| Merck & Co., Inc. |
| 35.75% | 25.6% | #1 | $1.88亿 | 1,404.5万股 | $8,946.6万 | 1,404.5万股 | 00.00% | 持仓不变 |
| ARK投资管理ARK Investment Management LLC |
| 0.72% | 0.39% | #14 | $1.11亿 | 827.1万股 | $5,060.4万 | 794.4万股 | +32.7万股+4.12% | 加仓 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #73 | $9,490.5万 | 708.2万股 | $3,433.4万 | 539.0万股 | +169.3万股+31.40% | 加仓 |
| Lightspeed Management Company, L.L.C. |
| 3.4% | 5.26% | #3 | $8,176.5万 | 610.2万股 | $5,198.4万 | 816.1万股 | -205.9万股-25.23% | 减仓 |
| 阿默普莱斯金融AMERIPRISE FINANCIAL INC |
| 0.02% | 0.01% | #38 | $8,155.7万 | 608.6万股 | $4,836.6万 | 759.3万股 | -150.6万股-19.84% | 减仓 |
| 深轨资本Deep Track Capital, LP |
| 0.78% | 0.31% | #13 | $5,360.0万 | 400.0万股 | $1,911.0万 | 300.0万股 | +100.0万股+33.33% | 加仓 |
| 安本标准投资Aberdeen Group plc |
| 0.07% | 0.04% | #26 | $5,021.4万 | 374.7万股 | $2,222.1万 | 348.8万股 | +25.9万股+7.42% | 加仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #89 | $4,033.6万 | 301.0万股 | $1,827.2万 | 286.8万股 | +14.2万股+4.94% | 加仓 |
| Casdin Capital, LLC |
| 1.71% | 0.77% | #5 | $3,417.0万 | 255.0万股 | $1,019.2万 | 160.0万股 | +95.0万股+59.38% | 加仓 |
| 肯尼迪资本管理KENNEDY CAPITAL MANAGEMENT LLC |
| 0.56% | 0.29% | #17 | $3,168.1万 | 236.4万股 | $1,390.9万 | 218.4万股 | +18.1万股+8.28% | 加仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #77 | $2,442.5万 | 182.2万股 | $826.8万 | 129.8万股 | +52.5万股+40.44% | 加仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #70 | $2,439.5万 | 182.1万股 | $70.9万 | 11.1万股 | +170.9万股+1,535.62% | 加仓 |
| AIGH Capital Management LLC |
| 1.45% | 2.52% | #7 | $2,298.1万 | 171.5万股 | $1,847.3万 | 290.0万股 | -118.5万股-40.86% | 减仓 |
| Blue Water Life Science Advisors, LP |
| 14.15% | 8.56% | #2 | $2,246.2万 | 167.6万股 | $1,067.8万 | 167.6万股 | 00.00% | 持仓不变 |
| 维度基金顾问DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #53 | $2,006.3万 | 149.7万股 | $679.1万 | 106.6万股 | +43.1万股+40.40% | 加仓 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #94 | $1,992.7万 | 148.7万股 | $722.5万 | 113.4万股 | +35.3万股+31.12% | 加仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #87 | $1,703.1万 | 127.1万股 | $223.0万 | 34.2万股 | +92.9万股+271.56% | 加仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #74 | $1,567.6万 | 117.0万股 | $469.6万 | 73.7万股 | +43.3万股+58.70% | 加仓 |
| HRT金融HRT FINANCIAL LP |
| 0.02% | <0.01% | #35 | $1,247.3万 | 93.1万股 | $133.0万 | 20.9万股 | +72.2万股+345.60% | 加仓 |
| 简街集团JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #83 | $1,160.1万 | 86.6万股 | $22.6万 | 3.6万股 | +83.0万股+2,338.71% | 加仓 |
| 纽文Nuveen, LLC |
| <0.01% | <0.01% | #58 | $1,009.0万 | 75.3万股 | $218.8万 | 34.4万股 | +40.9万股+119.20% | 加仓 |
| STEMPOINT CAPITAL LP |
| 1.33% | — | #8 | $933.1万 | 71.8万股 | $0 | 0股 | +71.8万股 | 新买入 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #105 | $884.2万 | 66.0万股 | $357.1万 | 56.1万股 | +9.9万股+17.71% | 加仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #82 | $848.0万 | 63.3万股 | $258.5万 | 40.6万股 | +22.7万股+55.94% | 加仓 |
| Trexquant投资Trexquant Investment LP |
| 0.05% | — | #28 | $804.3万 | 60.0万股 | $0 | 0股 | +60.0万股 | 新买入 |
