| RA资本管理RA CAPITAL MANAGEMENT, L.P. |
| 2.49% | — | #3 | $2.87亿 | 780.9万股 | $0 | 0股 | +780.9万股 | 新买入 |
| Novo Holdings A/S |
| 8.94% | — | #1 | $1.54亿 | 418.1万股 | $0 | 0股 | +418.1万股 | 新买入 |
| 富达投资FMR LLC |
| 0.01% | — | #27 | $1.36亿 | 369.8万股 | $0 | 0股 | +369.8万股 | 新买入 |
| 资本国际投资者Capital International Investors |
| 0.03% | — | #20 | $1.32亿 | 360.4万股 | $0 | 0股 | +360.4万股 | 新买入 |
| 深轨资本Deep Track Capital, LP |
| 1.93% | — | #4 | $1.32亿 | 360.2万股 | $0 | 0股 | +360.2万股 | 新买入 |
| Siren, L.L.C. |
| 1.55% | — | #5 | $7,664.9万 | 208.7万股 | $0 | 0股 | +208.7万股 | 新买入 |
| Avoro资本顾问Avoro Capital Advisors LLC |
| 0.63% | — | #7 | $7,071.1万 | 192.5万股 | $0 | 0股 | +192.5万股 | 新买入 |
| Bain Capital Life Sciences Investors, LLC |
| 3.6% | — | #2 | $6,060.5万 | 165.0万股 | $0 | 0股 | +165.0万股 | 新买入 |
| 摩根大通JPMORGAN CHASE & CO |
| <0.01% | — | #32 | $4,232.8万 | 115.2万股 | $0 | 0股 | +115.2万股 | 新买入 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | — | #38 | $2,867.7万 | 78.1万股 | $0 | 0股 | +78.1万股 | 新买入 |
| 普信集团PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | — | #30 | $2,740.2万 | 74.6万股 | $0 | 0股 | +74.6万股 | 新买入 |
| Driehaus资本管理DRIEHAUS CAPITAL MANAGEMENT LLC |
| 0.15% | — | #13 | $2,629.1万 | 71.6万股 | $0 | 0股 | +71.6万股 | 新买入 |
| Rock Springs Capital Management LP |
| 1.03% | — | #6 | $2,113.6万 | 57.5万股 | $0 | 0股 | +57.5万股 | 新买入 |
| Bellevue 集团Bellevue Group AG |
| 0.43% | — | #8 | $2,020.2万 | 55.0万股 | $0 | 0股 | +55.0万股 | 新买入 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | — | #33 | $1,922.6万 | 52.3万股 | $0 | 0股 | +52.3万股 | 新买入 |
| 贝莱德BlackRock, Inc. |
| <0.01% | — | #46 | $1,042.5万 | 28.4万股 | $0 | 0股 | +28.4万股 | 新买入 |
| Deerfield管理DEERFIELD MANAGEMENT COMPANY, L.P. |
| 0.11% | — | #14 | $1,010.1万 | 27.5万股 | $0 | 0股 | +27.5万股 | 新买入 |
| ExodusPoint资本ExodusPoint Capital Management, LP |
| 0.05% | — | #16 | $801.8万 | 21.8万股 | $0 | 0股 | +21.8万股 | 新买入 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | — | #42 | $778.4万 | 21.2万股 | $0 | 0股 | +21.2万股 | 新买入 |
| BRAIDWELL LP |
| 0.22% | — | #10 | $587.7万 | 16.0万股 | $0 | 0股 | +16.0万股 | 新买入 |
| 马歇尔·韦斯MARSHALL WACE, LLP |
| <0.01% | — | #28 | $568.1万 | 15.5万股 | $0 | 0股 | +15.5万股 | 新买入 |
| Woodline合伙人Woodline Partners LP |
| 0.02% | — | #21 | $551.1万 | 15.0万股 | $0 | 0股 | +15.0万股 | 新买入 |
| Affinity Asset Advisors, LLC |
| 0.23% | — | #9 | $507.0万 | 13.8万股 | $0 | 0股 | +13.8万股 | 新买入 |
| Ensign Peak顾问Ensign Peak Advisors, Inc |
| 0.01% | — | #26 | $423.8万 | 11.5万股 | $0 | 0股 | +11.5万股 | 新买入 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | — | #37 | $413.2万 | 11.2万股 | $0 | 0股 | +11.2万股 | 新买入 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | — | #41 | $397.6万 | 10.8万股 | $0 | 0股 | +10.8万股 | 新买入 |
