| RA资本管理RA CAPITAL MANAGEMENT, L.P. |
| 1.04% | 0.71% | #8 | $1.20亿 | 1,203.6万股 | $6,724.8万 | 934.0万股 | +269.6万股+28.87% | 加仓 |
| 洞察顾问PERCEPTIVE ADVISORS LLC |
| 1.79% | 1.68% | #5 | $1.19亿 | 1,190.7万股 | $8,572.8万 | 1,190.7万股 | 00.00% | 持仓不变 |
| Bain Capital Life Sciences Investors, LLC |
| 5.83% | 6.37% | #2 | $9,799.0万 | 980.9万股 | $7,062.3万 | 980.9万股 | 00.00% | 持仓不变 |
| Siren, L.L.C. |
| 1.55% | 1.53% | #6 | $7,682.7万 | 769.0万股 | $5,537.1万 | 769.0万股 | 00.00% | 持仓不变 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #74 | $6,927.3万 | 693.4万股 | $3,570.0万 | 495.8万股 | +197.6万股+39.85% | 加仓 |
| 富达投资FMR LLC |
| <0.01% | <0.01% | #52 | $6,869.1万 | 687.6万股 | $2,596.6万 | 360.6万股 | +327.0万股+90.66% | 加仓 |
| 停战资本ARMISTICE CAPITAL, LLC |
| 0.52% | 0.41% | #10 | $4,273.7万 | 427.8万股 | $2,304.0万 | 320.0万股 | +107.8万股+33.69% | 加仓 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #66 | $4,171.2万 | 417.5万股 | $810.4万 | 112.5万股 | +305.0万股+270.98% | 加仓 |
| 木星资产管理Jupiter Topco LLC |
| 0.02% | — | #36 | $4,037.5万 | 404.4万股 | $0 | 0股 | +404.4万股 | 新买入 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | — | #75 | $4,005.9万 | 401.0万股 | $0 | 0股 | +401.0万股 | 新买入 |
| RTW投资RTW INVESTMENTS, LP |
| 0.33% | — | #14 | $3,889.0万 | 389.3万股 | $0 | 0股 | +389.3万股 | 新买入 |
| 深轨资本Deep Track Capital, LP |
| 0.52% | 0.42% | #11 | $3,561.5万 | 356.5万股 | $2,566.8万 | 356.5万股 | 00.00% | 持仓不变 |
| 富兰克林资源FRANKLIN RESOURCES INC |
| 0.01% | <0.01% | #42 | $3,437.3万 | 344.1万股 | $1,578.9万 | 219.3万股 | +124.8万股+56.90% | 加仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #51 | $2,843.2万 | 284.6万股 | $1,906.7万 | 264.8万股 | +19.8万股+7.47% | 加仓 |
| Alyeska投资集团Alyeska Investment Group, L.P. |
| 0.06% | 0.05% | #23 | $2,278.2万 | 228.0万股 | $1,639.8万 | 228.0万股 | +359股+0.02% | 加仓 |
| 阿默普莱斯金融AMERIPRISE FINANCIAL INC |
| <0.01% | <0.01% | #47 | $2,223.6万 | 222.6万股 | $1,756.0万 | 243.9万股 | -21.3万股-8.74% | 减仓 |
| Vestal Point 资本Vestal Point Capital, LP |
| 0.5% | 1.01% | #13 | $2,157.8万 | 216.0万股 | $3,600.0万 | 500.0万股 | -284.0万股-56.80% | 减仓 |
| Redmile Group, LLC |
| 1.31% | 0.96% | #7 | $1,946.7万 | 194.9万股 | $1,448.6万 | 201.2万股 | -6.3万股-3.14% | 减仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #73 | $1,939.2万 | 194.1万股 | $933.3万 | 129.6万股 | +64.5万股+49.76% | 加仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #62 | $1,701.2万 | 170.3万股 | $673.6万 | 93.6万股 | +76.7万股+82.03% | 加仓 |
| Adage资本合伙人ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.02% | 0.02% | #31 | $1,505.0万 | 150.7万股 | $1,264.7万 | 175.7万股 | -25.0万股-14.23% | 减仓 |
| 维度基金顾问DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #54 | $1,264.5万 | 126.6万股 | $687.7万 | 95.6万股 | +31.0万股+32.44% | 加仓 |
| 威廉·布莱尔BLAIR WILLIAM & CO/IL |
| 0.02% | 0.01% | #34 | $755.5万 | 75.6万股 | $468.9万 | 65.1万股 | +10.5万股+16.13% | 加仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | — | #97 | $747.8万 | 74.9万股 | $0 | 0股 | +74.9万股 | 新买入 |
| Woodline合伙人Woodline Partners LP |
| 0.02% | 0.01% | #32 | $673.4万 | 67.4万股 | $356.5万 | 49.5万股 | +17.9万股+36.16% | 加仓 |
