| 木星资产管理Jupiter Topco LLC |
| 0.04% | — | #27 | $9,482.2万 | 134.9万股 | $0 | 0股 | +134.9万股 | 新买入 |
| Cormorant Asset Management, LP |
| 3.21% | 3.88% | #3 | $6,318.0万 | 90.0万股 | $7,729.9万 | 105.9万股 | -15.9万股-15.04% | 减仓 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #52 | $4,817.0万 | 68.6万股 | $4,538.2万 | 62.2万股 | +6.4万股+10.33% | 加仓 |
| Vivo Capital, LLC |
| 3.57% | 3.38% | #2 | $3,911.3万 | 55.7万股 | $4,065.7万 | 55.7万股 | 00.00% | 持仓不变 |
| Vestal Point 资本Vestal Point Capital, LP |
| 0.89% | 1% | #10 | $3,825.9万 | 54.5万股 | $3,592.5万 | 49.2万股 | +5.3万股+10.70% | 加仓 |
| BRAIDWELL LP |
| 1.26% | 1.31% | #9 | $3,396.4万 | 48.4万股 | $3,938.2万 | 54.0万股 | -5.6万股-10.35% | 减仓 |
| Driehaus资本管理DRIEHAUS CAPITAL MANAGEMENT LLC |
| 0.18% | 0.23% | #20 | $3,042.3万 | 43.3万股 | $3,156.1万 | 43.3万股 | +862股+0.20% | 加仓 |
| Balyasny资产管理BALYASNY ASSET MANAGEMENT L.P. |
| 0.03% | 0.03% | #29 | $2,422.3万 | 34.5万股 | $2,168.4万 | 29.7万股 | +4.8万股+16.12% | 加仓 |
| Adage资本合伙人ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.03% | 0.06% | #28 | $2,351.7万 | 33.5万股 | $3,617.4万 | 49.6万股 | -16.1万股-32.42% | 减仓 |
| Point72资产管理Point72 Asset Management, L.P. |
| 0.03% | — | #32 | $2,298.5万 | 32.7万股 | $0 | 0股 | +32.7万股 | 新买入 |
| Deerfield管理DEERFIELD MANAGEMENT COMPANY, L.P. |
| 0.21% | 0.24% | #18 | $1,986.7万 | 28.3万股 | $2,065.1万 | 28.3万股 | 00.00% | 持仓不变 |
| RA资本管理RA CAPITAL MANAGEMENT, L.P. |
| 0.16% | 0.2% | #21 | $1,860.3万 | 26.5万股 | $1,933.7万 | 26.5万股 | 00.00% | 持仓不变 |
| Parkman Healthcare Partners LLC |
| 1.47% | 0.3% | #6 | $1,439.5万 | 20.5万股 | $292.6万 | 4.0万股 | +16.5万股+411.38% | 加仓 |
| MPM BioImpact LLC |
| 0.87% | 1.2% | #11 | $1,418.8万 | 20.2万股 | $1,548.2万 | 21.2万股 | -1.0万股-4.74% | 减仓 |
| 惠灵顿管理集团WELLINGTON MANAGEMENT GROUP LLP |
| <0.01% | <0.01% | #41 | $1,202.6万 | 17.1万股 | $997.3万 | 13.7万股 | +3.5万股+25.34% | 加仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #50 | $938.5万 | 13.4万股 | $542.7万 | 7.4万股 | +5.9万股+79.76% | 加仓 |
| 暮色资产管理EVENTIDE ASSET MANAGEMENT, LLC |
| 0.12% | 0.16% | #23 | $912.7万 | 13.0万股 | $948.7万 | 13.0万股 | 00.00% | 持仓不变 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #62 | $857.7万 | 12.2万股 | $789.8万 | 10.8万股 | +1.4万股+12.88% | 加仓 |
| SEVEN GRAND MANAGERS, LLC |
| 0.34% | 0.59% | #16 | $842.4万 | 12.0万股 | $875.6万 | 12.0万股 | 00.00% | 持仓不变 |
| GREAT POINT PARTNERS LLC |
| 1.45% | 3.69% | #7 | $769.4万 | 11.0万股 | $1,605.3万 | 22.0万股 | -11.0万股-50.18% | 减仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #58 | $731.1万 | 10.4万股 | $647.4万 | 8.9万股 | +1.5万股+17.39% | 加仓 |
| 奥比梅德顾问ORBIMED ADVISORS LLC |
| 0.12% | 0.06% | #22 | $652.9万 | 9.3万股 | $291.9万 | 4.0万股 | +5.3万股+132.50% | 加仓 |
| ACUTA CAPITAL PARTNERS, LLC |
| 4.54% | 5.76% | #1 | $651.1万 | 9.3万股 | $817.2万 | 11.2万股 | -1.9万股-17.19% | 减仓 |
| Ikarian Capital, LLC |
| 0.66% | 0.99% | #13 | $624.4万 | 8.9万股 | $1,216.0万 | 16.7万股 | -7.8万股-46.62% | 减仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #63 | $562.0万 | 8.0万股 | $441.3万 | 6.0万股 | +2.0万股+32.37% | 加仓 |
