| 木星资产管理Jupiter Topco LLC |
| 0.03% | — | #40 | $7,731.6万 | 1,116.5万股 | $0 | 0股 | +1,116.5万股 | 新买入 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #77 | $5,139.3万 | 742.7万股 | $897.5万 | 129.0万股 | +613.7万股+475.92% | 加仓 |
| Squadron Capital Management LLC |
| 15.78% | 21.61% | #1 | $5,086.2万 | 735.0万股 | $5,898.3万 | 847.5万股 | -112.5万股-13.27% | 减仓 |
| Venrock Adviser, LLC |
| 1.44% | 1.26% | #7 | $4,736.3万 | 684.4万股 | $3,371.0万 | 484.3万股 | +200.1万股+41.31% | 加仓 |
| Spruce Street Capital LP |
| 8.68% | 10.34% | #2 | $4,422.8万 | 639.1万股 | $4,299.8万 | 626.2万股 | +12.9万股+2.06% | 加仓 |
| Adage资本合伙人ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.05% | 0.05% | #37 | $3,296.1万 | 476.3万股 | $3,315.2万 | 476.3万股 | 00.00% | 持仓不变 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #78 | $3,086.5万 | 446.0万股 | $2,141.3万 | 307.7万股 | +138.4万股+44.97% | 加仓 |
| Jones Hill Capital LP |
| 5.38% | 0.51% | #3 | $2,529.3万 | 365.5万股 | $238.6万 | 34.3万股 | +331.2万股+966.39% | 加仓 |
| 奥比梅德顾问ORBIMED ADVISORS LLC |
| 0.47% | 0.65% | #15 | $2,512.8万 | 363.1万股 | $3,282.2万 | 471.6万股 | -108.5万股-23.00% | 减仓 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #83 | $1,742.1万 | 251.8万股 | $248.5万 | 35.7万股 | +216.1万股+605.12% | 加仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #76 | $1,725.3万 | 249.3万股 | $591.0万 | 84.9万股 | +164.4万股+193.70% | 加仓 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| 0.01% | 0.01% | #52 | $1,634.4万 | 236.2万股 | $2,719.5万 | 390.7万股 | -154.5万股-39.55% | 减仓 |
| 马歇尔·韦斯MARSHALL WACE, LLP |
| 0.01% | 0.03% | #46 | $1,554.8万 | 224.7万股 | $3,119.2万 | 448.2万股 | -223.5万股-49.87% | 减仓 |
| Ikarian Capital, LLC |
| 1.58% | 1.52% | #5 | $1,486.7万 | 214.8万股 | $1,871.1万 | 268.8万股 | -54.0万股-20.09% | 减仓 |
| Driehaus资本管理DRIEHAUS CAPITAL MANAGEMENT LLC |
| 0.09% | 0.11% | #31 | $1,475.4万 | 213.2万股 | $1,483.9万 | 213.2万股 | 00.00% | 持仓不变 |
| 阿默普莱斯金融AMERIPRISE FINANCIAL INC |
| <0.01% | <0.01% | #63 | $1,341.1万 | 193.8万股 | $371.1万 | 53.3万股 | +140.5万股+263.42% | 加仓 |
| 暮色资产管理EVENTIDE ASSET MANAGEMENT, LLC |
| 0.17% | 0.1% | #25 | $1,286.0万 | 185.8万股 | $586.1万 | 84.2万股 | +101.6万股+120.69% | 加仓 |
| Balyasny资产管理BALYASNY ASSET MANAGEMENT L.P. |
| 0.01% | <0.01% | #45 | $1,052.3万 | 152.1万股 | $175.7万 | 25.2万股 | +126.8万股+502.36% | 加仓 |
| STEMPOINT CAPITAL LP |
| 1.44% | 0.77% | #6 | $1,010.4万 | 146.0万股 | $415.8万 | 59.7万股 | +86.3万股+144.40% | 加仓 |
| Commodore Capital LP |
| 0.59% | 0.26% | #12 | $986.1万 | 142.5万股 | $441.2万 | 63.4万股 | +79.1万股+124.80% | 加仓 |
| 极地资本控股Polar Capital Holdings Plc |
| 0.02% | 0.03% | #41 | $927.6万 | 134.0万股 | $984.6万 | 141.5万股 | -7.4万股-5.24% | 减仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #75 | $810.1万 | 117.1万股 | $16.9万 | 2.4万股 | +114.6万股+4,717.55% | 加仓 |
| Sio Capital Management, LLC |
| 1.15% | 0.96% | #9 | $694.5万 | 100.4万股 | $671.6万 | 96.5万股 | +3.9万股+4.00% | 加仓 |
| Opaleye Management Inc. |
| 0.59% | 0.86% | #13 | $647.0万 | 93.5万股 | $650.8万 | 93.5万股 | 00.00% | 持仓不变 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | — | #93 | $621.6万 | 89.8万股 | $0 | 0股 | +89.8万股 | 新买入 |
