| 木星资产管理Jupiter Topco LLC |
| 0.02% | — | #26 | $5,589.8万 | 2,074.1万股 | $0 | 0股 | +2,074.1万股 | 新买入 |
| 暮色资产管理EVENTIDE ASSET MANAGEMENT, LLC |
| 0.42% | 0.36% | #12 | $3,177.5万 | 1,181.2万股 | $2,201.6万 | 991.7万股 | +189.5万股+19.11% | 加仓 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #60 | $2,911.5万 | 1,082.3万股 | $340.4万 | 153.3万股 | +929.0万股+605.90% | 加仓 |
| RA资本管理RA CAPITAL MANAGEMENT, L.P. |
| 0.25% | 0.25% | #14 | $2,824.8万 | 1,050.1万股 | $2,378.5万 | 1,071.4万股 | -21.3万股-1.99% | 减仓 |
| Affinity Asset Advisors, LLC |
| 1.23% | 1.22% | #3 | $2,728.9万 | 1,014.5万股 | $2,361.3万 | 1,063.6万股 | -49.2万股-4.62% | 减仓 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #53 | $2,125.3万 | 790.1万股 | $115.5万 | 52.0万股 | +738.0万股+1,418.55% | 加仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #59 | $2,087.5万 | 776.0万股 | $1,167.3万 | 525.8万股 | +250.2万股+47.58% | 加仓 |
| ADAR1 Capital Management, LLC |
| 0.92% | 0.59% | #5 | $1,995.3万 | 741.7万股 | $1,008.8万 | 454.4万股 | +287.3万股+63.23% | 加仓 |
| Balyasny资产管理BALYASNY ASSET MANAGEMENT L.P. |
| 0.02% | 0.02% | #27 | $1,807.4万 | 671.9万股 | $1,228.3万 | 553.3万股 | +118.6万股+21.43% | 加仓 |
| Adage资本合伙人ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.02% | 0.02% | #24 | $1,658.1万 | 616.4万股 | $1,368.4万 | 616.4万股 | 00.00% | 持仓不变 |
| Federated HermesFEDERATED HERMES, INC. |
| 0.02% | 0.01% | #25 | $1,601.0万 | 595.2万股 | $792.8万 | 357.1万股 | +238.1万股+66.67% | 加仓 |
| BRAIDWELL LP |
| 0.59% | — | #9 | $1,592.3万 | 591.9万股 | $0 | 0股 | +591.9万股 | 新买入 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #54 | $1,095.8万 | 407.3万股 | $292.8万 | 131.8万股 | +275.5万股+208.98% | 加仓 |
| SILVERARC CAPITAL MANAGEMENT, LLC |
| 0.87% | 0.23% | #6 | $834.2万 | 310.1万股 | $222.0万 | 100.0万股 | +210.1万股+210.11% | 加仓 |
| STEMPOINT CAPITAL LP |
| 0.93% | — | #4 | $650.2万 | 241.7万股 | $0 | 0股 | +241.7万股 | 新买入 |
| Ikarian Capital, LLC |
| 0.65% | 0.52% | #8 | $610.6万 | 227.0万股 | $642.6万 | 289.5万股 | -62.5万股-21.59% | 减仓 |
| Point72资产管理Point72 Asset Management, L.P. |
| 0.01% | <0.01% | #35 | $523.4万 | 194.6万股 | $293.2万 | 132.1万股 | +62.5万股+47.34% | 加仓 |
| SPHERA FUNDS MANAGEMENT LTD. |
| 0.48% | 0.57% | #10 | $364.0万 | 135.3万股 | $360.3万 | 162.3万股 | -27.0万股-16.63% | 减仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #63 | $335.2万 | 124.6万股 | $56.6万 | 25.5万股 | +99.1万股+389.06% | 加仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #52 | $306.9万 | 114.1万股 | $153.9万 | 69.3万股 | +44.7万股+64.55% | 加仓 |
| Propel Bio Management, LLC |
| 1.57% | 1.28% | #1 | $300.1万 | 111.6万股 | $203.8万 | 92.1万股 | +19.4万股+21.06% | 加仓 |
| Rosalind Advisors, Inc. |
| 0.71% | 0.99% | #7 | $298.1万 | 110.8万股 | $246.0万 | 110.8万股 | 00.00% | 持仓不变 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | — | #81 | $277.3万 | 103.1万股 | $0 | 0股 | +103.1万股 | 新买入 |
| Sio Capital Management, LLC |
| 0.45% | 0.4% | #11 | $270.4万 | 100.5万股 | $278.0万 | 125.2万股 | -24.7万股-19.73% | 减仓 |
