| 富达投资FMR LLC |
| 0.01% | 0.01% | #57 | $1.23亿 | 3,271.5万股 | $1.50亿 | 3,195.6万股 | +75.9万股+2.38% | 加仓 |
| Kynam Capital Management, LP |
| 4.5% | 4.35% | #1 | $8,138.7万 | 2,170.3万股 | $7,056.2万 | 1,501.3万股 | +669.0万股+44.56% | 加仓 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #89 | $6,584.9万 | 1,756.0万股 | $2,457.3万 | 522.8万股 | +1,233.2万股+235.86% | 加仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #63 | $5,656.0万 | 1,508.3万股 | $4,795.3万 | 1,020.3万股 | +488.0万股+47.83% | 加仓 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #84 | $4,405.2万 | 1,174.7万股 | $2,661.8万 | 566.3万股 | +608.4万股+107.42% | 加仓 |
| 洞察顾问PERCEPTIVE ADVISORS LLC |
| 0.59% | 0.93% | #10 | $3,914.7万 | 1,043.9万股 | $4,746.4万 | 1,009.9万股 | +34.0万股+3.37% | 加仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #101 | $3,197.0万 | 852.5万股 | $4,104.6万 | 873.3万股 | -20.8万股-2.38% | 减仓 |
| Point72资产管理Point72 Asset Management, L.P. |
| 0.03% | 0.05% | #29 | $2,929.1万 | 781.1万股 | $3,701.4万 | 787.5万股 | -6.4万股-0.82% | 减仓 |
| 惠灵顿管理集团WELLINGTON MANAGEMENT GROUP LLP |
| <0.01% | <0.01% | #64 | $1,938.4万 | 516.9万股 | $1,684.0万 | 358.3万股 | +158.6万股+44.26% | 加仓 |
| Venrock Adviser, LLC |
| 0.57% | 1.75% | #12 | $1,868.3万 | 498.2万股 | $4,691.6万 | 998.2万股 | -500.0万股-50.09% | 减仓 |
| 贝克兄弟顾问BAKER BROS. ADVISORS LP |
| 0.09% | 0.13% | #24 | $1,865.9万 | 497.6万股 | $2,338.6万 | 497.6万股 | 00.00% | 持仓不变 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #91 | $1,754.8万 | 467.9万股 | $971.8万 | 206.7万股 | +261.2万股+126.40% | 加仓 |
| Elmind Capital, LP |
| 4.29% | 6.07% | #2 | $1,706.3万 | 455.0万股 | $2,138.5万 | 455.0万股 | 00.00% | 持仓不变 |
| Nextech Invest Ltd. |
| 0.79% | 1.47% | #5 | $1,668.7万 | 445.0万股 | $2,091.5万 | 445.0万股 | 00.00% | 持仓不变 |
| Two Sigma投资TWO SIGMA INVESTMENTS, LP |
| 0.01% | 0.01% | #43 | $1,549.7万 | 413.3万股 | $1,273.8万 | 271.0万股 | +142.2万股+52.49% | 加仓 |
| Eversept Partners, LP |
| 0.69% | 0.79% | #7 | $1,334.4万 | 355.8万股 | $1,498.6万 | 318.9万股 | +37.0万股+11.60% | 加仓 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #77 | $1,300.6万 | 346.8万股 | $1,466.5万 | 312.0万股 | +34.8万股+11.16% | 加仓 |
| Siren, L.L.C. |
| 0.26% | 0.45% | #17 | $1,296.6万 | 345.8万股 | $1,625.1万 | 345.8万股 | 00.00% | 持仓不变 |
| ADAR1 Capital Management, LLC |
| 0.58% | 0.94% | #11 | $1,261.9万 | 336.5万股 | $1,602.8万 | 341.0万股 | -4.5万股-1.32% | 减仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #81 | $1,248.8万 | 333.0万股 | $2,772.6万 | 589.9万股 | -256.9万股-43.55% | 减仓 |
| 马歇尔·韦斯MARSHALL WACE, LLP |
| 0.01% | 0.02% | #48 | $1,134.1万 | 302.4万股 | $1,944.9万 | 413.8万股 | -111.4万股-26.92% | 减仓 |
| Woodline合伙人Woodline Partners LP |
| 0.02% | 0.04% | #34 | $765.1万 | 204.0万股 | $940.4万 | 200.1万股 | +3.9万股+1.97% | 加仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #103 | $751.4万 | 200.4万股 | $686.1万 | 146.0万股 | +54.4万股+37.25% | 加仓 |
| 维度基金顾问DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #85 | $697.6万 | 186.0万股 | $907.1万 | 193.1万股 | -7.1万股-3.66% | 减仓 |
| Qube研究科技Qube Research & Technologies Ltd |