| GREAT POINT PARTNERS LLC |
| 1.1% | 1.35% | #10 | $582.7万 | 84.2万股 | $586.1万 | 84.2万股 | 00.00% | 持仓不变 |
| Soleus 资本管理Soleus Capital Management, L.P. |
| 0.2% | 0.24% | #22 | $582.7万 | 84.2万股 | $586.1万 | 84.2万股 | 00.00% | 持仓不变 |
| Boxer Capital Management, LLC |
| 0.44% | 0.77% | #16 | $582.7万 | 84.2万股 | $586.1万 | 84.2万股 | 00.00% | 持仓不变 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #88 | $561.9万 | 81.2万股 | $87.7万 | 12.6万股 | +68.6万股+544.79% | 加仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #80 | $544.1万 | 78.6万股 | $109.8万 | 15.8万股 | +62.9万股+398.47% | 加仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #84 | $531.2万 | 76.8万股 | $503.4万 | 72.3万股 | +4.4万股+6.12% | 加仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #72 | $508.1万 | 73.4万股 | $313.1万 | 45.0万股 | +28.4万股+63.22% | 加仓 |
| Corient私人财富Corient Private Wealth LLC |
| <0.01% | 0.01% | #60 | $493.3万 | 72.0万股 | $496.2万 | 72.0万股 | 00.00% | 持仓不变 |
| Qube研究科技Qube Research & Technologies Ltd |
| <0.01% | 0.01% | #57 | $478.5万 | 69.2万股 | $454.7万 | 65.3万股 | +3.8万股+5.85% | 加仓 |
| Walleye资本Walleye Capital LLC |
| 0.02% | — | #43 | $426.4万 | 61.6万股 | $0 | 0股 | +61.6万股 | 新买入 |
| 布斯湾基金管理BOOTHBAY FUND MANAGEMENT, LLC |
| 0.05% | 0.07% | #36 | $390.8万 | 56.5万股 | $507.4万 | 72.9万股 | -16.4万股-22.54% | 减仓 |
| ACADIAN ASSET MANAGEMENT LLC |
| <0.01% | 0.01% | #56 | $376.0万 | 54.3万股 | $495.5万 | 71.3万股 | -16.9万股-23.74% | 减仓 |
| Integral Health 资产管理Integral Health Asset Management, LLC |
| 0.14% | 0.15% | #28 | $346.0万 | 50.0万股 | $313.2万 | 45.0万股 | +5.0万股+11.11% | 加仓 |
| ADAR1 Capital Management, LLC |
| 0.14% | 0.19% | #27 | $312.7万 | 45.2万股 | $314.5万 | 45.2万股 | 00.00% | 持仓不变 |
| Knott David M Jr |
| 1.66% | 1.85% | #4 | $312.1万 | 45.1万股 | $305.8万 | 43.9万股 | +1.2万股+2.66% | 加仓 |
| HighVista Strategies LLC |
| 0.7% | — | #11 | $308.5万 | 44.6万股 | $0 | 0股 | +44.6万股 | 新买入 |
| AdvisorShares Investments LLC |
| 0.37% | 0.38% | #18 | $303.7万 | 43.9万股 | $205.9万 | 29.6万股 | +14.3万股+48.34% | 加仓 |
| Birchview Capital, LP |
| 1.28% | 1.62% | #8 | $282.4万 | 40.8万股 | $284.9万 | 40.9万股 | -1,287股-0.31% | 减仓 |
| DIADEMA PARTNERS LP |
| 0.31% | 0.24% | #21 | $250.1万 | 36.1万股 | $139.8万 | 20.1万股 | +16.1万股+79.93% | 加仓 |
| PARSONS CAPITAL MANAGEMENT INC/RI |
| 0.11% | 0.11% | #29 | $245.0万 | 35.4万股 | $245.3万 | 35.3万股 | +1,569股+0.45% | 加仓 |
| Seven Fleet Capital Management LP |
| 0.4% | — | #17 | $241.0万 | 34.8万股 | $0 | 0股 | +34.8万股 | 新买入 |
| Harvest Investment Services, LLC |
| 0.36% | — | #19 | $235.9万 | 34.1万股 | $0 | 0股 | +34.1万股 | 新买入 |
| Woodline合伙人Woodline Partners LP |
| 0.01% | 0.01% | #50 | $227.3万 | 32.8万股 | $293.1万 | 42.1万股 | -9.3万股-22.00% | 减仓 |
| DEUTSCHE 银行 AG\DEUTSCHE BANK AG\ |
| <0.01% | <0.01% | #79 | $220.7万 | 31.9万股 | $156.5万 | 22.5万股 | +9.4万股+41.83% | 加仓 |
| SEVEN GRAND MANAGERS, LLC |
| 0.09% | 0.15% | #30 | $218.5万 | 31.6万股 | $219.8万 | 31.6万股 | 00.00% | 持仓不变 |
