| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #80 | $9,981.3万 | 414.5万股 | $1.04亿 | 342.2万股 | +72.3万股+21.14% | 加仓 |
| TANG CAPITAL MANAGEMENT LLC |
| 4.48% | 5.25% | #1 | $9,872.6万 | 410.0万股 | $1.03亿 | 340.0万股 | +70.0万股+20.59% | 加仓 |
| 蒙塔诺瓦资本MONTANOVA CAPITAL, LLC |
| 1.8% | 2.97% | #7 | $9,855.4万 | 409.3万股 | $1.16亿 | 381.9万股 | +27.4万股+7.18% | 加仓 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #67 | $8,180.3万 | 339.7万股 | $6,633.0万 | 218.2万股 | +121.5万股+55.70% | 加仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #91 | $5,532.8万 | 229.8万股 | $6,164.3万 | 202.8万股 | +27.0万股+13.31% | 加仓 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #64 | $3,858.0万 | 160.2万股 | $4,149.8万 | 136.5万股 | +23.7万股+17.37% | 加仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #59 | $3,800.1万 | 157.8万股 | $2,772.4万 | 91.2万股 | +66.6万股+73.05% | 加仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | 0.01% | #54 | $3,722.9万 | 154.6万股 | $4,377.1万 | 144.0万股 | +10.6万股+7.38% | 加仓 |
| RA资本管理RA CAPITAL MANAGEMENT, L.P. |
| 0.32% | 0.49% | #14 | $3,630.9万 | 150.8万股 | $4,583.8万 | 150.8万股 | 00.00% | 持仓不变 |
| 洞察顾问PERCEPTIVE ADVISORS LLC |
| 0.54% | — | #11 | $3,612.0万 | 150.0万股 | $0 | 0股 | +150.0万股 | 新买入 |
| Boxer Capital Management, LLC |
| 2.53% | 2.35% | #4 | $3,359.5万 | 139.5万股 | $1,793.6万 | 59.0万股 | +80.5万股+136.47% | 加仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #74 | $3,305.0万 | 137.2万股 | $3,400.3万 | 111.8万股 | +25.4万股+22.71% | 加仓 |
| 富达投资FMR LLC |
| <0.01% | <0.01% | #90 | $2,739.7万 | 113.8万股 | $2,348.9万 | 77.3万股 | +36.5万股+47.25% | 加仓 |
| Ikarian Capital, LLC |
| 2.44% | 2.17% | #5 | $2,297.7万 | 95.4万股 | $2,669.2万 | 87.8万股 | +7.6万股+8.68% | 加仓 |
| DIADEMA PARTNERS LP |
| 2.57% | 5.34% | #3 | $2,079.8万 | 86.4万股 | $3,135.9万 | 103.2万股 | -16.8万股-16.27% | 减仓 |
| Soleus 资本管理Soleus Capital Management, L.P. |
| 0.63% | — | #10 | $1,834.3万 | 76.2万股 | $0 | 0股 | +76.2万股 | 新买入 |
| Caption管理Caption Management, LLC |
| 0.08% | 0.07% | #25 | $1,719.6万 | 71.4万股 | $1,120.5万 | 36.9万股 | +34.6万股+93.73% | 加仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #96 | $1,648.3万 | 68.5万股 | $397.8万 | 55.2万股 | +13.3万股+24.08% | 加仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #100 | $1,531.7万 | 63.6万股 | $1,152.8万 | 37.9万股 | +25.7万股+67.74% | 加仓 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #71 | $1,492.1万 | 62.0万股 | $1,130.8万 | 37.2万股 | +24.8万股+66.58% | 加仓 |
| DG Capital Management, LLC |
| 3.1% | 3.65% | #2 | $1,472.7万 | 61.2万股 | $1,192.0万 | 39.2万股 | +21.9万股+55.98% | 加仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #81 | $1,212.5万 | 50.4万股 | $1,269.3万 | 41.8万股 | +8.6万股+20.59% | 加仓 |
| Balyasny资产管理BALYASNY ASSET MANAGEMENT L.P. |
| 0.01% | 0.01% | #41 | $1,172.3万 | 48.7万股 | $903.3万 | 29.7万股 | +19.0万股+63.85% | 加仓 |
| J. Goldman & Co LP |
| 0.29% | 0.5% | #15 | $1,115.7万 | 46.3万股 | $1,707.0万 | 56.2万股 | -9.8万股-17.49% | 减仓 |
| D.E.肖D. E. Shaw & Co., Inc. |
| 0.01% | 0.01% | #51 | $1,056.5万 | 43.9万股 | $957.6万 | 31.5万股 | +12.4万股+39.28% | 加仓 |
