| TCG Crossover 管理TCG Crossover Management, LLC |
| 0.87% | — | #6 | $3,600.0万 | 1,111.1万股 | $0 | 0股 | +1,111.1万股 | 新买入 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #86 | $3,431.2万 | 1,059.0万股 | $2,288.0万 | 926.3万股 | +132.7万股+14.32% | 加仓 |
| RA资本管理RA CAPITAL MANAGEMENT, L.P. |
| 0.25% | — | #11 | $2,880.0万 | 888.9万股 | $0 | 0股 | +888.9万股 | 新买入 |
| Commodore Capital LP |
| 1.72% | — | #2 | $2,880.0万 | 888.9万股 | $0 | 0股 | +888.9万股 | 新买入 |
| ADAR1 Capital Management, LLC |
| 1.33% | — | #3 | $2,880.0万 | 888.9万股 | $0 | 0股 | +888.9万股 | 新买入 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #91 | $1,989.8万 | 614.1万股 | $1,038.5万 | 420.4万股 | +193.7万股+46.07% | 加仓 |
| 范式生物资本Paradigm Biocapital Advisors LP |
| 0.34% | — | #9 | $1,810.1万 | 558.7万股 | $0 | 0股 | +558.7万股 | 新买入 |
| Opaleye Management Inc. |
| 1.13% | 0.63% | #4 | $1,251.3万 | 386.2万股 | $476.0万 | 192.7万股 | +193.5万股+100.41% | 加仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #85 | $1,165.9万 | 359.8万股 | $777.7万 | 314.9万股 | +45.0万股+14.28% | 加仓 |
| Woodline合伙人Woodline Partners LP |
| 0.04% | — | #19 | $1,152.0万 | 355.5万股 | $0 | 0股 | +355.5万股 | 新买入 |
| Vivo Capital, LLC |
| 1.05% | — | #5 | $1,151.9万 | 355.5万股 | $0 | 0股 | +355.5万股 | 新买入 |
| GordonMD Global Investments LP |
| 4.01% | — | #1 | $1,013.1万 | 312.7万股 | $0 | 0股 | +312.7万股 | 新买入 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #78 | $846.9万 | 261.4万股 | $138.0万 | 55.9万股 | +205.5万股+367.98% | 加仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #89 | $832.6万 | 256.9万股 | $571.1万 | 231.2万股 | +25.7万股+11.13% | 加仓 |
| 文艺复兴科技RENAISSANCE TECHNOLOGIES LLC |
| 0.01% | 0.02% | #27 | $799.9万 | 246.9万股 | $981.1万 | 397.2万股 | -150.3万股-37.84% | 减仓 |
| Logos Global Management LP |
| 0.31% | — | #10 | $719.9万 | 222.2万股 | $0 | 0股 | +222.2万股 | 新买入 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #114 | $710.1万 | 219.2万股 | $512.8万 | 207.6万股 | +11.6万股+5.57% | 加仓 |
| 马歇尔·韦斯MARSHALL WACE, LLP |
| 0.01% | <0.01% | #37 | $660.1万 | 203.7万股 | $51.9万 | 21.0万股 | +182.7万股+868.72% | 加仓 |
| D.E.肖D. E. Shaw & Co., Inc. |
| <0.01% | <0.01% | #46 | $615.9万 | 190.1万股 | $480.1万 | 194.4万股 | -4.3万股-2.21% | 减仓 |
| 摩根大通JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #101 | $596.0万 | 186.2万股 | $434.3万 | 194.7万股 | -8.5万股-4.36% | 减仓 |
| AQR资本管理AQR CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #57 | $509.4万 | 157.2万股 | $338.5万 | 137.0万股 | +20.2万股+14.72% | 加仓 |
| Two Sigma投资TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #44 | $431.9万 | 133.3万股 | $382.6万 | 154.9万股 | -21.6万股-13.95% | 减仓 |
| Seven Fleet Capital Management LP |
| 0.71% | — | #7 | $431.1万 | 133.1万股 | $0 | 0股 | +133.1万股 | 新买入 |
| 雷蒙德詹姆斯金融RAYMOND JAMES FINANCIAL INC |
| <0.01% | <0.01% | #63 | $427.3万 | 131.9万股 | $319.6万 | 129.4万股 | +2.5万股+1.94% | 加仓 |
| ACADIAN ASSET MANAGEMENT LLC |
| <0.01% | 0.01% | #39 | $336.6万 | 103.9万股 | $359.6万 | 145.8万股 | -41.9万股-28.72% | 减仓 |
