| MPM BioImpact LLC |
| 9.5% | 6.68% | #2 | $1.56亿 | 483.6万股 | $8,651.4万 | 483.6万股 | 00.00% | 持仓不变 |
| EcoR1 Capital, LLC |
| 7.56% | 3.66% | #3 | $1.55亿 | 482.4万股 | $8,631.0万 | 482.4万股 | 00.00% | 持仓不变 |
| Blue Owl Capital Holdings LP |
| 14.41% | 15.2% | #1 | $9,895.3万 | 307.0万股 | $5,655.7万 | 316.1万股 | -9.1万股-2.88% | 减仓 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #46 | $7,343.1万 | 227.8万股 | $3,778.6万 | 211.2万股 | +16.6万股+7.87% | 加仓 |
| 普信投资管理T. Rowe Price Investment Management, Inc. |
| 0.04% | 0.03% | #17 | $6,611.8万 | 205.1万股 | $3,799.5万 | 212.4万股 | -7.2万股-3.41% | 减仓 |
| 惠灵顿管理集团WELLINGTON MANAGEMENT GROUP LLP |
| 0.01% | 0.01% | #26 | $6,337.2万 | 196.6万股 | $4,145.2万 | 231.7万股 | -35.1万股-15.14% | 减仓 |
| RTW投资RTW INVESTMENTS, LP |
| 0.44% | 0.28% | #9 | $5,131.2万 | 159.2万股 | $2,848.2万 | 159.2万股 | 00.00% | 持仓不变 |
| RA资本管理RA CAPITAL MANAGEMENT, L.P. |
| 0.37% | 0.28% | #10 | $4,236.3万 | 131.4万股 | $2,689.0万 | 150.3万股 | -18.9万股-12.55% | 减仓 |
| 木星资产管理Jupiter Topco LLC |
| 0.02% | — | #24 | $4,235.9万 | 131.4万股 | $0 | 0股 | +131.4万股 | 新买入 |
| 贝克兄弟顾问BAKER BROS. ADVISORS LP |
| 0.16% | 0.1% | #13 | $3,211.2万 | 99.6万股 | $1,782.5万 | 99.6万股 | 00.00% | 持仓不变 |
| Octagon Capital Advisors LP |
| 2.78% | 1.9% | #5 | $3,096.8万 | 96.1万股 | $1,719.0万 | 96.1万股 | 00.00% | 持仓不变 |
| Merck & Co., Inc. |
| 5.83% | 4.88% | #4 | $3,071.0万 | 95.3万股 | $1,704.6万 | 95.3万股 | 00.00% | 持仓不变 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #57 | $2,633.4万 | 81.7万股 | $1,491.9万 | 83.4万股 | -1.7万股-2.02% | 减仓 |
| 普信集团PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | <0.01% | #37 | $2,460.8万 | 76.3万股 | $2,798.5万 | 156.4万股 | -80.1万股-51.19% | 减仓 |
| TCG Crossover 管理TCG Crossover Management, LLC |
| 0.54% | — | #8 | $2,245.0万 | 69.7万股 | $0 | 0股 | +69.7万股 | 新买入 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #50 | $1,678.7万 | 52.1万股 | $880.3万 | 49.2万股 | +2.9万股+5.85% | 加仓 |
| 暮色资产管理EVENTIDE ASSET MANAGEMENT, LLC |
| 0.22% | 0.15% | #12 | $1,634.1万 | 50.7万股 | $907.0万 | 50.7万股 | 00.00% | 持仓不变 |
| Avidity Partners Management LP |
| 2.5% | 1.7% | #6 | $1,560.6万 | 48.4万股 | $838.3万 | 46.9万股 | +1.6万股+3.34% | 加仓 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #60 | $1,560.0万 | 48.4万股 | $766.1万 | 42.8万股 | +5.6万股+13.02% | 加仓 |
| Alyeska投资集团Alyeska Investment Group, L.P. |
| 0.02% | 0.01% | #22 | $934.7万 | 29.0万股 | $518.8万 | 29.0万股 | 00.00% | 持仓不变 |
| 富达投资FMR LLC |
| <0.01% | <0.01% | #65 | $920.6万 | 28.6万股 | $691.2万 | 38.6万股 | -10.1万股-26.07% | 减仓 |
| ArrowMark Colorado Holdings LLC |
| 0.33% | 0.16% | #11 | $792.4万 | 24.6万股 | $589.4万 | 32.9万股 | -8.4万股-25.37% | 减仓 |
| a16z资本管理a16z Capital Management, L.L.C. |
| 0.59% | 0.58% | #7 | $742.4万 | 41.5万股 | $742.4万 | 41.5万股 | 00.00% | 持仓不变 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #54 | $582.0万 | 18.1万股 | $267.4万 | 14.9万股 | +3.1万股+20.81% | 加仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #53 | $537.7万 | 16.7万股 | $289.8万 | 16.2万股 | +4,825股+2.98% | 加仓 |