| Jones Hill Capital LP |
| 2.15% | 5.93% | #6 | $1,013.2万 | 42.1万股 | $2,764.0万 | 90.9万股 | -48.8万股-53.72% | 减仓 |
| 美世全球顾问MERCER GLOBAL ADVISORS INC /ADV |
| 0.01% | 0.02% | #43 | $969.8万 | 40.3万股 | $1,225.1万 | 40.3万股 | -268股-0.07% | 减仓 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #60 | $968.6万 | 40.2万股 | $1,083.3万 | 35.6万股 | +4.6万股+12.87% | 加仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #70 | $897.1万 | 37.3万股 | $973.1万 | 32.0万股 | +5.2万股+16.38% | 加仓 |
| 摩根大通JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #111 | $868.5万 | 36.3万股 | $954.2万 | 34.4万股 | +1.9万股+5.50% | 加仓 |
| 布斯湾基金管理BOOTHBAY FUND MANAGEMENT, LLC |
| 0.1% | 0.11% | #22 | $719.7万 | 29.9万股 | $834.3万 | 27.4万股 | +2.4万股+8.90% | 加仓 |
| Group One交易GROUP ONE TRADING LLC |
| 0.01% | 0.01% | #47 | $656.4万 | 27.3万股 | $386.5万 | 12.7万股 | +14.5万股+114.42% | 加仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #115 | $605.0万 | 25.1万股 | $1,263.1万 | 41.5万股 | -16.4万股-39.53% | 减仓 |
| RTW投资RTW INVESTMENTS, LP |
| 0.05% | 0.08% | #27 | $602.0万 | 25.0万股 | $760.0万 | 25.0万股 | 00.00% | 持仓不变 |
| 纽文Nuveen, LLC |
| <0.01% | <0.01% | #84 | $569.8万 | 23.7万股 | $495.2万 | 16.3万股 | +7.4万股+45.24% | 加仓 |
| Palo Alto Investors LP |
| 0.81% | 1.07% | #8 | $553.3万 | 23.0万股 | $698.5万 | 23.0万股 | 00.00% | 持仓不变 |
| HBK索尔斯顾问HBK Sorce Advisory LLC |
| 0.1% | 0.12% | #20 | $535.4万 | 22.3万股 | $622.3万 | 20.5万股 | +1.8万股+8.90% | 加仓 |
| Trexquant投资Trexquant Investment LP |
| 0.03% | 0.05% | #32 | $476.3万 | 19.8万股 | $676.1万 | 22.2万股 | -2.5万股-11.07% | 减仓 |
| 雷蒙德詹姆斯金融RAYMOND JAMES FINANCIAL INC |
| <0.01% | <0.01% | #86 | $474.0万 | 19.7万股 | $596.8万 | 19.6万股 | +556股+0.28% | 加仓 |
| MOODY ALDRICH PARTNERS LLC |
| 0.77% | 1.24% | #9 | $428.0万 | 17.8万股 | $687.1万 | 22.6万股 | -4.8万股-21.36% | 减仓 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| <0.01% | <0.01% | #101 | $389.5万 | 16.2万股 | $397.4万 | 13.1万股 | +3.1万股+23.74% | 加仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #110 | $387.5万 | 16.1万股 | $383.1万 | 12.6万股 | +3.5万股+27.71% | 加仓 |
| 简街集团JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #124 | $338.3万 | 14.1万股 | $3,074.3万 | 101.1万股 | -87.1万股-86.11% | 减仓 |
| LMR合伙人LMR Partners LLP |
| 0.01% | 0.01% | #42 | $337.8万 | 14.0万股 | $264.8万 | 8.7万股 | +5.3万股+61.08% | 加仓 |
| Woodline合伙人Woodline Partners LP |
| 0.01% | 0.02% | #44 | $334.2万 | 13.9万股 | $418.5万 | 13.8万股 | +1,118股+0.81% | 加仓 |
| PFM Health Sciences, LP |
| 0.25% | 0.34% | #16 | $294.3万 | 12.2万股 | $376.4万 | 12.4万股 | -1,610股-1.30% | 减仓 |
| Pier Capital, LLC |
| 0.36% | 0.22% | #13 | $269.5万 | 11.2万股 | $135.0万 | 4.4万股 | +6.8万股+152.04% | 加仓 |
| 花旗集团CITIGROUP INC |
| <0.01% | <0.01% | #95 | $268.8万 | 11.2万股 | $129.3万 | 4.3万股 | +6.9万股+162.42% | 加仓 |
| 杰富瑞金融集团Jefferies Financial Group Inc. |
| 0.02% | 0.02% | #37 | $254.7万 | 10.6万股 | $317.3万 | 10.4万股 | +1,394股+1.34% | 加仓 |
| 惠灵顿管理集团WELLINGTON MANAGEMENT GROUP LLP |
| <0.01% | <0.01% | #113 | $241.4万 | 10.0万股 | $330.2万 | 10.9万股 | -8,358股-7.70% | 减仓 |
