| EQT Fund Management S.a r.l. |
| 8.15% | 11.1% | #4 | $7,028.2万 | 528.8万股 | $1.13亿 | 493.0万股 | +35.9万股+7.28% | 加仓 |
| RA资本管理RA CAPITAL MANAGEMENT, L.P. |
| 0.4% | 0.85% | #9 | $4,644.4万 | 349.5万股 | $8,034.2万 | 349.5万股 | 00.00% | 持仓不变 |
| 普信集团PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | <0.01% | #43 | $2,579.5万 | 194.1万股 | $2,572.7万 | 111.9万股 | +82.2万股+73.45% | 加仓 |
| Pivotal bioVenture Partners Investment Advisor LLC |
| 8.32% | 15.83% | #3 | $2,560.9万 | 192.7万股 | $4,430.0万 | 192.7万股 | 00.00% | 持仓不变 |
| 摩根大通JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #46 | $2,337.5万 | 155.3万股 | $3,210.7万 | 145.9万股 | +9.4万股+6.42% | 加仓 |
| RTW投资RTW INVESTMENTS, LP |
| 0.17% | 0.34% | #14 | $1,996.5万 | 150.2万股 | $3,453.6万 | 150.2万股 | 00.00% | 持仓不变 |
| Nan Fung Group Holdings Ltd |
| 14.56% | 27.32% | #1 | $1,915.1万 | 144.1万股 | $3,312.9万 | 144.1万股 | 00.00% | 持仓不变 |
| Point72资产管理Point72 Asset Management, L.P. |
| 0.02% | <0.01% | #27 | $1,907.2万 | 143.5万股 | $84.1万 | 3.7万股 | +139.8万股+3,823.36% | 加仓 |
| Andera Partners |
| 8.96% | 24.66% | #2 | $1,850.0万 | 139.2万股 | $4,362.0万 | 189.7万股 | -50.5万股-26.64% | 减仓 |
| 暮色资产管理EVENTIDE ASSET MANAGEMENT, LLC |
| 0.21% | 0.46% | #13 | $1,606.9万 | 120.9万股 | $2,779.8万 | 120.9万股 | 00.00% | 持仓不变 |
| Vestal Point 资本Vestal Point Capital, LP |
| 0.31% | — | #11 | $1,329.0万 | 100.0万股 | $0 | 0股 | +100.0万股 | 新买入 |
| 木星资产管理Jupiter Topco LLC |
| <0.01% | — | #37 | $1,191.7万 | 89.7万股 | $0 | 0股 | +89.7万股 | 新买入 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #72 | $1,178.2万 | 88.7万股 | $1,548.5万 | 67.4万股 | +21.3万股+31.62% | 加仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #65 | $1,172.0万 | 88.2万股 | $1,046.2万 | 45.5万股 | +42.7万股+93.80% | 加仓 |
| 贝克兄弟顾问BAKER BROS. ADVISORS LP |
| 0.06% | 0.11% | #18 | $1,126.2万 | 84.7万股 | $1,948.1万 | 84.7万股 | 00.00% | 持仓不变 |
| Defilade Capital Management, L.P. |
| 1.41% | 2.19% | #6 | $1,054.1万 | 79.3万股 | $1,560.1万 | 67.9万股 | +11.5万股+16.88% | 加仓 |
| 美国世纪投资AMERICAN CENTURY COMPANIES INC |
| <0.01% | 0.01% | #39 | $1,003.4万 | 75.5万股 | $1,133.3万 | 49.3万股 | +26.2万股+53.17% | 加仓 |
| Alyeska投资集团Alyeska Investment Group, L.P. |
| 0.02% | 0.05% | #25 | $936.2万 | 70.4万股 | $1,669.9万 | 72.6万股 | -2.2万股-3.02% | 减仓 |
| Balyasny资产管理BALYASNY ASSET MANAGEMENT L.P. |
| 0.01% | — | #31 | $833.3万 | 62.7万股 | $0 | 0股 | +62.7万股 | 新买入 |
| Affinity Asset Advisors, LLC |
| 0.3% | — | #12 | $664.6万 | 50.0万股 | $0 | 0股 | +50.0万股 | 新买入 |
| Velan Capital Investment Management LP |
| 3.65% | 6.43% | #5 | $599.7万 | 45.1万股 | $1,025.9万 | 44.6万股 | +5,000股+1.12% | 加仓 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #52 | $549.6万 | 41.4万股 | $686.0万 | 29.8万股 | +11.5万股+38.60% | 加仓 |
| Federated HermesFEDERATED HERMES, INC. |
| 0.01% | 0.01% | #35 | $431.9万 | 32.5万股 | $747.2万 | 32.5万股 | 00.00% | 持仓不变 |
| GREAT POINT PARTNERS LLC |
| 0.82% | 1.72% | #7 | $431.9万 | 32.5万股 | $747.2万 | 32.5万股 | 00.00% | 持仓不变 |
