| NEA Management Company, LLC |
| 9.49% | 7.6% | #1 | $1.51亿 | 2,447.1万股 | $1.34亿 | 2,447.1万股 | 00.00% | 持仓不变 |
| Bain Capital Life Sciences Investors, LLC |
| 6.45% | 8.67% | #2 | $1.08亿 | 1,760.1万股 | $9,609.9万 | 1,760.1万股 | 00.00% | 持仓不变 |
| Venrock Adviser, LLC |
| 2.75% | 2.8% | #6 | $9,083.5万 | 1,474.6万股 | $7,502.2万 | 1,374.0万股 | +100.6万股+7.32% | 加仓 |
| Deerfield管理DEERFIELD MANAGEMENT COMPANY, L.P. |
| 0.87% | 0.87% | #12 | $8,358.5万 | 1,356.9万股 | $7,408.7万 | 1,356.9万股 | 00.00% | 持仓不变 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #83 | $7,696.6万 | 1,249.4万股 | $6,165.0万 | 1,129.1万股 | +120.3万股+10.66% | 加仓 |
| TCG Crossover 管理TCG Crossover Management, LLC |
| 1.83% | 1.93% | #8 | $7,615.1万 | 1,236.2万股 | $6,749.8万 | 1,236.2万股 | 00.00% | 持仓不变 |
| Frazier Life Sciences 管理Frazier Life Sciences Management, L.P. |
| 1.3% | 1.37% | #10 | $5,988.0万 | 972.1万股 | $5,307.6万 | 972.1万股 | 00.00% | 持仓不变 |
| 极地资本控股Polar Capital Holdings Plc |
| 0.14% | 0.18% | #31 | $5,877.7万 | 954.2万股 | $5,209.8万 | 954.2万股 | 00.00% | 持仓不变 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #86 | $4,886.4万 | 793.3万股 | $4,250.0万 | 778.4万股 | +14.9万股+1.91% | 加仓 |
| Nantahala 资本管理Nantahala Capital Management, LLC |
| 1.43% | 1.48% | #9 | $4,297.7万 | 697.7万股 | $4,010.3万 | 734.5万股 | -36.8万股-5.01% | 减仓 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #80 | $4,036.9万 | 655.3万股 | $3,662.4万 | 670.8万股 | -15.4万股-2.30% | 减仓 |
| 马歇尔·韦斯MARSHALL WACE, LLP |
| 0.03% | 0.02% | #43 | $3,854.3万 | 625.7万股 | $2,464.8万 | 451.4万股 | +174.3万股+38.60% | 加仓 |
| RTW投资RTW INVESTMENTS, LP |
| 0.31% | 0.32% | #26 | $3,666.7万 | 595.2万股 | $3,250.0万 | 595.2万股 | 00.00% | 持仓不变 |
| Woodline合伙人Woodline Partners LP |
| 0.08% | 0.09% | #38 | $2,615.0万 | 424.5万股 | $2,317.8万 | 424.5万股 | 00.00% | 持仓不变 |
| 奥比梅德顾问ORBIMED ADVISORS LLC |
| 0.46% | 0.07% | #19 | $2,439.3万 | 396.0万股 | $346.7万 | 63.5万股 | +332.5万股+523.61% | 加仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #78 | $2,385.8万 | 387.2万股 | $1,963.0万 | 359.4万股 | +27.8万股+7.72% | 加仓 |
| Spruce Street Capital LP |
| 4.17% | 4.44% | #4 | $2,126.8万 | 345.3万股 | $1,847.2万 | 338.3万股 | +6.9万股+2.05% | 加仓 |
| Rosalind Advisors, Inc. |
| 4.64% | 7.03% | #3 | $1,957.7万 | 317.8万股 | $1,749.2万 | 320.4万股 | -2.6万股-0.80% | 减仓 |
| EMERALD ADVISERS, LLC |
| 0.46% | 0.58% | #20 | $1,939.4万 | 314.8万股 | $1,840.7万 | 337.1万股 | -22.3万股-6.61% | 减仓 |
| 百达资产管理Pictet Asset Management Holding SA |
| 0.02% | 0.01% | #47 | $1,702.0万 | 276.3万股 | $1,242.4万 | 227.5万股 | +48.8万股+21.43% | 加仓 |
| Vestal Point 资本Vestal Point Capital, LP |
| 0.39% | 0.4% | #22 | $1,675.5万 | 272.0万股 | $1,419.6万 | 260.0万股 | +12.0万股+4.61% | 加仓 |
| 惠灵顿管理集团WELLINGTON MANAGEMENT GROUP LLP |
| <0.01% | <0.01% | #66 | $1,660.0万 | 269.5万股 | $1,480.1万 | 271.1万股 | -1.6万股-0.59% | 减仓 |
| D.E.肖D. E. Shaw & Co., Inc. |
| 0.01% | 0.01% | #54 | $1,549.2万 | 251.5万股 | $1,153.1万 | 211.2万股 | +40.3万股+19.09% | 加仓 |
| Affinity Asset Advisors, LLC |
| 0.7% | 0.71% | #14 | $1,547.5万 | 251.2万股 | $1,371.6万 | 251.2万股 | 00.00% | 持仓不变 |
