| Opaleye Management Inc. |
| 9.38% | 9.3% | #1 | $1.04亿 | 286.0万股 | $7,058.5万 | 286.0万股 | 00.00% | 持仓不变 |
| EcoR1 Capital, LLC |
| 3.82% | 2.27% | #3 | $7,862.4万 | 217.2万股 | $5,360.3万 | 217.2万股 | 00.00% | 持仓不变 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #84 | $6,862.9万 | 189.6万股 | $4,238.3万 | 171.7万股 | +17.9万股+10.40% | 加仓 |
| Nantahala 资本管理Nantahala Capital Management, LLC |
| 1.42% | 1.07% | #9 | $4,256.9万 | 117.6万股 | $2,902.2万 | 117.6万股 | 00.00% | 持仓不变 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #91 | $3,535.2万 | 97.7万股 | $2,453.4万 | 99.4万股 | -1.8万股-1.76% | 减仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #76 | $2,780.1万 | 76.8万股 | $1,273.5万 | 58.6万股 | +18.2万股+31.04% | 加仓 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #92 | $2,540.5万 | 70.2万股 | $1,308.6万 | 53.0万股 | +17.2万股+32.36% | 加仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #80 | $2,361.9万 | 65.2万股 | $1,426.1万 | 57.8万股 | +7.5万股+12.92% | 加仓 |
| 奥伯维斯资产管理OBERWEIS ASSET MANAGEMENT INC/ |
| 0.38% | 0.32% | #14 | $1,815.8万 | 50.2万股 | $1,084.2万 | 43.9万股 | +6.2万股+14.18% | 加仓 |
| 美国国家慈善信托National Philanthropic Trust |
| 0.26% | 0.06% | #18 | $1,781.4万 | 49.2万股 | $215.5万 | 49.2万股 | 00.00% | 持仓不变 |
| Westside Investment Management, Inc. |
| 2.05% | 1.77% | #7 | $1,560.8万 | 43.1万股 | $1,154.8万 | 46.8万股 | -3.7万股-7.86% | 减仓 |
| Pillsbury Lake Capital LLC |
| 3.8% | 4.07% | #4 | $1,401.5万 | 38.7万股 | $900.7万 | 36.5万股 | +2.2万股+6.08% | 加仓 |
| 纽文Nuveen, LLC |
| <0.01% | <0.01% | #58 | $1,360.1万 | 37.6万股 | $143.0万 | 5.8万股 | +31.8万股+548.33% | 加仓 |
| 法国巴黎银行金融市场BNP PARIBAS FINANCIAL MARKETS |
| 0.01% | <0.01% | #52 | $1,167.3万 | 32.2万股 | $745.6万 | 30.2万股 | +2.0万股+6.74% | 加仓 |
| Woodline合伙人Woodline Partners LP |
| 0.03% | 0.02% | #32 | $1,125.4万 | 31.1万股 | $421.3万 | 17.1万股 | +14.0万股+82.12% | 加仓 |
| THOMPSON SIEGEL & WALMSLEY LLC |
| 0.19% | 0.18% | #22 | $1,076.0万 | 29.7万股 | $1,002.2万 | 40.6万股 | -10.9万股-26.81% | 减仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #82 | $926.2万 | 25.6万股 | $587.0万 | 23.8万股 | +1.8万股+7.58% | 加仓 |
| 马歇尔·韦斯MARSHALL WACE, LLP |
| 0.01% | <0.01% | #48 | $902.0万 | 24.9万股 | $204.2万 | 8.3万股 | +16.6万股+201.23% | 加仓 |
| 简街集团JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #96 | $796.0万 | 22.0万股 | $329.5万 | 13.4万股 | +8.6万股+64.69% | 加仓 |
| Panoramic Capital, LLC |
| 3.24% | 3.21% | #5 | $753.7万 | 20.8万股 | $456.6万 | 18.5万股 | +2.3万股+12.54% | 加仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #115 | $704.4万 | 19.5万股 | $374.5万 | 15.2万股 | +4.3万股+28.23% | 加仓 |
| 摩根大通JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #108 | $703.9万 | 19.2万股 | $383.6万 | 17.0万股 | +2.2万股+12.81% | 加仓 |
| D.E.肖D. E. Shaw & Co., Inc. |
| <0.01% | — | #57 | $682.2万 | 18.8万股 | $0 | 0股 | +18.8万股 | 新买入 |
| Lumbard & Kellner, LLC |
| 1.93% | 1.5% | #8 | $636.8万 | 17.6万股 | $434.1万 | 17.6万股 | -2股-0.00% | 减仓 |
| CANNELL CAPITAL LLC |
