| Darwin Global Management, Ltd. |
| 12.14% | 12.1% | #1 | $4.57亿 | 307.7万股 | $4.56亿 | 305.7万股 | +2.0万股+0.65% | 加仓 |
| 范式生物资本Paradigm Biocapital Advisors LP |
| 3.55% | 3.63% | #2 | $1.90亿 | 123.3万股 | $1.78亿 | 111.5万股 | +11.8万股+10.59% | 加仓 |
| RTW投资RTW INVESTMENTS, LP |
| 0.94% | 1.13% | #9 | $1.10亿 | 71.5万股 | $1.14亿 | 71.5万股 | 00.00% | 持仓不变 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| 0.03% | 0.04% | #31 | $7,615.5万 | 49.5万股 | $9,089.5万 | 57.0万股 | -7.6万股-13.25% | 减仓 |
| Maverick资本MAVERICK CAPITAL LTD |
| 0.54% | — | #13 | $6,102.6万 | 39.6万股 | $0 | 0股 | +39.6万股 | 新买入 |
| 暮色资产管理EVENTIDE ASSET MANAGEMENT, LLC |
| 0.8% | 0.94% | #10 | $6,018.2万 | 39.1万股 | $5,702.4万 | 35.8万股 | +3.3万股+9.28% | 加仓 |
| Deerfield管理DEERFIELD MANAGEMENT COMPANY, L.P. |
| 0.57% | 0.57% | #12 | $5,500.3万 | 35.7万股 | $4,847.2万 | 30.4万股 | +5.3万股+17.49% | 加仓 |
| Holocene顾问Holocene Advisors, LP |
| 0.09% | 0.19% | #21 | $3,865.6万 | 25.1万股 | $7,884.2万 | 49.4万股 | -24.3万股-49.23% | 减仓 |
| Logos Global Management LP |
| 1.66% | — | #6 | $3,849.6万 | 25.0万股 | $0 | 0股 | +25.0万股 | 新买入 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #49 | $3,619.7万 | 23.5万股 | $38.7万 | 5,230股 | +23.0万股+4,394.67% | 加仓 |
| 瑞银集团UBS Group AG |
| <0.01% | 0.02% | #43 | $3,464.5万 | 22.5万股 | $1.23亿 | 76.8万股 | -54.3万股-70.72% | 减仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #46 | $2,866.7万 | 18.6万股 | $32.0万 | 2,008股 | +18.4万股+9,171.31% | 加仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #48 | $2,559.0万 | 16.6万股 | $1,682.2万 | 10.6万股 | +6.1万股+57.51% | 加仓 |
| Affinity Asset Advisors, LLC |
| 1.15% | 0.54% | #8 | $2,540.8万 | 16.5万股 | $1,036.4万 | 6.5万股 | +10.0万股+153.85% | 加仓 |
| MPM BioImpact LLC |
| 1.29% | 1.08% | #7 | $2,112.8万 | 13.7万股 | $1,403.8万 | 8.8万股 | +4.9万股+55.84% | 加仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #55 | $1,921.5万 | 12.5万股 | $60.2万 | 3,778股 | +12.1万股+3,202.89% | 加仓 |
| Patient Square Capital LP |
| 2.62% | 3.3% | #3 | $1,693.8万 | 11.0万股 | $1,860.4万 | 11.7万股 | -6,684股-5.73% | 减仓 |
| 杜肯家族办公室Duquesne Family Office LLC |
| 0.31% | 0.5% | #16 | $1,633.8万 | 10.6万股 | $1,691.7万 | 10.6万股 | 00.00% | 持仓不变 |
| 普信集团PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | 0.01% | #52 | $1,630.1万 | 10.6万股 | $4,493.1万 | 28.2万股 | -17.6万股-62.44% | 减仓 |
| 简街集团JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #58 | $1,013.2万 | 6.6万股 | $194.9万 | 1.2万股 | +5.4万股+438.38% | 加仓 |
| 法国巴黎银行金融市场BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | <0.01% | #45 | $879.6万 | 5.7万股 | $518.6万 | 3.3万股 | +2.5万股+75.63% | 加仓 |
| 文艺复兴科技RENAISSANCE TECHNOLOGIES LLC |
| 0.01% | 0.01% | #36 | $858.7万 | 5.6万股 | $829.1万 | 5.2万股 | +3,763股+7.24% | 加仓 |
| Point72资产管理Point72 Asset Management, L.P. |
| 0.01% | — | #38 | $788.2万 | 5.1万股 | $0 | 0股 | +5.1万股 | 新买入 |
| Soleus 资本管理Soleus Capital Management, L.P. |
| 0.27% | — | #17 | $778.0万 | 5.1万股 | $0 | 0股 | +5.1万股 | 新买入 |
