| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #71 | $3,229.7万 | 882.4万股 | $4,134.6万 | 539.1万股 | +343.4万股+63.70% | 加仓 |
| EcoR1 Capital, LLC |
| 1.17% | — | #1 | $2,397.3万 | 655.0万股 | $0 | 0股 | +655.0万股 | 新买入 |
| TANG CAPITAL MANAGEMENT LLC |
| 1.08% | — | #3 | $2,386.8万 | 652.1万股 | $0 | 0股 | +652.1万股 | 新买入 |
| Nantahala 资本管理Nantahala Capital Management, LLC |
| 0.67% | 0.86% | #5 | $2,003.9万 | 547.5万股 | $2,339.4万 | 305.0万股 | +242.5万股+79.51% | 加仓 |
| 蒙塔诺瓦资本MONTANOVA CAPITAL, LLC |
| 0.25% | 1.29% | #10 | $1,347.2万 | 368.1万股 | $5,032.4万 | 656.1万股 | -288.0万股-43.90% | 减仓 |
| D.E.肖D. E. Shaw & Co., Inc. |
| 0.01% | 0.01% | #37 | $1,114.2万 | 304.4万股 | $1,245.1万 | 162.3万股 | +142.1万股+87.55% | 加仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #57 | $1,076.7万 | 294.2万股 | $1,036.0万 | 135.1万股 | +159.1万股+117.79% | 加仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #86 | $987.2万 | 269.7万股 | $2,065.5万 | 269.3万股 | +4,268股+0.16% | 加仓 |
| 简街集团JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #60 | $836.6万 | 228.6万股 | $254.4万 | 33.2万股 | +195.4万股+589.05% | 加仓 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #83 | $745.6万 | 203.7万股 | $1,188.7万 | 155.0万股 | +48.7万股+31.43% | 加仓 |
| Adage资本合伙人ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.01% | <0.01% | #30 | $732.0万 | 200.0万股 | $306.8万 | 40.0万股 | +160.0万股+400.00% | 加仓 |
| GSK plc |
| 1.09% | 2.29% | #2 | $653.6万 | 178.6万股 | $1,369.6万 | 178.6万股 | 00.00% | 持仓不变 |
| Qube研究科技Qube Research & Technologies Ltd |
| 0.01% | 0.01% | #34 | $639.9万 | 174.8万股 | $747.6万 | 97.5万股 | +77.4万股+79.38% | 加仓 |
| 文艺复兴科技RENAISSANCE TECHNOLOGIES LLC |
| 0.01% | <0.01% | #32 | $603.1万 | 164.8万股 | $10.4万 | 1.4万股 | +163.4万股+12,016.18% | 加仓 |
| ADAR1 Capital Management, LLC |
| 0.26% | 0.06% | #9 | $572.8万 | 156.5万股 | $100.1万 | 13.1万股 | +143.4万股+1,098.70% | 加仓 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #52 | $543.8万 | 148.6万股 | $273.4万 | 35.6万股 | +112.9万股+316.81% | 加仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #78 | $524.3万 | 143.2万股 | $1,140.4万 | 148.7万股 | -5.4万股-3.66% | 减仓 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #74 | $522.8万 | 142.8万股 | $257.0万 | 33.5万股 | +109.3万股+326.33% | 加仓 |
| 马歇尔·韦斯MARSHALL WACE, LLP |
| <0.01% | — | #43 | $497.2万 | 135.8万股 | $0 | 0股 | +135.8万股 | 新买入 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #64 | $458.9万 | 125.4万股 | $241.7万 | 31.5万股 | +93.9万股+297.83% | 加仓 |
| AQR资本管理AQR CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #55 | $403.8万 | 110.3万股 | $416.6万 | 54.3万股 | +56.0万股+103.12% | 加仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #75 | $400.6万 | 109.4万股 | $438.7万 | 57.2万股 | +52.3万股+91.36% | 加仓 |
| Ikarian Capital, LLC |
| 0.41% | 0.65% | #7 | $384.0万 | 104.9万股 | $804.7万 | 104.9万股 | 00.00% | 持仓不变 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #81 | $381.7万 | 104.3万股 | $97.1万 | 12.7万股 | +91.6万股+724.14% | 加仓 |
| ACADIAN ASSET MANAGEMENT LLC |
| <0.01% | 0.01% | #40 | $380.2万 | 103.9万股 | $557.1万 | 72.7万股 | +31.1万股+42.83% | 加仓 |
