| TANG CAPITAL MANAGEMENT LLC |
| 1.79% | 4.51% | #3 | $3,940.0万 | 1,799.1万股 | $8,882.3万 | 1,679.1万股 | +120.0万股+7.15% | 加仓 |
| 奥比梅德顾问ORBIMED ADVISORS LLC |
| 0.63% | 1.6% | #10 | $3,333.2万 | 1,522.0万股 | $8,051.4万 | 1,522.0万股 | 00.00% | 持仓不变 |
| 蒙塔诺瓦资本MONTANOVA CAPITAL, LLC |
| 0.56% | 1.93% | #12 | $3,088.2万 | 1,410.1万股 | $7,568.6万 | 1,430.7万股 | -20.6万股-1.44% | 减仓 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #114 | $2,470.7万 | 1,128.2万股 | $5,028.7万 | 950.6万股 | +177.6万股+18.68% | 加仓 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #94 | $2,179.9万 | 995.4万股 | $3,541.6万 | 669.5万股 | +325.9万股+48.67% | 加仓 |
| Enavate Sciences GP, LLC |
| 4.94% | 11.72% | #1 | $1,705.6万 | 778.8万股 | $4,119.9万 | 778.8万股 | 00.00% | 持仓不变 |
| Vivo Capital, LLC |
| 1.55% | 4.2% | #5 | $1,698.8万 | 775.7万股 | $5,049.6万 | 954.5万股 | -178.8万股-18.74% | 减仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #119 | $1,340.0万 | 611.9万股 | $3,193.7万 | 603.7万股 | +8.2万股+1.35% | 加仓 |
| Palo Alto Investors LP |
| 1.87% | 1.23% | #2 | $1,277.2万 | 583.2万股 | $801.2万 | 151.5万股 | +431.7万股+285.06% | 加仓 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #47 | $1,032.2万 | 471.3万股 | $447.7万 | 84.6万股 | +386.7万股+456.98% | 加仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #108 | $835.7万 | 381.5万股 | $1,886.8万 | 356.6万股 | +24.9万股+6.99% | 加仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #113 | $825.9万 | 377.1万股 | $572.7万 | 108.3万股 | +268.8万股+248.31% | 加仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #79 | $812.5万 | 371.0万股 | $471.4万 | 89.1万股 | +281.9万股+316.33% | 加仓 |
| Qube研究科技Qube Research & Technologies Ltd |
| 0.01% | 0.02% | #34 | $807.6万 | 368.7万股 | $1,349.1万 | 255.0万股 | +113.7万股+44.59% | 加仓 |
| Blue Owl Capital Holdings LP |
| 1.16% | 4.18% | #7 | $793.7万 | 362.4万股 | $1,556.1万 | 294.2万股 | +68.3万股+23.20% | 加仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #93 | $773.3万 | 353.1万股 | $1,055.6万 | 199.5万股 | +153.6万股+76.96% | 加仓 |
| Rock Springs Capital Management LP |
| 0.38% | 1.03% | #13 | $772.0万 | 352.5万股 | $1,748.5万 | 330.5万股 | +22.0万股+6.64% | 加仓 |
| AQR资本管理AQR CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #54 | $768.5万 | 350.9万股 | $106.0万 | 20.0万股 | +330.9万股+1,650.82% | 加仓 |
| Birchview Capital, LP |
| 1.66% | 4.41% | #4 | $366.8万 | 167.5万股 | $775.4万 | 146.6万股 | +20.9万股+14.27% | 加仓 |
| KINGDON CAPITAL MANAGEMENT, L.L.C. |
| 0.31% | — | #15 | $306.6万 | 140.0万股 | $0 | 0股 | +140.0万股 | 新买入 |
| 费雪资产管理Fisher Asset Management, LLC |
| <0.01% | <0.01% | #81 | $304.8万 | 139.2万股 | $713.2万 | 134.8万股 | +4.4万股+3.24% | 加仓 |
| Royce联营ROYCE & ASSOCIATES LP |
| 0.02% | 0.08% | #26 | $292.8万 | 133.7万股 | $856.9万 | 162.0万股 | -28.3万股-17.47% | 减仓 |
| 富达投资FMR LLC |
| <0.01% | <0.01% | #152 | $265.5万 | 121.2万股 | $953.1万 | 180.2万股 | -59.0万股-32.72% | 减仓 |
| Adage资本合伙人ADAGE CAPITAL PARTNERS GP, L.L.C. |
| <0.01% | 0.07% | #43 | $259.8万 | 118.7万股 | $4,489.4万 | 848.7万股 | -730.0万股-86.02% | 减仓 |
| ACADIAN ASSET MANAGEMENT LLC |
