| RA资本管理RA CAPITAL MANAGEMENT, L.P. |
| 0.76% | 0.92% | #7 | $8,699.6万 | 1,086.1万股 | $8,721.4万 | 1,086.1万股 | 00.00% | 持仓不变 |
| Rubric资本管理Rubric Capital Management LP |
| 0.63% | 0.68% | #8 | $6,841.2万 | 854.1万股 | $6,424.0万 | 800.0万股 | +54.1万股+6.76% | 加仓 |
| 奥比梅德顾问ORBIMED ADVISORS LLC |
| 1.25% | 1.32% | #5 | $6,639.1万 | 828.9万股 | $6,655.7万 | 828.9万股 | 00.00% | 持仓不变 |
| Deerfield管理DEERFIELD MANAGEMENT COMPANY, L.P. |
| 0.63% | 0.71% | #9 | $6,010.6万 | 750.4万股 | $6,025.6万 | 750.4万股 | 00.00% | 持仓不变 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #98 | $4,254.4万 | 531.1万股 | $4,024.8万 | 501.2万股 | +29.9万股+5.97% | 加仓 |
| Tyro Capital Management LLC |
| 8.01% | 2.59% | #1 | $3,571.9万 | 445.9万股 | $2,383.8万 | 296.9万股 | +149.1万股+50.22% | 加仓 |
| 安本标准投资Aberdeen Group plc |
| 0.05% | 0.05% | #39 | $3,340.7万 | 417.1万股 | $3,303.2万 | 411.4万股 | +5.7万股+1.39% | 加仓 |
| SR ONE CAPITAL MANAGEMENT, LP |
| 3.09% | 3.52% | #2 | $3,214.3万 | 401.3万股 | $3,222.4万 | 401.3万股 | 00.00% | 持仓不变 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #86 | $2,988.2万 | 373.1万股 | $2,926.9万 | 364.5万股 | +8.6万股+2.35% | 加仓 |
| 资本世界投资者Capital World Investors |
| <0.01% | — | #69 | $2,206.7万 | 275.5万股 | $0 | 0股 | +275.5万股 | 新买入 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #110 | $2,045.4万 | 255.4万股 | $2,041.6万 | 254.3万股 | +1.1万股+0.43% | 加仓 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| 0.01% | 0.02% | #58 | $2,019.3万 | 252.1万股 | $4,804.3万 | 598.3万股 | -346.2万股-57.86% | 减仓 |
| Janney Montgomery Scott LLC |
| 0.03% | 0.04% | #42 | $1,653.7万 | 206.4万股 | $1,619.2万 | 201.6万股 | +4.8万股+2.38% | 加仓 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #72 | $1,553.7万 | 194.0万股 | $1,815.0万 | 226.0万股 | -32.1万股-14.19% | 减仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #92 | $1,361.2万 | 169.9万股 | $1,226.3万 | 152.7万股 | +17.2万股+11.28% | 加仓 |
| 布斯湾基金管理BOOTHBAY FUND MANAGEMENT, LLC |
| 0.17% | 0.03% | #22 | $1,282.8万 | 160.2万股 | $201.2万 | 25.1万股 | +135.1万股+539.08% | 加仓 |
| GENERAL AMERICAN INVESTORS CO INC |
| 0.54% | 0.38% | #11 | $907.6万 | 113.3万股 | $583.9万 | 72.7万股 | +40.6万股+55.82% | 加仓 |
| 第三点对冲基金Third Point LLC |
| 0.17% | 0.39% | #24 | $801.0万 | 100.0万股 | $803.0万 | 100.0万股 | 00.00% | 持仓不变 |
| PEREGRINE 资本管理PEREGRINE CAPITAL MANAGEMENT LLC |
| 0.17% | — | #20 | $538.4万 | 67.2万股 | $0 | 0股 | +67.2万股 | 新买入 |
| Tejara Capital Ltd |
| 2% | 0.56% | #3 | $486.2万 | 60.7万股 | $169.0万 | 21.0万股 | +39.7万股+188.52% | 加仓 |
| ADAR1 Capital Management, LLC |
| 0.22% | 0.64% | #17 | $481.4万 | 60.1万股 | $1,093.3万 | 136.2万股 | -76.1万股-55.86% | 减仓 |
| Pavaki Capital Management LLC |
| 1.62% | — | #4 | $464.3万 | 58.0万股 | $0 | 0股 | +58.0万股 | 新买入 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #138 | $454.0万 | 56.7万股 | $410.0万 | 51.1万股 | +5.6万股+11.02% | 加仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #106 | $453.8万 | 56.7万股 | $1,477.4万 | 184.0万股 | -127.3万股-69.21% | 减仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #100 | $441.7万 | 55.1万股 | $428.3万 | 53.3万股 | +1.8万股+3.38% | 加仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #107 | $439.8万 | 54.9万股 | $425.0万 | 52.9万股 | +2.0万股+3.74% | 加仓 |
