| Samsara BioCapital, LLC |
| 4.44% | 3.36% | #1 | $5,400.4万 | 171.7万股 | $3,461.7万 | 171.7万股 | 00.00% | 持仓不变 |
| Casdin Capital, LLC |
| 2.43% | 2.17% | #4 | $4,860.2万 | 154.5万股 | $2,863.4万 | 142.0万股 | +12.5万股+8.80% | 加仓 |
| Redmile Group, LLC |
| 2.98% | 1.95% | #3 | $4,441.4万 | 141.2万股 | $2,942.6万 | 146.0万股 | -4.7万股-3.25% | 减仓 |
| RTW投资RTW INVESTMENTS, LP |
| 0.37% | 0.27% | #9 | $4,284.9万 | 136.2万股 | $2,746.7万 | 136.2万股 | 00.00% | 持仓不变 |
| EcoR1 Capital, LLC |
| 1.94% | 1.09% | #6 | $3,998.4万 | 127.1万股 | $2,563.0万 | 127.1万股 | 00.00% | 持仓不变 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #45 | $3,327.4万 | 105.8万股 | $2,026.2万 | 100.5万股 | +5.3万股+5.26% | 加仓 |
| 贝克兄弟顾问BAKER BROS. ADVISORS LP |
| 0.16% | 0.11% | #11 | $3,118.9万 | 99.2万股 | $1,999.2万 | 99.2万股 | 00.00% | 持仓不变 |
| Balyasny资产管理BALYASNY ASSET MANAGEMENT L.P. |
| 0.03% | 0.02% | #15 | $2,574.8万 | 81.9万股 | $1,448.3万 | 71.8万股 | +10.0万股+13.96% | 加仓 |
| Trails Edge Capital Partners, LP |
| 3.57% | 3.62% | #2 | $2,248.3万 | 71.5万股 | $1,578.1万 | 78.3万股 | -6.8万股-8.67% | 减仓 |
| 多伦多道明银行TORONTO DOMINION BANK |
| 0.02% | 0.02% | #17 | $2,142.8万 | 68.1万股 | $1,373.6万 | 68.1万股 | 00.00% | 持仓不变 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #53 | $1,687.4万 | 53.7万股 | $1,037.7万 | 51.5万股 | +2.2万股+4.23% | 加仓 |
| 詹尼森联营JENNISON ASSOCIATES LLC |
| 0.01% | 0.01% | #25 | $1,630.9万 | 51.9万股 | $1,063.8万 | 52.8万股 | -9,103股-1.73% | 减仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #34 | $1,370.2万 | 43.6万股 | $833.1万 | 41.3万股 | +2.2万股+5.43% | 加仓 |
| GREAT POINT PARTNERS LLC |
| 2.09% | 2.32% | #5 | $1,107.6万 | 35.2万股 | $1,008.0万 | 50.0万股 | -14.8万股-29.56% | 减仓 |
| ArrowMark Colorado Holdings LLC |
| 0.45% | 0.28% | #8 | $1,077.0万 | 34.2万股 | $1,058.0万 | 52.5万股 | -18.2万股-34.75% | 减仓 |
| 富达投资FMR LLC |
| <0.01% | <0.01% | #49 | $929.5万 | 29.6万股 | $771.4万 | 38.3万股 | -8.7万股-22.76% | 减仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #46 | $922.3万 | 29.3万股 | $562.6万 | 27.9万股 | +1.4万股+5.08% | 加仓 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #63 | $705.5万 | 22.4万股 | $631.0万 | 31.3万股 | -8.9万股-28.33% | 减仓 |
| 富兰克林资源FRANKLIN RESOURCES INC |
| <0.01% | — | #35 | $642.5万 | 20.4万股 | $0 | 0股 | +20.4万股 | 新买入 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #58 | $603.0万 | 19.2万股 | $739.3万 | 42.7万股 | -23.5万股-55.06% | 减仓 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #42 | $538.7万 | 17.1万股 | $374.3万 | 18.6万股 | -1.4万股-7.75% | 减仓 |
| 威廉·布莱尔BLAIR WILLIAM & CO/IL |
| 0.01% | 0.01% | #22 | $462.0万 | 14.7万股 | $339.1万 | 16.8万股 | -2.1万股-12.67% | 减仓 |
| Driehaus资本管理DRIEHAUS CAPITAL MANAGEMENT LLC |
| 0.03% | <0.01% | #16 | $451.4万 | 14.4万股 | $66.1万 | 3.3万股 | +11.1万股+338.05% | 加仓 |
| Point72资产管理Point72 Asset Management, L.P. |
| <0.01% | — | #28 | $446.3万 | 14.2万股 | $0 | 0股 | +14.2万股 | 新买入 |
| 摩尔资本管理MOORE CAPITAL MANAGEMENT, LP |
