| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #72 | $3,511.5万 | 919.2万股 | $3,283.3万 | 619.5万股 | +299.8万股+48.39% | 加仓 |
| 停战资本ARMISTICE CAPITAL, LLC |
| 0.33% | 0.43% | #10 | $2,683.2万 | 702.4万股 | $2,433.8万 | 459.2万股 | +243.2万股+52.96% | 加仓 |
| RTW投资RTW INVESTMENTS, LP |
| 0.22% | 0.35% | #16 | $2,534.9万 | 663.6万股 | $3,485.4万 | 657.6万股 | +5.9万股+0.90% | 加仓 |
| 深轨资本Deep Track Capital, LP |
| 0.32% | 0.5% | #11 | $2,193.0万 | 574.1万股 | $3,042.7万 | 574.1万股 | 00.00% | 持仓不变 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #68 | $1,961.1万 | 513.4万股 | $1,863.8万 | 351.7万股 | +161.7万股+45.99% | 加仓 |
| Rosalind Advisors, Inc. |
| 3.61% | 4.55% | #1 | $1,522.8万 | 398.7万股 | $1,133.4万 | 213.8万股 | +184.8万股+86.42% | 加仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #78 | $1,471.3万 | 385.2万股 | $1,761.1万 | 332.3万股 | +52.9万股+15.91% | 加仓 |
| Nantahala 资本管理Nantahala Capital Management, LLC |
| 0.46% | 0.7% | #9 | $1,369.4万 | 358.5万股 | $1,900.0万 | 358.5万股 | 00.00% | 持仓不变 |
| Stonepine Capital Management, LLC |
| 1.96% | 7.01% | #3 | $1,279.6万 | 335.0万股 | $1,750.2万 | 330.2万股 | +4.7万股+1.43% | 加仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #69 | $1,247.9万 | 326.7万股 | $401.1万 | 75.7万股 | +251.0万股+331.63% | 加仓 |
| Foresite Capital Management VI LLC |
| 1.87% | 3.62% | #4 | $1,202.0万 | 314.7万股 | $1,667.7万 | 314.7万股 | 00.00% | 持仓不变 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #58 | $1,039.5万 | 272.1万股 | $786.5万 | 148.4万股 | +123.7万股+83.37% | 加仓 |
| 贝克兄弟顾问BAKER BROS. ADVISORS LP |
| 0.05% | 0.02% | #23 | $954.7万 | 249.9万股 | $309.9万 | 58.5万股 | +191.5万股+327.41% | 加仓 |
| Alyeska投资集团Alyeska Investment Group, L.P. |
| 0.02% | 0.03% | #27 | $874.6万 | 229.0万股 | $1,086.5万 | 205.0万股 | +24.0万股+11.69% | 加仓 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| <0.01% | 0.01% | #44 | $826.4万 | 216.3万股 | $1,278.3万 | 241.2万股 | -24.9万股-10.31% | 减仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #74 | $792.5万 | 207.4万股 | $910.5万 | 171.8万股 | +35.7万股+20.76% | 加仓 |
| AIGH Capital Management LLC |
| 0.46% | 1.45% | #8 | $736.1万 | 192.7万股 | $1,060.0万 | 200.0万股 | -7.3万股-3.65% | 减仓 |
| Opaleye Management Inc. |
| 0.62% | — | #7 | $687.6万 | 180.0万股 | $0 | 0股 | +180.0万股 | 新买入 |
| Balyasny资产管理BALYASNY ASSET MANAGEMENT L.P. |
| 0.01% | <0.01% | #34 | $644.3万 | 168.7万股 | $217.2万 | 41.0万股 | +127.7万股+311.58% | 加仓 |
| Qube研究科技Qube Research & Technologies Ltd |
| 0.01% | 0.01% | #37 | $622.1万 | 162.8万股 | $782.3万 | 147.6万股 | +15.2万股+10.33% | 加仓 |
| ACORN CAPITAL ADVISORS, LLC |
| 1.53% | 2.21% | #5 | $561.2万 | 146.9万股 | $778.7万 | 146.9万股 | 00.00% | 持仓不变 |
| NEXTBio Capital Management LP |
| 2.3% | 3.22% | #2 | $499.2万 | 130.7万股 | $692.6万 | 130.7万股 | 00.00% | 持仓不变 |
| 富兰克林资源FRANKLIN RESOURCES INC |
| <0.01% | <0.01% | #60 | $422.1万 | 110.5万股 | $586.1万 | 110.6万股 | -864股-0.08% | 减仓 |
| Pinnacle金融合伙人Pinnacle Financial Partners, Inc. |
| 0.03% | 0.02% | #24 | $415.0万 | 108.6万股 | $262.5万 | 49.5万股 | +59.1万股+119.36% | 加仓 |
