| 暮色资产管理EVENTIDE ASSET MANAGEMENT, LLC |
| 1.31% | 0.99% | #6 | $9,805.4万 | 625.4万股 | $5,956.7万 | 594.5万股 | +30.8万股+5.18% | 加仓 |
| Soleus 资本管理Soleus Capital Management, L.P. |
| 2.37% | 1.77% | #5 | $6,884.9万 | 439.4万股 | $4,363.2万 | 435.5万股 | +3.9万股+0.90% | 加仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #36 | $6,686.1万 | 426.7万股 | $7,474.3万 | 376.2万股 | +50.5万股+13.43% | 加仓 |
| Sands Capital Alternatives, LLC |
| 9.47% | 8.82% | #3 | $5,810.5万 | 370.8万股 | $3,715.5万 | 370.8万股 | 00.00% | 持仓不变 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #55 | $5,234.0万 | 334.0万股 | $3,044.7万 | 303.9万股 | +30.2万股+9.92% | 加仓 |
| Point72资产管理Point72 Asset Management, L.P. |
| 0.04% | 0.03% | #23 | $3,533.1万 | 225.5万股 | $2,530.1万 | 252.5万股 | -27.0万股-10.71% | 减仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #66 | $2,792.9万 | 178.2万股 | $1,731.4万 | 172.8万股 | +5.4万股+3.15% | 加仓 |
| Vestal Point 资本Vestal Point Capital, LP |
| 0.59% | 0.62% | #9 | $2,507.2万 | 160.0万股 | $2,215.9万 | 221.2万股 | -61.2万股-27.65% | 减仓 |
| RTW投资RTW INVESTMENTS, LP |
| 0.2% | 0.2% | #15 | $2,350.5万 | 150.0万股 | $2,004.0万 | 200.0万股 | -50.0万股-25.00% | 减仓 |
| Deerfield管理DEERFIELD MANAGEMENT COMPANY, L.P. |
| 0.22% | 0.16% | #14 | $2,074.7万 | 132.4万股 | $1,326.6万 | 132.4万股 | 00.00% | 持仓不变 |
| Omega Fund Management, LLC |
| 11.11% | 8.08% | #2 | $2,062.5万 | 131.6万股 | $1,318.8万 | 131.6万股 | 00.00% | 持仓不变 |
| Eversept Partners, LP |
| 1.02% | 0.75% | #7 | $1,957.9万 | 124.9万股 | $1,417.7万 | 141.5万股 | -16.5万股-11.69% | 减仓 |
| Divisadero Street 资本管理Divisadero Street Capital Management, LP |
| 0.4% | — | #10 | $1,745.3万 | 111.4万股 | $0 | 0股 | +111.4万股 | 新买入 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #54 | $1,682.5万 | 107.3万股 | $934.8万 | 93.3万股 | +14.1万股+15.09% | 加仓 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #73 | $1,520.3万 | 97.0万股 | $948.0万 | 94.6万股 | +2.4万股+2.55% | 加仓 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| 0.01% | <0.01% | #34 | $1,498.4万 | 95.6万股 | $862.6万 | 86.1万股 | +9.5万股+11.08% | 加仓 |
| Balyasny资产管理BALYASNY ASSET MANAGEMENT L.P. |
| 0.02% | 0.01% | #28 | $1,340.9万 | 85.6万股 | $619.2万 | 61.8万股 | +23.8万股+38.48% | 加仓 |
| 洞察顾问PERCEPTIVE ADVISORS LLC |
| 0.2% | 0.17% | #16 | $1,305.2万 | 83.3万股 | $844.6万 | 84.3万股 | -1.0万股-1.19% | 减仓 |
| 摩根大通JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #61 | $1,195.7万 | 70.3万股 | $302.9万 | 30.7万股 | +39.6万股+128.94% | 加仓 |
| Bruce & Co., Inc. |
| 2.92% | 1.58% | #4 | $1,043.2万 | 66.6万股 | $551.8万 | 55.1万股 | +11.5万股+20.88% | 加仓 |
| 法伦资本FARALLON CAPITAL MANAGEMENT, L.L.C. |
| 0.04% | 0.21% | #22 | $932.4万 | 59.5万股 | $3,615.1万 | 360.8万股 | -301.3万股-83.51% | 减仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #68 | $856.6万 | 54.7万股 | $136.5万 | 13.6万股 | +41.0万股+301.31% | 加仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #58 | $841.6万 | 53.7万股 | $121.6万 | 12.1万股 | +41.6万股+342.67% | 加仓 |
| Trexquant投资Trexquant Investment LP |
| 0.05% | 0.02% | #21 | $774.8万 | 49.4万股 | $242.1万 | 24.2万股 | +25.3万股+104.65% | 加仓 |
| Tri Locum Partners LP |
