| 蒙塔诺瓦资本MONTANOVA CAPITAL, LLC |
| 2.87% | 2.59% | #9 | $1.57亿 | 451.6万股 | $1.02亿 | 440.1万股 | +11.4万股+2.60% | 加仓 |
| INFINITUM ASSET MANAGEMENT, LLC |
| 15.68% | 11.95% | #3 | $1.54亿 | 443.8万股 | $9,571.6万 | 414.9万股 | +28.9万股+6.98% | 加仓 |
| 高瓴资本Hillhouse Capital Advisors, Ltd. |
| 16.4% | 5.42% | #2 | $1.36亿 | 392.9万股 | $9,064.5万 | 392.9万股 | 00.00% | 持仓不变 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #73 | $1.13亿 | 325.0万股 | $5,837.4万 | 253.0万股 | +72.0万股+28.46% | 加仓 |
| 奥比梅德顾问ORBIMED ADVISORS LLC |
| 1.98% | 1.38% | #11 | $1.05亿 | 302.7万股 | $6,984.0万 | 302.7万股 | 00.00% | 持仓不变 |
| 富达投资FMR LLC |
| <0.01% | <0.01% | #55 | $9,654.1万 | 277.9万股 | $6,958.2万 | 301.6万股 | -23.7万股-7.86% | 减仓 |
| Octagon Capital Advisors LP |
| 6.15% | 5.03% | #4 | $6,847.4万 | 197.1万股 | $4,547.2万 | 197.1万股 | 00.00% | 持仓不变 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #83 | $6,165.9万 | 177.5万股 | $3,527.2万 | 152.9万股 | +24.6万股+16.09% | 加仓 |
| Sofinnova Investments, Inc. |
| 3.05% | 1.49% | #7 | $5,894.5万 | 169.7万股 | $3,914.4万 | 169.7万股 | 00.00% | 持仓不变 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #72 | $5,881.4万 | 169.3万股 | $3,279.2万 | 142.1万股 | +27.2万股+19.11% | 加仓 |
| Vivo Capital, LLC |
| 5.34% | 1.7% | #5 | $5,843.6万 | 168.2万股 | $2,043.8万 | 88.6万股 | +79.6万股+89.87% | 加仓 |
| Novo Holdings A/S |
| 3.04% | 3.63% | #8 | $5,211.0万 | 150.0万股 | $4,480.5万 | 194.2万股 | -44.2万股-22.77% | 减仓 |
| General Catalyst Group Management, LLC |
| 27.55% | 18.79% | #1 | $5,192.9万 | 149.5万股 | $3,448.5万 | 149.5万股 | 00.00% | 持仓不变 |
| Logos Global Management LP |
| 1.5% | 0.4% | #16 | $3,474.0万 | 100.0万股 | $807.5万 | 35.0万股 | +65.0万股+185.71% | 加仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #71 | $3,379.6万 | 97.3万股 | $1,854.4万 | 80.4万股 | +16.9万股+21.03% | 加仓 |
| D.E.肖D. E. Shaw & Co., Inc. |
| 0.01% | 0.01% | #42 | $3,029.4万 | 87.2万股 | $850.8万 | 36.9万股 | +50.3万股+136.45% | 加仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #64 | $2,965.8万 | 85.4万股 | $1,968.9万 | 85.3万股 | +296股+0.03% | 加仓 |
| HSG Holding Ltd |
| 1.92% | 0.86% | #13 | $2,304.3万 | 66.3万股 | $1,398.3万 | 66.3万股 | 00.00% | 持仓不变 |
| Point72资产管理Point72 Asset Management, L.P. |
| 0.02% | 0.02% | #36 | $1,969.0万 | 56.7万股 | $1,726.1万 | 74.8万股 | -18.1万股-24.24% | 减仓 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #76 | $1,962.7万 | 56.5万股 | $439.9万 | 19.1万股 | +37.4万股+196.27% | 加仓 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| 0.01% | <0.01% | #54 | $1,523.9万 | 43.9万股 | $982.6万 | 42.6万股 | +1.3万股+2.99% | 加仓 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #67 | $1,523.7万 | 43.9万股 | $1,121.8万 | 48.6万股 | -4.8万股-9.80% | 减仓 |
| Balyasny资产管理BALYASNY ASSET MANAGEMENT L.P. |
| 0.02% | 0.01% | #37 | $1,373.8万 | 39.5万股 | $983.4万 | 42.6万股 | -3.1万股-7.23% | 减仓 |
| 阿默普莱斯金融AMERIPRISE FINANCIAL INC |