| AQR资本管理AQR CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #53 | $357.0万 | 93.5万股 | $35.0万 | 6.6万股 | +86.9万股+1,314.61% | 加仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #86 | $340.0万 | 89.0万股 | $221.0万 | 41.7万股 | +47.3万股+113.43% | 加仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #100 | $273.4万 | 71.6万股 | $1,394.7万 | 157.9万股 | -86.4万股-54.68% | 减仓 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #92 | $260.5万 | 68.2万股 | $204.0万 | 38.5万股 | +29.7万股+77.14% | 加仓 |
| PanAgora资产管理PANAGORA ASSET MANAGEMENT INC |
| 0.01% | <0.01% | #35 | $254.7万 | 66.7万股 | $129.4万 | 24.4万股 | +42.3万股+173.19% | 加仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #80 | $248.9万 | 65.1万股 | $273.4万 | 51.6万股 | +13.6万股+26.31% | 加仓 |
| J. Goldman & Co LP |
| 0.06% | 0.26% | #21 | $248.3万 | 65.0万股 | $890.8万 | 168.1万股 | -103.1万股-61.32% | 减仓 |
| SPHERA FUNDS MANAGEMENT LTD. |
| 0.32% | 0.29% | #13 | $241.7万 | 63.3万股 | $182.1万 | 34.4万股 | +28.9万股+84.08% | 加仓 |
| 富达投资FMR LLC |
| <0.01% | <0.01% | #108 | $239.2万 | 62.6万股 | $251.0万 | 47.4万股 | +15.3万股+32.23% | 加仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #73 | $235.6万 | 61.7万股 | $262.2万 | 49.5万股 | +12.2万股+24.70% | 加仓 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #79 | $230.9万 | 60.4万股 | $288.2万 | 54.4万股 | +6.1万股+11.18% | 加仓 |
| Hennion & Walsh Asset Management, Inc. |
| 0.06% | 0.04% | #22 | $217.4万 | 56.9万股 | $117.3万 | 22.1万股 | +34.8万股+157.18% | 加仓 |
| XTX资本XTX Topco Ltd |
| 0.03% | 0.04% | #25 | $214.6万 | 56.2万股 | $209.8万 | 39.6万股 | +16.6万股+41.93% | 加仓 |
| 杰富瑞金融集团Jefferies Financial Group Inc. |
| 0.01% | 0.02% | #29 | $189.7万 | 49.7万股 | $294.7万 | 55.6万股 | -5.9万股-10.70% | 减仓 |
| TORRAY INVESTMENT PARTNERS LLC |
| 0.25% | 0.23% | #15 | $182.4万 | 47.7万股 | $158.4万 | 29.9万股 | +17.8万股+59.71% | 加仓 |
| 多伦多道明银行TORONTO DOMINION BANK |
| <0.01% | <0.01% | #49 | $175.9万 | 46.0万股 | $244.0万 | 46.0万股 | 00.00% | 持仓不变 |
| Exome Asset Management LLC |
| 1.01% | 1.75% | #6 | $163.9万 | 42.9万股 | $337.5万 | 63.7万股 | -20.8万股-32.61% | 减仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #93 | $157.4万 | 41.2万股 | $1,259.4万 | 237.6万股 | -196.4万股-82.66% | 减仓 |
| Palo Alto Investors LP |
| 0.17% | 0.2% | #17 | $118.3万 | 31.0万股 | $130.4万 | 24.6万股 | +6.4万股+25.84% | 加仓 |
| 跳跃金融Jump Financial, LLC |
| 0.01% | 0.01% | #32 | $117.5万 | 30.8万股 | $62.8万 | 11.8万股 | +18.9万股+159.55% | 加仓 |
| Virtus Investment Advisers, LLC |
| 0.25% | 0.04% | #14 | $108.3万 | 28.4万股 | $15.0万 | 2.8万股 | +25.5万股+899.61% | 加仓 |
| Diametric Capital, LP |
| 0.11% | — | #18 | $101.4万 | 26.6万股 | $0 | 0股 | +26.6万股 | 新买入 |
| 纽文Nuveen, LLC |
| <0.01% | <0.01% | #84 | $98.9万 | 25.9万股 | $109.2万 | 20.6万股 | +5.3万股+25.64% | 加仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #102 | $93.2万 | 24.4万股 | $104.1万 | 19.7万股 | +4.7万股+24.15% | 加仓 |
| 维度基金顾问DIMENSIONAL FUND ADVISORS LP |
| <0.01% | — | #97 | $89.8万 | 23.5万股 | $0 | 0股 | +23.5万股 | 新买入 |
| Ikarian Capital, LLC |
| 0.09% | 0.09% | #20 | $81.7万 | 21.4万股 | $113.3万 | 21.4万股 | 00.00% | 持仓不变 |
