| EcoR1 Capital, LLC |
| 3.11% | — | #3 | $6,387.1万 | 317.5万股 | $0 | 0股 | +317.5万股 | 新买入 |
| TCG Crossover 管理TCG Crossover Management, LLC |
| 1.4% | — | #8 | $5,825.4万 | 289.5万股 | $0 | 0股 | +289.5万股 | 新买入 |
| 富达投资FMR LLC |
| <0.01% | — | #49 | $4,132.9万 | 205.4万股 | $0 | 0股 | +205.4万股 | 新买入 |
| Affinity Asset Advisors, LLC |
| 1.85% | — | #5 | $4,088.4万 | 203.2万股 | $0 | 0股 | +203.2万股 | 新买入 |
| 贝莱德BlackRock, Inc. |
| <0.01% | — | #72 | $3,950.6万 | 196.4万股 | $0 | 0股 | +196.4万股 | 新买入 |
| Trails Edge Capital Partners, LP |
| 4.84% | — | #2 | $3,046.2万 | 151.4万股 | $0 | 0股 | +151.4万股 | 新买入 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | — | #71 | $2,921.2万 | 145.2万股 | $0 | 0股 | +145.2万股 | 新买入 |
| 木星资产管理Jupiter Topco LLC |
| 0.01% | — | #35 | $2,196.0万 | 109.1万股 | $0 | 0股 | +109.1万股 | 新买入 |
| Vestal Point 资本Vestal Point Capital, LP |
| 0.48% | — | #12 | $2,038.2万 | 101.3万股 | $0 | 0股 | +101.3万股 | 新买入 |
| Woodline合伙人Woodline Partners LP |
| 0.06% | — | #23 | $1,845.4万 | 91.7万股 | $0 | 0股 | +91.7万股 | 新买入 |
| Sanofi |
| 3.1% | — | #4 | $1,653.7万 | 82.2万股 | $0 | 0股 | +82.2万股 | 新买入 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | — | #64 | $1,572.4万 | 78.2万股 | $0 | 0股 | +78.2万股 | 新买入 |
| 683 Capital Management, LLC |
| 0.74% | — | #9 | $1,509.0万 | 75.0万股 | $0 | 0股 | +75.0万股 | 新买入 |
| Adage资本合伙人ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.02% | — | #27 | $1,466.7万 | 72.9万股 | $0 | 0股 | +72.9万股 | 新买入 |
| Balyasny资产管理BALYASNY ASSET MANAGEMENT L.P. |
| 0.02% | — | #29 | $1,438.5万 | 71.5万股 | $0 | 0股 | +71.5万股 | 新买入 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | — | #68 | $1,412.9万 | 70.2万股 | $0 | 0股 | +70.2万股 | 新买入 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | — | #63 | $1,303.7万 | 64.8万股 | $0 | 0股 | +64.8万股 | 新买入 |
| STEMPOINT CAPITAL LP |
| 1.78% | — | #6 | $1,252.9万 | 62.3万股 | $0 | 0股 | +62.3万股 | 新买入 |
| Palo Alto Investors LP |
| 1.77% | — | #7 | $1,214.2万 | 60.3万股 | $0 | 0股 | +60.3万股 | 新买入 |
| Sofinnova Investments, Inc. |
| 0.59% | — | #10 | $1,137.2万 | 56.5万股 | $0 | 0股 | +56.5万股 | 新买入 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | — | #75 | $1,100.5万 | 54.7万股 | $0 | 0股 | +54.7万股 | 新买入 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | — | #61 | $980.3万 | 48.7万股 | $0 | 0股 | +48.7万股 | 新买入 |
| Point72资产管理Point72 Asset Management, L.P. |
| 0.01% | — | #34 | $821.6万 | 40.8万股 | $0 | 0股 | +40.8万股 | 新买入 |
| 瑞银集团UBS Group AG |
| <0.01% | — | #66 | $625.5万 | 31.1万股 | $0 | 0股 | +31.1万股 | 新买入 |
| 箭街资本ARROWSTREET CAPITAL, LIMITED PARTNERSHIP |
| <0.01% | — | #46 | $602.6万 | 30.0万股 | $0 | 0股 | +30.0万股 | 新买入 |
| Federated HermesFEDERATED HERMES, INC. |