| <0.01% | <0.01% | #62 | $1,325.6万 | 38.2万股 | $415.3万 | 18.0万股 | +20.2万股+111.96% | 加仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #106 | $1,164.9万 | 33.5万股 | $585.6万 | 25.4万股 | +8.1万股+32.09% | 加仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #80 | $1,156.0万 | 33.3万股 | $620.1万 | 26.9万股 | +6.4万股+23.79% | 加仓 |
| Foresite Capital Management VI LLC |
| 1.63% | — | #15 | $1,046.9万 | 30.1万股 | $0 | 0股 | +30.1万股 | 新买入 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #79 | $1,022.1万 | 29.4万股 | $597.0万 | 25.9万股 | +3.5万股+13.70% | 加仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #66 | $900.8万 | 25.9万股 | $500.9万 | 21.7万股 | +4.2万股+19.42% | 加仓 |
| Seven Fleet Capital Management LP |
| 1.41% | 0.37% | #17 | $856.7万 | 24.7万股 | $115.9万 | 5.0万股 | +19.6万股+390.74% | 加仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #88 | $828.0万 | 23.8万股 | $815.0万 | 35.3万股 | -11.5万股-32.53% | 减仓 |
| ACUTA CAPITAL PARTNERS, LLC |
| 5.29% | — | #6 | $759.7万 | 21.9万股 | $0 | 0股 | +21.9万股 | 新买入 |
| 维度基金顾问DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #81 | $734.8万 | 21.2万股 | $291.8万 | 12.7万股 | +8.5万股+67.17% | 加仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #115 | $659.7万 | 19.0万股 | $723.3万 | 39.2万股 | -20.2万股-51.56% | 减仓 |
| Squadron Capital Management LLC |
| 1.97% | 0.93% | #12 | $635.7万 | 18.3万股 | $253.8万 | 11.0万股 | +7.3万股+66.36% | 加仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #112 | $607.5万 | 17.5万股 | $185.0万 | 8.0万股 | +9.5万股+118.02% | 加仓 |
| 野村控股NOMURA HOLDINGS INC |
| 0.01% | 0.01% | #51 | $537.1万 | 15.5万股 | $558.4万 | 24.2万股 | -8.7万股-36.12% | 减仓 |
| Woodline合伙人Woodline Partners LP |
| 0.02% | 0.01% | #38 | $512.9万 | 14.8万股 | $340.6万 | 14.8万股 | 00.00% | 持仓不变 |
| 简街集团JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #110 | $505.1万 | 14.5万股 | $283.4万 | 12.3万股 | +2.3万股+18.35% | 加仓 |
| Affinity Asset Advisors, LLC |
| 0.2% | 0.21% | #20 | $434.3万 | 12.5万股 | $403.7万 | 17.5万股 | -5.0万股-28.57% | 减仓 |
| HRT金融HRT FINANCIAL LP |
| 0.01% | <0.01% | #50 | $421.1万 | 12.1万股 | $108.5万 | 4.7万股 | +7.4万股+157.63% | 加仓 |
| E Fund Management Co., Ltd. |
| 0.09% | 0.06% | #29 | $379.8万 | 10.9万股 | $216.7万 | 9.4万股 | +1.5万股+16.36% | 加仓 |
| 纽文Nuveen, LLC |
| <0.01% | <0.01% | #91 | $374.7万 | 10.8万股 | $131.1万 | 5.7万股 | +5.1万股+89.75% | 加仓 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| <0.01% | <0.01% | #99 | $361.1万 | 10.4万股 | $174.1万 | 7.5万股 | +2.8万股+37.75% | 加仓 |
| KVP Capital Advisors, LP |
| 2.6% | — | #10 | $354.3万 | 10.2万股 | $0 | 0股 | +10.2万股 | 新买入 |
| 惠灵顿管理集团WELLINGTON MANAGEMENT GROUP LLP |
| <0.01% | <0.01% | #98 | $350.4万 | 10.1万股 | $180.4万 | 7.8万股 | +2.3万股+28.95% | 加仓 |
| Burkehill Global 管理Burkehill Global Management, LP |
| 0.13% | 0.11% | #26 | $347.4万 | 10.0万股 | $230.7万 | 10.0万股 | 00.00% | 持仓不变 |
| SECTORAL ASSET MANAGEMENT INC |
| 1.92% | 0.6% | #14 | $274.6万 | 7.9万股 | $72.0万 | 3.0万股 | +4.9万股+163.36% | 加仓 |
| Trexquant投资Trexquant Investment LP |
| 0.01% | — | #40 | $249.6万 | 7.2万股 | $0 | 0股 | +7.2万股 | 新买入 |
| 巴克莱BARCLAYS PLC |
| <0.01% | <0.01% | #108 | $246.5万 | 7.1万股 | $150.9万 | 6.5万股 | +5,562股+8.50% | 加仓 |