| 阿默普莱斯金融AMERIPRISE FINANCIAL INC |
| <0.01% | — | #39 | $300.9万 | 8.2万股 | $0 | 0股 | +8.2万股 | 新买入 |
| Burkehill Global 管理Burkehill Global Management, LP |
| 0.1% | — | #15 | $275.5万 | 7.5万股 | $0 | 0股 | +7.5万股 | 新买入 |
| 安本标准投资Aberdeen Group plc |
| <0.01% | — | #31 | $191.4万 | 5.2万股 | $0 | 0股 | +5.2万股 | 新买入 |
| Opaleye Management Inc. |
| 0.16% | — | #12 | $175.0万 | 4.8万股 | $0 | 0股 | +4.8万股 | 新买入 |
| 瑞银集团UBS Group AG |
| <0.01% | — | #44 | $173.9万 | 4.7万股 | $0 | 0股 | +4.7万股 | 新买入 |
| Parkman Healthcare Partners LLC |
| 0.17% | — | #11 | $165.3万 | 4.5万股 | $0 | 0股 | +4.5万股 | 新买入 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | — | #45 | $148.7万 | 4.0万股 | $0 | 0股 | +4.0万股 | 新买入 |
| 吉萨洛资本管理Ghisallo Capital Management LLC |
| 0.01% | — | #23 | $146.9万 | 4.0万股 | $0 | 0股 | +4.0万股 | 新买入 |
| 道明资产管理TD ASSET MANAGEMENT INC |
| <0.01% | — | #36 | $121.6万 | 3.3万股 | $0 | 0股 | +3.3万股 | 新买入 |
| SEVEN GRAND MANAGERS, LLC |
| 0.04% | — | #17 | $110.2万 | 3.0万股 | $0 | 0股 | +3.0万股 | 新买入 |
| 索罗斯基金管理SOROS FUND MANAGEMENT LLC |
| 0.01% | — | #22 | $91.8万 | 2.5万股 | $0 | 0股 | +2.5万股 | 新买入 |
| 宏利人寿MANUFACTURERS LIFE INSURANCE COMPANY, THE |
| <0.01% | — | #40 | $68.8万 | 1.9万股 | $0 | 0股 | +1.9万股 | 新买入 |
| GSA CAPITAL PARTNERS LLP |
| 0.04% | — | #18 | $64.9万 | 1.8万股 | $0 | 0股 | +1.8万股 | 新买入 |
| XTX资本XTX Topco Ltd |
| 0.01% | — | #24 | $63.9万 | 1.7万股 | $0 | 0股 | +1.7万股 | 新买入 |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. |
| 0.03% | — | #19 | $48.4万 | 1.3万股 | $0 | 0股 | +1.3万股 | 新买入 |
| 哈德逊湾资本管理Hudson Bay Capital Management LP |
| <0.01% | — | #35 | $44.8万 | 1.2万股 | $0 | 0股 | +1.2万股 | 新买入 |
| Schonfeld战略顾问Schonfeld Strategic Advisors LLC |
| <0.01% | — | #34 | $39.7万 | 1.1万股 | $0 | 0股 | +1.1万股 | 新买入 |
| 韦斯资产管理Weiss Asset Management LP |
| <0.01% | — | #29 | $36.7万 | 1.0万股 | $0 | 0股 | +1.0万股 | 新买入 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | — | #50 | $30.0万 | 8,169股 | $0 | 0股 | +8,169股 | 新买入 |
| 先锋环球顾问Vanguard Global Advisers, LLC |
| <0.01% | — | #48 | $28.0万 | 7,616股 | $0 | 0股 | +7,616股 | 新买入 |
| SquarepointSquarepoint Ops LLC |
| <0.01% | — | #43 | $23.0万 | 6,252股 | $0 | 0股 | +6,252股 | 新买入 |
| Two Sigma投资TWO SIGMA INVESTMENTS, LP |
| <0.01% | — | #47 | $20.9万 | 5,680股 | $0 | 0股 | +5,680股 | 新买入 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | — | #51 | $15.0万 | 4,078股 | $0 | 0股 | +4,078股 | 新买入 |
| China Universal Asset Management Co., Ltd. |
| 0.01% | — | #25 | $13.2万 | 3,600股 | $0 | 0股 | +3,600股 | 新买入 |