| HOWLAND 资本管理HOWLAND CAPITAL MANAGEMENT LLC |
| 0.27% | 0.14% | #21 | $744.6万 | 55.6万股 | $348.5万 | 54.7万股 | +8,526股+1.56% | 加仓 |
| 密歇根州退休系统STATE OF MICHIGAN RETIREMENT SYSTEM |
| 0.03% | 0.02% | #33 | $661.7万 | 49.4万股 | $314.5万 | 49.4万股 | 00.00% | 持仓不变 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #75 | $607.4万 | 45.3万股 | $216.3万 | 34.0万股 | +11.4万股+33.50% | 加仓 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #63 | $603.2万 | 45.0万股 | $267.0万 | 41.9万股 | +3.1万股+7.40% | 加仓 |
| 三井住友信托集团Sumitomo Mitsui Trust Group, Inc. |
| <0.01% | <0.01% | #54 | $559.4万 | 41.7万股 | $308.5万 | 48.4万股 | -6.7万股-13.79% | 减仓 |
| Amova资产管理Amova Asset Management Americas, Inc. |
| 0.07% | 0.04% | #25 | $559.0万 | 41.7万股 | $307.5万 | 48.4万股 | -6.7万股-13.79% | 减仓 |
| 法国巴黎银行金融市场BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | <0.01% | #59 | $488.8万 | 36.5万股 | $8.7万 | 1.4万股 | +35.1万股+2,575.40% | 加仓 |
| IQ EQ FUND MANAGEMENT (IRELAND) Ltd |
| 0.3% | 0.16% | #19 | $471.3万 | 35.2万股 | $206.0万 | 32.3万股 | +2.8万股+8.77% | 加仓 |
| Wellington Shields Capital Management, LLC |
| 0.58% | 0.32% | #16 | $455.2万 | 34.0万股 | $216.4万 | 34.0万股 | 00.00% | 持仓不变 |
| Wellington Shields & Co., LLC |
| 0.88% | 0.47% | #10 | $391.9万 | 29.2万股 | $186.3万 | 29.2万股 | 00.00% | 持仓不变 |
| Militia 资本管理Militia Capital Management LLC |
| 0.12% | — | #23 | $391.1万 | 29.2万股 | $0 | 0股 | +29.2万股 | 新买入 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #113 | $374.1万 | 27.9万股 | $143.8万 | 22.6万股 | +5.3万股+23.68% | 加仓 |
| 吉尔德·加尼翁·豪GILDER GAGNON HOWE & CO LLC |
| 0.04% | — | #29 | $373.2万 | 27.8万股 | $0 | 0股 | +27.8万股 | 新买入 |
| 都铎投资TUDOR INVESTMENT CORP ET AL |
| 0.01% | <0.01% | #49 | $367.6万 | 27.4万股 | $133.7万 | 21.0万股 | +6.4万股+30.74% | 加仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #103 | $350.5万 | 26.2万股 | $25.4万 | 4.0万股 | +22.2万股+557.28% | 加仓 |
| PERKINS CAPITAL MANAGEMENT INC |
| 2.53% | 1.43% | #4 | $320.3万 | 23.9万股 | $152.2万 | 23.9万股 | 00.00% | 持仓不变 |
| Bruce & Co., Inc. |
| 0.87% | 0.42% | #11 | $312.2万 | 23.3万股 | $148.4万 | 23.3万股 | 00.00% | 持仓不变 |
| 第一曼哈顿FIRST MANHATTAN CO. LLC. |
| 0.01% | <0.01% | #46 | $309.0万 | 23.1万股 | $146.9万 | 23.1万股 | 00.00% | 持仓不变 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #106 | $280.5万 | 20.9万股 | $92.1万 | 14.5万股 | +6.5万股+44.73% | 加仓 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| <0.01% | <0.01% | #100 | $253.3万 | 18.9万股 | $79.4万 | 12.5万股 | +6.4万股+51.69% | 加仓 |
| 弗雷德·阿尔杰管理FRED ALGER MANAGEMENT, LLC |
| 0.01% | — | #47 | $221.9万 | 16.6万股 | $0 | 0股 | +16.6万股 | 新买入 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #115 | $220.8万 | 16.5万股 | $244.3万 | 38.4万股 | -21.9万股-57.04% | 减仓 |
| 普信集团PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | <0.01% | #121 | $212.8万 | 15.9万股 | $1,051.3万 | 165.0万股 | -149.1万股-90.37% | 减仓 |
| NANO CAP NEW MILLENNIUM GROWTH FUND L P |
| 1.63% | 1.4% | #6 | $211.1万 | 15.8万股 | $149.7万 | 23.5万股 | -7.8万股-32.98% | 减仓 |
| 瑞士央行Swiss National Bank |
| <0.01% | <0.01% | #84 | $182.9万 | 13.7万股 | $67.1万 | 10.5万股 | +3.1万股+29.51% | 加仓 |
