| 阿尔法浪潮全球Alpha Wave Global, LP |
| 1.57% | 10.54% | #5 | $9,784.8万 | 370.8万股 | $8,335.0万 | 370.8万股 | 00.00% | 持仓不变 |
| Commodore Capital LP |
| 4.28% | 3.54% | #3 | $7,186.5万 | 272.3万股 | $6,121.7万 | 272.3万股 | 00.00% | 持仓不变 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #61 | $5,597.3万 | 212.1万股 | $1,497.6万 | 66.6万股 | +145.5万股+218.38% | 加仓 |
| 洞察顾问PERCEPTIVE ADVISORS LLC |
| 0.64% | 0.88% | #10 | $4,248.5万 | 161.0万股 | $4,518.2万 | 201.0万股 | -40.0万股-19.90% | 减仓 |
| Adage资本合伙人ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.06% | 0.01% | #25 | $4,222.4万 | 160.0万股 | $865.5万 | 38.5万股 | +121.5万股+315.58% | 加仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #62 | $3,666.8万 | 138.9万股 | $2,713.4万 | 120.7万股 | +18.2万股+15.12% | 加仓 |
| Spruce Street Capital LP |
| 7.01% | 7% | #2 | $3,570.7万 | 135.3万股 | $2,911.6万 | 132.5万股 | +2.8万股+2.10% | 加仓 |
| Vivo Capital, LLC |
| 2.91% | 1.94% | #4 | $3,190.2万 | 120.9万股 | $2,327.9万 | 103.6万股 | +17.3万股+16.74% | 加仓 |
| 富兰克林资源FRANKLIN RESOURCES INC |
| 0.01% | 0.01% | #34 | $2,674.1万 | 101.3万股 | $2,477.0万 | 110.2万股 | -8.9万股-8.04% | 减仓 |
| 停战资本ARMISTICE CAPITAL, LLC |
| 0.28% | 0.36% | #14 | $2,280.1万 | 86.4万股 | $2,050.2万 | 91.2万股 | -4.8万股-5.26% | 减仓 |
| Affinity Asset Advisors, LLC |
| 1.01% | 0.58% | #8 | $2,243.2万 | 85.0万股 | $1,124.0万 | 50.0万股 | +35.0万股+70.00% | 加仓 |
| Vestal Point 资本Vestal Point Capital, LP |
| 0.48% | 1.3% | #12 | $2,071.6万 | 78.5万股 | $4,640.0万 | 206.4万股 | -127.9万股-61.97% | 减仓 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #70 | $1,810.2万 | 68.6万股 | $448.5万 | 20.0万股 | +48.6万股+243.83% | 加仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #59 | $1,790.2万 | 67.8万股 | $658.8万 | 29.3万股 | +38.5万股+131.55% | 加仓 |
| 72 Investment Holdings, LLC |
| 35.27% | 30.26% | #1 | $1,762.3万 | 66.8万股 | $1,501.2万 | 66.8万股 | 00.00% | 持仓不变 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #44 | $1,669.7万 | 63.3万股 | $1,064.2万 | 47.3万股 | +15.9万股+33.65% | 加仓 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| <0.01% | 0.01% | #35 | $1,473.4万 | 55.8万股 | $1,847.8万 | 82.2万股 | -26.4万股-32.08% | 减仓 |
| Point72资产管理Point72 Asset Management, L.P. |
| 0.01% | 0.01% | #31 | $1,327.3万 | 50.3万股 | $1,130.9万 | 50.3万股 | -137股-0.03% | 减仓 |
| Venrock Adviser, LLC |
| 0.4% | 0.42% | #13 | $1,319.5万 | 50.0万股 | $1,124.0万 | 50.0万股 | 00.00% | 持仓不变 |
| Integral Health 资产管理Integral Health Asset Management, LLC |
| 0.52% | 0.54% | #11 | $1,319.5万 | 50.0万股 | $1,124.0万 | 50.0万股 | 00.00% | 持仓不变 |
| Driehaus资本管理DRIEHAUS CAPITAL MANAGEMENT LLC |
| 0.07% | 0.08% | #22 | $1,286.7万 | 48.8万股 | $1,094.2万 | 48.7万股 | +850股+0.17% | 加仓 |
| Parkman Healthcare Partners LLC |
| 1.16% | — | #6 | $1,132.2万 | 42.9万股 | $0 | 0股 | +42.9万股 | 新买入 |
| Ikarian Capital, LLC |
| 1.14% | 0.94% | #7 | $1,075.0万 | 40.7万股 | $1,157.7万 | 51.5万股 | -10.8万股-20.91% | 减仓 |
| 普信集团PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | <0.01% | #60 | $945.5万 | 35.8万股 | $834.6万 | 37.1万股 | -1.3万股-3.48% | 减仓 |
| 奥比梅德顾问ORBIMED ADVISORS LLC |
