| 富达投资FMR LLC |
| <0.01% | <0.01% | #52 | $5,736.2万 | 394.2万股 | $515.8万 | 32.3万股 | +362.0万股+1,122.06% | 加仓 |
| Vivo Capital, LLC |
| 3.32% | 0.28% | #2 | $3,637.5万 | 250.0万股 | $333.1万 | 20.8万股 | +229.2万股+1,100.00% | 加仓 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #74 | $2,514.2万 | 172.8万股 | $27.1万 | 1.7万股 | +171.1万股+10,078.41% | 加仓 |
| 洞察顾问PERCEPTIVE ADVISORS LLC |
| 0.37% | 0.45% | #11 | $2,473.5万 | 170.0万股 | $2,315.0万 | 144.8万股 | +25.2万股+17.42% | 加仓 |
| Ikarian Capital, LLC |
| 1.82% | 1.47% | #3 | $1,712.8万 | 117.7万股 | $1,809.9万 | 113.2万股 | +4.5万股+4.00% | 加仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #75 | $1,669.1万 | 114.7万股 | $421.2万 | 26.3万股 | +88.4万股+335.47% | 加仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #56 | $1,302.9万 | 89.5万股 | $243.9万 | 15.3万股 | +74.3万股+487.13% | 加仓 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #43 | $1,274.9万 | 87.6万股 | $853.7万 | 53.4万股 | +34.2万股+64.12% | 加仓 |
| 康得利安资管Candriam S.C.A. |
| 0.05% | — | #24 | $1,089.6万 | 75.0万股 | $0 | 0股 | +75.0万股 | 新买入 |
| Caption管理Caption Management, LLC |
| 0.05% | — | #25 | $1,050.1万 | 72.2万股 | $0 | 0股 | +72.2万股 | 新买入 |
| RTW投资RTW INVESTMENTS, LP |
| 0.09% | 0.06% | #22 | $1,013.5万 | 69.7万股 | $592.0万 | 37.0万股 | +32.6万股+88.14% | 加仓 |
| Stonepine Capital Management, LLC |
| 1.47% | 6.24% | #5 | $960.3万 | 66.0万股 | $1,559.3万 | 97.5万股 | -31.5万股-32.32% | 减仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #72 | $930.8万 | 64.0万股 | $110.6万 | 6.9万股 | +57.0万股+824.72% | 加仓 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #65 | $903.8万 | 62.1万股 | $46.3万 | 2.9万股 | +59.2万股+2,043.64% | 加仓 |
| Velan Capital Investment Management LP |
| 5.48% | 5.84% | #1 | $900.2万 | 61.9万股 | $932.7万 | 58.3万股 | +3.5万股+6.06% | 加仓 |
| 普信集团PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | 0.01% | #61 | $884.1万 | 60.8万股 | $4,718.9万 | 295.1万股 | -234.3万股-79.41% | 减仓 |
| 马歇尔·韦斯MARSHALL WACE, LLP |
| 0.01% | 0.01% | #39 | $852.0万 | 58.6万股 | $563.8万 | 35.3万股 | +23.3万股+66.09% | 加仓 |
| BRAIDWELL LP |
| 0.31% | — | #12 | $850.3万 | 58.4万股 | $0 | 0股 | +58.4万股 | 新买入 |
| Point72资产管理Point72 Asset Management, L.P. |
| 0.01% | 0.01% | #36 | $810.1万 | 55.7万股 | $853.8万 | 53.4万股 | +2.3万股+4.27% | 加仓 |
| Adage资本合伙人ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.01% | 0.01% | #35 | $785.9万 | 54.0万股 | $863.7万 | 54.0万股 | 00.00% | 持仓不变 |
| Woodline合伙人Woodline Partners LP |
| 0.02% | 0.02% | #28 | $773.0万 | 53.1万股 | $517.9万 | 32.4万股 | +20.7万股+64.01% | 加仓 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #86 | $743.2万 | 51.1万股 | $46.4万 | 2.9万股 | +48.2万股+1,662.04% | 加仓 |
| Sofinnova Investments, Inc. |
| 0.38% | 0.06% | #10 | $727.6万 | 50.0万股 | $166.9万 | 10.4万股 | +39.6万股+378.96% | 加仓 |
| 木星资产管理Jupiter Topco LLC |
| <0.01% | — | #51 | $656.8万 | 45.1万股 | $0 | 0股 | +45.1万股 | 新买入 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #80 | $628.9万 | 43.2万股 | $135.7万 | 17.8万股 | +25.4万股+142.37% | 加仓 |
