| RTW投资RTW INVESTMENTS, LP |
| 0.52% | 0.63% | #6 | $6,049.2万 | 1,768.8万股 | $6,332.2万 | 1,768.8万股 | 00.00% | 持仓不变 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #78 | $3,394.0万 | 992.4万股 | $2,804.9万 | 783.5万股 | +208.9万股+26.67% | 加仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #59 | $1,987.0万 | 581.0万股 | $1,679.1万 | 469.0万股 | +112.0万股+23.88% | 加仓 |
| 花旗集团CITIGROUP INC |
| 0.01% | 0.01% | #29 | $1,664.0万 | 486.6万股 | $1,828.6万 | 510.8万股 | -24.2万股-4.74% | 减仓 |
| 马歇尔·韦斯MARSHALL WACE, LLP |
| 0.01% | 0.01% | #25 | $1,378.0万 | 402.9万股 | $1,087.9万 | 303.9万股 | +99.1万股+32.60% | 加仓 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #30 | $1,368.1万 | 400.0万股 | $1,116.3万 | 311.8万股 | +88.2万股+28.29% | 加仓 |
| Newtyn Management, LLC |
| 1.71% | 1.21% | #1 | $1,368.0万 | 400.0万股 | $1,133.4万 | 316.6万股 | +83.4万股+26.35% | 加仓 |
| Maverick资本MAVERICK CAPITAL LTD |
| 0.12% | 0.15% | #11 | $1,342.0万 | 392.4万股 | $1,277.1万 | 356.7万股 | +35.7万股+10.00% | 加仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #100 | $1,294.3万 | 378.4万股 | $1,351.7万 | 377.6万股 | +8,651股+0.23% | 加仓 |
| AQR资本管理AQR CAPITAL MANAGEMENT LLC |
| <0.01% | 0.01% | #33 | $1,158.1万 | 338.6万股 | $1,099.0万 | 307.0万股 | +31.6万股+10.30% | 加仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #61 | $1,016.9万 | 297.3万股 | $666.3万 | 186.1万股 | +111.2万股+59.77% | 加仓 |
| Monaco Asset Management SAM |
| 0.67% | 1.36% | #4 | $848.3万 | 248.0万股 | $736.9万 | 205.8万股 | +42.2万股+20.51% | 加仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #83 | $811.0万 | 237.1万股 | $783.9万 | 218.9万股 | +18.1万股+8.29% | 加仓 |
| Federated HermesFEDERATED HERMES, INC. |
| 0.01% | 0.01% | #24 | $788.0万 | 230.4万股 | $366.5万 | 102.4万股 | +128.0万股+125.08% | 加仓 |
| Jacobs Levy股票管理JACOBS LEVY EQUITY MANAGEMENT, INC |
| 0.02% | 0.01% | #17 | $675.4万 | 197.5万股 | $149.1万 | 41.7万股 | +155.8万股+374.13% | 加仓 |
| 摩根大通JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #89 | $670.1万 | 198.8万股 | $274.3万 | 79.6万股 | +119.2万股+149.73% | 加仓 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #113 | $622.5万 | 182.0万股 | $1,606.0万 | 448.6万股 | -266.6万股-59.43% | 减仓 |
| 维度基金顾问DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #70 | $384.9万 | 112.6万股 | $103.2万 | 28.8万股 | +83.7万股+290.44% | 加仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #111 | $363.4万 | 106.3万股 | $1,188.9万 | 364.7万股 | -258.5万股-70.87% | 减仓 |
| Opaleye Management Inc. |
| 0.31% | 0.45% | #8 | $342.0万 | 100.0万股 | $341.9万 | 95.5万股 | +4.5万股+4.71% | 加仓 |
| D.E.肖D. E. Shaw & Co., Inc. |
| <0.01% | <0.01% | #50 | $325.1万 | 95.1万股 | $776.7万 | 217.0万股 | -121.9万股-56.19% | 减仓 |
| 跳跃金融Jump Financial, LLC |
| 0.02% | 0.02% | #18 | $296.8万 | 86.8万股 | $170.6万 | 47.6万股 | +39.1万股+82.15% | 加仓 |
| 文艺复兴科技RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | <0.01% | #34 | $271.2万 | 79.3万股 | $228.1万 | 63.7万股 | +15.6万股+24.45% | 加仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #92 | $256.2万 | 74.9万股 | $259.3万 | 72.4万股 | +2.5万股+3.41% | 加仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #96 | $251.4万 | 73.5万股 | $229.4万 | 64.1万股 | +9.4万股+14.71% | 加仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #117 | $251.2万 | 73.5万股 | $225.6万 | 63.0万股 | +10.4万股+16.58% | 加仓 |