| 0.95% | — | #8 | $773.1万 | 49.3万股 | $0 | 0股 | +49.3万股 | 新买入 |
| 安大略医疗养老基金(HOOPP)HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND |
| 0.01% | 0.01% | #31 | $641.4万 | 40.9万股 | $547.2万 | 54.6万股 | -13.7万股-25.05% | 减仓 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #56 | $605.8万 | 38.7万股 | $624.5万 | 62.3万股 | -23.7万股-37.97% | 减仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #57 | $549.8万 | 35.1万股 | $323.1万 | 32.2万股 | +2.8万股+8.81% | 加仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #65 | $520.2万 | 33.2万股 | $296.4万 | 29.6万股 | +3.6万股+12.22% | 加仓 |
| AQR资本管理AQR CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #45 | $483.4万 | 30.8万股 | $60.4万 | 6.0万股 | +24.8万股+411.67% | 加仓 |
| Granahan 投资管理Granahan Investment Management, LLC |
| 0.17% | 0.12% | #18 | $469.5万 | 30.0万股 | $248.9万 | 24.8万股 | +5.1万股+20.60% | 加仓 |
| PURA VIDA INVESTMENTS, LLC |
| 11.91% | 18.94% | #1 | $440.6万 | 28.1万股 | $281.8万 | 28.1万股 | -86股-0.03% | 减仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #88 | $427.8万 | 27.3万股 | $229.5万 | 22.9万股 | +4.4万股+19.19% | 加仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #53 | $419.8万 | 26.8万股 | $272.6万 | 27.2万股 | -4,171股-1.53% | 减仓 |
| MarinerMariner, LLC |
| <0.01% | — | #35 | $345.3万 | 22.0万股 | $0 | 0股 | +22.0万股 | 新买入 |
| Jain GlobalJain Global LLC |
| 0.01% | <0.01% | #29 | $270.4万 | 17.3万股 | $56.7万 | 5.7万股 | +11.6万股+204.83% | 加仓 |
| SquarepointSquarepoint Ops LLC |
| <0.01% | — | #39 | $252.4万 | 16.1万股 | $0 | 0股 | +16.1万股 | 新买入 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| <0.01% | <0.01% | #78 | $192.6万 | 12.3万股 | $99.0万 | 9.9万股 | +2.4万股+24.38% | 加仓 |
| 拉扎德资产管理LAZARD ASSET MANAGEMENT LLC |
| <0.01% | <0.01% | #42 | $149.7万 | 9.6万股 | $72.0万 | 7.2万股 | +2.4万股+32.89% | 加仓 |
| 纽文Nuveen, LLC |
| <0.01% | <0.01% | #77 | $143.2万 | 9.1万股 | $86.1万 | 8.6万股 | +5,443股+6.33% | 加仓 |
| 花旗集团CITIGROUP INC |
| <0.01% | <0.01% | #76 | $116.0万 | 7.4万股 | $2.0万 | 2,013股 | +7.2万股+3,578.84% | 加仓 |
| Bellevue 集团Bellevue Group AG |
| 0.02% | 0.02% | #25 | $113.1万 | 7.2万股 | $72.3万 | 7.2万股 | 00.00% | 持仓不变 |
| 未来资产环球ETFMIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
| <0.01% | <0.01% | #49 | $109.6万 | 7.0万股 | $71.4万 | 7.1万股 | -1,252股-1.76% | 减仓 |
| 都铎投资TUDOR INVESTMENT CORP ET AL |
| <0.01% | <0.01% | #48 | $100.0万 | 6.4万股 | $218.5万 | 21.8万股 | -15.4万股-70.74% | 减仓 |
| Y截距(香港)Y-Intercept (Hong Kong) Ltd |
| 0.02% | 0.09% | #27 | $98.8万 | 6.3万股 | $486.8万 | 48.6万股 | -42.3万股-87.03% | 减仓 |
| 简街集团JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #106 | $90.3万 | 5.8万股 | $19.0万 | 1.9万股 | +3.9万股+203.16% | 加仓 |
| Archon Capital Management LLC |
| 0.34% | — | #12 | $84.4万 | 5.4万股 | $0 | 0股 | +5.4万股 | 新买入 |
| RhumbLine顾问RHUMBLINE ADVISERS |
| <0.01% | <0.01% | #64 | $80.3万 | 5.1万股 | $46.5万 | 4.6万股 | +4,824股+10.39% | 加仓 |
| Values First Advisors, Inc. |
| 0.36% | 0.25% | #11 | $79.8万 | 5.1万股 | $47.6万 | 4.8万股 | +3,349股+7.04% | 加仓 |
| DEUTSCHE 银行 AG\DEUTSCHE BANK AG\ |
| <0.01% | <0.01% | #86 | $75.6万 | 4.8万股 | $43.8万 | 4.4万股 | +4,521股+10.35% | 加仓 |
