| 富达投资FMR LLC |
| <0.01% | <0.01% | #45 | $5,648.7万 | 816.3万股 | $7,291.4万 | 810.2万股 | +6.1万股+0.76% | 加仓 |
| 奥比梅德顾问ORBIMED ADVISORS LLC |
| 0.74% | 1.02% | #4 | $3,940.0万 | 569.4万股 | $5,124.2万 | 569.4万股 | 00.00% | 持仓不变 |
| 挪威央行投资管理NORGES BANK |
| <0.01% | <0.01% | #44 | $2,607.9万 | 376.9万股 | $593.6万 | 97.0万股 | +279.9万股+288.55% | 加仓 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #74 | $2,597.3万 | 375.3万股 | $3,033.6万 | 337.1万股 | +38.3万股+11.35% | 加仓 |
| Decheng Capital LLC |
| 2.58% | 3.71% | #2 | $1,885.6万 | 272.5万股 | $2,452.4万 | 272.5万股 | 00.00% | 持仓不变 |
| Enavate Sciences GP, LLC |
| 4.93% | 6.3% | #1 | $1,702.1万 | 246.0万股 | $2,213.7万 | 246.0万股 | 00.00% | 持仓不变 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #79 | $1,298.7万 | 187.7万股 | $1,686.2万 | 187.4万股 | +3,160股+0.17% | 加仓 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #43 | $791.5万 | 114.4万股 | $843.6万 | 93.7万股 | +20.6万股+22.03% | 加仓 |
| D.E.肖D. E. Shaw & Co., Inc. |
| <0.01% | <0.01% | #41 | $716.9万 | 103.6万股 | $738.4万 | 82.0万股 | +21.6万股+26.27% | 加仓 |
| 摩根大通JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #73 | $701.3万 | 101.2万股 | $406.5万 | 46.3万股 | +54.9万股+118.58% | 加仓 |
| Qube研究科技Qube Research & Technologies Ltd |
| 0.01% | 0.01% | #33 | $677.1万 | 97.9万股 | $557.4万 | 61.9万股 | +35.9万股+58.00% | 加仓 |
| Parkman Healthcare Partners LLC |
| 0.66% | 0.73% | #5 | $647.2万 | 93.5万股 | $708.1万 | 78.7万股 | +14.8万股+18.87% | 加仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #76 | $644.6万 | 93.1万股 | $855.7万 | 95.1万股 | -1.9万股-2.04% | 减仓 |
| SEB资产管理SEB Asset Management AB |
| 0.02% | 0.03% | #19 | $607.9万 | 87.8万股 | $790.6万 | 87.8万股 | 00.00% | 持仓不变 |
| Woodline合伙人Woodline Partners LP |
| 0.02% | 0.03% | #23 | $575.4万 | 83.1万股 | $748.3万 | 83.1万股 | 00.00% | 持仓不变 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #95 | $530.3万 | 76.6万股 | $634.8万 | 70.5万股 | +6.1万股+8.64% | 加仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #87 | $493.2万 | 71.3万股 | $654.9万 | 72.8万股 | -1.5万股-2.07% | 减仓 |
| Y截距(香港)Y-Intercept (Hong Kong) Ltd |
| 0.09% | 0.17% | #12 | $479.9万 | 69.4万股 | $900.6万 | 100.1万股 | -30.7万股-30.69% | 减仓 |
| Bain Capital Life Sciences Investors, LLC |
| 0.25% | 0.7% | #7 | $415.9万 | 60.1万股 | $780.5万 | 86.7万股 | -26.6万股-30.70% | 减仓 |
| AQR资本管理AQR CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #53 | $377.0万 | 54.5万股 | $65.0万 | 7.2万股 | +47.3万股+654.97% | 加仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #92 | $363.0万 | 52.5万股 | $164.7万 | 8.8万股 | +43.7万股+499.34% | 加仓 |
| 法国巴黎银行金融市场BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | <0.01% | #51 | $354.0万 | 51.2万股 | $113.4万 | 12.6万股 | +38.6万股+305.99% | 加仓 |
| Walleye资本Walleye Capital LLC |
| 0.01% | — | #26 | $345.0万 | 49.8万股 | $0 | 0股 | +49.8万股 | 新买入 |
| Trexquant投资Trexquant Investment LP |
| 0.02% | 0.01% | #22 | $322.8万 | 46.6万股 | $159.0万 | 17.7万股 | +29.0万股+164.03% | 加仓 |
| Point72资产管理Point72 Asset Management, L.P. |
