| Logos Global Management LP |
| 1.87% | 1.04% | #7 | $4,341.0万 | 300.0万股 | $2,074.8万 | 195.0万股 | +105.0万股+53.85% | 加仓 |
| 贝克兄弟顾问BAKER BROS. ADVISORS LP |
| 0.19% | 0.16% | #16 | $3,875.7万 | 267.8万股 | $2,751.5万 | 258.6万股 | +9.2万股+3.58% | 加仓 |
| Driehaus资本管理DRIEHAUS CAPITAL MANAGEMENT LLC |
| 0.22% | 0.14% | #14 | $3,850.6万 | 266.1万股 | $1,856.7万 | 174.5万股 | +91.6万股+52.50% | 加仓 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #68 | $3,849.1万 | 266.0万股 | $2,270.3万 | 213.4万股 | +52.6万股+24.66% | 加仓 |
| Caption管理Caption Management, LLC |
| 0.18% | 0.01% | #17 | $3,788.4万 | 261.8万股 | $92.3万 | 8.7万股 | +253.1万股+2,919.44% | 加仓 |
| Point72资产管理Point72 Asset Management, L.P. |
| 0.04% | 0.04% | #26 | $3,424.3万 | 236.6万股 | $2,897.0万 | 272.3万股 | -35.6万股-13.09% | 减仓 |
| Trails Edge Capital Partners, LP |
| 4.6% | 2.08% | #2 | $2,895.9万 | 200.1万股 | $906.5万 | 85.2万股 | +114.9万股+134.89% | 加仓 |
| Frazier Life Sciences 管理Frazier Life Sciences Management, L.P. |
| 0.57% | — | #10 | $2,618.9万 | 181.0万股 | $0 | 0股 | +181.0万股 | 新买入 |
| Vivo Capital, LLC |
| 2.13% | 1.43% | #5 | $2,333.9万 | 161.3万股 | $1,716.1万 | 161.3万股 | 00.00% | 持仓不变 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #74 | $2,273.3万 | 157.1万股 | $1,436.2万 | 135.0万股 | +22.1万股+16.38% | 加仓 |
| Almitas Capital LLC |
| 3.46% | 3.68% | #3 | $1,485.9万 | 102.7万股 | $1,628.3万 | 153.0万股 | -50.3万股-32.90% | 减仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #62 | $1,387.2万 | 95.8万股 | $737.1万 | 69.3万股 | +26.6万股+38.40% | 加仓 |
| Sofinnova Investments, Inc. |
| 0.65% | — | #9 | $1,251.9万 | 86.5万股 | $0 | 0股 | +86.5万股 | 新买入 |
| 富达投资FMR LLC |
| <0.01% | <0.01% | #73 | $1,123.5万 | 77.6万股 | $849.5万 | 79.8万股 | -2.2万股-2.75% | 减仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #67 | $1,107.6万 | 76.5万股 | $132.5万 | 17.6万股 | +58.9万股+334.92% | 加仓 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #84 | $1,065.3万 | 73.6万股 | $701.8万 | 66.0万股 | +7.7万股+11.62% | 加仓 |
| Woodline合伙人Woodline Partners LP |
| 0.03% | 0.04% | #27 | $1,013.4万 | 70.0万股 | $1,023.0万 | 96.2万股 | -26.1万股-27.16% | 减仓 |
| 维度基金顾问DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #49 | $1,005.2万 | 69.5万股 | $459.3万 | 43.2万股 | +26.3万股+60.88% | 加仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #58 | $950.1万 | 65.7万股 | $537.0万 | 50.5万股 | +15.2万股+30.09% | 加仓 |
| Jacobs Levy股票管理JACOBS LEVY EQUITY MANAGEMENT, INC |
| 0.03% | 0.01% | #29 | $818.4万 | 56.6万股 | $307.9万 | 28.9万股 | +27.6万股+95.45% | 加仓 |
| ACADIAN ASSET MANAGEMENT LLC |
| 0.01% | 0.01% | #31 | $777.7万 | 53.7万股 | $655.5万 | 61.6万股 | -7.9万股-12.81% | 减仓 |
| Siren, L.L.C. |
| 0.15% | — | #18 | $757.1万 | 52.3万股 | $0 | 0股 | +52.3万股 | 新买入 |
| Qube研究科技Qube Research & Technologies Ltd |
| 0.01% | <0.01% | #36 | $632.5万 | 43.7万股 | $36.4万 | 3.4万股 | +40.3万股+1,178.64% | 加仓 |
| 文艺复兴科技RENAISSANCE TECHNOLOGIES LLC |
| 0.01% | 0.01% | #33 | $561.3万 | 38.8万股 | $434.3万 | 40.8万股 | -2.0万股-4.97% | 减仓 |
