| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #97 | $1.35亿 | 2,557.5万股 | $2,419.7万 | 683.5万股 | +1,873.9万股+274.15% | 加仓 |
| 深轨资本Deep Track Capital, LP |
| 1.11% | 0.69% | #6 | $7,598.0万 | 1,441.7万股 | $4,248.0万 | 1,200.0万股 | +241.7万股+20.15% | 加仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #115 | $6,190.8万 | 1,174.7万股 | $4,163.5万 | 1,176.1万股 | -1.4万股-0.12% | 减仓 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #117 | $4,367.3万 | 828.7万股 | $405.1万 | 114.4万股 | +714.3万股+624.17% | 加仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #98 | $3,654.3万 | 693.3万股 | $888.9万 | 251.0万股 | +442.3万股+176.23% | 加仓 |
| Adage资本合伙人ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.04% | 0.03% | #37 | $2,973.7万 | 564.3万股 | $1,997.5万 | 564.3万股 | 00.00% | 持仓不变 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #88 | $2,331.8万 | 442.5万股 | $2,629.1万 | 742.7万股 | -300.2万股-40.42% | 减仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | — | #129 | $2,164.1万 | 410.6万股 | $0 | 0股 | +410.6万股 | 新买入 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | — | #127 | $2,025.4万 | 384.3万股 | $0 | 0股 | +384.3万股 | 新买入 |
| 康得利安资管Candriam S.C.A. |
| 0.07% | — | #33 | $1,600.2万 | 303.9万股 | $0 | 0股 | +303.9万股 | 新买入 |
| Foresite Capital Management VI LLC |
| 2.26% | 2.12% | #3 | $1,449.3万 | 275.0万股 | $973.5万 | 275.0万股 | 00.00% | 持仓不变 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #107 | $1,364.5万 | 258.9万股 | $190.5万 | 53.8万股 | +205.1万股+381.21% | 加仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #109 | $1,327.8万 | 252.0万股 | $190.7万 | 53.9万股 | +198.1万股+367.71% | 加仓 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #130 | $1,212.3万 | 230.0万股 | $2,124.0万 | 600.0万股 | -370.0万股-61.66% | 减仓 |
| RTW投资RTW INVESTMENTS, LP |
| 0.09% | 0.07% | #23 | $1,054.0万 | 200.0万股 | $708.0万 | 200.0万股 | 00.00% | 持仓不变 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #113 | $1,035.9万 | 196.6万股 | $418.3万 | 118.2万股 | +78.4万股+66.36% | 加仓 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| <0.01% | 0.01% | #85 | $933.1万 | 177.1万股 | $1,544.9万 | 436.4万股 | -259.4万股-59.43% | 减仓 |
| Eagle Health Investments LP |
| 1.49% | 1.06% | #4 | $900.8万 | 170.9万股 | $605.1万 | 170.9万股 | 00.00% | 持仓不变 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #102 | $830.7万 | 157.6万股 | $444.9万 | 125.7万股 | +32.0万股+25.43% | 加仓 |
| Halter Ferguson Financial Inc. |
| 1.27% | — | #5 | $782.9万 | 148.6万股 | $0 | 0股 | +148.6万股 | 新买入 |
| 第一信托顾问FIRST TRUST ADVISORS LP |
| <0.01% | — | #76 | $724.9万 | 137.6万股 | $0 | 0股 | +137.6万股 | 新买入 |
| 普信集团PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | — | #138 | $711.8万 | 135.1万股 | $0 | 0股 | +135.1万股 | 新买入 |
| 纽文Nuveen, LLC |
| <0.01% | <0.01% | #105 | $682.6万 | 129.5万股 | $62.7万 | 17.7万股 | +111.8万股+631.28% | 加仓 |
| Newtyn Management, LLC |
| 0.78% | 0.67% | #9 | $626.0万 | 118.8万股 | $630.7万 | 178.2万股 | -59.4万股-33.33% | 减仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #154 | $540.8万 | 102.6万股 | $212.7万 | 60.1万股 | +42.5万股+70.76% | 加仓 |
