| 普信投资管理T. Rowe Price Investment Management, Inc. |
| 0.15% | 0.15% | #16 | $2.27亿 | 2,236.5万股 | $2.13亿 | 2,165.2万股 | +71.3万股+3.29% | 加仓 |
| RTW投资RTW INVESTMENTS, LP |
| 1.12% | 1.26% | #6 | $1.31亿 | 1,294.6万股 | $1.27亿 | 1,286.9万股 | +7.7万股+0.60% | 加仓 |
| 蒙塔诺瓦资本MONTANOVA CAPITAL, LLC |
| 2.07% | 2.81% | #1 | $1.13亿 | 1,119.0万股 | $1.10亿 | 1,119.0万股 | 00.00% | 持仓不变 |
| 洞察顾问PERCEPTIVE ADVISORS LLC |
| 1.58% | 2% | #4 | $1.05亿 | 1,038.3万股 | $1.02亿 | 1,038.3万股 | 00.00% | 持仓不变 |
| 贝克兄弟顾问BAKER BROS. ADVISORS LP |
| 0.48% | 0.62% | #9 | $9,632.2万 | 950.9万股 | $1.07亿 | 1,091.7万股 | -140.8万股-12.90% | 减仓 |
| 杰富瑞金融集团Jefferies Financial Group Inc. |
| 0.43% | 0.34% | #10 | $6,591.4万 | 650.7万股 | $4,978.6万 | 506.0万股 | +144.7万股+28.60% | 加仓 |
| Vestal Point 资本Vestal Point Capital, LP |
| 1.46% | 1.7% | #5 | $6,255.3万 | 617.5万股 | $6,076.2万 | 617.5万股 | 00.00% | 持仓不变 |
| Sofinnova Investments, Inc. |
| 1.92% | 1.36% | #2 | $3,717.0万 | 366.9万股 | $3,572.4万 | 363.0万股 | +3.9万股+1.07% | 加仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #50 | $2,214.9万 | 218.6万股 | $1,878.9万 | 220.5万股 | -1.9万股-0.85% | 减仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #47 | $1,853.0万 | 182.9万股 | $1,844.6万 | 187.5万股 | -4.5万股-2.42% | 减仓 |
| 惠灵顿管理集团WELLINGTON MANAGEMENT GROUP LLP |
| <0.01% | <0.01% | #44 | $1,669.3万 | 164.8万股 | $1,536.9万 | 156.2万股 | +8.6万股+5.50% | 加仓 |
| Point72资产管理Point72 Asset Management, L.P. |
| 0.02% | 0.02% | #27 | $1,468.4万 | 145.0万股 | $1,469.9万 | 149.4万股 | -4.4万股-2.96% | 减仓 |
| Woodline合伙人Woodline Partners LP |
| 0.03% | 0.04% | #26 | $912.4万 | 90.1万股 | $984.6万 | 100.1万股 | -10.0万股-9.98% | 减仓 |
| SPHERA FUNDS MANAGEMENT LTD. |
| 0.95% | 1.09% | #7 | $729.4万 | 72.0万股 | $685.0万 | 69.6万股 | +2.4万股+3.44% | 加仓 |
| UNIVERSITY OF TEXAS/TEXAS AM INVESTMENT MANAGEMENT CO |
| 0.82% | 1% | #8 | $706.5万 | 69.7万股 | $686.3万 | 69.7万股 | 00.00% | 持仓不变 |
| 安本标准投资Aberdeen Group plc |
| 0.01% | 0.01% | #29 | $662.1万 | 65.4万股 | $807.6万 | 82.1万股 | -16.7万股-20.36% | 减仓 |
| Qube研究科技Qube Research & Technologies Ltd |
| <0.01% | <0.01% | #35 | $530.0万 | 52.3万股 | $360.9万 | 36.7万股 | +15.6万股+42.65% | 加仓 |
| Boxer Capital Management, LLC |
| 0.36% | — | #11 | $481.2万 | 47.5万股 | $0 | 0股 | +47.5万股 | 新买入 |
| 道明资产管理TD ASSET MANAGEMENT INC |
| <0.01% | <0.01% | #39 | $455.2万 | 44.9万股 | $462.9万 | 47.0万股 | -2.1万股-4.48% | 减仓 |
| Wasatch顾问WASATCH ADVISORS LP |
| 0.03% | 0.03% | #24 | $447.2万 | 44.2万股 | $457.4万 | 46.5万股 | -2.3万股-5.02% | 减仓 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #64 | $425.2万 | 42.0万股 | $449.7万 | 45.7万股 | -3.7万股-8.16% | 减仓 |
| 普信集团PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | <0.01% | #56 | $416.1万 | 41.1万股 | $641.8万 | 65.2万股 | -24.1万股-37.02% | 减仓 |
| Balyasny资产管理BALYASNY ASSET MANAGEMENT L.P. |
| 0.01% | 0.01% | #34 | $406.9万 | 40.2万股 | $967.1万 | 98.3万股 | -58.1万股-59.14% | 减仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #58 | $389.2万 | 38.4万股 | $212.5万 | 21.6万股 | +16.8万股+77.88% | 加仓 |
| SECTORAL ASSET MANAGEMENT INC |
