| MPM BioImpact LLC |
| 10.81% | 8.39% | #2 | $1.77亿 | 973.1万股 | $1.09亿 | 764.8万股 | +208.3万股+27.24% | 加仓 |
| Lynx1 Capital Management LP |
| 32.16% | 20.13% | #1 | $1.63亿 | 896.4万股 | $1.27亿 | 896.4万股 | 00.00% | 持仓不变 |
| BVF INC/IL |
| 2.68% | 2.6% | #7 | $1.05亿 | 575.1万股 | $8,171.7万 | 575.1万股 | 00.00% | 持仓不变 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #81 | $9,528.9万 | 523.3万股 | $6,323.4万 | 445.0万股 | +78.3万股+17.59% | 加仓 |
| 普信集团PRICE T ROWE ASSOCIATES INC /MD/ |
| 0.01% | <0.01% | #52 | $6,967.1万 | 382.6万股 | $2,884.3万 | 203.0万股 | +179.6万股+88.50% | 加仓 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #73 | $6,680.6万 | 366.9万股 | $3,615.2万 | 254.4万股 | +112.5万股+44.20% | 加仓 |
| Kynam Capital Management, LP |
| 3.13% | 2.73% | #5 | $5,670.8万 | 311.4万股 | $4,425.2万 | 311.4万股 | 00.00% | 持仓不变 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #93 | $4,760.2万 | 261.4万股 | $3,528.4万 | 248.3万股 | +13.1万股+5.28% | 加仓 |
| RTW投资RTW INVESTMENTS, LP |
| 0.37% | 0.24% | #16 | $4,305.5万 | 236.4万股 | $2,424.2万 | 170.6万股 | +65.8万股+38.59% | 加仓 |
| Siren, L.L.C. |
| 0.7% | 0.47% | #13 | $3,447.9万 | 189.3万股 | $1,695.8万 | 119.3万股 | +70.0万股+58.66% | 加仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #78 | $2,818.2万 | 154.7万股 | $1,944.7万 | 136.8万股 | +17.9万股+13.09% | 加仓 |
| Blue Owl Capital Holdings LP |
| 4.08% | 7.29% | #3 | $2,803.9万 | 154.0万股 | $2,713.8万 | 191.0万股 | -37.0万股-19.37% | 减仓 |
| Venrock Adviser, LLC |
| 0.76% | 0.73% | #11 | $2,512.9万 | 138.0万股 | $1,960.9万 | 138.0万股 | 00.00% | 持仓不变 |
| 布斯湾基金管理BOOTHBAY FUND MANAGEMENT, LLC |
| 0.26% | 0.2% | #19 | $1,971.4万 | 108.3万股 | $1,581.3万 | 111.3万股 | -3.0万股-2.71% | 减仓 |
| 维度基金顾问DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #57 | $1,906.1万 | 104.7万股 | $1,287.0万 | 90.6万股 | +14.1万股+15.53% | 加仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #76 | $1,823.9万 | 100.2万股 | $647.2万 | 45.5万股 | +54.6万股+119.91% | 加仓 |
| Affinity Asset Advisors, LLC |
| 0.72% | 0.57% | #12 | $1,594.8万 | 87.6万股 | $1,110.2万 | 78.1万股 | +9.5万股+12.10% | 加仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #111 | $1,345.2万 | 73.9万股 | $785.2万 | 55.3万股 | +18.6万股+33.70% | 加仓 |
| BOONE CAPITAL MANAGEMENT LLC |
| 3% | — | #6 | $1,282.8万 | 70.4万股 | $0 | 0股 | +70.4万股 | 新买入 |
| Elmind Capital, LP |
| 3.16% | 2.14% | #4 | $1,256.5万 | 69.0万股 | $753.1万 | 53.0万股 | +16.0万股+30.19% | 加仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #112 | $1,145.5万 | 62.9万股 | $237.3万 | 40.0万股 | +22.9万股+57.20% | 加仓 |
| TWIN FOCUS CAPITAL PARTNERS, LLC |
| 1.1% | 0.97% | #8 | $1,084.4万 | 59.5万股 | $846.2万 | 59.5万股 | 00.00% | 持仓不变 |
| AQR资本管理AQR CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #55 | $1,058.6万 | 58.1万股 | $512.8万 | 36.1万股 | +22.0万股+61.09% | 加仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #88 | $1,039.9万 | 57.1万股 | $638.4万 | 44.9万股 | +12.2万股+27.12% | 加仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #92 | $934.5万 | 51.3万股 | $415.5万 | 29.2万股 | +22.1万股+75.52% | 加仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #113 | $929.3万 | 51.0万股 | $734.3万 | 51.7万股 | -6,399股-1.24% | 减仓 |