| <0.01% | <0.01% | #40 | $313.5万 | 45.3万股 | $170.7万 | 19.0万股 | +26.3万股+138.84% | 加仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #94 | $271.1万 | 39.2万股 | $43.6万 | 4.8万股 | +34.3万股+708.42% | 加仓 |
| 维度基金顾问DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #67 | $264.1万 | 38.2万股 | $71.9万 | 8.0万股 | +30.2万股+377.00% | 加仓 |
| 阿尔茨舒勒·沙哈姆Altshuler Shaham Ltd |
| 0.03% | 0.06% | #18 | $263.0万 | 38.0万股 | $342.1万 | 38.0万股 | 00.00% | 持仓不变 |
| 箭街资本ARROWSTREET CAPITAL, LIMITED PARTNERSHIP |
| <0.01% | <0.01% | #56 | $247.6万 | 35.8万股 | $166.6万 | 18.5万股 | +17.3万股+93.29% | 加仓 |
| Samsara BioCapital, LLC |
| 0.2% | 0.64% | #9 | $244.8万 | 35.4万股 | $662.4万 | 73.6万股 | -38.2万股-51.94% | 减仓 |
| Propel Bio Management, LLC |
| 1.27% | 1.95% | #3 | $242.5万 | 35.0万股 | $310.0万 | 34.2万股 | +8,610股+2.52% | 加仓 |
| 惠灵顿管理集团WELLINGTON MANAGEMENT GROUP LLP |
| <0.01% | <0.01% | #72 | $236.9万 | 34.2万股 | $308.1万 | 34.2万股 | 00.00% | 持仓不变 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #83 | $205.8万 | 29.7万股 | $234.9万 | 26.1万股 | +3.6万股+13.93% | 加仓 |
| SquarepointSquarepoint Ops LLC |
| <0.01% | <0.01% | #46 | $201.3万 | 29.1万股 | $40.2万 | 4.5万股 | +24.6万股+551.87% | 加仓 |
| 沃利昂资本管理Voleon Capital Management LP |
| 0.04% | — | #15 | $197.4万 | 28.5万股 | $0 | 0股 | +28.5万股 | 新买入 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #82 | $181.6万 | 26.2万股 | $232.0万 | 25.8万股 | +4,727股+1.83% | 加仓 |
| Jacobs Levy股票管理JACOBS LEVY EQUITY MANAGEMENT, INC |
| 0.01% | — | #32 | $175.1万 | 25.3万股 | $0 | 0股 | +25.3万股 | 新买入 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #97 | $170.9万 | 24.7万股 | $284.9万 | 31.7万股 | -7.0万股-22.01% | 减仓 |
| XTX资本XTX Topco Ltd |
| 0.02% | 0.03% | #20 | $167.7万 | 24.2万股 | $188.3万 | 20.9万股 | +3.3万股+15.80% | 加仓 |
| DEUTSCHE 银行 AG\DEUTSCHE BANK AG\ |
| <0.01% | <0.01% | #66 | $167.1万 | 24.1万股 | $162.8万 | 18.1万股 | +6.1万股+33.48% | 加仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #75 | $165.8万 | 24.0万股 | $201.7万 | 22.4万股 | +1.5万股+6.90% | 加仓 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #90 | $162.4万 | 23.5万股 | $208.1万 | 23.1万股 | +3,460股+1.50% | 加仓 |
| Schonfeld战略顾问Schonfeld Strategic Advisors LLC |
| 0.01% | 0.01% | #35 | $156.2万 | 22.6万股 | $145.2万 | 16.1万股 | +6.4万股+39.92% | 加仓 |
| 跳跃金融Jump Financial, LLC |
| 0.01% | 0.04% | #25 | $154.5万 | 22.3万股 | $287.5万 | 31.9万股 | -9.6万股-30.11% | 减仓 |
| SPHERA FUNDS MANAGEMENT LTD. |
| 0.2% | 0.51% | #10 | $152.0万 | 22.0万股 | $322.2万 | 35.8万股 | -13.8万股-38.63% | 减仓 |
| ACADIAN ASSET MANAGEMENT LLC |
| <0.01% | — | #52 | $121.2万 | 17.5万股 | $0 | 0股 | +17.5万股 | 新买入 |
| HRT金融HRT FINANCIAL LP |
| <0.01% | — | #47 | $118.0万 | 17.1万股 | $0 | 0股 | +17.1万股 | 新买入 |
| Boxer Capital Management, LLC |
| 0.08% | 0.18% | #14 | $103.8万 | 15.0万股 | $135.0万 | 15.0万股 | 00.00% | 持仓不变 |
| 文艺复兴科技RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | <0.01% | #54 | $90.9万 | 13.1万股 | $55.9万 | 6.2万股 | +6.9万股+111.43% | 加仓 |
| EntryPoint Capital, LLC |
| 0.22% | 0.19% | #8 | $89.6万 | 12.9万股 | $66.2万 | 7.4万股 | +5.6万股+75.95% | 加仓 |
