| Nextech Invest Ltd. |
| 3.7% | 6.39% | #4 | $7,757.1万 | 716.3万股 | $9,075.1万 | 716.3万股 | 00.00% | 持仓不变 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #93 | $7,390.4万 | 682.4万股 | $7,582.4万 | 598.5万股 | +83.9万股+14.03% | 加仓 |
| EcoR1 Capital, LLC |
| 3.54% | 3.62% | #5 | $7,286.5万 | 672.8万股 | $8,524.5万 | 672.8万股 | 00.00% | 持仓不变 |
| 普信集团PRICE T ROWE ASSOCIATES INC /MD/ |
| 0.01% | 0.01% | #60 | $7,166.8万 | 661.8万股 | $6,826.4万 | 538.8万股 | +123.0万股+22.83% | 加仓 |
| 维京全球投资VIKING GLOBAL INVESTORS LP |
| 0.16% | 0.21% | #30 | $5,552.3万 | 512.7万股 | $7,379.7万 | 582.5万股 | -69.8万股-11.98% | 减仓 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #86 | $5,300.2万 | 489.4万股 | $4,690.7万 | 370.2万股 | +119.2万股+32.19% | 加仓 |
| SR ONE CAPITAL MANAGEMENT, LP |
| 4.81% | 6.39% | #3 | $4,998.5万 | 461.5万股 | $5,847.7万 | 451.5万股 | +10.0万股+2.22% | 加仓 |
| Venrock Adviser, LLC |
| 1.42% | 2.04% | #15 | $4,678.3万 | 432.0万股 | $5,473.1万 | 432.0万股 | 00.00% | 持仓不变 |
| NEA Management Company, LLC |
| 2.81% | 2.97% | #7 | $4,460.5万 | 411.9万股 | $5,218.3万 | 411.9万股 | 00.00% | 持仓不变 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #98 | $4,279.1万 | 395.1万股 | $4,671.4万 | 368.7万股 | +26.4万股+7.16% | 加仓 |
| AIHC Capital Management Ltd |
| 39.77% | 26.04% | #2 | $4,146.2万 | 382.8万股 | $3,116.3万 | 246.0万股 | +136.9万股+55.66% | 加仓 |
| Alkeon资本管理ALKEON CAPITAL MANAGEMENT LLC |
| 0.05% | 0.1% | #41 | $4,049.4万 | 373.9万股 | $5,706.7万 | 450.4万股 | -76.5万股-16.98% | 减仓 |
| Column Group LLC |
| 43.53% | 44.55% | #1 | $3,834.7万 | 354.1万股 | $4,486.2万 | 354.1万股 | 00.00% | 持仓不变 |
| Siren, L.L.C. |
| 0.66% | 1.05% | #21 | $3,247.0万 | 299.8万股 | $3,798.7万 | 299.8万股 | 00.00% | 持仓不变 |
| 富达投资FMR LLC |
| <0.01% | <0.01% | #91 | $2,854.2万 | 263.5万股 | $3,084.0万 | 243.4万股 | +20.1万股+8.27% | 加仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #68 | $2,838.9万 | 262.1万股 | $3,082.3万 | 243.3万股 | +18.9万股+7.75% | 加仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #75 | $2,655.3万 | 245.2万股 | $1,869.7万 | 147.6万股 | +97.6万股+66.14% | 加仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #92 | $2,264.0万 | 209.0万股 | $2,330.2万 | 183.9万股 | +25.1万股+13.67% | 加仓 |
| First Turn Management, LLC |
| 2.34% | 2.86% | #10 | $2,184.7万 | 201.7万股 | $2,555.9万 | 201.7万股 | 00.00% | 持仓不变 |
| 奥比梅德顾问ORBIMED ADVISORS LLC |
| 0.41% | 0.68% | #24 | $2,182.2万 | 201.5万股 | $3,413.2万 | 269.4万股 | -67.9万股-25.20% | 减仓 |
| Integral Health 资产管理Integral Health Asset Management, LLC |
| 0.81% | 0.85% | #20 | $2,057.7万 | 190.0万股 | $1,773.8万 | 140.0万股 | +50.0万股+35.71% | 加仓 |
| MPM BioImpact LLC |
| 1.24% | 1.77% | #16 | $2,038.4万 | 188.2万股 | $2,285.6万 | 180.4万股 | +7.8万股+4.34% | 加仓 |
| Vivo Capital, LLC |
| 1.83% | 1.95% | #12 | $2,002.2万 | 184.9万股 | $2,342.4万 | 184.9万股 | 00.00% | 持仓不变 |
| 维度基金顾问DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #66 | $1,950.3万 | 180.1万股 | $1,863.7万 | 147.1万股 | +33.0万股+22.44% | 加仓 |
| 富兰克林资源FRANKLIN RESOURCES INC |