| Trexquant投资Trexquant Investment LP |
| 0.04% | 0.02% | #25 | $762.5万 | 5.0万股 | $240.3万 | 1.5万股 | +3.4万股+228.53% | 加仓 |
| Two Sigma投资TWO SIGMA INVESTMENTS, LP |
| <0.01% | — | #44 | $586.7万 | 3.8万股 | $0 | 0股 | +3.8万股 | 新买入 |
| PFM Health Sciences, LP |
| 0.46% | 0.86% | #14 | $535.9万 | 3.5万股 | $947.6万 | 5.9万股 | -2.5万股-41.44% | 减仓 |
| 摩根大通JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #63 | $513.1万 | 3.3万股 | $448 | 3股 | +3.3万股+1,105,933.33% | 加仓 |
| Walleye资本Walleye Capital LLC |
| 0.02% | — | #34 | $488.5万 | 3.2万股 | $0 | 0股 | +3.2万股 | 新买入 |
| Artia Global Partners LP |
| 0.71% | 0.8% | #11 | $384.8万 | 2.5万股 | $398.4万 | 2.5万股 | 00.00% | 持仓不变 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #65 | $348.6万 | 2.3万股 | $166.2万 | 1.0万股 | +1.2万股+117.13% | 加仓 |
| BALANCE CAPITAL PARTNERS L.P. |
| 2.49% | 2.63% | #4 | $346.5万 | 2.3万股 | $231.2万 | 1.5万股 | +8,000股+55.17% | 加仓 |
| 加拿大国家银行NATIONAL BANK OF CANADA /FI/ |
| <0.01% | — | #47 | $308.0万 | 2.0万股 | $0 | 0股 | +2.0万股 | 新买入 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #69 | $245.2万 | 1.6万股 | $255.9万 | 1.6万股 | -124股-0.77% | 减仓 |
| Verdad Advisers, LP |
| 2.03% | 2.48% | #5 | $211.9万 | 1.4万股 | $220.2万 | 1.4万股 | -55股-0.40% | 减仓 |
| 奥比梅德顾问ORBIMED ADVISORS LLC |
| 0.04% | — | #29 | $204.8万 | 1.3万股 | $0 | 0股 | +1.3万股 | 新买入 |
| 道明资产管理TD ASSET MANAGEMENT INC |
| <0.01% | <0.01% | #51 | $200.3万 | 1.3万股 | $532.7万 | 3.3万股 | -2.0万股-61.06% | 减仓 |
| 布斯湾基金管理BOOTHBAY FUND MANAGEMENT, LLC |
| 0.03% | — | #30 | $196.1万 | 1.3万股 | $0 | 0股 | +1.3万股 | 新买入 |
| Qube研究科技Qube Research & Technologies Ltd |
| <0.01% | — | #50 | $187.4万 | 1.2万股 | $0 | 0股 | +1.2万股 | 新买入 |
| Lighthouse Investment 合伙人Lighthouse Investment Partners, LLC |
| 0.04% | — | #28 | $154.0万 | 1.0万股 | $0 | 0股 | +1.0万股 | 新买入 |
| 宏利人寿MANUFACTURERS LIFE INSURANCE COMPANY, THE |
| <0.01% | <0.01% | #56 | $151.2万 | 9,820股 | $312.5万 | 2.0万股 | -9,780股-49.90% | 减仓 |
| HighVista Strategies LLC |
| 0.34% | 0.35% | #15 | $147.1万 | 9,554股 | $128.1万 | 8,033股 | +1,521股+18.93% | 加仓 |
| SquarepointSquarepoint Ops LLC |
| <0.01% | <0.01% | #53 | $135.3万 | 8,785股 | $270.7万 | 1.7万股 | -8,196股-48.27% | 减仓 |
| 巴克莱BARCLAYS PLC |
| <0.01% | <0.01% | #64 | $105.0万 | 6,822股 | $108.8万 | 6,822股 | 00.00% | 持仓不变 |
| Capricorn Fund Managers Ltd |
| 0.08% | — | #23 | $98.6万 | 6,400股 | $0 | 0股 | +6,400股 | 新买入 |
| 沃利昂资本管理Voleon Capital Management LP |
| 0.02% | 0.03% | #33 | $96.8万 | 6,289股 | $125.7万 | 7,883股 | -1,594股-20.22% | 减仓 |
| GSA CAPITAL PARTNERS LLP |
| 0.04% | 0.02% | #27 | $67.2万 | 4,364股 | $26.2万 | 1,645股 | +2,719股+165.29% | 加仓 |
| SmartHarvest Portfolios, LLC |
| 0.22% | 0.28% | #18 | $67.1万 | 4,359股 | $66.8万 | 4,187股 | +172股+4.11% | 加仓 |
| XTX资本XTX Topco Ltd |
| 0.01% | 0.04% | #39 | $66.7万 | 4,333股 | $240.1万 | 1.5万股 | -1.1万股-71.22% | 减仓 |
| MarinerMariner, LLC |
| <0.01% | — | #59 | $59.1万 | 3,835股 | $0 | 0股 | +3,835股 | 新买入 |