| 4.14% | 5.32% | #2 | $618.1万 | 17.1万股 | $844.0万 | 34.2万股 | -17.1万股-50.07% | 减仓 |
| 挪威央行投资管理NORGES BANK |
| <0.01% | — | #100 | $613.6万 | 17.0万股 | $0 | 0股 | +17.0万股 | 新买入 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #79 | $610.1万 | 16.9万股 | $406.5万 | 16.5万股 | +3,824股+2.32% | 加仓 |
| Informed Momentum Co LLC |
| 0.51% | 0.14% | #13 | $572.1万 | 15.8万股 | $120.0万 | 4.9万股 | +10.9万股+225.04% | 加仓 |
| Prospect Capital Advisors, LLC |
| 2.58% | — | #6 | $569.1万 | 15.7万股 | $0 | 0股 | +15.7万股 | 新买入 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #106 | $532.9万 | 14.7万股 | $443.7万 | 18.0万股 | -3.3万股-18.12% | 减仓 |
| Aristides Capital LLC |
| 1.04% | 1.01% | #10 | $526.4万 | 14.5万股 | $459.1万 | 18.6万股 | -4.1万股-21.84% | 减仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #114 | $515.0万 | 14.2万股 | $356.3万 | 14.4万股 | -2,110股-1.46% | 减仓 |
| PRELUDE CAPITAL MANAGEMENT, LLC |
| 0.34% | 0.36% | #15 | $498.0万 | 13.8万股 | $466.0万 | 18.9万股 | -5.1万股-27.13% | 减仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #105 | $480.0万 | 13.3万股 | $536.7万 | 21.7万股 | -8.5万股-39.03% | 减仓 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| <0.01% | <0.01% | #94 | $428.1万 | 11.8万股 | $274.6万 | 11.1万股 | +6,994股+6.29% | 加仓 |
| Two Sigma投资TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #61 | $421.0万 | 11.6万股 | $262.6万 | 10.6万股 | +9,898股+9.30% | 加仓 |
| 富国银行WELLS FARGO & COMPANY/MN |
| <0.01% | <0.01% | #95 | $415.1万 | 11.5万股 | $23.6万 | 9,559股 | +10.5万股+1,099.45% | 加仓 |
| Wasatch顾问WASATCH ADVISORS LP |
| 0.02% | — | #39 | $335.7万 | 9.3万股 | $0 | 0股 | +9.3万股 | 新买入 |
| Bridge City Capital, LLC |
| 0.73% | 0.14% | #12 | $319.0万 | 8.8万股 | $52.2万 | 2.1万股 | +6.7万股+316.70% | 加仓 |
| Walleye资本Walleye Capital LLC |
| 0.01% | 0.01% | #43 | $312.2万 | 8.6万股 | $202.3万 | 8.2万股 | +4,286股+5.23% | 加仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #111 | $309.0万 | 8.5万股 | $374.4万 | 15.2万股 | -6.6万股-43.73% | 减仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #110 | $278.9万 | 7.7万股 | $169.8万 | 6.9万股 | +8,237股+11.97% | 加仓 |
| 惠灵顿管理集团WELLINGTON MANAGEMENT GROUP LLP |
| <0.01% | <0.01% | #103 | $275.5万 | 7.6万股 | $173.1万 | 7.0万股 | +5,979股+8.53% | 加仓 |
| Diametric Capital, LP |
| 0.28% | 1.01% | #16 | $264.6万 | 7.3万股 | $387.3万 | 15.7万股 | -8.4万股-53.42% | 减仓 |
| Numerai GP LLC |
| 0.21% | 0.09% | #20 | $253.8万 | 7.0万股 | $92.2万 | 3.7万股 | +3.3万股+87.69% | 加仓 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #116 | $236.8万 | 6.5万股 | $417.0万 | 16.9万股 | -10.4万股-61.28% | 减仓 |
| SquarepointSquarepoint Ops LLC |
| <0.01% | — | #67 | $215.6万 | 6.0万股 | $0 | 0股 | +6.0万股 | 新买入 |
| 布斯湾基金管理BOOTHBAY FUND MANAGEMENT, LLC |
| 0.03% | 0.02% | #35 | $208.2万 | 5.8万股 | $137.2万 | 5.6万股 | +1,911股+3.44% | 加仓 |
| 巴克莱BARCLAYS PLC |
| <0.01% | <0.01% | #109 | $203.4万 | 5.6万股 | $121.9万 | 4.9万股 | +6,807股+13.79% | 加仓 |
| HighTower顾问HighTower Advisors, LLC |
| <0.01% | <0.01% | #71 | $191.5万 | 5.3万股 | $45.5万 | 1.8万股 | +3.4万股+187.18% | 加仓 |
