| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #60 | $4,141.0万 | 886.7万股 | $1,103.8万 | 497.2万股 | +389.5万股+78.34% | 加仓 |
| RA资本管理RA CAPITAL MANAGEMENT, L.P. |
| 0.32% | 0.22% | #12 | $3,736.0万 | 800.0万股 | $2,104.0万 | 800.0万股 | 00.00% | 持仓不变 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #91 | $3,687.8万 | 789.7万股 | $538.8万 | 204.9万股 | +584.8万股+285.48% | 加仓 |
| Squadron Capital Management LLC |
| 11.01% | 2.17% | #1 | $3,549.2万 | 760.0万股 | $591.8万 | 225.0万股 | +535.0万股+237.78% | 加仓 |
| Lynx1 Capital Management LP |
| 6.74% | 2.91% | #2 | $3,421.6万 | 732.7万股 | $1,840.7万 | 699.9万股 | +32.8万股+4.68% | 加仓 |
| Bain Capital Life Sciences Investors, LLC |
| 1.99% | 1.7% | #3 | $3,349.3万 | 717.2万股 | $1,886.2万 | 717.2万股 | 00.00% | 持仓不变 |
| 摩根大通JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #74 | $2,065.1万 | 474.7万股 | $757.4万 | 322.3万股 | +152.4万股+47.30% | 加仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #96 | $2,063.1万 | 441.8万股 | $1,015.7万 | 386.2万股 | +55.6万股+14.39% | 加仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #59 | $2,000.8万 | 428.4万股 | $680.8万 | 258.9万股 | +169.6万股+65.50% | 加仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #71 | $1,649.0万 | 353.1万股 | $627.9万 | 238.7万股 | +114.4万股+47.90% | 加仓 |
| Wasatch顾问WASATCH ADVISORS LP |
| 0.11% | 0.05% | #17 | $1,645.1万 | 352.3万股 | $778.9万 | 296.2万股 | +56.1万股+18.94% | 加仓 |
| Two Sigma投资TWO SIGMA INVESTMENTS, LP |
| 0.01% | 0.01% | #33 | $1,620.4万 | 347.0万股 | $798.4万 | 303.6万股 | +43.4万股+14.30% | 加仓 |
| Soleus 资本管理Soleus Capital Management, L.P. |
| 0.54% | 0.41% | #9 | $1,577.5万 | 337.8万股 | $1,000.4万 | 380.4万股 | -42.6万股-11.20% | 减仓 |
| SILVERARC CAPITAL MANAGEMENT, LLC |
| 1.47% | 0.51% | #5 | $1,416.0万 | 303.2万股 | $502.8万 | 191.2万股 | +112.0万股+58.60% | 加仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #84 | $1,240.5万 | 265.6万股 | $620.5万 | 235.9万股 | +29.7万股+12.59% | 加仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #87 | $1,178.1万 | 252.2万股 | $250.2万 | 95.1万股 | +157.1万股+165.20% | 加仓 |
| Ikarian Capital, LLC |
| 1.21% | — | #7 | $1,136.2万 | 243.3万股 | $0 | 0股 | +243.3万股 | 新买入 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #105 | $988.0万 | 211.6万股 | $100.7万 | 38.3万股 | +173.3万股+452.42% | 加仓 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #85 | $947.9万 | 203.0万股 | $366.7万 | 139.4万股 | +63.5万股+45.56% | 加仓 |
| ACADIAN ASSET MANAGEMENT LLC |
| 0.01% | 0.01% | #35 | $843.5万 | 180.6万股 | $496.8万 | 189.1万股 | -8.5万股-4.48% | 减仓 |
| 康得利安资管Candriam S.C.A. |
| 0.04% | — | #25 | $838.4万 | 179.7万股 | $0 | 0股 | +179.7万股 | 新买入 |
| D.E.肖D. E. Shaw & Co., Inc. |
| <0.01% | <0.01% | #50 | $813.0万 | 174.1万股 | $278.9万 | 106.0万股 | +68.1万股+64.19% | 加仓 |
| Patient Square Capital LP |
| 1.16% | — | #8 | $751.3万 | 160.9万股 | $0 | 0股 | +160.9万股 | 新买入 |
| HighVista Strategies LLC |
| 1.44% | — | #6 | $629.6万 | 134.8万股 | $0 | 0股 | +134.8万股 | 新买入 |
| 文艺复兴科技RENAISSANCE TECHNOLOGIES LLC |
| 0.01% | 0.01% | #38 | $555.6万 | 119.0万股 | $647.5万 | 246.2万股 | -127.2万股-51.67% | 减仓 |
