| 富达投资FMR LLC |
| 0.01% | 0.01% | #62 | $2.27亿 | 656.5万股 | $1.78亿 | 628.4万股 | +28.1万股+4.47% | 加仓 |
| GENERAL ATLANTIC, L.P. |
| 7.79% | 10.56% | #5 | $2.27亿 | 655.1万股 | $2.27亿 | 803.1万股 | -148.0万股-18.43% | 减仓 |
| Foresite Capital Management IV, LLC |
| 56.95% | 56.94% | #1 | $1.65亿 | 477.9万股 | $1.35亿 | 477.9万股 | 00.00% | 持仓不变 |
| venBio Partners LLC |
| 30.92% | 46.71% | #2 | $1.61亿 | 464.3万股 | $1.31亿 | 463.9万股 | +4,126股+0.09% | 加仓 |
| 维京全球投资VIKING GLOBAL INVESTORS LP |
| 0.36% | 0.29% | #33 | $1.26亿 | 365.3万股 | $1.03亿 | 365.3万股 | 00.00% | 持仓不变 |
| EQT Fund Management S.a r.l. |
| 13.73% | 9.48% | #3 | $1.18亿 | 342.5万股 | $9,674.5万 | 342.5万股 | 00.00% | 持仓不变 |
| Deerfield管理DEERFIELD MANAGEMENT COMPANY, L.P. |
| 1.22% | 1.04% | #24 | $1.17亿 | 337.6万股 | $8,831.1万 | 312.6万股 | +25.0万股+8.00% | 加仓 |
| Bain Capital Life Sciences Investors, LLC |
| 5.5% | 6.82% | #8 | $9,251.9万 | 267.6万股 | $7,558.3万 | 267.6万股 | 00.00% | 持仓不变 |
| 惠灵顿管理集团WELLINGTON MANAGEMENT GROUP LLP |
| 0.01% | 0.01% | #60 | $8,274.8万 | 239.3万股 | $5,985.9万 | 211.9万股 | +27.4万股+12.93% | 加仓 |
| 极地资本控股Polar Capital Holdings Plc |
| 0.19% | 0.08% | #37 | $8,044.7万 | 232.6万股 | $2,206.4万 | 78.1万股 | +154.5万股+197.87% | 加仓 |
| Point72资产管理Point72 Asset Management, L.P. |
| 0.06% | 0.04% | #45 | $5,675.3万 | 164.1万股 | $2,844.8万 | 100.7万股 | +63.4万股+62.98% | 加仓 |
| Commodore Capital LP |
| 2.93% | 3.14% | #14 | $4,927.7万 | 142.5万股 | $5,421.1万 | 191.9万股 | -49.4万股-25.74% | 减仓 |
| Novo Holdings A/S |
| 2.82% | 4.01% | #15 | $4,841.2万 | 140.0万股 | $4,943.8万 | 175.0万股 | -35.0万股-20.00% | 减仓 |
| Saturn V Capital Management LP |
| 6.52% | 6.15% | #6 | $4,544.2万 | 131.4万股 | $3,394.0万 | 120.1万股 | +11.3万股+9.38% | 加仓 |
| TCG Crossover 管理TCG Crossover Management, LLC |
| 0.84% | — | #28 | $3,486.5万 | 100.8万股 | $0 | 0股 | +100.8万股 | 新买入 |
| Sofinnova Investments, Inc. |
| 1.58% | 0.88% | #19 | $3,047.5万 | 88.1万股 | $2,311.8万 | 81.8万股 | +6.3万股+7.70% | 加仓 |
| 5AM Venture Management, LLC |
| 9.58% | 6.26% | #4 | $2,758.1万 | 79.8万股 | $2,253.2万 | 79.8万股 | 00.00% | 持仓不变 |
| Seven Fleet Capital Management LP |
| 4.42% | 1.55% | #12 | $2,678.2万 | 77.5万股 | $488.0万 | 17.3万股 | +60.2万股+348.39% | 加仓 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #99 | $2,667.7万 | 77.1万股 | $2,139.1万 | 75.7万股 | +1.4万股+1.88% | 加仓 |
| Cormorant Asset Management, LP |
| 1.32% | 1.42% | #21 | $2,593.5万 | 75.0万股 | $2,825.0万 | 100.0万股 | -25.0万股-25.00% | 减仓 |
| Soleus 资本管理Soleus Capital Management, L.P. |
| 0.87% | 0.8% | #27 | $2,527.5万 | 73.1万股 | $1,983.3万 | 70.2万股 | +2.9万股+4.11% | 加仓 |
| Jones Hill Capital LP |
| 4.98% | 1.01% | #9 | $2,344.1万 | 67.8万股 | $471.8万 | 16.7万股 | +51.1万股+305.88% | 加仓 |
| Patient Square Capital LP |
| 3.6% | 2.47% | #13 | $2,321.0万 | 67.1万股 | $1,392.7万 | 49.3万股 | +17.8万股+36.15% | 加仓 |
| Foresite Capital Management V, LLC |
| 6.34% | 2.02% | #7 | $2,296.6万 | 66.4万股 | $548.4万 | 19.4万股 | +47.0万股+242.12% | 加仓 |
| Kynam Capital Management, LP |