| <0.01% | <0.01% | #64 | $1,946.6万 | 179.7万股 | $1,840.7万 | 145.3万股 | +34.5万股+23.72% | 加仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #95 | $1,942.9万 | 179.4万股 | $894.6万 | 74.6万股 | +104.8万股+140.64% | 加仓 |
| D.E.肖D. E. Shaw & Co., Inc. |
| 0.01% | <0.01% | #58 | $1,711.4万 | 158.0万股 | $56.2万 | 4.4万股 | +153.6万股+3,459.85% | 加仓 |
| Woodline合伙人Woodline Partners LP |
| 0.04% | 0.06% | #43 | $1,351.1万 | 124.8万股 | $1,580.6万 | 124.8万股 | 00.00% | 持仓不变 |
| Algert全球ALGERT GLOBAL LLC |
| 0.16% | 0.03% | #31 | $1,316.2万 | 121.5万股 | $172.8万 | 13.6万股 | +107.9万股+791.30% | 加仓 |
| BRAIDWELL LP |
| 0.49% | 0.48% | #23 | $1,315.3万 | 121.5万股 | $1,429.2万 | 112.8万股 | +8.7万股+7.67% | 加仓 |
| 康得利安资管Candriam S.C.A. |
| 0.06% | — | #40 | $1,276.5万 | 118.0万股 | $0 | 0股 | +118.0万股 | 新买入 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #105 | $1,167.5万 | 107.8万股 | $1,321.7万 | 104.3万股 | +3.5万股+3.35% | 加仓 |
| Adage资本合伙人ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.02% | 0.01% | #48 | $1,139.2万 | 105.2万股 | $436.2万 | 34.4万股 | +70.8万股+205.51% | 加仓 |
| Defilade Capital Management, L.P. |
| 1.52% | 1.5% | #14 | $1,134.6万 | 104.8万股 | $1,068.0万 | 84.3万股 | +20.5万股+24.29% | 加仓 |
| Euclidean Capital LLC |
| 2.44% | 3.2% | #9 | $1,071.5万 | 98.9万股 | $1,253.6万 | 98.9万股 | 00.00% | 持仓不变 |
| Royce联营ROYCE & ASSOCIATES LP |
| 0.09% | 0.15% | #37 | $1,061.0万 | 98.0万股 | $1,529.6万 | 120.7万股 | -22.8万股-18.85% | 减仓 |
| 暮色资产管理EVENTIDE ASSET MANAGEMENT, LLC |
| 0.14% | 0.2% | #32 | $1,033.8万 | 95.5万股 | $1,207.9万 | 95.3万股 | +1,317股+0.14% | 加仓 |
| SPHERA FUNDS MANAGEMENT LTD. |
| 1.21% | 1.08% | #17 | $923.8万 | 85.3万股 | $681.2万 | 53.8万股 | +31.5万股+58.66% | 加仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #96 | $873.2万 | 80.6万股 | $900.7万 | 71.1万股 | +9.5万股+13.43% | 加仓 |
| Qube研究科技Qube Research & Technologies Ltd |
| 0.01% | 0.01% | #59 | $860.5万 | 79.5万股 | $1,089.0万 | 85.9万股 | -6.5万股-7.56% | 减仓 |
| Jones Hill Capital LP |
| 1.72% | — | #13 | $809.3万 | 74.7万股 | $0 | 0股 | +74.7万股 | 新买入 |
| SILVERARC CAPITAL MANAGEMENT, LLC |
| 0.83% | 1.42% | #19 | $800.2万 | 73.9万股 | $1,393.7万 | 110.0万股 | -36.1万股-32.83% | 减仓 |
| NEXTBio Capital Management LP |
| 3.52% | 3.08% | #6 | $764.7万 | 70.6万股 | $663.4万 | 52.4万股 | +18.3万股+34.85% | 加仓 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #72 | $755.6万 | 69.8万股 | $43.1万 | 3.4万股 | +66.4万股+1,951.32% | 加仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #97 | $734.1万 | 67.8万股 | $766.6万 | 60.5万股 | +7.3万股+12.03% | 加仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #126 | $680.9万 | 62.9万股 | $723.1万 | 57.1万股 | +5.8万股+10.16% | 加仓 |
| Two Sigma投资TWO SIGMA INVESTMENTS, LP |
| <0.01% | — | #62 | $653.8万 | 60.4万股 | $0 | 0股 | +60.4万股 | 新买入 |
| ArrowMark Colorado Holdings LLC |
| 0.26% | 0.32% | #27 | $631.3万 | 58.3万股 | $1,217.0万 | 96.1万股 | -37.8万股-39.32% | 减仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #90 | $613.0万 | 56.6万股 | $642.7万 | 50.7万股 | +5.9万股+11.58% | 加仓 |
| Connor Clark & Lunn投资管理Connor, Clark & Lunn Investment Management Ltd. |
| 0.01% | 0.02% | #55 | $561.5万 | 51.8万股 | $661.5万 | 52.2万股 | -3,601股-0.69% | 减仓 |
