| Beutel, Goodman & Co Ltd. |
| 0.18% | 0.18% | #13 | $2,398.0万 | 362.8万股 | $2,637.7万 | 366.6万股 | -3.9万股-1.05% | 减仓 |
| Affinity Asset Advisors, LLC |
| 0.49% | 0.59% | #8 | $1,090.7万 | 165.0万股 | $1,150.4万 | 158.9万股 | +6.1万股+3.84% | 加仓 |
| Balyasny资产管理BALYASNY ASSET MANAGEMENT L.P. |
| 0.01% | 0.01% | #27 | $892.4万 | 135.0万股 | $977.4万 | 135.0万股 | +15股+0.00% | 加仓 |
| Vivo Capital, LLC |
| 0.81% | 0.81% | #4 | $892.4万 | 135.0万股 | $977.4万 | 135.0万股 | 00.00% | 持仓不变 |
| 丰业资本SCOTIA CAPITAL INC. |
| 0.03% | 0.03% | #20 | $878.2万 | 134.4万股 | $724.4万 | 134.2万股 | +1,548股+0.12% | 加仓 |
| PFM Health Sciences, LP |
| 0.69% | 0.36% | #5 | $800.2万 | 121.1万股 | $391.6万 | 54.1万股 | +67.0万股+123.84% | 加仓 |
| GREAT POINT PARTNERS LLC |
| 1.5% | 2% | #1 | $793.2万 | 120.0万股 | $868.8万 | 120.0万股 | 00.00% | 持仓不变 |
| 木星资产管理Jupiter Topco LLC |
| <0.01% | — | #36 | $685.1万 | 104.6万股 | $0 | 0股 | +104.6万股 | 新买入 |
| Rubric资本管理Rubric Capital Management LP |
| 0.05% | 0.05% | #17 | $573.4万 | 86.7万股 | $500.4万 | 69.1万股 | +17.6万股+25.50% | 加仓 |
| Ikarian Capital, LLC |
| 0.57% | 0.71% | #7 | $535.2万 | 81.0万股 | $879.5万 | 121.5万股 | -40.5万股-33.34% | 减仓 |
| Woodline合伙人Woodline Partners LP |
| 0.02% | 0.01% | #23 | $493.7万 | 74.7万股 | $319.0万 | 44.1万股 | +30.6万股+69.53% | 加仓 |
| Point72资产管理Point72 Asset Management, L.P. |
| 0.01% | 0.01% | #31 | $482.8万 | 73.0万股 | $700.5万 | 96.8万股 | -23.7万股-24.52% | 减仓 |
| 阿默普莱斯金融AMERIPRISE FINANCIAL INC |
| <0.01% | <0.01% | #44 | $470.0万 | 71.1万股 | $379.6万 | 52.4万股 | +18.7万股+35.63% | 加仓 |
| Redmile Group, LLC |
| 0.27% | 0.34% | #11 | $404.1万 | 61.1万股 | $506.8万 | 70.0万股 | -8.9万股-12.66% | 减仓 |
| Seven Fleet Capital Management LP |
| 0.67% | 1% | #6 | $403.7万 | 61.1万股 | $313.9万 | 43.4万股 | +17.7万股+40.89% | 加仓 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #48 | $343.2万 | 51.9万股 | $552.1万 | 76.3万股 | -24.3万股-31.92% | 减仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #49 | $331.8万 | 50.2万股 | $166.6万 | 23.0万股 | +27.2万股+118.10% | 加仓 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| <0.01% | — | #42 | $291.9万 | 44.2万股 | $0 | 0股 | +44.2万股 | 新买入 |
| Alyeska投资集团Alyeska Investment Group, L.P. |
| 0.01% | 0.01% | #29 | $247.9万 | 37.5万股 | $271.5万 | 37.5万股 | 00.00% | 持仓不变 |
| Picton Mahoney资产管理PICTON MAHONEY ASSET MANAGEMENT |
| 0.02% | — | #22 | $238.5万 | 36.1万股 | $0 | 0股 | +36.1万股 | 新买入 |
| Velan Capital Investment Management LP |
| 1.42% | 1.6% | #3 | $232.7万 | 35.2万股 | $254.8万 | 35.2万股 | 00.00% | 持仓不变 |
| 简街集团JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #55 | $215.8万 | 32.9万股 | $25.4万 | 3.5万股 | +29.4万股+834.54% | 加仓 |
| Aisling Capital Management LP |
| 0.46% | 0.49% | #9 | $214.8万 | 32.5万股 | $235.3万 | 32.5万股 | 00.00% | 持仓不变 |
| SummitTX 资本SummitTX Capital, L.P. |
| 0.05% | 0.07% | #16 | $210.7万 | 31.9万股 | $237.5万 | 32.8万股 | -9,213股-2.81% | 减仓 |
| 加拿大皇家银行ROYAL BANK OF CANADA |