| SILVERARC CAPITAL MANAGEMENT, LLC |
| 0.69% | — | #9 | $667.8万 | 66.8万股 | $0 | 0股 | +66.8万股 | 新买入 |
| Birchview Capital, LP |
| 3.01% | 2.57% | #3 | $665.5万 | 66.6万股 | $450.7万 | 62.6万股 | +4.0万股+6.42% | 加仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #79 | $603.0万 | 60.4万股 | $301.1万 | 41.8万股 | +18.5万股+44.34% | 加仓 |
| 摩尔资本管理MOORE CAPITAL MANAGEMENT, LP |
| 0.09% | 0.05% | #20 | $602.9万 | 60.3万股 | $233.8万 | 32.5万股 | +27.9万股+85.83% | 加仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #98 | $523.6万 | 52.4万股 | $278.5万 | 38.7万股 | +13.7万股+35.50% | 加仓 |
| Monashee Investment Management LLC |
| 8.38% | 5.56% | #1 | $499.5万 | 50.0万股 | $1,022.6万 | 142.0万股 | -92.0万股-64.80% | 减仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | — | #71 | $494.2万 | 49.5万股 | $0 | 0股 | +49.5万股 | 新买入 |
| Point72资产管理Point72 Asset Management, L.P. |
| <0.01% | 0.02% | #45 | $447.6万 | 44.8万股 | $1,476.6万 | 205.1万股 | -160.3万股-78.15% | 减仓 |
| STEMPOINT CAPITAL LP |
| 0.51% | 0.26% | #12 | $358.4万 | 35.9万股 | $140.7万 | 19.5万股 | +16.3万股+83.61% | 加仓 |
| Boxer Capital Management, LLC |
| 0.23% | 0.28% | #16 | $299.7万 | 30.0万股 | $216.0万 | 30.0万股 | 00.00% | 持仓不变 |
| 摩根大通JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #119 | $266.7万 | 28.2万股 | $179.4万 | 27.6万股 | +5,261股+1.90% | 加仓 |
| Ally Bridge Group (NY) LLC |
| 2.26% | 4.46% | #4 | $255.7万 | 25.6万股 | $552.2万 | 76.7万股 | -51.1万股-66.63% | 减仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #123 | $254.9万 | 25.5万股 | $159.1万 | 25.8万股 | -2,651股-1.03% | 减仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #99 | $244.2万 | 24.4万股 | $115.7万 | 16.1万股 | +8.4万股+52.06% | 加仓 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| <0.01% | <0.01% | #93 | $242.9万 | 24.3万股 | $99.3万 | 13.8万股 | +10.5万股+76.27% | 加仓 |
| J. Goldman & Co LP |
| 0.06% | 0.06% | #22 | $241.9万 | 24.2万股 | $204.8万 | 28.4万股 | -4.2万股-14.87% | 减仓 |
| 纽文Nuveen, LLC |
| <0.01% | <0.01% | #81 | $241.4万 | 24.2万股 | $288.2万 | 40.0万股 | -15.9万股-39.63% | 减仓 |
| D.E.肖D. E. Shaw & Co., Inc. |
| <0.01% | <0.01% | #72 | $222.6万 | 22.3万股 | $92.4万 | 12.8万股 | +9.4万股+73.58% | 加仓 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #115 | $213.5万 | 21.4万股 | $414.6万 | 57.6万股 | -36.2万股-62.88% | 减仓 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #105 | $188.2万 | 18.8万股 | $71.3万 | 9.9万股 | +8.9万股+90.29% | 加仓 |
| Algert全球ALGERT GLOBAL LLC |
| 0.02% | 0.01% | #28 | $187.2万 | 18.7万股 | $52.3万 | 7.3万股 | +11.5万股+157.96% | 加仓 |
| 惠灵顿管理集团WELLINGTON MANAGEMENT GROUP LLP |
| <0.01% | <0.01% | #100 | $185.2万 | 18.5万股 | $116.1万 | 16.1万股 | +2.4万股+14.94% | 加仓 |
| Balyasny资产管理BALYASNY ASSET MANAGEMENT L.P. |
| <0.01% | <0.01% | #56 | $178.1万 | 17.8万股 | $120.2万 | 17.8万股 | 00.00% | 持仓不变 |
| APIS CAPITAL ADVISORS, LLC |
| 0.16% | 0.18% | #18 | $159.8万 | 16.0万股 | $115.2万 | 16.0万股 | 00.00% | 持仓不变 |
| Soleus 资本管理Soleus Capital Management, L.P. |
| 0.05% | — | #24 | $149.9万 | 15.0万股 | $0 | 0股 | +15.0万股 | 新买入 |