| 纽文Nuveen, LLC |
| <0.01% | <0.01% | #71 | $859.4万 | 47.2万股 | $1,144.9万 | 80.6万股 | -33.4万股-41.42% | 减仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #89 | $845.0万 | 46.4万股 | $615.1万 | 43.3万股 | +3.1万股+7.19% | 加仓 |
| 洞察顾问PERCEPTIVE ADVISORS LLC |
| 0.12% | — | #25 | $776.6万 | 42.6万股 | $0 | 0股 | +42.6万股 | 新买入 |
| TCG Crossover 管理TCG Crossover Management, LLC |
| 0.18% | 0.17% | #21 | $740.8万 | 40.7万股 | $578.0万 | 40.7万股 | 00.00% | 持仓不变 |
| DEUTSCHE 银行 AG\DEUTSCHE BANK AG\ |
| <0.01% | <0.01% | #72 | $697.2万 | 38.3万股 | $522.8万 | 36.8万股 | +1.5万股+4.06% | 加仓 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #68 | $666.9万 | 36.6万股 | $520.9万 | 36.7万股 | -350股-0.10% | 减仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #79 | $661.3万 | 36.3万股 | $487.2万 | 34.3万股 | +2.0万股+5.92% | 加仓 |
| 文艺复兴科技RENAISSANCE TECHNOLOGIES LLC |
| 0.01% | 0.01% | #50 | $595.1万 | 32.7万股 | $460.6万 | 32.4万股 | +2,700股+0.83% | 加仓 |
| GREAT POINT PARTNERS LLC |
| 1.03% | 0.98% | #9 | $546.3万 | 30.0万股 | $426.3万 | 30.0万股 | 00.00% | 持仓不变 |
| Connor Clark & Lunn投资管理Connor, Clark & Lunn Investment Management Ltd. |
| 0.01% | 0.01% | #49 | $532.6万 | 29.3万股 | $410.8万 | 28.9万股 | +3,385股+1.17% | 加仓 |
| 摩根大通JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #137 | $520.6万 | 28.3万股 | $398.9万 | 29.7万股 | -1.5万股-4.91% | 减仓 |
| Two Sigma投资TWO SIGMA INVESTMENTS, LP |
| <0.01% | 0.01% | #56 | $496.4万 | 27.3万股 | $741.8万 | 52.2万股 | -24.9万股-47.79% | 减仓 |
| Bleichroeder LP |
| 0.81% | 0.25% | #10 | $455.3万 | 25.0万股 | $142.1万 | 10.0万股 | +15.0万股+150.00% | 加仓 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #114 | $452.7万 | 24.9万股 | $287.6万 | 20.2万股 | +4.6万股+22.85% | 加仓 |
| 富达投资FMR LLC |
| <0.01% | <0.01% | #149 | $437.2万 | 24.0万股 | $10.3万 | 7,232股 | +23.3万股+3,220.17% | 加仓 |
| Adage资本合伙人ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.01% | — | #53 | $433.4万 | 23.8万股 | $0 | 0股 | +23.8万股 | 新买入 |
| 萨斯奎汉纳组合策略Susquehanna Portfolio Strategies, LLC |
| 0.07% | 0.05% | #27 | $425.8万 | 23.4万股 | $332.3万 | 23.4万股 | 00.00% | 持仓不变 |
| PFM Health Sciences, LP |
| 0.3% | 0.29% | #18 | $350.4万 | 19.2万股 | $323.1万 | 22.7万股 | -3.5万股-15.38% | 减仓 |
| 摩尔资本管理MOORE CAPITAL MANAGEMENT, LP |
| 0.05% | 0.03% | #28 | $345.9万 | 19.0万股 | $150.6万 | 10.6万股 | +8.4万股+79.26% | 加仓 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| <0.01% | <0.01% | #119 | $311.4万 | 17.1万股 | $204.2万 | 14.4万股 | +2.7万股+19.01% | 加仓 |
| SquarepointSquarepoint Ops LLC |
| <0.01% | — | #58 | $306.1万 | 16.8万股 | $0 | 0股 | +16.8万股 | 新买入 |
| 保德信金融PRUDENTIAL FINANCIAL INC |
| <0.01% | <0.01% | #60 | $305.1万 | 16.8万股 | $212.4万 | 14.9万股 | +1.8万股+12.12% | 加仓 |
| 惠灵顿管理集团WELLINGTON MANAGEMENT GROUP LLP |
| <0.01% | <0.01% | #117 | $299.9万 | 16.5万股 | $212.6万 | 15.0万股 | +1.5万股+10.09% | 加仓 |
| 美国世纪投资AMERICAN CENTURY COMPANIES INC |
| <0.01% | <0.01% | #87 | $284.7万 | 15.6万股 | $204.8万 | 14.4万股 | +1.2万股+8.47% | 加仓 |