| 0.13% | 0.07% | #18 | $680.5万 | 25.8万股 | $376.5万 | 16.8万股 | +9.0万股+53.94% | 加仓 |
| Schonfeld战略顾问Schonfeld Strategic Advisors LLC |
| 0.02% | — | #27 | $679.9万 | 25.8万股 | $0 | 0股 | +25.8万股 | 新买入 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #69 | $625.0万 | 23.7万股 | $235.4万 | 10.5万股 | +13.2万股+126.16% | 加仓 |
| 马歇尔·韦斯MARSHALL WACE, LLP |
| <0.01% | <0.01% | #36 | $595.1万 | 22.6万股 | $396.4万 | 17.6万股 | +4.9万股+27.87% | 加仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #52 | $557.5万 | 21.1万股 | $371.5万 | 16.5万股 | +4.6万股+27.82% | 加仓 |
| 阿默普莱斯金融AMERIPRISE FINANCIAL INC |
| <0.01% | <0.01% | #56 | $504.0万 | 19.1万股 | $30.0万 | 1.3万股 | +17.8万股+1,333.47% | 加仓 |
| Saturn V Capital Management LP |
| 0.69% | 0.36% | #9 | $482.5万 | 18.3万股 | $200.1万 | 8.9万股 | +9.4万股+105.43% | 加仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | — | #79 | $477.9万 | 18.1万股 | $0 | 0股 | +18.1万股 | 新买入 |
| Two Sigma投资TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #41 | $388.7万 | 14.7万股 | $485.8万 | 21.6万股 | -6.9万股-31.84% | 减仓 |
| Eversept Partners, LP |
| 0.18% | 0.15% | #17 | $338.5万 | 12.8万股 | $281.4万 | 12.5万股 | +3,118股+2.49% | 加仓 |
| 布斯湾基金管理BOOTHBAY FUND MANAGEMENT, LLC |
| 0.04% | 0.04% | #26 | $280.4万 | 10.6万股 | $313.2万 | 13.9万股 | -3.3万股-23.74% | 减仓 |
| Alkeon资本管理ALKEON CAPITAL MANAGEMENT LLC |
| <0.01% | 0.01% | #40 | $269.4万 | 10.2万股 | $510.5万 | 22.7万股 | -12.5万股-55.04% | 减仓 |
| Stifel金融STIFEL FINANCIAL CORP |
| <0.01% | <0.01% | #45 | $225.6万 | 8.5万股 | $194.1万 | 8.6万股 | -855股-0.99% | 减仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #78 | $212.7万 | 8.1万股 | $38.3万 | 1.7万股 | +6.4万股+373.52% | 加仓 |
| AWM Investment Company, Inc. |
| 0.18% | 0.42% | #16 | $211.1万 | 8.0万股 | $382.2万 | 17.0万股 | -9.0万股-52.94% | 减仓 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| <0.01% | — | #74 | $201.4万 | 7.6万股 | $0 | 0股 | +7.6万股 | 新买入 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #88 | $197.8万 | 7.5万股 | $24.5万 | 6.1万股 | +1.4万股+22.78% | 加仓 |
| 文艺复兴科技RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | <0.01% | #43 | $188.4万 | 7.1万股 | $232.7万 | 10.3万股 | -3.2万股-31.01% | 减仓 |
| 惠灵顿管理集团WELLINGTON MANAGEMENT GROUP LLP |
| <0.01% | <0.01% | #75 | $187.1万 | 7.1万股 | $134.4万 | 6.0万股 | +1.1万股+18.59% | 加仓 |
| AdvisorShares Investments LLC |
| 0.23% | 0.17% | #15 | $186.7万 | 7.1万股 | $92.2万 | 4.1万股 | +3.0万股+72.46% | 加仓 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #85 | $182.9万 | 6.9万股 | $1,433.3万 | 63.8万股 | -56.8万股-89.13% | 减仓 |
| 纽文Nuveen, LLC |
| <0.01% | — | #72 | $164.5万 | 6.2万股 | $0 | 0股 | +6.2万股 | 新买入 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #83 | $154.9万 | 5.9万股 | $38.8万 | 1.7万股 | +4.1万股+240.27% | 加仓 |
| ACADIAN ASSET MANAGEMENT LLC |
| <0.01% | <0.01% | #47 | $146.5万 | 5.6万股 | $134.6万 | 6.0万股 | -4,567股-7.60% | 减仓 |
| 桥道资本管理BRIDGEWAY CAPITAL MANAGEMENT, LLC |
| 0.02% | 0.02% | #28 | $133.7万 | 5.1万股 | $118.4万 | 5.3万股 | -2,000股-3.80% | 减仓 |
| XTX资本XTX Topco Ltd |
| 0.02% | 0.02% | #30 | $123.0万 | 4.7万股 | $89.6万 | 4.0万股 | +6,760股+16.97% | 加仓 |