| 0.01% | 0.01% | #54 | $684.2万 | 182.5万股 | $1,057.3万 | 225.0万股 | -42.5万股-18.89% | 减仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #120 | $656.7万 | 175.1万股 | $373.5万 | 79.5万股 | +95.6万股+120.34% | 加仓 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| <0.01% | 0.01% | #70 | $632.2万 | 168.6万股 | $1,720.3万 | 366.0万股 | -197.4万股-53.94% | 减仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #97 | $628.2万 | 167.5万股 | $287.7万 | 61.2万股 | +106.3万股+173.66% | 加仓 |
| 都铎投资TUDOR INVESTMENT CORP ET AL |
| 0.01% | — | #51 | $536.6万 | 143.1万股 | $0 | 0股 | +143.1万股 | 新买入 |
| Caption管理Caption Management, LLC |
| 0.02% | 0.05% | #33 | $532.5万 | 142.0万股 | $889.8万 | 189.3万股 | -47.3万股-25.00% | 减仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #88 | $475.3万 | 126.7万股 | $518.4万 | 110.3万股 | +16.5万股+14.92% | 加仓 |
| Seven Fleet Capital Management LP |
| 0.67% | 0.55% | #8 | $407.0万 | 108.5万股 | $174.6万 | 37.1万股 | +71.4万股+192.25% | 加仓 |
| SPHERA FUNDS MANAGEMENT LTD. |
| 0.43% | 0.16% | #13 | $329.6万 | 87.9万股 | $103.4万 | 22.0万股 | +65.9万股+299.55% | 加仓 |
| Ally Bridge Group (NY) LLC |
| 2.57% | 3.42% | #3 | $290.6万 | 77.5万股 | $423.0万 | 90.0万股 | -12.5万股-13.89% | 减仓 |
| DV EQUITIES, LLC |
| 0.38% | — | #14 | $267.8万 | 71.4万股 | $0 | 0股 | +71.4万股 | 新买入 |
| 吉尔德·加尼翁·豪GILDER GAGNON HOWE & CO LLC |
| 0.03% | 0.06% | #32 | $264.2万 | 70.4万股 | $526.5万 | 112.0万股 | -41.6万股-37.12% | 减仓 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| <0.01% | <0.01% | #113 | $256.7万 | 68.5万股 | $136.2万 | 29.0万股 | +39.5万股+136.16% | 加仓 |
| DEUTSCHE 银行 AG\DEUTSCHE BANK AG\ |
| <0.01% | <0.01% | #98 | $248.6万 | 66.3万股 | $217.8万 | 46.3万股 | +20.0万股+43.07% | 加仓 |
| 第一信托顾问FIRST TRUST ADVISORS LP |
| <0.01% | <0.01% | #83 | $224.9万 | 60.0万股 | $267.2万 | 56.9万股 | +3.1万股+5.48% | 加仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #124 | $206.2万 | 55.0万股 | $60.5万 | 12.9万股 | +42.1万股+326.93% | 加仓 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #133 | $204.2万 | 54.5万股 | $1,447.6万 | 308.0万股 | -253.5万股-82.32% | 减仓 |
| Ensign Peak顾问Ensign Peak Advisors, Inc |
| <0.01% | 0.01% | #66 | $189.4万 | 50.5万股 | $278.5万 | 59.2万股 | -8.7万股-14.75% | 减仓 |
| 雷蒙德詹姆斯金融RAYMOND JAMES FINANCIAL INC |
| <0.01% | <0.01% | #107 | $181.6万 | 48.4万股 | $178.7万 | 38.0万股 | +10.4万股+27.37% | 加仓 |
| SCHULHOFF & CO INC |
| 0.72% | 0.92% | #6 | $179.1万 | 47.8万股 | $224.4万 | 47.8万股 | 00.00% | 持仓不变 |
| Exome Asset Management LLC |
| 1.06% | 1.27% | #4 | $172.5万 | 46.0万股 | $245.1万 | 52.1万股 | -6.1万股-11.77% | 减仓 |
| 纽文Nuveen, LLC |
| <0.01% | — | #114 | $168.0万 | 44.8万股 | $0 | 0股 | +44.8万股 | 新买入 |
| DAFNA Capital Management LLC |
| 0.31% | 0.25% | #15 | $164.4万 | 43.8万股 | $108.1万 | 23.0万股 | +20.8万股+90.61% | 加仓 |
| Assenagon资产管理Assenagon Asset Management S.A. |
| <0.01% | <0.01% | #75 | $136.6万 | 36.4万股 | $171.2万 | 36.4万股 | 00.00% | 持仓不变 |
| 跳跃金融Jump Financial, LLC |
| 0.01% | <0.01% | #47 | $130.3万 | 34.7万股 | $5.0万 | 1.1万股 | +33.7万股+3,139.46% | 加仓 |
| 瑞士央行Swiss National Bank |
| <0.01% | <0.01% | #104 | $122.0万 | 32.5万股 | $150.2万 | 32.0万股 | +5,800股+1.81% | 加仓 |