| 1.59% | 0.57% | #3 | $227.9万 | 22.5万股 | $69.3万 | 6.7万股 | +15.8万股+236.57% | 加仓 |
| Atom Investors LP |
| 0.19% | 0.18% | #14 | $219.2万 | 21.6万股 | $250.1万 | 25.4万股 | -3.8万股-14.86% | 减仓 |
| 摩尔资本管理MOORE CAPITAL MANAGEMENT, LP |
| 0.03% | — | #25 | $195.3万 | 19.3万股 | $0 | 0股 | +19.3万股 | 新买入 |
| 施罗德投资管理SCHRODER INVESTMENT MANAGEMENT GROUP |
| <0.01% | <0.01% | #48 | $188.6万 | 19.7万股 | $374.2万 | 40.2万股 | -20.5万股-50.96% | 减仓 |
| Tidal投资Tidal Investments LLC |
| <0.01% | <0.01% | #43 | $173.7万 | 17.1万股 | $167.7万 | 17.0万股 | +1,110股+0.65% | 加仓 |
| Burkehill Global 管理Burkehill Global Management, LP |
| 0.05% | 0.07% | #20 | $152.0万 | 15.0万股 | $147.6万 | 15.0万股 | 00.00% | 持仓不变 |
| SummitTX 资本SummitTX Capital, L.P. |
| 0.04% | 0.05% | #23 | $148.3万 | 14.6万股 | $148.7万 | 15.1万股 | -4,761股-3.15% | 减仓 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #54 | $146.9万 | 14.5万股 | $212.3万 | 21.6万股 | -7.1万股-32.78% | 减仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #68 | $143.2万 | 14.1万股 | $132.1万 | 13.4万股 | +7,123股+5.30% | 加仓 |
| ALPS顾问ALPS ADVISORS INC |
| 0.01% | 0.01% | #32 | $137.4万 | 13.6万股 | $107.4万 | 10.9万股 | +2.6万股+24.25% | 加仓 |
| 摩根大通JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #69 | $131.0万 | 13.7万股 | $130.6万 | 14.0万股 | -3,391股-2.41% | 减仓 |
| MYDA Advisors LLC |
| 0.18% | 0.19% | #15 | $121.6万 | 12.0万股 | $118.1万 | 12.0万股 | 00.00% | 持仓不变 |
| DAFNA Capital Management LLC |
| 0.23% | 0.51% | #12 | $118.5万 | 11.7万股 | $222.2万 | 22.6万股 | -10.9万股-48.22% | 减仓 |
| 跳跃金融Jump Financial, LLC |
| 0.01% | 0.01% | #30 | $107.4万 | 10.6万股 | $47.6万 | 4.8万股 | +5.8万股+119.38% | 加仓 |
| 简街集团JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #66 | $105.9万 | 10.5万股 | $18.6万 | 1.9万股 | +8.6万股+451.91% | 加仓 |
| SG Americas Securities, LLC |
| <0.01% | <0.01% | #55 | $88.4万 | 8.7万股 | $97.8万 | 9.9万股 | -1.2万股-12.23% | 减仓 |
| 花旗集团CITIGROUP INC |
| <0.01% | <0.01% | #60 | $67.8万 | 6.7万股 | $59.9万 | 6.1万股 | +6,019股+9.88% | 加仓 |
| 都铎投资TUDOR INVESTMENT CORP ET AL |
| <0.01% | <0.01% | #52 | $67.3万 | 6.6万股 | $66.0万 | 6.7万股 | -614股-0.92% | 减仓 |
| D.E.肖D. E. Shaw & Co., Inc. |
| <0.01% | — | #59 | $59.9万 | 5.9万股 | $0 | 0股 | +5.9万股 | 新买入 |
| 麦格理集团MACQUARIE GROUP LTD |
| <0.01% | — | #45 | $54.2万 | 5.4万股 | $0 | 0股 | +5.4万股 | 新买入 |
| 工程师之门Engineers Gate Manager LP |
| 0.01% | <0.01% | #31 | $51.5万 | 5.1万股 | $39.6万 | 4.0万股 | +1.1万股+26.43% | 加仓 |
| 先锋领航个性化指数管理Vanguard Personalized Indexing Management, LLC |
| <0.01% | <0.01% | #38 | $50.0万 | 4.9万股 | $44.2万 | 4.5万股 | +4,475股+9.97% | 加仓 |
| Ikarian Capital, LLC |
| 0.05% | 0.04% | #21 | $49.2万 | 4.9万股 | $47.8万 | 4.9万股 | 00.00% | 持仓不变 |
| 巴克莱BARCLAYS PLC |
| <0.01% | <0.01% | #65 | $46.9万 | 4.6万股 | $63.6万 | 6.5万股 | -1.8万股-28.44% | 减仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #75 | $44.2万 | 4.4万股 | $25.0万 | 2.5万股 | +1.8万股+71.92% | 加仓 |
| 法国巴黎银行金融市场BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | <0.01% | #61 | $43.9万 | 4.3万股 | $102.4万 | 10.4万股 | -6.1万股-58.38% | 减仓 |