| 巴克莱BARCLAYS PLC |
| <0.01% | <0.01% | #49 | $488.9万 | 15.2万股 | $17.4万 | 9,724股 | +14.2万股+1,460.02% | 加仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #71 | $468.0万 | 14.5万股 | $215.3万 | 12.0万股 | +2.5万股+20.69% | 加仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #48 | $431.3万 | 13.4万股 | $227.9万 | 12.7万股 | +6,439股+5.05% | 加仓 |
| 道明资产管理TD ASSET MANAGEMENT INC |
| <0.01% | <0.01% | #36 | $341.3万 | 10.6万股 | $180.6万 | 10.1万股 | +4,940股+4.89% | 加仓 |
| Woodline合伙人Woodline Partners LP |
| 0.01% | 0.01% | #28 | $322.3万 | 10.0万股 | $178.9万 | 10.0万股 | 00.00% | 持仓不变 |
| 索罗斯基金管理SOROS FUND MANAGEMENT LLC |
| 0.04% | 0.02% | #18 | $322.3万 | 10.0万股 | $178.9万 | 10.0万股 | 00.00% | 持仓不变 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #64 | $322.2万 | 10.0万股 | $632.0万 | 35.3万股 | -25.3万股-71.70% | 减仓 |
| 文艺复兴科技RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | — | #33 | $307.5万 | 9.5万股 | $0 | 0股 | +9.5万股 | 新买入 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #75 | $234.7万 | 7.3万股 | $125.1万 | 7.0万股 | +2,909股+4.16% | 加仓 |
| Polen资本管理POLEN CAPITAL MANAGEMENT LLC |
| 0.02% | — | #23 | $204.7万 | 6.4万股 | $0 | 0股 | +6.4万股 | 新买入 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | — | #82 | $201.9万 | 6.3万股 | $0 | 0股 | +6.3万股 | 新买入 |
| Tidal投资Tidal Investments LLC |
| <0.01% | — | #35 | $183.9万 | 5.7万股 | $0 | 0股 | +5.7万股 | 新买入 |
| 雷蒙德詹姆斯金融RAYMOND JAMES FINANCIAL INC |
| <0.01% | — | #62 | $162.6万 | 5.0万股 | $0 | 0股 | +5.0万股 | 新买入 |
| 纽文Nuveen, LLC |
| <0.01% | <0.01% | #66 | $160.6万 | 5.0万股 | $43.8万 | 2.4万股 | +2.5万股+103.60% | 加仓 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| <0.01% | <0.01% | #70 | $158.7万 | 4.9万股 | $76.7万 | 4.3万股 | +6,349股+14.80% | 加仓 |
| AQR资本管理AQR CAPITAL MANAGEMENT LLC |
| <0.01% | — | #58 | $155.1万 | 4.8万股 | $0 | 0股 | +4.8万股 | 新买入 |
| 宏利人寿MANUFACTURERS LIFE INSURANCE COMPANY, THE |
| <0.01% | <0.01% | #45 | $154.8万 | 4.8万股 | $84.1万 | 4.7万股 | +1,051股+2.24% | 加仓 |
| Quantinno资本管理Quantinno Capital Management LP |
| <0.01% | — | #39 | $151.1万 | 4.7万股 | $0 | 0股 | +4.7万股 | 新买入 |
| 五大湖顾问GREAT LAKES ADVISORS, LLC |
| 0.01% | — | #27 | $140.6万 | 4.4万股 | $0 | 0股 | +4.4万股 | 新买入 |
| Mirador Capital Partners LP |
| 0.16% | — | #14 | $129.3万 | 4.0万股 | $0 | 0股 | +4.0万股 | 新买入 |
| SquarepointSquarepoint Ops LLC |
| <0.01% | — | #43 | $123.7万 | 3.8万股 | $0 | 0股 | +3.8万股 | 新买入 |
| 跳跃金融Jump Financial, LLC |
| 0.01% | — | #29 | $105.6万 | 3.3万股 | $0 | 0股 | +3.3万股 | 新买入 |
| Sofinnova Investments, Inc. |
| 0.05% | — | #16 | $104.5万 | 3.2万股 | $0 | 0股 | +3.2万股 | 新买入 |
| Two Sigma投资TWO SIGMA INVESTMENTS, LP |
| <0.01% | — | #52 | $99.6万 | 3.1万股 | $0 | 0股 | +3.1万股 | 新买入 |
| 富国银行WELLS FARGO & COMPANY/MN |
| <0.01% | <0.01% | #76 | $89.1万 | 2.8万股 | $13.6万 | 7,611股 | +2.0万股+263.41% | 加仓 |