| 0.07% | — | #14 | $445.4万 | 14.2万股 | $0 | 0股 | +14.2万股 | 新买入 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #61 | $336.8万 | 10.7万股 | $308.9万 | 15.3万股 | -4.6万股-30.09% | 减仓 |
| Rock Springs Capital Management LP |
| 0.16% | 0.12% | #10 | $335.7万 | 10.7万股 | $210.3万 | 10.4万股 | +2,411股+2.31% | 加仓 |
| DEUTSCHE 银行 AG\DEUTSCHE BANK AG\ |
| <0.01% | <0.01% | #37 | $335.4万 | 10.7万股 | $214.2万 | 10.6万股 | +405股+0.38% | 加仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #52 | $326.0万 | 10.4万股 | $196.8万 | 9.8万股 | +6,020股+6.17% | 加仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #60 | $318.5万 | 10.1万股 | $217.2万 | 10.8万股 | -6,438股-5.98% | 减仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #76 | $300.7万 | 9.6万股 | $131.2万 | 6.5万股 | +3.1万股+46.90% | 加仓 |
| DAFNA Capital Management LLC |
| 0.53% | 0.26% | #7 | $280.0万 | 8.9万股 | $114.2万 | 5.7万股 | +3.2万股+57.20% | 加仓 |
| Woodline合伙人Woodline Partners LP |
| 0.01% | 0.01% | #26 | $263.7万 | 8.4万股 | $169.0万 | 8.4万股 | 00.00% | 持仓不变 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #44 | $233.6万 | 7.4万股 | $140.5万 | 7.0万股 | +4,550股+6.53% | 加仓 |
| Trexquant投资Trexquant Investment LP |
| 0.01% | — | #20 | $232.0万 | 7.4万股 | $0 | 0股 | +7.4万股 | 新买入 |
| 摩根大通JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #79 | $199.8万 | 6.2万股 | $125.3万 | 6.5万股 | -3,040股-4.68% | 减仓 |
| XTX资本XTX Topco Ltd |
| 0.02% | 0.01% | #18 | $174.3万 | 5.5万股 | $55.3万 | 2.7万股 | +2.8万股+102.05% | 加仓 |
| 施罗德投资管理SCHRODER INVESTMENT MANAGEMENT GROUP |
| <0.01% | <0.01% | #36 | $168.8万 | 5.2万股 | $100.9万 | 5.2万股 | 00.00% | 持仓不变 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #48 | $134.4万 | 4.3万股 | $412.9万 | 20.5万股 | -16.2万股-79.13% | 减仓 |
| 赖夫艾森国际银行Raiffeisen Bank International AG |
| 0.01% | 0.01% | #21 | $109.8万 | 3.4万股 | $83.0万 | 4.3万股 | -9,000股-20.93% | 减仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #75 | $103.0万 | 3.3万股 | $60.6万 | 3.0万股 | +2,684股+8.93% | 加仓 |
| 维度基金顾问DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #68 | $102.6万 | 3.3万股 | $23.0万 | 1.1万股 | +2.1万股+185.83% | 加仓 |
| 惠灵顿管理集团WELLINGTON MANAGEMENT GROUP LLP |
| <0.01% | — | #69 | $98.7万 | 3.1万股 | $0 | 0股 | +3.1万股 | 新买入 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| <0.01% | <0.01% | #72 | $90.4万 | 2.9万股 | $52.5万 | 2.6万股 | +2,698股+10.36% | 加仓 |
| 纽文Nuveen, LLC |
| <0.01% | <0.01% | #64 | $87.5万 | 2.8万股 | $50.8万 | 2.5万股 | +2,614股+10.37% | 加仓 |
| 简街集团JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #86 | $82.0万 | 2.6万股 | $49.2万 | 2.4万股 | +1,689股+6.92% | 加仓 |
| 正交资本Quadrature Capital Ltd |
| 0.01% | — | #27 | $76.5万 | 2.4万股 | $0 | 0股 | +2.4万股 | 新买入 |
| 美国世纪投资AMERICAN CENTURY COMPANIES INC |
| <0.01% | <0.01% | #57 | $73.4万 | 2.3万股 | $37.4万 | 1.9万股 | +4,790股+25.84% | 加仓 |
| Seven Fleet Capital Management LP |
| 0.11% | — | #12 | $69.4万 | 2.2万股 | $0 | 0股 | +2.2万股 | 新买入 |
| 文艺复兴科技RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | <0.01% | #39 | $64.2万 | 2.0万股 | $87.5万 | 4.3万股 | -2.3万股-52.98% | 减仓 |