| Ensign Peak顾问Ensign Peak Advisors, Inc |
| <0.01% | — | #39 | $265.8万 | 98.8万股 | $0 | 0股 | +98.8万股 | 新买入 |
| 纽文Nuveen, LLC |
| <0.01% | — | #55 | $240.3万 | 89.3万股 | $0 | 0股 | +89.3万股 | 新买入 |
| Two Sigma投资TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #41 | $223.9万 | 83.2万股 | $279.0万 | 125.7万股 | -42.4万股-33.77% | 减仓 |
| 富国银行WELLS FARGO & COMPANY/MN |
| <0.01% | <0.01% | #64 | $222.2万 | 82.6万股 | $158.4万 | 71.4万股 | +11.3万股+15.78% | 加仓 |
| 奥比梅德顾问ORBIMED ADVISORS LLC |
| 0.04% | — | #22 | $200.9万 | 74.7万股 | $0 | 0股 | +74.7万股 | 新买入 |
| 布斯湾基金管理BOOTHBAY FUND MANAGEMENT, LLC |
| 0.03% | 0.03% | #23 | $198.5万 | 73.8万股 | $206.0万 | 92.8万股 | -19.0万股-20.49% | 减仓 |
| Saturn V Capital Management LP |
| 0.26% | 1.68% | #13 | $178.4万 | 66.3万股 | $925.0万 | 416.7万股 | -350.4万股-84.09% | 减仓 |
| Ally Bridge Group (NY) LLC |
| 1.49% | 5.05% | #2 | $168.0万 | 62.5万股 | $625.7万 | 281.8万股 | -219.4万股-77.84% | 减仓 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #79 | $123.4万 | 45.9万股 | $61.6万 | 27.8万股 | +18.1万股+65.28% | 加仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #78 | $119.4万 | 44.4万股 | $16.0万 | 7.2万股 | +37.2万股+516.73% | 加仓 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| <0.01% | <0.01% | #73 | $112.0万 | 41.6万股 | $12.2万 | 5.5万股 | +36.1万股+656.42% | 加仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #89 | $110.2万 | 40.9万股 | $64.5万 | 29.0万股 | +11.9万股+40.99% | 加仓 |
| 维度基金顾问DIMENSIONAL FUND ADVISORS LP |
| <0.01% | — | #72 | $104.3万 | 38.8万股 | $0 | 0股 | +38.8万股 | 新买入 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #88 | $89.5万 | 33.3万股 | $33.9万 | 15.3万股 | +18.0万股+117.66% | 加仓 |
| Informed Momentum Co LLC |
| 0.06% | 0.07% | #19 | $69.8万 | 26.0万股 | $60.0万 | 27.0万股 | -1.1万股-3.95% | 减仓 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #98 | $69.2万 | 25.7万股 | $482.0万 | 217.1万股 | -191.4万股-88.14% | 减仓 |
| Atom Investors LP |
| 0.06% | — | #20 | $67.7万 | 25.2万股 | $0 | 0股 | +25.2万股 | 新买入 |
| CIBC世界市场CIBC WORLD MARKET INC. |
| <0.01% | <0.01% | #48 | $58.9万 | 21.9万股 | $55.4万 | 24.9万股 | -3.1万股-12.23% | 减仓 |
| Parkman Healthcare Partners LLC |
| 0.05% | 0.05% | #21 | $53.2万 | 19.8万股 | $46.2万 | 20.8万股 | -1.0万股-4.93% | 减仓 |
| SEI投资SEI INVESTMENTS CO |
| <0.01% | <0.01% | #57 | $52.9万 | 19.7万股 | $73.0万 | 32.9万股 | -13.2万股-40.20% | 减仓 |
| 花旗集团CITIGROUP INC |
| <0.01% | <0.01% | #75 | $51.4万 | 19.1万股 | $25.4万 | 11.4万股 | +7.7万股+67.24% | 加仓 |
| 景顺Invesco Ltd. |
| <0.01% | <0.01% | #104 | $47.0万 | 17.5万股 | $22.6万 | 10.2万股 | +7.3万股+72.18% | 加仓 |
| RhumbLine顾问RHUMBLINE ADVISERS |
| <0.01% | — | #65 | $45.8万 | 17.0万股 | $0 | 0股 | +17.0万股 | 新买入 |
| 美国世纪投资AMERICAN CENTURY COMPANIES INC |
| <0.01% | — | #71 | $45.6万 | 16.9万股 | $0 | 0股 | +16.9万股 | 新买入 |
| DEUTSCHE 银行 AG\DEUTSCHE BANK AG\ |
| <0.01% | — | #83 | $40.2万 | 14.9万股 | $0 | 0股 | +14.9万股 | 新买入 |
| Rafferty资产管理Rafferty Asset Management, LLC |
| <0.01% | — | #50 | $36.8万 | 13.7万股 | $0 | 0股 | +13.7万股 | 新买入 |