| Sio Capital Management, LLC |
| 0.86% | 0.9% | #12 | $519.1万 | 7.4万股 | $628.1万 | 8.6万股 | -1.2万股-14.09% | 减仓 |
| Trexquant投资Trexquant Investment LP |
| 0.03% | <0.01% | #30 | $495.7万 | 7.1万股 | $54.4万 | 7,451股 | +6.3万股+847.73% | 加仓 |
| B Group, Inc. |
| 2.22% | 3.65% | #4 | $473.9万 | 6.8万股 | $492.5万 | 6.8万股 | 00.00% | 持仓不变 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #43 | $468.5万 | 6.7万股 | $385.5万 | 5.3万股 | +1.4万股+26.32% | 加仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | — | #55 | $467.1万 | 6.7万股 | $0 | 0股 | +6.7万股 | 新买入 |
| Schonfeld战略顾问Schonfeld Strategic Advisors LLC |
| 0.02% | 0.01% | #34 | $465.3万 | 6.6万股 | $96.6万 | 1.3万股 | +5.3万股+400.43% | 加仓 |
| Walleye资本Walleye Capital LLC |
| 0.02% | 0.02% | #33 | $464.1万 | 6.6万股 | $391.9万 | 5.4万股 | +1.2万股+23.09% | 加仓 |
| Woodline合伙人Woodline Partners LP |
| 0.01% | 0.01% | #36 | $320.6万 | 4.6万股 | $333.2万 | 4.6万股 | 00.00% | 持仓不变 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #59 | $298.1万 | 4.2万股 | $272.7万 | 3.7万股 | +5,088股+13.61% | 加仓 |
| Artia Global Partners LP |
| 0.5% | 0.56% | #14 | $269.6万 | 3.8万股 | $280.3万 | 3.8万股 | 00.00% | 持仓不变 |
| 阿默普莱斯金融AMERIPRISE FINANCIAL INC |
| <0.01% | <0.01% | #54 | $266.1万 | 3.8万股 | $365.0万 | 5.0万股 | -1.2万股-24.24% | 减仓 |
| 洛杉矶资本管理LOS ANGELES CAPITAL MANAGEMENT LLC |
| 0.01% | — | #37 | $250.9万 | 3.6万股 | $0 | 0股 | +3.6万股 | 新买入 |
| KVP Capital Advisors, LP |
| 1.64% | 1.73% | #5 | $223.3万 | 3.2万股 | $232.1万 | 3.2万股 | 00.00% | 持仓不变 |
| SUPERSTRING CAPITAL MANAGEMENT LP |
| 1.35% | 0.69% | #8 | $213.8万 | 3.0万股 | $97.1万 | 1.3万股 | +1.7万股+128.80% | 加仓 |
| ADAR1 Capital Management, LLC |
| 0.1% | 0.15% | #24 | $212.7万 | 3.0万股 | $247.4万 | 3.4万股 | -3,600股-10.62% | 减仓 |
| 布斯湾基金管理BOOTHBAY FUND MANAGEMENT, LLC |
| 0.03% | 0.05% | #31 | $195.6万 | 2.8万股 | $374.3万 | 5.1万股 | -2.3万股-45.66% | 减仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #74 | $189.3万 | 2.7万股 | $141.7万 | 1.9万股 | +7,544股+38.84% | 加仓 |
| AdvisorShares Investments LLC |
| 0.21% | 0.17% | #19 | $170.4万 | 2.4万股 | $92.0万 | 1.3万股 | +1.2万股+92.45% | 加仓 |
| Aquatic 资本管理Aquatic Capital Management LLC |
| 0.05% | <0.01% | #26 | $146.2万 | 2.1万股 | $14.9万 | 2,045股 | +1.9万股+918.63% | 加仓 |
| PLATINUM INVESTMENT MANAGEMENT LTD |
| 0.33% | 0.35% | #17 | $134.3万 | 1.9万股 | $139.6万 | 1.9万股 | 00.00% | 持仓不变 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #80 | $130.6万 | 1.9万股 | $1,169.9万 | 19.3万股 | -17.4万股-90.36% | 减仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #67 | $126.6万 | 1.8万股 | $111.8万 | 1.5万股 | +2,714股+17.72% | 加仓 |
| 纽文Nuveen, LLC |
| <0.01% | <0.01% | #61 | $118.6万 | 1.7万股 | $60.8万 | 8,329股 | +8,560股+102.77% | 加仓 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #71 | $109.1万 | 1.6万股 | $96.9万 | 1.3万股 | +2,256股+16.99% | 加仓 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| <0.01% | <0.01% | #66 | $104.6万 | 1.5万股 | $96.7万 | 1.3万股 | +1,649股+12.44% | 加仓 |