| Qube研究科技Qube Research & Technologies Ltd |
| 0.01% | <0.01% | #41 | $625.5万 | 43.0万股 | $45.2万 | 2.8万股 | +40.2万股+1,419.86% | 加仓 |
| Siren, L.L.C. |
| 0.13% | 0.19% | #18 | $621.5万 | 42.7万股 | $683.0万 | 42.7万股 | 00.00% | 持仓不变 |
| 简街集团JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #70 | $614.8万 | 42.3万股 | $53.8万 | 3.4万股 | +38.9万股+1,156.56% | 加仓 |
| 布斯湾基金管理BOOTHBAY FUND MANAGEMENT, LLC |
| 0.08% | 0.08% | #23 | $614.3万 | 42.2万股 | $639.4万 | 40.0万股 | +2.2万股+5.58% | 加仓 |
| Two Sigma投资TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #45 | $514.2万 | 35.3万股 | $109.7万 | 6.9万股 | +28.5万股+415.24% | 加仓 |
| BVF INC/IL |
| 0.13% | 0.17% | #17 | $494.0万 | 34.0万股 | $542.9万 | 34.0万股 | 00.00% | 持仓不变 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| <0.01% | — | #64 | $473.3万 | 32.5万股 | $0 | 0股 | +32.5万股 | 新买入 |
| Trexquant投资Trexquant Investment LP |
| 0.03% | 0.01% | #26 | $467.9万 | 32.2万股 | $81.1万 | 5.1万股 | +27.1万股+534.18% | 加仓 |
| DIADEMA PARTNERS LP |
| 0.55% | 0.49% | #7 | $446.7万 | 30.7万股 | $287.4万 | 18.0万股 | +12.7万股+70.80% | 加仓 |
| Logos Global Management LP |
| 0.19% | 0.5% | #14 | $436.5万 | 30.0万股 | $999.4万 | 62.5万股 | -32.5万股-52.00% | 减仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #76 | $400.0万 | 27.5万股 | $50.9万 | 3.2万股 | +24.3万股+763.14% | 加仓 |
| Avidity Partners Management LP |
| 0.62% | 0.7% | #6 | $386.9万 | 26.6万股 | $345.3万 | 21.6万股 | +5.0万股+23.16% | 加仓 |
| 维度基金顾问DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #66 | $368.6万 | 25.4万股 | $100.1万 | 6.3万股 | +19.1万股+303.78% | 加仓 |
| SPHERA FUNDS MANAGEMENT LTD. |
| 0.47% | 0.35% | #9 | $360.5万 | 24.8万股 | $217.5万 | 13.6万股 | +11.2万股+82.19% | 加仓 |
| ADAR1 Capital Management, LLC |
| 0.15% | 0.2% | #16 | $320.8万 | 22.0万股 | $341.3万 | 21.3万股 | +7,000股+3.28% | 加仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #78 | $289.7万 | 19.9万股 | $19.3万 | 1.2万股 | +18.7万股+1,552.70% | 加仓 |
| Balyasny资产管理BALYASNY ASSET MANAGEMENT L.P. |
| <0.01% | <0.01% | #47 | $282.3万 | 19.4万股 | $311.2万 | 19.5万股 | -616股-0.32% | 减仓 |
| ExodusPoint资本ExodusPoint Capital Management, LP |
| 0.02% | — | #32 | $268.4万 | 18.5万股 | $0 | 0股 | +18.5万股 | 新买入 |
| Ensign Peak顾问Ensign Peak Advisors, Inc |
| <0.01% | — | #44 | $257.4万 | 17.7万股 | $0 | 0股 | +17.7万股 | 新买入 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | — | #95 | $245.7万 | 16.9万股 | $0 | 0股 | +16.9万股 | 新买入 |
| Integral Health 资产管理Integral Health Asset Management, LLC |
| 0.1% | 0.13% | #21 | $243.0万 | 16.7万股 | $267.0万 | 16.7万股 | 00.00% | 持仓不变 |
| 文艺复兴科技RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | <0.01% | #49 | $238.6万 | 16.4万股 | $244.0万 | 15.3万股 | +1.1万股+7.47% | 加仓 |
| 纽文Nuveen, LLC |
| <0.01% | — | #67 | $234.5万 | 16.1万股 | $0 | 0股 | +16.1万股 | 新买入 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #71 | $228.5万 | 15.7万股 | $53.5万 | 3.3万股 | +12.4万股+369.76% | 加仓 |
| PanAgora资产管理PANAGORA ASSET MANAGEMENT INC |
| 0.01% | — | #38 | $227.1万 | 15.6万股 | $0 | 0股 | +15.6万股 | 新买入 |