| <0.01% | — | #51 | $254.3万 | 116.1万股 | $0 | 0股 | +116.1万股 | 新买入 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #118 | $249.9万 | 114.1万股 | $554.7万 | 104.9万股 | +9.2万股+8.81% | 加仓 |
| Atle Fund Management AB |
| 0.62% | 0.99% | #11 | $229.6万 | 104.9万股 | $305.1万 | 4.2万股 | +100.7万股+2,406.74% | 加仓 |
| 纽文Nuveen, LLC |
| <0.01% | <0.01% | #101 | $221.3万 | 101.1万股 | $153.9万 | 29.1万股 | +72.0万股+247.31% | 加仓 |
| SquarepointSquarepoint Ops LLC |
| <0.01% | <0.01% | #58 | $220.6万 | 100.8万股 | $26.6万 | 5.0万股 | +95.7万股+1,906.91% | 加仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #107 | $219.2万 | 100.1万股 | $528.0万 | 99.8万股 | +2,798股+0.28% | 加仓 |
| 黑石集团Blackstone Inc. |
| 0.01% | 0.04% | #36 | $197.1万 | 90.0万股 | $982.8万 | 185.8万股 | -95.8万股-51.56% | 减仓 |
| 第一信托顾问FIRST TRUST ADVISORS LP |
| <0.01% | — | #74 | $176.7万 | 80.7万股 | $0 | 0股 | +80.7万股 | 新买入 |
| 摩根大通JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #160 | $170.5万 | 78.9万股 | $432.3万 | 84.8万股 | -5.8万股-6.88% | 减仓 |
| KVP Capital Advisors, LP |
| 1.24% | 1.98% | #6 | $168.8万 | 77.1万股 | $264.5万 | 50.0万股 | +27.1万股+54.20% | 加仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #164 | $161.0万 | 73.5万股 | $65.4万 | 18.7万股 | +54.8万股+293.25% | 加仓 |
| 花旗集团CITIGROUP INC |
| <0.01% | <0.01% | #103 | $156.3万 | 71.4万股 | $316.5万 | 59.8万股 | +11.6万股+19.33% | 加仓 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #133 | $156.1万 | 71.3万股 | $1,265.0万 | 239.1万股 | -167.9万股-70.19% | 减仓 |
| Burkehill Global 管理Burkehill Global Management, LP |
| 0.06% | 0.18% | #23 | $153.3万 | 70.0万股 | $370.3万 | 70.0万股 | 00.00% | 持仓不变 |
| Point72资产管理Point72 Asset Management, L.P. |
| <0.01% | — | #64 | $150.4万 | 68.7万股 | $0 | 0股 | +68.7万股 | 新买入 |
| ACUTA CAPITAL PARTNERS, LLC |
| 0.91% | 3.17% | #8 | $130.4万 | 59.5万股 | $449.2万 | 84.9万股 | -25.4万股-29.90% | 减仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #169 | $124.2万 | 56.7万股 | $457.9万 | 86.6万股 | -29.9万股-34.51% | 减仓 |
| CM Management, LLC |
| 0.77% | — | #9 | $120.5万 | 55.0万股 | $0 | 0股 | +55.0万股 | 新买入 |
| 维度基金顾问DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #127 | $118.5万 | 54.1万股 | $232.4万 | 44.0万股 | +10.1万股+23.06% | 加仓 |
| Connor Clark & Lunn投资管理Connor, Clark & Lunn Investment Management Ltd. |
| <0.01% | 0.01% | #59 | $114.7万 | 52.4万股 | $263.3万 | 49.8万股 | +2.6万股+5.21% | 加仓 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #174 | $87.0万 | 39.7万股 | $207.2万 | 39.2万股 | +5,370股+1.37% | 加仓 |
| Artia Global Partners LP |
| 0.15% | — | #16 | $83.9万 | 38.3万股 | $0 | 0股 | +38.3万股 | 新买入 |
| 惠灵顿管理集团WELLINGTON MANAGEMENT GROUP LLP |
| <0.01% | <0.01% | #144 | $82.9万 | 37.9万股 | $190.5万 | 36.0万股 | +1.9万股+5.15% | 加仓 |
| ArrowMark Colorado Holdings LLC |
| 0.03% | 0.07% | #25 | $79.9万 | 36.5万股 | $272.3万 | 51.5万股 | -15.0万股-29.15% | 减仓 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| <0.01% | <0.01% | #147 | $76.9万 | 35.1万股 | $157.3万 | 29.7万股 | +5.4万股+18.07% | 加仓 |
| 马歇尔·韦斯MARSHALL WACE, LLP |
| <0.01% | — | #99 | $73.3万 | 33.5万股 | $0 | 0股 | +33.5万股 | 新买入 |