| 肯尼迪资本管理KENNEDY CAPITAL MANAGEMENT LLC |
| 0.06% | 0.06% | #18 | $334.4万 | 103.2万股 | $260.0万 | 105.2万股 | -2.0万股-1.93% | 减仓 |
| 麦肯齐金融MACKENZIE FINANCIAL CORP |
| <0.01% | <0.01% | #47 | $284.5万 | 87.8万股 | $180.3万 | 73.0万股 | +14.8万股+20.27% | 加仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #99 | $281.2万 | 86.8万股 | $212.7万 | 86.1万股 | +6,706股+0.78% | 加仓 |
| Nantahala 资本管理Nantahala Capital Management, LLC |
| 0.09% | — | #14 | $276.3万 | 85.3万股 | $0 | 0股 | +85.3万股 | 新买入 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #104 | $265.6万 | 82.0万股 | $183.4万 | 74.2万股 | +7.7万股+10.40% | 加仓 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #103 | $243.2万 | 75.1万股 | $97.3万 | 39.4万股 | +35.7万股+90.67% | 加仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #84 | $240.7万 | 74.3万股 | $151.7万 | 61.4万股 | +12.9万股+20.99% | 加仓 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #118 | $238.1万 | 73.5万股 | $89.1万 | 36.1万股 | +37.4万股+103.72% | 加仓 |
| PEAK6PEAK6 LLC |
| <0.01% | <0.01% | #40 | $184.3万 | 56.9万股 | $14.8万 | 6.0万股 | +50.9万股+851.41% | 加仓 |
| 纽文Nuveen, LLC |
| <0.01% | <0.01% | #94 | $168.9万 | 52.1万股 | $488.4万 | 197.8万股 | -145.6万股-73.64% | 减仓 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| <0.01% | — | #83 | $161.7万 | 49.9万股 | $0 | 0股 | +49.9万股 | 新买入 |
| 萨斯奎汉纳组合策略Susquehanna Portfolio Strategies, LLC |
| 0.02% | 0.01% | #22 | $154.6万 | 47.7万股 | $82.2万 | 33.3万股 | +14.4万股+43.30% | 加仓 |
| Eversept Partners, LP |
| 0.08% | 0.04% | #15 | $148.7万 | 45.9万股 | $71.9万 | 29.1万股 | +16.8万股+57.71% | 加仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #120 | $147.6万 | 45.6万股 | $216.3万 | 87.6万股 | -42.0万股-47.97% | 减仓 |
| Casdin Capital, LLC |
| 0.07% | — | #17 | $144.2万 | 44.5万股 | $0 | 0股 | +44.5万股 | 新买入 |
| DIADEMA PARTNERS LP |
| 0.16% | — | #12 | $129.6万 | 40.0万股 | $0 | 0股 | +40.0万股 | 新买入 |
| GSA CAPITAL PARTNERS LLP |
| 0.08% | 0.07% | #16 | $119.0万 | 36.7万股 | $107.3万 | 43.4万股 | -6.7万股-15.48% | 减仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #159 | $110.9万 | 34.2万股 | $377.5万 | 108.8万股 | -74.6万股-68.55% | 减仓 |
| BIT Capital GmbH |
| 0.03% | — | #21 | $105.6万 | 32.6万股 | $0 | 0股 | +32.6万股 | 新买入 |
| 惠灵顿管理集团WELLINGTON MANAGEMENT GROUP LLP |
| <0.01% | — | #119 | $100.2万 | 30.9万股 | $0 | 0股 | +30.9万股 | 新买入 |
| 洛杉矶资本管理LOS ANGELES CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #43 | $87.9万 | 27.1万股 | $34.7万 | 14.0万股 | +13.1万股+93.11% | 加仓 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| <0.01% | <0.01% | #131 | $85.1万 | 26.3万股 | $67.3万 | 27.3万股 | -9,942股-3.65% | 减仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #167 | $75.1万 | 23.2万股 | $33.3万 | 13.5万股 | +9.7万股+71.89% | 加仓 |
| LPL金融LPL Financial LLC |
| <0.01% | <0.01% | #121 | $74.9万 | 23.1万股 | $17.2万 | 7.0万股 | +16.1万股+231.10% | 加仓 |
| 奥地利Erste资产管理Erste Asset Management GmbH |
| 0.01% | — | #36 | $73.6万 | 23.0万股 | $0 | 0股 | +23.0万股 | 新买入 |