| 0.01% | — | #36 | $583.5万 | 29.0万股 | $0 | 0股 | +29.0万股 | 新买入 |
| Ally Bridge Group (NY) LLC |
| 5.06% | — | #1 | $572.0万 | 28.4万股 | $0 | 0股 | +28.4万股 | 新买入 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | — | #69 | $516.8万 | 25.7万股 | $0 | 0股 | +25.7万股 | 新买入 |
| Nantahala 资本管理Nantahala Capital Management, LLC |
| 0.17% | — | #17 | $503.0万 | 25.0万股 | $0 | 0股 | +25.0万股 | 新买入 |
| Granahan 投资管理Granahan Investment Management, LLC |
| 0.17% | — | #16 | $479.5万 | 23.8万股 | $0 | 0股 | +23.8万股 | 新买入 |
| APIS CAPITAL ADVISORS, LLC |
| 0.44% | — | #13 | $454.7万 | 22.6万股 | $0 | 0股 | +22.6万股 | 新买入 |
| 弗雷德·阿尔杰管理FRED ALGER MANAGEMENT, LLC |
| 0.01% | — | #30 | $439.4万 | 21.8万股 | $0 | 0股 | +21.8万股 | 新买入 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | — | #78 | $404.6万 | 20.1万股 | $0 | 0股 | +20.1万股 | 新买入 |
| 阿默普莱斯金融AMERIPRISE FINANCIAL INC |
| <0.01% | — | #67 | $388.7万 | 19.3万股 | $0 | 0股 | +19.3万股 | 新买入 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | — | #62 | $384.7万 | 19.1万股 | $0 | 0股 | +19.1万股 | 新买入 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | — | #81 | $339.6万 | 16.9万股 | $0 | 0股 | +16.9万股 | 新买入 |
| Connor Clark & Lunn投资管理Connor, Clark & Lunn Investment Management Ltd. |
| 0.01% | — | #40 | $331.6万 | 16.5万股 | $0 | 0股 | +16.5万股 | 新买入 |
| 马歇尔·韦斯MARSHALL WACE, LLP |
| <0.01% | — | #47 | $329.7万 | 16.4万股 | $0 | 0股 | +16.4万股 | 新买入 |
| D.E.肖D. E. Shaw & Co., Inc. |
| <0.01% | — | #54 | $257.8万 | 12.8万股 | $0 | 0股 | +12.8万股 | 新买入 |
| 洛克菲勒资本管理Rockefeller Capital Management L.P. |
| <0.01% | — | #42 | $235.3万 | 11.7万股 | $0 | 0股 | +11.7万股 | 新买入 |
| Ensign Peak顾问Ensign Peak Advisors, Inc |
| <0.01% | — | #41 | $233.3万 | 11.6万股 | $0 | 0股 | +11.6万股 | 新买入 |
| Jain GlobalJain Global LLC |
| 0.01% | — | #37 | $199.1万 | 9.9万股 | $0 | 0股 | +9.9万股 | 新买入 |
| 野村资产管理国际NOMURA ASSET MANAGEMENT INTERNATIONAL INC. |
| <0.01% | — | #44 | $188.6万 | 9.4万股 | $0 | 0股 | +9.4万股 | 新买入 |
| Financial Enhancement Group LLC |
| 0.18% | — | #15 | $149.8万 | 7.4万股 | $0 | 0股 | +7.4万股 | 新买入 |
| ADAR1 Capital Management, LLC |
| 0.07% | — | #22 | $144.7万 | 7.2万股 | $0 | 0股 | +7.2万股 | 新买入 |
| 景顺Invesco Ltd. |
| <0.01% | — | #113 | $142.9万 | 7.1万股 | $0 | 0股 | +7.1万股 | 新买入 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| <0.01% | — | #99 | $140.5万 | 7.0万股 | $0 | 0股 | +7.0万股 | 新买入 |
| 挪威央行投资管理NORGES BANK |
| <0.01% | — | #111 | $139.0万 | 6.9万股 | $0 | 0股 | +6.9万股 | 新买入 |
| Opaleye Management Inc. |
| 0.12% | — | #18 | $130.8万 | 6.5万股 | $0 | 0股 | +6.5万股 | 新买入 |
| Quantinno资本管理Quantinno Capital Management LP |
| <0.01% | — | #50 | $125.7万 | 6.2万股 | $0 | 0股 | +6.2万股 | 新买入 |