| EMERALD MUTUAL FUND ADVISERS 信托EMERALD MUTUAL FUND ADVISERS TRUST |
| 0.51% | 0.63% | #18 | $1,463.6万 | 237.6万股 | $1,293.3万 | 236.9万股 | +7,330股+0.31% | 加仓 |
| NAN FUNG TRINITY (HK) Ltd |
| 1.12% | 1.1% | #11 | $1,134.9万 | 184.2万股 | $1,005.9万 | 184.2万股 | 00.00% | 持仓不变 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #107 | $1,007.7万 | 163.6万股 | $751.0万 | 137.5万股 | +26.0万股+18.93% | 加仓 |
| ADAR1 Capital Management, LLC |
| 0.4% | 0.47% | #21 | $864.5万 | 140.3万股 | $799.6万 | 146.5万股 | -6.1万股-4.17% | 减仓 |
| SILVERARC CAPITAL MANAGEMENT, LLC |
| 0.87% | 0.8% | #13 | $835.0万 | 135.5万股 | $781.3万 | 143.1万股 | -7.6万股-5.28% | 减仓 |
| Algert全球ALGERT GLOBAL LLC |
| 0.1% | 0.07% | #36 | $818.8万 | 132.9万股 | $472.1万 | 86.5万股 | +46.5万股+53.74% | 加仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #89 | $802.6万 | 130.3万股 | $649.7万 | 119.0万股 | +11.3万股+9.49% | 加仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #88 | $721.2万 | 117.1万股 | $622.6万 | 114.0万股 | +3.1万股+2.68% | 加仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #76 | $641.3万 | 104.1万股 | $548.6万 | 100.5万股 | +3.6万股+3.61% | 加仓 |
| Longaeva 合伙人Longaeva Partners L.P. |
| 0.14% | 0.26% | #32 | $625.8万 | 101.6万股 | $696.2万 | 127.5万股 | -25.9万股-20.32% | 减仓 |
| 法国巴黎银行资产管理BNP Paribas Asset Management Holding S.A. |
| 0.01% | — | #55 | $622.0万 | 101.0万股 | $0 | 0股 | +101.0万股 | 新买入 |
| SUPERSTRING CAPITAL MANAGEMENT LP |
| 3.8% | 6.19% | #5 | $602.1万 | 97.7万股 | $865.9万 | 158.6万股 | -60.9万股-38.37% | 减仓 |
| DEUTSCHE 银行 AG\DEUTSCHE BANK AG\ |
| <0.01% | <0.01% | #75 | $532.8万 | 86.5万股 | $463.2万 | 84.8万股 | +1.7万股+1.95% | 加仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #108 | $510.9万 | 82.9万股 | $316.7万 | 58.0万股 | +24.9万股+42.98% | 加仓 |
| SPHERA FUNDS MANAGEMENT LTD. |
| 0.61% | 0.64% | #16 | $465.8万 | 75.6万股 | $403.6万 | 73.9万股 | +1.7万股+2.30% | 加仓 |
| 瑞典银行Swedbank AB |
| <0.01% | <0.01% | #59 | $441.0万 | 71.6万股 | $382.2万 | 70.0万股 | +1.6万股+2.27% | 加仓 |
| Voya投资管理VOYA INVESTMENT MANAGEMENT LLC |
| <0.01% | <0.01% | #60 | $426.4万 | 69.2万股 | $413.2万 | 75.7万股 | -6.5万股-8.53% | 减仓 |
| F/m Investments LLC |
| 0.21% | 0.24% | #28 | $405.5万 | 65.8万股 | $355.5万 | 65.1万股 | +7,330股+1.13% | 加仓 |
| Sio Capital Management, LLC |
| 0.63% | 0.48% | #15 | $380.5万 | 61.8万股 | $335.2万 | 61.4万股 | +3,787股+0.62% | 加仓 |
| KVP Capital Advisors, LP |
| 2.74% | 2.47% | #7 | $372.9万 | 60.5万股 | $330.5万 | 60.5万股 | 00.00% | 持仓不变 |
| Integral Health 资产管理Integral Health Asset Management, LLC |
| 0.15% | 0.16% | #30 | $369.6万 | 60.0万股 | $327.6万 | 60.0万股 | 00.00% | 持仓不变 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #129 | $320.5万 | 52.0万股 | $321.2万 | 58.8万股 | -6.8万股-11.53% | 减仓 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #111 | $316.0万 | 51.3万股 | $325.8万 | 59.7万股 | -8.4万股-14.02% | 减仓 |
| MOODY ALDRICH PARTNERS LLC |
| 0.53% | 0.6% | #17 | $297.4万 | 48.3万股 | $335.4万 | 61.4万股 | -13.1万股-21.40% | 减仓 |
| 木星资产管理Jupiter Topco LLC |
| <0.01% | — | #81 | $287.5万 | 46.7万股 | $0 | 0股 | +46.7万股 | 新买入 |
| Y截距(香港)Y-Intercept (Hong Kong) Ltd |
| 0.05% | — | #40 | $252.9万 | 41.1万股 | $0 | 0股 | +41.1万股 | 新买入 |