| Prosight Management, LP |
| 0.41% | 0.4% | #7 | $239.4万 | 70.0万股 | $244.8万 | 68.4万股 | +1.6万股+2.36% | 加仓 |
| Point72资产管理Point72 Asset Management, L.P. |
| <0.01% | <0.01% | #40 | $229.3万 | 67.1万股 | $362.3万 | 101.2万股 | -34.2万股-33.75% | 减仓 |
| Qube研究科技Qube Research & Technologies Ltd |
| <0.01% | — | #42 | $220.5万 | 64.5万股 | $0 | 0股 | +64.5万股 | 新买入 |
| Woodline合伙人Woodline Partners LP |
| 0.01% | 0.01% | #27 | $219.3万 | 64.1万股 | $229.6万 | 64.1万股 | 00.00% | 持仓不变 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #82 | $202.8万 | 59.3万股 | $211.5万 | 59.1万股 | +2,094股+0.35% | 加仓 |
| 富达投资FMR LLC |
| <0.01% | <0.01% | #140 | $167.0万 | 48.8万股 | $165.6万 | 46.3万股 | +2.6万股+5.55% | 加仓 |
| IEQ资本IEQ CAPITAL, LLC |
| 0.01% | 0.01% | #26 | $150.6万 | 44.0万股 | $136.7万 | 38.2万股 | +5.8万股+15.30% | 加仓 |
| ADAR1 Capital Management, LLC |
| 0.07% | 0.09% | #13 | $148.9万 | 43.6万股 | $154.8万 | 43.3万股 | +3,000股+0.69% | 加仓 |
| 安本标准投资Aberdeen Group plc |
| <0.01% | <0.01% | #46 | $136.0万 | 39.8万股 | $238.0万 | 66.5万股 | -26.7万股-40.18% | 减仓 |
| 法国巴黎银行金融市场BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | <0.01% | #73 | $132.4万 | 38.7万股 | $96.4万 | 26.9万股 | +11.8万股+43.78% | 加仓 |
| 景顺Invesco Ltd. |
| <0.01% | <0.01% | #129 | $131.1万 | 38.3万股 | $124.4万 | 34.8万股 | +3.6万股+10.29% | 加仓 |
| 洛杉矶资本管理LOS ANGELES CAPITAL MANAGEMENT LLC |
| <0.01% | — | #31 | $119.0万 | 34.8万股 | $0 | 0股 | +34.8万股 | 新买入 |
| 萨斯奎汉纳组合策略Susquehanna Portfolio Strategies, LLC |
| 0.02% | 0.01% | #20 | $113.6万 | 33.2万股 | $93.4万 | 26.1万股 | +7.1万股+27.34% | 加仓 |
| LPL金融LPL Financial LLC |
| <0.01% | <0.01% | #103 | $110.1万 | 32.2万股 | $55.9万 | 15.6万股 | +16.6万股+106.19% | 加仓 |
| Two Sigma投资TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #62 | $108.0万 | 31.6万股 | $392.9万 | 109.8万股 | -78.2万股-71.23% | 减仓 |
| BIT Capital GmbH |
| 0.03% | — | #16 | $101.9万 | 29.8万股 | $0 | 0股 | +29.8万股 | 新买入 |
| 阿默普莱斯金融AMERIPRISE FINANCIAL INC |
| <0.01% | <0.01% | #112 | $94.1万 | 27.5万股 | $4.7万 | 1.3万股 | +26.2万股+2,015.78% | 加仓 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| <0.01% | <0.01% | #122 | $88.9万 | 26.0万股 | $85.9万 | 24.0万股 | +2.0万股+8.33% | 加仓 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #143 | $84.6万 | 24.7万股 | $198.2万 | 55.4万股 | -30.6万股-55.34% | 减仓 |
| Privium Fund Management B.V. |
| 0.15% | 0.18% | #9 | $83.5万 | 24.4万股 | $86.7万 | 24.2万股 | +2,000股+0.83% | 加仓 |
| Hennion & Walsh Asset Management, Inc. |
| 0.02% | 0.03% | #19 | $76.9万 | 22.5万股 | $103.0万 | 28.8万股 | -6.3万股-21.85% | 减仓 |
| M28 Capital Management LP |
| 1.53% | 1.4% | #2 | $72.1万 | 21.1万股 | $75.5万 | 21.1万股 | 00.00% | 持仓不变 |
| 联博ALLIANCEBERNSTEIN L.P. |
| <0.01% | <0.01% | #107 | $70.0万 | 19.6万股 | $47.6万 | 13.6万股 | +6.0万股+44.32% | 加仓 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #135 | $69.0万 | 20.2万股 | $464.7万 | 129.8万股 | -109.7万股-84.47% | 减仓 |
