| RA资本管理RA CAPITAL MANAGEMENT, L.P. |
| 6.88% | — | #5 | $7.92亿 | 2,893.3万股 | $0 | 0股 | +2,893.3万股 | 新买入 |
| 富达投资FMR LLC |
| 0.01% | — | #30 | $2.82亿 | 1,029.3万股 | $0 | 0股 | +1,029.3万股 | 新买入 |
| ARCH Venture Management, LLC |
| 15.95% | — | #4 | $1.76亿 | 641.3万股 | $0 | 0股 | +641.3万股 | 新买入 |
| venBio Partners LLC |
| 27.75% | — | #2 | $1.44亿 | 526.7万股 | $0 | 0股 | +526.7万股 | 新买入 |
| Nextech Invest Ltd. |
| 6.08% | — | #7 | $1.28亿 | 466.3万股 | $0 | 0股 | +466.3万股 | 新买入 |
| Cormorant Asset Management, LP |
| 6.41% | — | #6 | $1.26亿 | 461.6万股 | $0 | 0股 | +461.6万股 | 新买入 |
| REGENERON PHARMACEUTICALS, INC. |
| 64.35% | — | #1 | $1.14亿 | 416.7万股 | $0 | 0股 | +416.7万股 | 新买入 |
| Siren, L.L.C. |
| 1.66% | — | #10 | $8,189.8万 | 299.2万股 | $0 | 0股 | +299.2万股 | 新买入 |
| 法伦资本FARALLON CAPITAL MANAGEMENT, L.L.C. |
| 0.3% | — | #21 | $6,481.8万 | 236.8万股 | $0 | 0股 | +236.8万股 | 新买入 |
| 木星资产管理Jupiter Topco LLC |
| 0.03% | — | #28 | $6,271.0万 | 229.7万股 | $0 | 0股 | +229.7万股 | 新买入 |
| Frazier Life Sciences 管理Frazier Life Sciences Management, L.P. |
| 1.14% | — | #14 | $5,257.2万 | 192.1万股 | $0 | 0股 | +192.1万股 | 新买入 |
| Deerfield管理DEERFIELD MANAGEMENT COMPANY, L.P. |
| 0.54% | — | #18 | $5,147.5万 | 188.1万股 | $0 | 0股 | +188.1万股 | 新买入 |
| General Catalyst Group Management, LLC |
| 23.24% | — | #3 | $4,381.8万 | 160.1万股 | $0 | 0股 | +160.1万股 | 新买入 |
| GENERAL ATLANTIC, L.P. |
| 1.45% | — | #11 | $4,210.8万 | 153.8万股 | $0 | 0股 | +153.8万股 | 新买入 |
| Soleus 资本管理Soleus Capital Management, L.P. |
| 1.38% | — | #12 | $4,009.9万 | 146.5万股 | $0 | 0股 | +146.5万股 | 新买入 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | — | #50 | $3,564.9万 | 130.2万股 | $0 | 0股 | +130.2万股 | 新买入 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | — | #56 | $3,166.6万 | 115.7万股 | $0 | 0股 | +115.7万股 | 新买入 |
| 摩根大通JPMORGAN CHASE & CO |
| <0.01% | — | #49 | $3,043.9万 | 104.3万股 | $0 | 0股 | +104.3万股 | 新买入 |
| Foresite Capital Management VI LLC |
| 4.26% | — | #8 | $2,734.4万 | 99.9万股 | $0 | 0股 | +99.9万股 | 新买入 |
| Catalio Capital Management, LP |
| 4.24% | — | #9 | $2,255.4万 | 82.4万股 | $0 | 0股 | +82.4万股 | 新买入 |
| 联博ALLIANCEBERNSTEIN L.P. |
| 0.01% | — | #35 | $2,217.7万 | 81.0万股 | $0 | 0股 | +81.0万股 | 新买入 |
| 普信集团PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | — | #43 | $2,058.1万 | 75.2万股 | $0 | 0股 | +75.2万股 | 新买入 |
| Casdin Capital, LLC |
| 0.88% | — | #15 | $1,767.3万 | 64.6万股 | $0 | 0股 | +64.6万股 | 新买入 |
| Venrock Adviser, LLC |
| 0.52% | — | #19 | $1,710.6万 | 62.5万股 | $0 | 0股 | +62.5万股 | 新买入 |
| Rock Springs Capital Management LP |
| 0.77% | — | #16 | $1,582.1万 | 57.8万股 | $0 | 0股 | +57.8万股 | 新买入 |