| 跳跃金融Jump Financial, LLC |
| 0.03% | 0.04% | #20 | $367.8万 | 100.5万股 | $283.6万 | 37.0万股 | +63.5万股+171.76% | 加仓 |
| 维度基金顾问DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #62 | $351.6万 | 96.1万股 | $866.3万 | 113.0万股 | -17.0万股-15.02% | 减仓 |
| Assenagon资产管理Assenagon Asset Management S.A. |
| <0.01% | 0.01% | #44 | $305.7万 | 83.5万股 | $915.7万 | 119.4万股 | -35.9万股-30.04% | 减仓 |
| Two Sigma投资TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #49 | $297.5万 | 81.3万股 | $106.6万 | 13.9万股 | +67.4万股+484.72% | 加仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #98 | $286.3万 | 78.2万股 | $459.7万 | 59.9万股 | +18.3万股+30.49% | 加仓 |
| Connor Clark & Lunn投资管理Connor, Clark & Lunn Investment Management Ltd. |
| 0.01% | 0.01% | #38 | $272.8万 | 74.5万股 | $565.0万 | 73.7万股 | +8,633股+1.17% | 加仓 |
| Balyasny资产管理BALYASNY ASSET MANAGEMENT L.P. |
| <0.01% | 0.02% | #46 | $253.4万 | 69.2万股 | $1,672.0万 | 218.0万股 | -148.8万股-68.24% | 减仓 |
| Y截距(香港)Y-Intercept (Hong Kong) Ltd |
| 0.05% | 0.02% | #14 | $249.6万 | 68.2万股 | $117.6万 | 15.3万股 | +52.8万股+344.64% | 加仓 |
| Point72资产管理Point72 Asset Management, L.P. |
| <0.01% | 0.02% | #47 | $238.4万 | 65.1万股 | $1,591.4万 | 207.5万股 | -142.3万股-68.60% | 减仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #89 | $178.6万 | 48.8万股 | $362.8万 | 47.3万股 | +1.5万股+3.15% | 加仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #85 | $158.6万 | 43.3万股 | $327.4万 | 42.7万股 | +6,351股+1.49% | 加仓 |
| SILVERARC CAPITAL MANAGEMENT, LLC |
| 0.15% | 0.33% | #12 | $143.4万 | 39.2万股 | $322.1万 | 42.0万股 | -2.8万股-6.68% | 减仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #79 | $126.5万 | 34.6万股 | $253.0万 | 33.0万股 | +1.6万股+4.78% | 加仓 |
| 布斯湾基金管理BOOTHBAY FUND MANAGEMENT, LLC |
| 0.01% | 0.03% | #26 | $111.3万 | 30.4万股 | $233.2万 | 30.4万股 | 00.00% | 持仓不变 |
| BESSEMER GROUP INC |
| <0.01% | <0.01% | #54 | $105.0万 | 28.7万股 | $220.1万 | 28.7万股 | 00.00% | 持仓不变 |
| Peapod Lane Capital LLC |
| 0.71% | — | #4 | $104.6万 | 28.6万股 | $0 | 0股 | +28.6万股 | 新买入 |
| 惠灵顿管理集团WELLINGTON MANAGEMENT GROUP LLP |
| <0.01% | <0.01% | #94 | $104.3万 | 28.5万股 | $91.0万 | 11.9万股 | +16.6万股+140.37% | 加仓 |
| Simplex交易SIMPLEX TRADING, LLC |
| <0.01% | <0.01% | #66 | $90.0万 | 24.6万股 | $32.2万 | 4.2万股 | +20.4万股+486.55% | 加仓 |
| 工程师之门Engineers Gate Manager LP |
| 0.01% | 0.01% | #27 | $88.6万 | 24.2万股 | $96.7万 | 12.6万股 | +11.6万股+91.90% | 加仓 |
| Hennion & Walsh Asset Management, Inc. |
| 0.02% | — | #22 | $85.6万 | 23.4万股 | $0 | 0股 | +23.4万股 | 新买入 |
| EntryPoint Capital, LLC |
| 0.19% | 0.1% | #11 | $79.5万 | 21.7万股 | $34.7万 | 4.5万股 | +17.2万股+380.02% | 加仓 |
| XTX资本XTX Topco Ltd |
| 0.01% | 0.01% | #31 | $76.6万 | 20.9万股 | $54.9万 | 7.2万股 | +13.8万股+192.23% | 加仓 |
| 正交资本Quadrature Capital Ltd |
| 0.01% | — | #35 | $69.2万 | 18.9万股 | $0 | 0股 | +18.9万股 | 新买入 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #127 | $67.4万 | 18.4万股 | $224.3万 | 24.4万股 | -6.0万股-24.46% | 减仓 |
| 美国世纪投资AMERICAN CENTURY COMPANIES INC |
| <0.01% | <0.01% | #80 | $57.0万 | 15.6万股 | $119.8万 | 15.6万股 | -374股-0.24% | 减仓 |