| 1.26% | 1.12% | #23 | $2,288.5万 | 66.2万股 | $1,809.1万 | 64.0万股 | +2.1万股+3.34% | 加仓 |
| Rock Springs Capital Management LP |
| 1.09% | 1.07% | #26 | $2,241.9万 | 64.8万股 | $1,823.6万 | 64.6万股 | +2,800股+0.43% | 加仓 |
| Elmind Capital, LP |
| 4.57% | 3.82% | #11 | $1,818.0万 | 52.6万股 | $1,344.0万 | 47.6万股 | +5.0万股+10.51% | 加仓 |
| Balyasny资产管理BALYASNY ASSET MANAGEMENT L.P. |
| 0.02% | 0.02% | #56 | $1,813.0万 | 52.4万股 | $1,305.9万 | 46.2万股 | +6.2万股+13.42% | 加仓 |
| DV EQUITIES, LLC |
| 2.39% | — | #16 | $1,668.6万 | 48.3万股 | $0 | 0股 | +48.3万股 | 新买入 |
| D.E.肖D. E. Shaw & Co., Inc. |
| 0.01% | 0.01% | #63 | $1,630.1万 | 47.1万股 | $907.3万 | 32.1万股 | +15.0万股+46.78% | 加仓 |
| Octagon Capital Advisors LP |
| 1.42% | 0.52% | #20 | $1,579.3万 | 45.7万股 | $466.1万 | 16.5万股 | +29.2万股+176.80% | 加仓 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #66 | $1,478.0万 | 42.7万股 | $514.0万 | 18.2万股 | +24.5万股+134.91% | 加仓 |
| Alyeska投资集团Alyeska Investment Group, L.P. |
| 0.04% | 0.01% | #48 | $1,406.8万 | 40.7万股 | $353.1万 | 12.5万股 | +28.2万股+225.46% | 加仓 |
| Eversept Partners, LP |
| 0.69% | 0.61% | #29 | $1,336.1万 | 38.6万股 | $1,149.7万 | 40.7万股 | -2.1万股-5.06% | 减仓 |
| 普信集团PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | <0.01% | #77 | $1,238.9万 | 35.8万股 | $1,249.4万 | 44.2万股 | -8.4万股-18.99% | 减仓 |
| Ikarian Capital, LLC |
| 1.13% | 1.12% | #25 | $1,068.0万 | 30.9万股 | $1,375.4万 | 48.7万股 | -17.8万股-36.56% | 减仓 |
| Tetragon Partners GP Ltd |
| 1.61% | 1.22% | #18 | $1,022.3万 | 29.6万股 | $626.1万 | 22.2万股 | +7.4万股+33.40% | 加仓 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #79 | $881.1万 | 25.5万股 | $203.2万 | 7.2万股 | +18.3万股+254.17% | 加仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #81 | $865.8万 | 25.0万股 | $476.4万 | 16.9万股 | +8.2万股+48.48% | 加仓 |
| EcoR1 Capital, LLC |
| 0.4% | — | #32 | $812.6万 | 23.5万股 | $0 | 0股 | +23.5万股 | 新买入 |
| 简街集团JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #90 | $753.7万 | 21.8万股 | $127.7万 | 4.5万股 | +17.3万股+382.22% | 加仓 |
| Two Sigma投资TWO SIGMA INVESTMENTS, LP |
| 0.01% | <0.01% | #65 | $749.1万 | 21.7万股 | $356.2万 | 12.6万股 | +9.1万股+71.83% | 加仓 |
| 奥比梅德顾问ORBIMED ADVISORS LLC |
| 0.13% | 0.12% | #40 | $710.3万 | 20.5万股 | $580.3万 | 20.5万股 | 00.00% | 持仓不变 |
| Walleye资本Walleye Capital LLC |
| 0.02% | — | #55 | $693.0万 | 20.0万股 | $0 | 0股 | +20.0万股 | 新买入 |
| Kalehua Capital Management LLC |
| 4.93% | 3.97% | #10 | $687.4万 | 19.9万股 | $561.5万 | 19.9万股 | 00.00% | 持仓不变 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #105 | $583.1万 | 16.9万股 | $432.1万 | 15.3万股 | +1.6万股+10.26% | 加仓 |
| Cinctive 资本管理Cinctive Capital Management LP |
| 0.21% | — | #36 | $557.1万 | 16.1万股 | $0 | 0股 | +16.1万股 | 新买入 |
| HighVista Strategies LLC |
| 1.27% | 0.76% | #22 | $555.0万 | 16.0万股 | $276.5万 | 9.8万股 | +6.3万股+63.99% | 加仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #96 | $518.6万 | 15.0万股 | $403.8万 | 14.3万股 | +7,049股+4.93% | 加仓 |
| Qube研究科技Qube Research & Technologies Ltd |
| <0.01% | <0.01% | #68 | $483.6万 | 14.0万股 | $201.2万 | 7.1万股 | +6.9万股+96.39% | 加仓 |