| 维度基金顾问DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #77 | $554.6万 | 118.9万股 | $116.0万 | 44.3万股 | +74.6万股+168.58% | 加仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #86 | $542.0万 | 116.1万股 | $49.8万 | 18.9万股 | +97.1万股+512.49% | 加仓 |
| 国会资产管理CONGRESS ASSET MANAGEMENT CO |
| 0.03% | 0.02% | #28 | $468.6万 | 100.3万股 | $218.5万 | 83.1万股 | +17.3万股+20.81% | 加仓 |
| 富达投资FMR LLC |
| <0.01% | <0.01% | #111 | $417.5万 | 89.4万股 | $71.6万 | 27.2万股 | +62.2万股+228.25% | 加仓 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #93 | $387.1万 | 82.9万股 | $56.8万 | 21.6万股 | +61.3万股+284.00% | 加仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #94 | $364.8万 | 78.1万股 | $118.9万 | 45.2万股 | +32.9万股+72.71% | 加仓 |
| 布斯湾基金管理BOOTHBAY FUND MANAGEMENT, LLC |
| 0.05% | — | #24 | $343.9万 | 73.6万股 | $0 | 0股 | +73.6万股 | 新买入 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | — | #117 | $317.6万 | 68.0万股 | $0 | 0股 | +68.0万股 | 新买入 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #88 | $284.5万 | 60.9万股 | $127.3万 | 48.4万股 | +12.5万股+25.82% | 加仓 |
| ExodusPoint资本ExodusPoint Capital Management, LP |
| 0.02% | — | #30 | $271.0万 | 58.0万股 | $0 | 0股 | +58.0万股 | 新买入 |
| Velan Capital Investment Management LP |
| 1.62% | — | #4 | $266.2万 | 57.0万股 | $0 | 0股 | +57.0万股 | 新买入 |
| STEMPOINT CAPITAL LP |
| 0.35% | 0.22% | #11 | $244.5万 | 52.4万股 | $119.2万 | 45.3万股 | +7.0万股+15.54% | 加仓 |
| 洛克菲勒资本管理Rockefeller Capital Management L.P. |
| <0.01% | — | #53 | $231.5万 | 49.6万股 | $0 | 0股 | +49.6万股 | 新买入 |
| 纽文Nuveen, LLC |
| <0.01% | — | #92 | $226.0万 | 48.4万股 | $0 | 0股 | +48.4万股 | 新买入 |
| 富国银行WELLS FARGO & COMPANY/MN |
| <0.01% | <0.01% | #102 | $211.4万 | 45.3万股 | $228.3万 | 86.8万股 | -41.5万股-47.84% | 减仓 |
| 英仕曼集团Man Group plc |
| <0.01% | <0.01% | #54 | $190.8万 | 40.9万股 | $67.5万 | 25.6万股 | +15.2万股+59.34% | 加仓 |
| PLATINUM INVESTMENT MANAGEMENT LTD |
| 0.44% | 0.26% | #10 | $179.7万 | 38.5万股 | $101.2万 | 38.5万股 | 00.00% | 持仓不变 |
| Seven Fleet Capital Management LP |
| 0.29% | 0.05% | #13 | $178.0万 | 38.1万股 | $15.0万 | 5.7万股 | +32.4万股+567.83% | 加仓 |
| Qube研究科技Qube Research & Technologies Ltd |
| <0.01% | <0.01% | #68 | $173.0万 | 37.1万股 | $197.8万 | 75.2万股 | -38.2万股-50.73% | 减仓 |
| Atom Investors LP |
| 0.15% | 0.03% | #15 | $170.2万 | 36.4万股 | $35.8万 | 13.6万股 | +22.8万股+167.81% | 加仓 |
| 简街集团JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #120 | $164.9万 | 35.3万股 | $354.2万 | 134.7万股 | -99.4万股-73.79% | 减仓 |
| 萨斯奎汉纳组合策略Susquehanna Portfolio Strategies, LLC |
| 0.02% | 0.01% | #29 | $156.5万 | 33.5万股 | $68.5万 | 26.0万股 | +7.5万股+28.74% | 加仓 |
| Adage资本合伙人ADAGE CAPITAL PARTNERS GP, L.L.C. |
| <0.01% | — | #61 | $151.8万 | 32.5万股 | $0 | 0股 | +32.5万股 | 新买入 |
| Connor Clark & Lunn投资管理Connor, Clark & Lunn Investment Management Ltd. |
| <0.01% | <0.01% | #56 | $140.4万 | 30.1万股 | $72.9万 | 27.7万股 | +2.4万股+8.50% | 加仓 |
| ADAR1 Capital Management, LLC |
| 0.06% | 0.01% | #22 | $136.3万 | 29.2万股 | $11.3万 | 4.3万股 | +24.9万股+578.97% | 加仓 |