| 肯尼迪资本管理KENNEDY CAPITAL MANAGEMENT LLC |
| 0.1% | 0.06% | #21 | $555.7万 | 38.4万股 | $288.9万 | 27.2万股 | +11.2万股+41.42% | 加仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #66 | $511.1万 | 35.3万股 | $319.5万 | 30.0万股 | +5.3万股+17.62% | 加仓 |
| Algert全球ALGERT GLOBAL LLC |
| 0.05% | 0.03% | #25 | $428.4万 | 29.6万股 | $217.8万 | 20.5万股 | +9.1万股+44.62% | 加仓 |
| ACUTA CAPITAL PARTNERS, LLC |
| 2.85% | 1.1% | #4 | $408.9万 | 28.3万股 | $155.2万 | 14.6万股 | +13.7万股+93.67% | 加仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #71 | $392.5万 | 27.1万股 | $256.9万 | 24.1万股 | +3.0万股+12.33% | 加仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #94 | $363.8万 | 25.1万股 | $147.4万 | 13.9万股 | +11.3万股+81.46% | 加仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #63 | $333.1万 | 23.0万股 | $208.2万 | 19.6万股 | +3.5万股+17.66% | 加仓 |
| 保德信金融PRUDENTIAL FINANCIAL INC |
| <0.01% | <0.01% | #43 | $324.4万 | 22.4万股 | $48.7万 | 4.6万股 | +17.8万股+389.35% | 加仓 |
| D.E.肖D. E. Shaw & Co., Inc. |
| <0.01% | <0.01% | #54 | $283.1万 | 19.6万股 | $500.4万 | 47.0万股 | -27.5万股-58.40% | 减仓 |
| Eversept Partners, LP |
| 0.14% | — | #19 | $274.9万 | 19.0万股 | $0 | 0股 | +19.0万股 | 新买入 |
| KVP Capital Advisors, LP |
| 1.96% | — | #6 | $267.7万 | 18.5万股 | $0 | 0股 | +18.5万股 | 新买入 |
| J. Goldman & Co LP |
| 0.07% | — | #23 | $255.8万 | 17.7万股 | $0 | 0股 | +17.7万股 | 新买入 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #64 | $213.7万 | 14.8万股 | $115.9万 | 10.9万股 | +3.9万股+35.61% | 加仓 |
| 雷蒙德詹姆斯金融RAYMOND JAMES FINANCIAL INC |
| <0.01% | <0.01% | #70 | $200.4万 | 13.9万股 | $115.4万 | 10.8万股 | +3.0万股+27.73% | 加仓 |
| Balyasny资产管理BALYASNY ASSET MANAGEMENT L.P. |
| <0.01% | — | #48 | $160.8万 | 11.1万股 | $0 | 0股 | +11.1万股 | 新买入 |
| Elmind Capital, LP |
| 0.39% | 0.63% | #11 | $156.1万 | 10.8万股 | $221.2万 | 20.8万股 | -10.0万股-48.10% | 减仓 |
| 纽文Nuveen, LLC |
| <0.01% | <0.01% | #81 | $151.6万 | 10.5万股 | $134.9万 | 12.7万股 | -2.2万股-17.41% | 减仓 |
| DAFNA Capital Management LLC |
| 0.28% | — | #12 | $148.5万 | 10.3万股 | $0 | 0股 | +10.3万股 | 新买入 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #95 | $138.7万 | 9.6万股 | $246.3万 | 23.2万股 | -13.6万股-58.59% | 减仓 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| <0.01% | <0.01% | #90 | $133.2万 | 9.2万股 | $84.7万 | 8.0万股 | +1.2万股+15.60% | 加仓 |
| China Universal Asset Management Co., Ltd. |
| 0.08% | 0.03% | #22 | $130.1万 | 9.0万股 | $37.4万 | 3.5万股 | +5.5万股+156.17% | 加仓 |
| SummitTX 资本SummitTX Capital, L.P. |
| 0.03% | — | #28 | $116.7万 | 8.1万股 | $0 | 0股 | +8.1万股 | 新买入 |
| 美国世纪投资AMERICAN CENTURY COMPANIES INC |
| <0.01% | <0.01% | #72 | $111.2万 | 7.7万股 | $69.8万 | 6.6万股 | +1.1万股+17.04% | 加仓 |
| Palumbo Wealth Management LLC |
| 0.22% | 0.19% | #15 | $103.8万 | 7.2万股 | $76.0万 | 7.1万股 | +336股+0.47% | 加仓 |
| AQR资本管理AQR CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #82 | $102.9万 | 7.1万股 | $27.6万 | 2.6万股 | +4.5万股+173.97% | 加仓 |
