| 富达投资FMR LLC |
| 0.01% | 0.01% | #29 | $2.40亿 | 923.3万股 | $2.34亿 | 904.5万股 | +18.7万股+2.07% | 加仓 |
| Fairmount Funds Management LLC |
| 14.98% | 16.3% | #1 | $2.27亿 | 871.3万股 | $2.26亿 | 871.3万股 | 00.00% | 持仓不变 |
| Avoro资本顾问Avoro Capital Advisors LLC |
| 0.88% | 0.96% | #13 | $9,839.6万 | 378.3万股 | $9,798.0万 | 378.3万股 | 00.00% | 持仓不变 |
| Venrock Adviser, LLC |
| 2.84% | 3.48% | #5 | $9,373.0万 | 360.4万股 | $9,333.3万 | 360.4万股 | 00.00% | 持仓不变 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #48 | $8,224.5万 | 316.2万股 | $576.1万 | 22.2万股 | +294.0万股+1,321.56% | 加仓 |
| FCPM III SERVICES B.V. |
| 8.46% | 8.75% | #3 | $6,349.0万 | 244.1万股 | $6,322.2万 | 244.1万股 | 00.00% | 持仓不变 |
| RA资本管理RA CAPITAL MANAGEMENT, L.P. |
| 0.54% | 0.66% | #15 | $6,241.6万 | 240.0万股 | $6,214.2万 | 239.9万股 | +392股+0.02% | 加仓 |
| 维京全球投资VIKING GLOBAL INVESTORS LP |
| 0.17% | 0.17% | #23 | $6,011.1万 | 231.1万股 | $5,985.7万 | 231.1万股 | 00.00% | 持仓不变 |
| 木星资产管理Jupiter Topco LLC |
| 0.02% | — | #28 | $5,928.4万 | 228.3万股 | $0 | 0股 | +228.3万股 | 新买入 |
| Remedium Capital Partners, LLC |
| 11.78% | 18.84% | #2 | $5,320.3万 | 204.5万股 | $5,297.8万 | 204.5万股 | 00.00% | 持仓不变 |
| Commodore Capital LP |
| 3% | 2.91% | #4 | $5,043.3万 | 193.9万股 | $5,022.0万 | 193.9万股 | 00.00% | 持仓不变 |
| 摩根大通JPMORGAN CHASE & CO |
| <0.01% | — | #39 | $4,984.7万 | 205.9万股 | $0 | 0股 | +205.9万股 | 新买入 |
| BRAIDWELL LP |
| 1.56% | 0.77% | #8 | $4,214.6万 | 162.0万股 | $2,317.7万 | 89.5万股 | +72.6万股+81.08% | 加仓 |
| Bellevue 集团Bellevue Group AG |
| 0.89% | 1.42% | #12 | $4,210.6万 | 161.9万股 | $5,951.8万 | 229.8万股 | -67.9万股-29.55% | 减仓 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #49 | $4,019.8万 | 154.6万股 | $476.4万 | 18.4万股 | +136.2万股+740.30% | 加仓 |
| a16z资本管理a16z Capital Management, L.L.C. |
| 2.55% | 2.48% | #7 | $3,201.6万 | 123.6万股 | $3,201.6万 | 123.6万股 | 00.00% | 持仓不变 |
| Balyasny资产管理BALYASNY ASSET MANAGEMENT L.P. |
| 0.04% | 0.05% | #27 | $3,197.0万 | 122.9万股 | $3,750.3万 | 144.8万股 | -21.9万股-15.12% | 减仓 |
| 洞察顾问PERCEPTIVE ADVISORS LLC |
| 0.48% | 0.62% | #18 | $3,181.0万 | 122.3万股 | $3,167.6万 | 122.3万股 | 00.00% | 持仓不变 |
| 惠灵顿管理集团WELLINGTON MANAGEMENT GROUP LLP |
| <0.01% | 0.01% | #34 | $2,751.9万 | 105.8万股 | $2,740.2万 | 105.8万股 | 00.00% | 持仓不变 |
| 黑石集团Blackstone Inc. |
| 0.08% | 0.05% | #25 | $2,608.7万 | 100.3万股 | $1,304.1万 | 50.4万股 | +49.9万股+99.19% | 加仓 |
| Cormorant Asset Management, LP |
| 1.32% | 1.98% | #9 | $2,601.0万 | 100.0万股 | $3,949.8万 | 152.5万股 | -52.5万股-34.43% | 减仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #45 | $2,511.2万 | 96.5万股 | $624.8万 | 24.1万股 | +72.4万股+300.36% | 加仓 |
| Siren, L.L.C. |
| 0.47% | 0.65% | #19 | $2,340.9万 | 90.0万股 | $2,331.0万 | 90.0万股 | 00.00% | 持仓不变 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #38 | $2,185.6万 | 84.0万股 | $415.5万 | 16.0万股 | +68.0万股+423.82% | 加仓 |
| Vestal Point 资本Vestal Point Capital, LP |
