| Novo Holdings A/S |
| 7.7% | 6.07% | #5 | $1.32亿 | 368.7万股 | $7,494.9万 | 368.7万股 | 00.00% | 持仓不变 |
| FCPM III SERVICES B.V. |
| 15.41% | 9.08% | #2 | $1.16亿 | 322.6万股 | $6,559.3万 | 322.6万股 | 00.00% | 持仓不变 |
| 普信投资管理T. Rowe Price Investment Management, Inc. |
| 0.07% | 0.04% | #20 | $9,969.7万 | 278.2万股 | $5,696.4万 | 280.2万股 | -2.0万股-0.72% | 减仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| 0.01% | <0.01% | #32 | $6,982.8万 | 194.8万股 | $4,055.6万 | 199.5万股 | -4.7万股-2.33% | 减仓 |
| 普信集团PRICE T ROWE ASSOCIATES INC /MD/ |
| 0.01% | <0.01% | #33 | $5,099.8万 | 142.3万股 | $229.3万 | 11.3万股 | +131.0万股+1,162.50% | 加仓 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #58 | $3,674.1万 | 102.5万股 | $2,723.7万 | 134.0万股 | -31.5万股-23.48% | 减仓 |
| Nan Fung Group Holdings Ltd |
| 26.47% | 16.28% | #1 | $3,481.0万 | 97.1万股 | $1,974.6万 | 97.1万股 | 00.00% | 持仓不变 |
| 5AM Venture Management, LLC |
| 11.83% | 5.36% | #3 | $3,404.8万 | 95.0万股 | $1,931.4万 | 95.0万股 | 00.00% | 持仓不变 |
| Sanofi |
| 6.12% | 5.52% | #7 | $3,268.8万 | 91.2万股 | $1,854.2万 | 91.2万股 | 00.00% | 持仓不变 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #52 | $3,054.1万 | 85.2万股 | $689.4万 | 33.9万股 | +51.3万股+151.29% | 加仓 |
| 富达投资FMR LLC |
| <0.01% | <0.01% | #46 | $2,951.6万 | 82.4万股 | $415.8万 | 20.5万股 | +61.9万股+302.71% | 加仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #56 | $2,810.4万 | 78.4万股 | $1,463.4万 | 72.0万股 | +6.4万股+8.94% | 加仓 |
| Blue Owl Capital Holdings LP |
| 3.81% | 5.49% | #8 | $2,616.1万 | 73.0万股 | $2,045.1万 | 100.6万股 | -27.6万股-27.44% | 减仓 |
| 范式生物资本Paradigm Biocapital Advisors LP |
| 0.46% | — | #12 | $2,458.1万 | 68.6万股 | $0 | 0股 | +68.6万股 | 新买入 |
| Pivotal bioVenture Partners Investment Advisor LLC |
| 7.12% | 4.44% | #6 | $2,191.4万 | 61.1万股 | $1,243.1万 | 61.1万股 | -1股-0.00% | 减仓 |
| Velan Capital Investment Management LP |
| 10.76% | 6.28% | #4 | $1,766.5万 | 49.3万股 | $1,002.1万 | 49.3万股 | 00.00% | 持仓不变 |
| Siren, L.L.C. |
| 0.33% | 0.25% | #13 | $1,612.8万 | 45.0万股 | $914.9万 | 45.0万股 | 00.00% | 持仓不变 |
| 资本世界投资者Capital World Investors |
| <0.01% | — | #39 | $1,490.0万 | 41.6万股 | $0 | 0股 | +41.6万股 | 新买入 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #54 | $1,441.4万 | 40.2万股 | $978.5万 | 48.1万股 | -7.9万股-16.45% | 减仓 |
| 贝克兄弟顾问BAKER BROS. ADVISORS LP |
| 0.07% | 0.04% | #19 | $1,307.1万 | 36.5万股 | $741.4万 | 36.5万股 | 00.00% | 持仓不变 |
| DAFNA Capital Management LLC |
| 1.17% | 0.79% | #10 | $612.9万 | 17.1万股 | $347.7万 | 17.1万股 | 00.00% | 持仓不变 |
| 法国巴黎银行资产管理BNP Paribas Asset Management Holding S.A. |
| 0.01% | — | #31 | $612.4万 | 17.1万股 | $0 | 0股 | +17.1万股 | 新买入 |
| Freestone Grove合伙人Freestone Grove Partners LP |
| 0.04% | 0.05% | #23 | $605.4万 | 16.9万股 | $638.3万 | 31.4万股 | -14.5万股-46.20% | 减仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #55 | $490.4万 | 13.7万股 | $327.6万 | 16.1万股 | -2.4万股-15.10% | 减仓 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| <0.01% | — | #42 | $461.8万 | 12.9万股 | $0 | 0股 | +12.9万股 | 新买入 |