| LEVIN CAPITAL STRATEGIES, L.P. |
| 0.29% | 0.34% | #15 | $439.7万 | 54.9万股 | $443.7万 | 55.3万股 | -3,596股-0.65% | 减仓 |
| Empire Life Investments Inc. |
| 0.21% | 0.25% | #18 | $378.0万 | 47.2万股 | $404.8万 | 49.9万股 | -2.7万股-5.47% | 减仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #129 | $371.1万 | 46.3万股 | $229.4万 | 28.6万股 | +17.8万股+62.13% | 加仓 |
| 瑞银资产管理(美洲)UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
| <0.01% | <0.01% | #96 | $369.6万 | 46.1万股 | $373.1万 | 46.5万股 | -3,297股-0.71% | 减仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #88 | $369.3万 | 46.1万股 | $358.4万 | 44.6万股 | +1.5万股+3.29% | 加仓 |
| FIL(富达国际)FIL Ltd |
| <0.01% | <0.01% | #70 | $364.9万 | 45.6万股 | $365.8万 | 45.6万股 | 00.00% | 持仓不变 |
| K2 PRINCIPAL FUND, L.P. |
| 0.36% | 0.43% | #13 | $338.9万 | 42.3万股 | $459.9万 | 57.3万股 | -15.0万股-26.12% | 减仓 |
| 摩根大通JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #143 | $311.0万 | 36.3万股 | $299.2万 | 38.3万股 | -1.9万股-5.09% | 减仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #127 | $305.0万 | 38.1万股 | $581.5万 | 72.4万股 | -34.3万股-47.42% | 减仓 |
| Eversept Partners, LP |
| 0.16% | 0.06% | #28 | $302.0万 | 37.7万股 | $109.4万 | 13.6万股 | +24.1万股+176.73% | 加仓 |
| INVESTMENT MANAGEMENT ASSOCIATES INC /ADV |
| 0.61% | 0.69% | #10 | $299.2万 | 37.3万股 | $288.3万 | 35.9万股 | +1.4万股+4.02% | 加仓 |
| 富达投资FMR LLC |
| <0.01% | <0.01% | #154 | $279.7万 | 34.9万股 | $274.7万 | 34.2万股 | +7,122股+2.08% | 加仓 |
| 雷蒙德詹姆斯金融RAYMOND JAMES FINANCIAL INC |
| <0.01% | <0.01% | #94 | $255.2万 | 31.9万股 | $421.8万 | 52.5万股 | -20.7万股-39.34% | 减仓 |
| Trexquant投资Trexquant Investment LP |
| 0.01% | — | #50 | $229.7万 | 28.7万股 | $0 | 0股 | +28.7万股 | 新买入 |
| 跳跃金融Jump Financial, LLC |
| 0.02% | — | #46 | $204.4万 | 25.5万股 | $0 | 0股 | +25.5万股 | 新买入 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #148 | $186.5万 | 23.3万股 | $205.4万 | 25.6万股 | -2.3万股-8.96% | 减仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #161 | $183.5万 | 22.9万股 | $703.9万 | 70.0万股 | -47.1万股-67.29% | 减仓 |
| FAS Wealth Partners, Inc. |
| 0.09% | 0.1% | #32 | $171.8万 | 21.5万股 | $164.9万 | 20.5万股 | +9,100股+4.43% | 加仓 |
| Hennion & Walsh Asset Management, Inc. |
| 0.04% | — | #41 | $140.7万 | 17.6万股 | $0 | 0股 | +17.6万股 | 新买入 |
| Quinn Opportunity Partners LLC |
| 0.07% | 0.06% | #35 | $140.2万 | 17.5万股 | $124.5万 | 15.5万股 | +2.0万股+12.90% | 加仓 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| <0.01% | <0.01% | #134 | $134.7万 | 16.8万股 | $131.7万 | 16.4万股 | +4,072股+2.48% | 加仓 |
| DAFNA Capital Management LLC |
| 0.25% | 0.25% | #16 | $131.6万 | 16.4万股 | $111.8万 | 13.9万股 | +2.5万股+17.95% | 加仓 |
| 纽文Nuveen, LLC |
| <0.01% | <0.01% | #122 | $129.2万 | 16.1万股 | $121.0万 | 15.1万股 | +1.1万股+7.06% | 加仓 |
| Ishara Investments LP |
| 0.83% | — | #6 | $114.9万 | 14.3万股 | $0 | 0股 | +14.3万股 | 新买入 |