| Samsara BioCapital, LLC |
| 1.25% | — | #13 | $1,521.9万 | 55.6万股 | $0 | 0股 | +55.6万股 | 新买入 |
| Logos Global Management LP |
| 0.62% | — | #17 | $1,436.9万 | 52.5万股 | $0 | 0股 | +52.5万股 | 新买入 |
| 贝克兄弟顾问BAKER BROS. ADVISORS LP |
| 0.07% | — | #25 | $1,368.5万 | 50.0万股 | $0 | 0股 | +50.0万股 | 新买入 |
| Bellevue 集团Bellevue Group AG |
| 0.29% | — | #22 | $1,368.5万 | 50.0万股 | $0 | 0股 | +50.0万股 | 新买入 |
| 马歇尔·韦斯MARSHALL WACE, LLP |
| 0.01% | — | #34 | $1,218.9万 | 44.5万股 | $0 | 0股 | +44.5万股 | 新买入 |
| 富兰克林资源FRANKLIN RESOURCES INC |
| <0.01% | — | #42 | $1,044.1万 | 38.1万股 | $0 | 0股 | +38.1万股 | 新买入 |
| ICONIQ 资本ICONIQ Capital, LLC |
| 0.28% | — | #23 | $958.0万 | 35.0万股 | $0 | 0股 | +35.0万股 | 新买入 |
| MFS马萨诸塞金融服务MASSACHUSETTS FINANCIAL SERVICES CO /MA/ |
| <0.01% | — | #39 | $810.0万 | 29.6万股 | $0 | 0股 | +29.6万股 | 新买入 |
| Kynam Capital Management, LP |
| 0.38% | — | #20 | $684.3万 | 25.0万股 | $0 | 0股 | +25.0万股 | 新买入 |
| Federated HermesFEDERATED HERMES, INC. |
| 0.01% | — | #33 | $673.8万 | 24.6万股 | $0 | 0股 | +24.6万股 | 新买入 |
| 阿默普莱斯金融AMERIPRISE FINANCIAL INC |
| <0.01% | — | #53 | $478.4万 | 17.5万股 | $0 | 0股 | +17.5万股 | 新买入 |
| Driehaus资本管理DRIEHAUS CAPITAL MANAGEMENT LLC |
| 0.02% | — | #29 | $273.7万 | 10.0万股 | $0 | 0股 | +10.0万股 | 新买入 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | — | #66 | $271.9万 | 9.9万股 | $0 | 0股 | +9.9万股 | 新买入 |
| 道明资产管理TD ASSET MANAGEMENT INC |
| <0.01% | — | #44 | $210.7万 | 7.7万股 | $0 | 0股 | +7.7万股 | 新买入 |
| SquarepointSquarepoint Ops LLC |
| <0.01% | — | #51 | $132.7万 | 4.8万股 | $0 | 0股 | +4.8万股 | 新买入 |
| 都铎投资TUDOR INVESTMENT CORP ET AL |
| <0.01% | — | #48 | $120.6万 | 4.4万股 | $0 | 0股 | +4.4万股 | 新买入 |
| 瑞银集团UBS Group AG |
| <0.01% | — | #67 | $105.9万 | 3.9万股 | $0 | 0股 | +3.9万股 | 新买入 |
| WINTON 集团WINTON GROUP Ltd |
| 0.03% | — | #27 | $95.5万 | 3.5万股 | $0 | 0股 | +3.5万股 | 新买入 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | — | #65 | $76.1万 | 2.8万股 | $0 | 0股 | +2.8万股 | 新买入 |
| Balyasny资产管理BALYASNY ASSET MANAGEMENT L.P. |
| <0.01% | — | #54 | $66.4万 | 2.4万股 | $0 | 0股 | +2.4万股 | 新买入 |
| 哈德逊湾资本管理Hudson Bay Capital Management LP |
| <0.01% | — | #47 | $62.1万 | 2.3万股 | $0 | 0股 | +2.3万股 | 新买入 |
| Brevan Howard资本管理Brevan Howard Capital Management LP |
| <0.01% | — | #36 | $61.8万 | 2.3万股 | $0 | 0股 | +2.3万股 | 新买入 |
| 吉萨洛资本管理Ghisallo Capital Management LLC |
| <0.01% | — | #37 | $54.7万 | 2.0万股 | $0 | 0股 | +2.0万股 | 新买入 |
| 三菱UFJ资产管理Mitsubishi UFJ Asset Management Co., Ltd. |
| <0.01% | — | #60 | $52.6万 | 1.9万股 | $0 | 0股 | +1.9万股 | 新买入 |
| 先锋领航个性化指数管理Vanguard Personalized Indexing Management, LLC |
| <0.01% | — | #40 | $32.1万 | 1.2万股 | $0 | 0股 | +1.2万股 | 新买入 |