| SUPERSTRING CAPITAL MANAGEMENT LP |
| 2.84% | 2.79% | #9 | $449.5万 | 12.5万股 | $390.6万 | 19.2万股 | -6.7万股-34.72% | 减仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #50 | $441.3万 | 12.3万股 | $266.8万 | 13.1万股 | -8,096股-6.17% | 减仓 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #57 | $437.3万 | 12.2万股 | $480.8万 | 23.7万股 | -11.4万股-48.41% | 减仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #60 | $418.1万 | 11.7万股 | $297.2万 | 14.6万股 | -3.0万股-20.20% | 减仓 |
| STEMPOINT CAPITAL LP |
| 0.55% | 0.37% | #11 | $383.2万 | 10.7万股 | $203.3万 | 10.0万股 | +6,906股+6.91% | 加仓 |
| SEVEN GRAND MANAGERS, LLC |
| 0.14% | 0.14% | #15 | $358.4万 | 10.0万股 | $203.3万 | 10.0万股 | 00.00% | 持仓不变 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #77 | $346.8万 | 9.7万股 | $228.9万 | 11.3万股 | -1.6万股-14.07% | 减仓 |
| 拉扎德资产管理LAZARD ASSET MANAGEMENT LLC |
| <0.01% | <0.01% | #36 | $287.0万 | 8.0万股 | $288.7万 | 14.2万股 | -6.2万股-43.61% | 减仓 |
| Burkehill Global 管理Burkehill Global Management, LP |
| 0.1% | 0.08% | #17 | $268.8万 | 7.5万股 | $152.5万 | 7.5万股 | 00.00% | 持仓不变 |
| Boxer Capital Management, LLC |
| 0.2% | — | #14 | $268.8万 | 7.5万股 | $0 | 0股 | +7.5万股 | 新买入 |
| 法国巴黎银行金融市场BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | <0.01% | #47 | $252.6万 | 7.0万股 | $75.8万 | 3.7万股 | +3.3万股+88.96% | 加仓 |
| Trexquant投资Trexquant Investment LP |
| 0.01% | — | #25 | $228.6万 | 6.4万股 | $0 | 0股 | +6.4万股 | 新买入 |
| 道明资产管理TD ASSET MANAGEMENT INC |
| <0.01% | <0.01% | #41 | $195.4万 | 5.5万股 | $97.1万 | 4.8万股 | +6,758股+14.15% | 加仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #80 | $195.2万 | 5.4万股 | $38.4万 | 1.9万股 | +3.6万股+188.64% | 加仓 |
| HRT金融HRT FINANCIAL LP |
| <0.01% | — | #37 | $186.3万 | 5.2万股 | $0 | 0股 | +5.2万股 | 新买入 |
| 惠灵顿管理集团WELLINGTON MANAGEMENT GROUP LLP |
| <0.01% | <0.01% | #64 | $186.1万 | 5.2万股 | $93.9万 | 4.6万股 | +5,709股+12.36% | 加仓 |
| Jain GlobalJain Global LLC |
| 0.01% | — | #30 | $163.3万 | 4.6万股 | $0 | 0股 | +4.6万股 | 新买入 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | — | #73 | $153.2万 | 4.3万股 | $0 | 0股 | +4.3万股 | 新买入 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | — | #85 | $137.3万 | 3.8万股 | $0 | 0股 | +3.8万股 | 新买入 |
| 桥道资本管理BRIDGEWAY CAPITAL MANAGEMENT, LLC |
| 0.02% | — | #24 | $125.4万 | 3.5万股 | $0 | 0股 | +3.5万股 | 新买入 |
| 韦斯资产管理Weiss Asset Management LP |
| 0.01% | — | #26 | $118.6万 | 3.3万股 | $0 | 0股 | +3.3万股 | 新买入 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| <0.01% | <0.01% | #72 | $109.0万 | 3.0万股 | $80.2万 | 3.9万股 | -9,055股-22.94% | 减仓 |
| ADAR1 Capital Management, LLC |
| 0.04% | 0.45% | #22 | $95.0万 | 2.6万股 | $762.2万 | 37.5万股 | -34.8万股-92.93% | 减仓 |
| 跳跃金融Jump Financial, LLC |
| 0.01% | — | #28 | $90.4万 | 2.5万股 | $0 | 0股 | +2.5万股 | 新买入 |
| XTX资本XTX Topco Ltd |
| 0.01% | <0.01% | #27 | $89.3万 | 2.5万股 | $20.9万 | 1.0万股 | +1.5万股+142.85% | 加仓 |