| 摩尔资本管理MOORE CAPITAL MANAGEMENT, LP |
| 0.07% | 0.07% | #30 | $501.9万 | 95.2万股 | $337.1万 | 95.2万股 | 00.00% | 持仓不变 |
| ADAR1 Capital Management, LLC |
| 0.22% | 0.19% | #14 | $481.3万 | 91.3万股 | $323.3万 | 91.3万股 | 00.00% | 持仓不变 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| <0.01% | <0.01% | #135 | $470.1万 | 89.2万股 | $16.1万 | 4.6万股 | +84.6万股+1,855.72% | 加仓 |
| AdvisorShares Investments LLC |
| 0.56% | 0.37% | #10 | $465.3万 | 88.3万股 | $200.9万 | 56.8万股 | +31.5万股+55.55% | 加仓 |
| Two Sigma投资TWO SIGMA INVESTMENTS, LP |
| <0.01% | 0.01% | #86 | $433.4万 | 82.2万股 | $699.3万 | 197.6万股 | -115.3万股-58.37% | 减仓 |
| 奥比梅德顾问ORBIMED ADVISORS LLC |
| 0.08% | 0.02% | #28 | $420.3万 | 79.8万股 | $122.8万 | 34.7万股 | +45.1万股+129.83% | 加仓 |
| Group One交易GROUP ONE TRADING LLC |
| 0.01% | 0.01% | #71 | $413.0万 | 78.4万股 | $331.9万 | 93.8万股 | -15.4万股-16.43% | 减仓 |
| Woodline合伙人Woodline Partners LP |
| 0.01% | 0.01% | #58 | $316.2万 | 60.0万股 | $212.4万 | 60.0万股 | 00.00% | 持仓不变 |
| JGP Global Gestao de Recursos Ltda. |
| 5.8% | — | #1 | $263.5万 | 50.0万股 | $0 | 0股 | +50.0万股 | 新买入 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #186 | $258.5万 | 49.0万股 | $290.2万 | 82.0万股 | -32.9万股-40.17% | 减仓 |
| 瑞银资产管理(美洲)UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
| <0.01% | <0.01% | #153 | $258.3万 | 49.0万股 | $94.2万 | 26.6万股 | +22.4万股+84.26% | 加仓 |
| 三井住友信托集团Sumitomo Mitsui Trust Group, Inc. |
| <0.01% | <0.01% | #110 | $258.0万 | 49.0万股 | $200.9万 | 56.8万股 | -7.8万股-13.74% | 减仓 |
| Amova资产管理Amova Asset Management Americas, Inc. |
| 0.03% | 0.03% | #39 | $254.6万 | 48.4万股 | $200.4万 | 56.8万股 | -8.4万股-14.73% | 减仓 |
| 瑞士央行Swiss National Bank |
| <0.01% | <0.01% | #116 | $249.6万 | 47.4万股 | $115.4万 | 32.6万股 | +14.8万股+45.35% | 加仓 |
| RhumbLine顾问RHUMBLINE ADVISERS |
| <0.01% | — | #106 | $210.5万 | 39.9万股 | $0 | 0股 | +39.9万股 | 新买入 |
| Simplex交易SIMPLEX TRADING, LLC |
| <0.01% | <0.01% | #123 | $193.5万 | 36.7万股 | $151.1万 | 42.7万股 | -6.0万股-13.94% | 减仓 |
| 英仕曼集团Man Group plc |
| <0.01% | <0.01% | #87 | $189.1万 | 35.9万股 | $192.4万 | 54.4万股 | -18.5万股-33.98% | 减仓 |
| DEUTSCHE 银行 AG\DEUTSCHE BANK AG\ |
| <0.01% | <0.01% | #148 | $181.8万 | 34.5万股 | $2.4万 | 6,911股 | +33.8万股+4,892.65% | 加仓 |
| BIT Capital GmbH |
| 0.05% | 0.03% | #36 | $168.9万 | 32.1万股 | $64.6万 | 18.3万股 | +13.8万股+75.58% | 加仓 |
| Voya投资管理VOYA INVESTMENT MANAGEMENT LLC |
| <0.01% | — | #112 | $160.5万 | 30.5万股 | $0 | 0股 | +30.5万股 | 新买入 |
| 富国银行WELLS FARGO & COMPANY/MN |
| <0.01% | <0.01% | #174 | $157.0万 | 29.8万股 | $2.3万 | 6,535股 | +29.1万股+4,458.81% | 加仓 |
| 摩根大通JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #208 | $154.1万 | 27.3万股 | $65.5万 | 19.3万股 | +8.1万股+41.99% | 加仓 |
| 杰富瑞金融集团Jefferies Financial Group Inc. |
| 0.01% | 0.01% | #59 | $145.4万 | 27.6万股 | $97.7万 | 27.6万股 | 00.00% | 持仓不变 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
| <0.01% | — | #118 | $139.3万 | 26.4万股 | $0 | 0股 | +26.4万股 | 新买入 |
| Warm Springs Advisors Inc. |
| 0.96% | 0.41% | #8 | $138.6万 | 26.3万股 | $48.3万 | 13.6万股 | +12.7万股+92.82% | 加仓 |