| Freestone Grove合伙人Freestone Grove Partners LP |
| 0.03% | 0.05% | #24 | $407.1万 | 30.6万股 | $775.4万 | 33.7万股 | -3.1万股-9.18% | 减仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #70 | $401.1万 | 30.2万股 | $571.7万 | 24.9万股 | +5.3万股+21.38% | 加仓 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #78 | $390.1万 | 29.4万股 | $412.7万 | 18.0万股 | +11.4万股+63.51% | 加仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | — | #71 | $385.6万 | 29.0万股 | $0 | 0股 | +29.0万股 | 新买入 |
| 简街集团JANE STREET GROUP, LLC |
| <0.01% | — | #62 | $347.7万 | 26.2万股 | $0 | 0股 | +26.2万股 | 新买入 |
| Caption管理Caption Management, LLC |
| 0.02% | — | #28 | $324.9万 | 24.4万股 | $0 | 0股 | +24.4万股 | 新买入 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #69 | $256.5万 | 19.3万股 | $354.8万 | 15.4万股 | +3.9万股+25.06% | 加仓 |
| Blue Owl Capital Holdings LP |
| 0.35% | 0.62% | #10 | $239.2万 | 18.0万股 | $229.9万 | 10.0万股 | +8.0万股+80.00% | 加仓 |
| 巴克莱BARCLAYS PLC |
| <0.01% | <0.01% | #55 | $237.5万 | 17.9万股 | $4.5万 | 1,978股 | +17.7万股+8,935.89% | 加仓 |
| Eversept Partners, LP |
| 0.12% | 0.07% | #16 | $231.9万 | 17.4万股 | $125.7万 | 5.5万股 | +12.0万股+219.06% | 加仓 |
| 奥比梅德顾问ORBIMED ADVISORS LLC |
| 0.04% | — | #21 | $214.0万 | 16.1万股 | $0 | 0股 | +16.1万股 | 新买入 |
| 法国巴黎银行金融市场BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | <0.01% | #49 | $177.2万 | 13.3万股 | $5.1万 | 2,200股 | +13.1万股+5,961.36% | 加仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #67 | $176.9万 | 13.3万股 | $218.3万 | 9.5万股 | +3.8万股+40.15% | 加仓 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | — | #77 | $167.0万 | 12.6万股 | $0 | 0股 | +12.6万股 | 新买入 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #86 | $159.4万 | 12.0万股 | $140.2万 | 6.1万股 | +5.9万股+96.62% | 加仓 |
| NEXTBio Capital Management LP |
| 0.73% | 1.96% | #8 | $158.2万 | 11.9万股 | $423.2万 | 18.4万股 | -6.5万股-35.31% | 减仓 |
| LMR合伙人LMR Partners LLP |
| 0.01% | — | #36 | $157.4万 | 11.8万股 | $0 | 0股 | +11.8万股 | 新买入 |
| Longaeva 合伙人Longaeva Partners L.P. |
| 0.03% | — | #23 | $155.0万 | 11.7万股 | $0 | 0股 | +11.7万股 | 新买入 |
| Holocene顾问Holocene Advisors, LP |
| <0.01% | — | #41 | $147.7万 | 11.1万股 | $0 | 0股 | +11.1万股 | 新买入 |
| ADAR1 Capital Management, LLC |
| 0.06% | 0.25% | #17 | $138.3万 | 10.4万股 | $423.2万 | 18.4万股 | -8.0万股-43.48% | 减仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #73 | $134.8万 | 10.1万股 | $183.4万 | 8.0万股 | +2.2万股+27.14% | 加仓 |
| SEVEN GRAND MANAGERS, LLC |
| 0.05% | 0.25% | #20 | $120.4万 | 9.1万股 | $378.6万 | 16.5万股 | -7.4万股-45.00% | 减仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #64 | $117.2万 | 8.8万股 | $166.9万 | 7.3万股 | +1.6万股+21.52% | 加仓 |
| 阿默普莱斯金融AMERIPRISE FINANCIAL INC |
| <0.01% | <0.01% | #68 | $115.6万 | 8.7万股 | $210.2万 | 9.1万股 | -4,411股-4.82% | 减仓 |
| Avidity Partners Management LP |
| 0.16% | — | #15 | $99.7万 | 7.5万股 | $0 | 0股 | +7.5万股 | 新买入 |
| 正交资本Quadrature Capital Ltd |
| 0.01% | — | #32 | $92.1万 | 6.9万股 | $0 | 0股 | +6.9万股 | 新买入 |