| 0.35% | 0.43% | #20 | $1,495.6万 | 57.5万股 | $1,554.0万 | 60.0万股 | -2.5万股-4.17% | 减仓 |
| Affinity Asset Advisors, LLC |
| 0.5% | 0.6% | #16 | $1,105.4万 | 42.5万股 | $1,165.5万 | 45.0万股 | -2.5万股-5.56% | 减仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | — | #69 | $950.7万 | 36.5万股 | $0 | 0股 | +36.5万股 | 新买入 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #51 | $935.6万 | 36.0万股 | $100.7万 | 3.9万股 | +32.1万股+825.12% | 加仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #61 | $882.7万 | 33.9万股 | $228.8万 | 8.8万股 | +25.1万股+284.19% | 加仓 |
| Ikarian Capital, LLC |
| 0.93% | 0.71% | #11 | $873.2万 | 33.6万股 | $869.5万 | 33.6万股 | 00.00% | 持仓不变 |
| 阿默普莱斯金融AMERIPRISE FINANCIAL INC |
| <0.01% | <0.01% | #43 | $845.1万 | 32.5万股 | $304.8万 | 11.8万股 | +20.7万股+176.12% | 加仓 |
| Seven Fleet Capital Management LP |
| 1.22% | 0.83% | #10 | $739.8万 | 28.4万股 | $262.2万 | 10.1万股 | +18.3万股+180.92% | 加仓 |
| ADAR1 Capital Management, LLC |
| 0.34% | 0.43% | #21 | $728.3万 | 28.0万股 | $722.6万 | 27.9万股 | +1,000股+0.36% | 加仓 |
| Nantahala 资本管理Nantahala Capital Management, LLC |
| 0.24% | 0.27% | #22 | $723.1万 | 27.8万股 | $720.0万 | 27.8万股 | 00.00% | 持仓不变 |
| STEMPOINT CAPITAL LP |
| 0.8% | — | #14 | $562.3万 | 21.6万股 | $0 | 0股 | +21.6万股 | 新买入 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #87 | $553.0万 | 21.3万股 | $522.8万 | 20.2万股 | +1.1万股+5.33% | 加仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | — | #65 | $432.7万 | 16.6万股 | $0 | 0股 | +16.6万股 | 新买入 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| <0.01% | — | #62 | $392.8万 | 15.1万股 | $0 | 0股 | +15.1万股 | 新买入 |
| 纽文Nuveen, LLC |
| <0.01% | — | #55 | $389.1万 | 15.0万股 | $0 | 0股 | +15.0万股 | 新买入 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #66 | $369.7万 | 14.2万股 | $32.4万 | 1.3万股 | +13.0万股+1,037.10% | 加仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #60 | $368.9万 | 14.2万股 | $250.4万 | 9.7万股 | +4.5万股+46.73% | 加仓 |
| Kalehua Capital Management LLC |
| 2.59% | 2.55% | #6 | $361.5万 | 13.9万股 | $360.0万 | 13.9万股 | 00.00% | 持仓不变 |
| DV EQUITIES, LLC |
| 0.48% | — | #17 | $338.1万 | 13.0万股 | $0 | 0股 | +13.0万股 | 新买入 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | — | #85 | $309.6万 | 11.9万股 | $0 | 0股 | +11.9万股 | 新买入 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #84 | $255.6万 | 9.8万股 | $40.5万 | 1.6万股 | +8.3万股+528.13% | 加仓 |
| 瑞士央行Swiss National Bank |
| <0.01% | — | #53 | $188.8万 | 7.3万股 | $0 | 0股 | +7.3万股 | 新买入 |
| RhumbLine顾问RHUMBLINE ADVISERS |
| <0.01% | — | #47 | $171.2万 | 6.6万股 | $0 | 0股 | +6.6万股 | 新买入 |
| 联博ALLIANCEBERNSTEIN L.P. |
| <0.01% | — | #67 | $144.9万 | 5.6万股 | $0 | 0股 | +5.6万股 | 新买入 |
| DEUTSCHE 银行 AG\DEUTSCHE BANK AG\ |
| <0.01% | — | #71 | $137.3万 | 5.3万股 | $0 | 0股 | +5.3万股 | 新买入 |
| Point72资产管理Point72 Asset Management, L.P. |
| <0.01% | 0.04% | #44 | $126.8万 | 4.9万股 | $3,091.7万 | 119.4万股 | -114.5万股-95.92% | 减仓 |