| <0.01% | <0.01% | #51 | $205.8万 | 31.1万股 | $189.3万 | 26.1万股 | +5.0万股+19.15% | 加仓 |
| DV EQUITIES, LLC |
| 0.26% | — | #12 | $182.4万 | 27.6万股 | $0 | 0股 | +27.6万股 | 新买入 |
| 奥比梅德顾问ORBIMED ADVISORS LLC |
| 0.03% | — | #19 | $177.8万 | 26.9万股 | $0 | 0股 | +26.9万股 | 新买入 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #58 | $175.0万 | 26.5万股 | $194.2万 | 26.8万股 | -3,500股-1.30% | 减仓 |
| Ally Bridge Group (NY) LLC |
| 1.47% | 3.86% | #2 | $166.7万 | 25.2万股 | $478.1万 | 66.0万股 | -40.8万股-61.81% | 减仓 |
| CIBC世界市场CIBC WORLD MARKET INC. |
| <0.01% | <0.01% | #37 | $153.9万 | 23.5万股 | $109.0万 | 15.1万股 | +8.4万股+55.46% | 加仓 |
| DAFNA Capital Management LLC |
| 0.28% | — | #10 | $149.1万 | 22.6万股 | $0 | 0股 | +22.6万股 | 新买入 |
| Two Sigma投资TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #40 | $146.1万 | 22.1万股 | $7.8万 | 1.1万股 | +21.0万股+1,947.07% | 加仓 |
| 布斯湾基金管理BOOTHBAY FUND MANAGEMENT, LLC |
| 0.02% | 0.03% | #21 | $140.6万 | 21.3万股 | $234.5万 | 32.4万股 | -11.1万股-34.33% | 减仓 |
| 马歇尔·韦斯MARSHALL WACE, LLP |
| <0.01% | <0.01% | #45 | $104.5万 | 15.8万股 | $114.5万 | 15.8万股 | 00.00% | 持仓不变 |
| Delaney Capital Management Ltd. |
| 0.12% | — | #14 | $76.8万 | 11.7万股 | $0 | 0股 | +11.7万股 | 新买入 |
| 道明加拿大TD Waterhouse Canada Inc. |
| <0.01% | <0.01% | #38 | $53.5万 | 8.0万股 | $59.0万 | 8.2万股 | -2,118股-2.59% | 减仓 |
| XTX资本XTX Topco Ltd |
| 0.01% | — | #30 | $46.4万 | 7.0万股 | $0 | 0股 | +7.0万股 | 新买入 |
| INGALLS & SNYDER LLC |
| 0.01% | 0.02% | #26 | $45.2万 | 6.8万股 | $54.8万 | 7.6万股 | -7,200股-9.52% | 减仓 |
| Annis Gardner Whiting Capital Advisors, LLC |
| 0.06% | — | #15 | $39.7万 | 6.0万股 | $0 | 0股 | +6.0万股 | 新买入 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #62 | $38.4万 | 5.8万股 | $38.4万 | 5.3万股 | +4,978股+9.38% | 加仓 |
| 雷蒙德詹姆斯金融RAYMOND JAMES FINANCIAL INC |
| <0.01% | <0.01% | #59 | $35.4万 | 5.4万股 | $36.6万 | 5.1万股 | +2,943股+5.82% | 加仓 |
| 1832资产管理1832 Asset Management L.P. |
| <0.01% | <0.01% | #56 | $33.3万 | 5.0万股 | $43.4万 | 6.0万股 | -9,568股-15.95% | 减仓 |
| 法国巴黎银行金融市场BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | <0.01% | #57 | $30.5万 | 4.6万股 | $4.7万 | 6,429股 | +4.0万股+617.76% | 加仓 |
| Stonepine Capital Management, LLC |
| 0.04% | — | #18 | $28.7万 | 4.3万股 | $0 | 0股 | +4.3万股 | 新买入 |
| 蒙特利尔银行BANK OF MONTREAL /CAN/ |
| <0.01% | <0.01% | #60 | $25.2万 | 3.8万股 | $27.6万 | 3.8万股 | +207股+0.54% | 加仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #64 | $23.9万 | 3.6万股 | $18.5万 | 2.6万股 | +1.1万股+41.38% | 加仓 |
| Brevan Howard资本管理Brevan Howard Capital Management LP |
| <0.01% | — | #39 | $23.0万 | 3.5万股 | $0 | 0股 | +3.5万股 | 新买入 |
| Qube研究科技Qube Research & Technologies Ltd |
| <0.01% | — | #53 | $22.6万 | 3.4万股 | $0 | 0股 | +3.4万股 | 新买入 |
| 多伦多道明银行TORONTO DOMINION BANK |
| <0.01% | <0.01% | #52 | $20.3万 | 3.1万股 | $23.7万 | 3.3万股 | -1,978股-6.01% | 减仓 |
| AXQ CAPITAL, LP |
| 0.02% | 0.01% | #24 | $14.0万 | 2.1万股 | $11.4万 | 1.6万股 | +5,390股+34.20% | 加仓 |
